OOIR: Observatory of International Research

Papers

(The TQCC of Organic Process Research & Development is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	191
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	111
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	68
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	68
Application of an Interdisciplinary Approach to Form Selection in Drug Development	60
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	58
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	57
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	57
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	55
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	54
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	52
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	50
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	50
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	46
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	45
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	45
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	40
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	39
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	38
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	38
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	34
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	34
Issue Publication Information	32
Issue Editorial Masthead	32
Issue Publication Information	32

A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	32
Issue Editorial Masthead	30
Issue Editorial Masthead	30
Issue Editorial Masthead	30
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	30
Issue Publication Information	30
A Scalable Process for Synthesizing a Reactive Silicone-Acrylate Monomer	29
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	29
Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754	28
Enhancing the Sustainability and Scalability of Transition-Metal-Free Stereoretentive Decarboxylative Amidation with Dioxazolones	27
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	27
RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy	27
Risk Assessment Study of Nitrosamines for the API Temozolomide Industrial Process	26
Excellence in Industrial Organic Synthesis 2021	26
Screening Platform for Immobilized Biocatalysts Utilizing Miniature Rotating Bed Reactors	26
Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions	25
Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties	25
Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence	25
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	25
One-Pot Synthesis of Guanidinium 5,5′-Azotetrazolate Avoiding Isolation of Hazardous Sodium 5,5′-Azotetrazolate	25
Process Development for Continuous Manufacturing of Baloxavir Marboxil. Part 2: Step 2 Synthesis	24
Efficient and Improved Solution-Phase Synthesis of Modified RNA Dinucleotides: Versatile Synthons in Cap 1 mRNA Therapeutics	23
Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009	23
Regulatory Highlights	23
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl₂-BINOL	22
Some Items of Interest to Process R&D Chemists and Engineers	22
Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities	22
Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs	22
Lessons Learned in Developing a Manufacturing Facility for Flow Chemistry	22
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation	22
Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991	22
Asymmetric Synthesis of Optically Active 3-Cyclohexene-1-carboxylic Acid Utilizing Lactic Ester as a Chiral Auxiliary in the Diastereoselective Diels–Alder Reaction	22
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena	21
Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry	21
Development of a Sustainable Chemoenzymatic Process for (S)-Pregabalin Synthesis via Nitrilase-Catalyzed Hydrolysis and Continuous Flow Racemization	21
Highly Selective Hydrogenation of Phenols to Cyclohexanone Derivatives Using a Palladium@N-Doped Carbon/SiO₂ Catalyst	21
Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole	21
Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents	20
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1H-Tetrazoles	20
Thermal Hazard Assessment of the Synthesis of 1,1′-Azobis-1,2,3-triazole	20
Optimizing the CHF6523 Isocoumarin Core Scaffold: From the Preclinical Stage to Large-Scale Production	20
Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718	20
Issue Publication Information	20
Issue Publication Information	19
Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183	19
Issue Editorial Masthead	19
Approaches and Considerations for the Investigation and Synthesis of N-Nitrosamine Drug Substance-Related Impurities (NDSRIs)	19
Issue Publication Information	19
Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors	18
Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker	18

Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O	18
Thermal Decomposition Kinetics of Benzoyl Peroxide Based on Thermogravimetric Analysis and DFT Simulations	18
Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug	18
Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876	18
Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling Reaction	18
Development and Scale-Up of an Enabling Synthetic Route to KTX-005, a Muscarinic Acetylcholine Receptor Agonist for the Potential Treatment of Schizophrenia	18
Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development	18
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment	18
“On-Water” Reaction of (Thio)isocyanate: A Sustainable Process for the Synthesis of Unsymmetrical (Thio)ureas	17
Economic, One-Pot Synthesis of Diethyl Furoxan Dicarboxylate	17
Properties of Packed Bed Structures Formed during Filtration: A Two and Three-Dimensional Model	17
Low-Level Quantification of tert-Butyl Nitrite in a Pharmaceutical Intermediate	17
Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis	17
Novel Baeyer–Villiger Oxidation of Nucleosides Applied to the Large-Scale Synthesis of MeMOP: A Key Amidite in the GalXC Platform	17
Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol	17
Reaction of Irbesartan with Nitrous Acid Produces Irbesartan Oxime Derivatives, rather than N-Nitrosoirbesartan	17
Characterization, Solubility, and Hygroscopicity of BMS-817399	17
Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707	17
Some Items of Interest to Process R&D Chemists and Engineers	16
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19	16
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	16
Practical Kilogram Synthesis of (S)-1-Benzyl-4-Bromo-3-Methyl-1,2,3,6-Tetrahydropyridine	16
Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy	16
Thermal and Kinetic Research on a Highly Exothermic Condensation Reaction by Powerful Calorimeters	15
Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents	15
A Critical Account of Synthetic Approaches toward Vildagliptin, an Antidiabetic Drug	15
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	15
Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations	15
Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment	15
New Saturated Bicyclic Pyrrolidines: The Multigram Synthesis and Orthogonal Functionalization	15
Polymorph and Salt/Cocrystal Screening to Identify a Suitable Physical Form for an LPAR1 Antagonist, GS-2278	15
Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate	15
Automated Image-Based Color Analysis as an Accessible and Widely Applicable PAT Tool	15
Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis	14
A Short Review on the Synthetic Routes for the Antiepileptic Drug (S)-Levetiracetam	14
Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease	14
Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients	14
An Easy and Adjustable One-Pot Access to Pheromonal Blends of Fall Armyworm (Spodoptera frugiperda) Relying on a Key Ligand- and Additive-Free Iron-Catalyzed Cross-Coupling	14
Discovery of Oxazole Byproduct Formation in the Modified Dakin–West Reaction and Efficient Synthesis of Diastereomeric α-Ketoamide Cysteine Protease Inhibitors	14
Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence	14
Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies	14
Continuous Flow Synthesis of Esomeprazole via Asymmetric Sulfoxidation	14
Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO₂SCF₂H	14
Evaluating Resonant Acoustic Mixing as a Wet Granulation Process	14
Unique Superbase TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene): From Catalytic Activity and One-Pot Synthesis to Broader Application in Industrial Chemistry	14
Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRAS^G12C Inhibitors	14
Evaluation and Removal of Production Process Constraints in the Synthesis of 3,5-Dibromopyrazole	13
Development of a Scalable Anodic Oxidation Process for (R)-Troloxamide Quinone (EPI-589) Using a Continuous Flow Approach	13
Commercially Viable Synthesis of Medetomidine Using a Classical Approach to the Imidazole Ring Formation	13
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	13
Recent Advances in Nonprecious Metal Catalysis	13
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides	13
Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases	13
Some Items of Interest to Process R&D Chemists and Engineers	13
Synthesis of a Pyridoazepine Scaffold via Rhodium-Catalyzed Ring Expansion and Nitroacetamide Condensation	13
Manufacturable Process of a Novel EGFR Inhibitor (Larotinib) for the Treatment of ESCC	13
Developing and Optimizing a Quench-Crystallization Operation in Drug Substance Manufacturing	13
Optimization of Nitrosation Reaction for Synthesis of 4-Aminoantipyrine by Response Surface Methodology and Its Reaction Mechanism	13
Expeditious and Automated Dispensing of ChemBeads for High-Throughput Experimentation in 384-Well Microtiter Plates	13
Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes	12
Optimization and Development of a Scalable Palladium-Catalyzed C–H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator	12
Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands	12
Engineering a Transaminase for the Efficient Synthesis of a Key Intermediate for Rimegepant	12
Issue Publication Information	12
Nitrosamine Risk Assessments in Oligonucleotides	12
Issue Publication Information	12
Hybrid Flow-Batch Model for the Efficient Synthesis of 2-(Dimethylamino)-6-methylpyridin-4-ol	12
Multigram-Scale Synthesis and Study of Reactivity of Two Difluoromethylating Reagents Based on Sulfoximine Skeletons	12
Strategies for the Production of [¹¹C]LY2795050 for Clinical Use	12
Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol	12
Issue Publication Information	12
Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source	12
Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient	12
Issue Publication Information	12
An Alternative Route to the Anticancer Agent: 2-Fluorofucose from Readily Available L-(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination Reaction	12
Issue Editorial Masthead	12
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy	12
Continuous Flow Intensification for the Synthesis of High-Purity Warfarin	11
Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction	11
Issue Editorial Masthead	11

