OOIR: Observatory of International Research

Papers

(The TQCC of Organic Process Research & Development is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	227
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	129
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	82
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	81
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	75
Issue Editorial Masthead	74
Issue Publication Information	65
Issue Publication Information	64
Issue Editorial Masthead	62
Issue Editorial Masthead	61
Issue Editorial Masthead	61
Issue Publication Information	61
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	59
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	57
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	51
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	48
Application of an Interdisciplinary Approach to Form Selection in Drug Development	47
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	46
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	42
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	41
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	37
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	37
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	36
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	36
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	34

Model Aided Scale-up for Wet Milling	34
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	33
Solvent Effects on Crystallization Kinetics: Investigating Trends across Scales, Methods, and Process Analytical Technologies	33
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	32
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	31
Evolution of the Synthesis Route for CC-99677: From Discovery toward Commercialization	31
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	30
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	30
A Scalable Process for Synthesizing a Reactive Silicone-Acrylate Monomer	29
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	29
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	28
Issue Publication Information	28
Lessons Learned in Developing a Manufacturing Facility for Flow Chemistry	28
Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities	28
Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents	27
Issue Publication Information	27
Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009	27
Issue Publication Information	27
Regulatory Highlights	26
Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991	26
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl₂-BINOL	26
Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs	26
Efficient and Improved Solution-Phase Synthesis of Modified RNA Dinucleotides: Versatile Synthons in Cap 1 mRNA Therapeutics	25
Excellence in Industrial Organic Synthesis 2021	25
Enhancing the Sustainability and Scalability of Transition-Metal-Free Stereoretentive Decarboxylative Amidation with Dioxazolones	25
Asymmetric Synthesis of Optically Active 3-Cyclohexene-1-carboxylic Acid Utilizing Lactic Ester as a Chiral Auxiliary in the Diastereoselective Diels–Alder Reaction	25
RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy	25
One-Pot Synthesis of Guanidinium 5,5′-Azotetrazolate Avoiding Isolation of Hazardous Sodium 5,5′-Azotetrazolate	24
Thermal Hazard Assessment of the Synthesis of 1,1′-Azobis-1,2,3-triazole	24
Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718	24
Optimizing the CHF6523 Isocoumarin Core Scaffold: From the Preclinical Stage to Large-Scale Production	24
Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties	24
Process Development for Continuous Manufacturing of Baloxavir Marboxil. Part 2: Step 2 Synthesis	24
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1H-Tetrazoles	24
Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754	23
Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole	23
Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry	23
Tetramethylchloroformamidinium Hexafluorophosphate– N -Methylimidazole Amidation in Water: Successes, Limitations, and a Regression Model for Prediction	23
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	22
Development of a Sustainable Chemoenzymatic Process for (S)-Pregabalin Synthesis via Nitrilase-Catalyzed Hydrolysis and Continuous Flow Racemization	22
Screening Platform for Immobilized Biocatalysts Utilizing Miniature Rotating Bed Reactors	22
Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence	22
Accelerating Process Innovation through Communications and Technical Notes	21
Aqueous S _N Ar Reactions without a Surfactant: A Scalable Method That Uses Only Water from Start to Finish	21
Risk Assessment Study of Nitrosamines for the API Temozolomide Industrial Process	21
Process Development of the Novel LpxC Inhibitor T-1228. Part 4: Control of Mutagenic Impurities during API Synthesis	20
Approaches and Considerations for the Investigation and Synthesis of N-Nitrosamine Drug Substance-Related Impurities (NDSRIs)	19
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena	19
Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions	19
Design Space Visualization and Technoeconomic Evaluation of a Batch Manufacturing Process for the Green Production of an Anti-cancer Drug (Adavosertib) Precursor	19