Some Items of Interest to Process R&D Chemists and Engineers	11
Practical and Efficient Approach to Scalable Synthesis of Rucaparib	11
Green and Low-Cost Synthesis of Thermally Stable Cation-Exchange Resin-Supported Diazonium Salt: An Example of Weakly Basic p-Nitroaniline Diazotization	11
Issue Publication Information	11
Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod	11
Continuous Crystallization of Atorvastatin Calcium at a Multitonnage Scale Using Dynamically Mixed Flow Reactors for Target Polymorph Control	11
Ketoprofen Solubility in Pure Organic Solvents Using In Situ FTIR and UV–Vis and Analysis of Solution Thermodynamics	11
Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale	11
Integrated Flow Emulsion Electrosynthetic System by In Situ Generation of Emulsions, Subsequent Emulsion Electrolysis, and Final Phase Separation	11
Mass Transport of Diazomethane across Teflon AF2400 Membrane for Scale-Up Development	11
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19	11
Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF₄) and Dialkylamines in Continuous Flow Mode	11
Practical One-Pot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis-(2-nitrophenyl)-disulfides	11
Robust Analytical Methods for Monitoring the Formation of a Chiral Oxazaborolidine Catalyst	11
A Confined Impinging Jet Reactor for High-Throughput Continuous Flow Mononitration of Salicylic Acid	11
Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes	10
Continuous Flow Synthesis of Crotonic Acid from Crotonaldehyde	10
Stereoselective Construction of 3-(Aminoalkylidene)oxindoles in One Pot: Development of a Novel, Robust, and Scalable Process for the Multigram-Scale Preparation of Nintedanib	10
Process Development and Scale-Up of the Novel β-Lactamase Inhibitor WCK 6395	10
Practical and Scalable Synthesis of 1,3-Adamantanediol	10
Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling	10
Green Chemistry Articles of Interest to the Pharmaceutical Industry	10
Continuous-Flow Oxidation of Amines Based on Nitrogen-Rich Heterocycles: A Facile and Sustainable Approach for Promising Nitro Derivatives	10
Optimized Method to Achieve 1-Hydroxy-5-aminotetrazole (HAT)	10
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part III. Assembly of Drug Substance, Salt Formation, and Impurity Control	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination	10
Reliable Calorimetric Method to Study the Incompatibilities between Hydrazine Hydrate and Metallic Impurities	10
Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Regulatory Highlights	10
Correction to “Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts”	10
Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up	10
Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine	10
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry	10
In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195)	9
Continuous Purification of a Conjugated Short Interfering RNA Therapeutic Using Anion Exchange Twin-Column Chromatography (MCSGP)	9
Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode	9
Efficient Synthesis of a Key Intermediate for Baloxavir Marboxil from a Greener Starting Material: Ethylene Glycol	9
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	9
Development of a Continuous Flow Synthesis of Lorazepam	9
Issue Publication Information	9
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223	9
Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactio	9
Preparation of Impurity-Spiked Good Laboratory Practice Toxicological Batches of Active Pharmaceutical Ingredient Using Resonant Acoustic Mixing	9
Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis	9
Study on the Safety Design of 3-Amino-6-Bromo-1,2,4-Triazine Drying Process Based on Thermal Analysis Technology	9
Green Chemistry Articles of Interest to the Pharmaceutical Industry	9
Technology Transfer and Process Development of Danicopan to Enable Process Validation	9
Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis	9
Quantum Mechanical Methods for Thermal Hazard Risk Assessment in Early Phase Pharmaceutical Development	9
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	9
Multigram, Chromatography-Free Synthesis of the Flavonol Morin	9
Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling	9
Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities	9
Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative	9
Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode	9
Benchtop NMR-Based In-Line Analysis of Diastereoselective Enzymatic α-Amino Acid Synthesis: Quantification and Validation	9
Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors	9
Highly Efficient and Selective Hydrogenation of Sugars Catalyzed by Ru-MACHO-BH: Practical Synthesis of Sugar Alcohols	9
Issue Editorial Masthead	9
Process Safety from Bench to Pilot to Plant	9
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling	9
Issue Editorial Masthead	8
Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A	8
Thermal Safety and Structure-Related Reactivity Investigation of Five-Membered Cyclic Sulfamidates	8
Development of a Scalable Asymmetric Process for the Synthesis of Selective PDE4B Inhibitor Nerandomilast (BI 1015550)	8
A Scalable Solution to Constant-Potential Flow Electrochemistry	8
Issue Publication Information	8
Issue Editorial Masthead	8
Opportunities for Machine Learning and Artificial Intelligence to Advance Synthetic Drug Substance Process Development	8
Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid	8
Kilogram-Scale Preparation of the Amino Alcohol Fragment of Selgantolimod by Enzymatic Resolution of an α,α-Disubstituted Amino Ester	8
Determining Phase Separation Dynamics with an Automated Image Processing Algorithm	8
Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline	8
Efficient Total Synthesis of Bilirubin IXα from Butyrolactone	8
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	8
Actual Process Impurity or an Analytical Artifact? A Case Study Involving Conversion of Amide to Nitrile to Uncover the Truth and Mitigate	8
Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B₁	8
An Ultrafast Production of Imidazoles at Low Temperature with a 3D-Printed Microflow Reactor	8
Acetonitrile Regeneration from Oligonucleotide Production Waste Streams	8
Recent Advances in Nonprecious Metal Catalysis	8
Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture	8
Recent Highlights in Micellar Catalysis: An Industrial Outlook	8
Development of a Safe and Scalable Method to Prepare 3-Bromo-N-alkyl-1,6-naphthyridones via Enamine Cyclization	8
Quantification of Nitrite in Excipients and Chemicals: A Versatile and Highly Sensitive Method Using Headspace Gas Chromatography Coupled to Mass Spectrometry	8
Issue Editorial Masthead	8
Issue Publication Information	8
Advances and Opportunities Concerning Nucleation Measurement and Control Technology in Crystallization	8