Correction to “Evolution of the Synthesis Route for CC-99677: From Discovery Towards Commercialization”	19
Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker	18
A Short Review on the Synthetic Routes for the Antiepileptic Drug (S)-Levetiracetam	18
Bulk Mixing in a Milligram-Scale Solid Phase Batch Reactor	18
Development and Scale-Up of an Enabling Synthetic Route to KTX-005, a Muscarinic Acetylcholine Receptor Agonist for the Potential Treatment of Schizophrenia	18
New Saturated Bicyclic Pyrrolidines: The Multigram Synthesis and Orthogonal Functionalization	18
Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183	18
Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment	17
Some Items of Interest to Process R&D Chemists and Engineers	17
Characterization, Solubility, and Hygroscopicity of BMS-817399	17
Novel Baeyer–Villiger Oxidation of Nucleosides Applied to the Large-Scale Synthesis of MeMOP: A Key Amidite in the GalXC Platform	17
Polymorph and Salt/Cocrystal Screening to Identify a Suitable Physical Form for an LPAR1 Antagonist, GS-2278	17
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	17
Continuous Reduction of an Ester to Aldehyde in CSTR: From Laboratory to Industrial Plant	17
Co-Catalyst Enabled Biotransformation of Polyunsaturated Fatty Acids for Biobased Monomers	17
Properties of Packed Bed Structures Formed during Filtration: A Two and Three-Dimensional Model	17
Discovery of Oxazole Byproduct Formation in the Modified Dakin–West Reaction and Efficient Synthesis of Diastereomeric α-Ketoamide Cysteine Protease Inhibitors	17
Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents	16
“On-Water” Reaction of (Thio)isocyanate: A Sustainable Process for the Synthesis of Unsymmetrical (Thio)ureas	16
Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy	16
Thermal and Kinetic Research on a Highly Exothermic Condensation Reaction by Powerful Calorimeters	15
Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development	15
Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence	15
Thermal Hazard Evaluation and Safety Considerations for the Use of O-Benzoyl-N-alkyl Hydroxylamines as Synthetic Reagents	15
Economic, One-Pot Synthesis of Diethyl Furoxan Dicarboxylate	15
Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors	15
Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate	15
Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling Reaction	15
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	15
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment	15
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19	15
Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis	15
Reaction of Irbesartan with Nitrous Acid Produces Irbesartan Oxime Derivatives, rather than N -Nitrosoirbesartan	15
Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug	15
Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol	15
Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876	14
Automated Image-Based Color Analysis as an Accessible and Widely Applicable PAT Tool	14
Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease	14
Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O	14
Major Progress in the Liquid-Phase Synthesis of N -Alkyl-Rich Cyclic Peptides: Kilogram-Scale GMP Production of the KRAS Inhibitor LUNA18	14
Evaluating Resonant Acoustic Mixing as a Wet Granulation Process	14
An Easy and Adjustable One-Pot Access to Pheromonal Blends of Fall Armyworm (Spodoptera frugiperda) Relying on a Key Ligand- and Additive-Free Iron-Catalyzed Cross-Coupling	14
A Critical Account of Synthetic Approaches toward Vildagliptin, an Antidiabetic Drug	14
Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707	14
Thermal Decomposition Kinetics of Benzoyl Peroxide Based on Thermogravimetric Analysis and DFT Simulations	14
Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients	13
Synthesis of a Pyridoazepine Scaffold via Rhodium-Catalyzed Ring Expansion and Nitroacetamide Condensation	13
Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO₂SCF₂H	13
Developing and Optimizing a Quench-Crystallization Operation in Drug Substance Manufacturing	13
Commercially Viable Synthesis of Medetomidine Using a Classical Approach to the Imidazole Ring Formation	13
Issue Publication Information	13
Optimization of Nitrosation Reaction for Synthesis of 4-Aminoantipyrine by Response Surface Methodology and Its Reaction Mechanism	13
Strategies for the Production of [¹¹C]LY2795050 for Clinical Use	13
Some Items of Interest to Process R&D Chemists and Engineers	13
Issue Publication Information	12
Nitrosamine Risk Assessments in Oligonucleotides	12
Development and Optimization of a Scalable Enzymatic Cascade-Carbamate Formation Telescope Process for the Synthesis of CDK2 Selective Candidate Tegtociclib (PF-07104091)	12
Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies	12
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides	12
An Alternative Route to the Anticancer Agent: 2-Fluorofucose from Readily Available L-(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination Reaction	12
Solid Acid-Enabled N -Boc Deprotection and Acetal Hydrolysis in the Synthesis of Vepdegestrant	12
Continuous Flow Synthesis of Esomeprazole via Asymmetric Sulfoxidation	12
Issue Publication Information	12
Manufacturable Process of a Novel EGFR Inhibitor (Larotinib) for the Treatment of ESCC	12
Recent Advances in Nonprecious Metal Catalysis	12
Expeditious and Automated Dispensing of ChemBeads for High-Throughput Experimentation in 384-Well Microtiter Plates	12
Evaluation and Removal of Production Process Constraints in the Synthesis of 3,5-Dibromopyrazole	11
Engineering a Transaminase for the Efficient Synthesis of a Key Intermediate for Rimegepant	11
Development of a Scalable Anodic Oxidation Process for (R)-Troloxamide Quinone (EPI-589) Using a Continuous Flow Approach	11
Issue Publication Information	11
Mass Transport of Diazomethane across Teflon AF2400 Membrane for Scale-Up Development	11
Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale	11
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy	11
Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis	11
Unique Superbase TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene): From Catalytic Activity and One-Pot Synthesis to Broader Application in Industrial Chemistry	11
Development of a Reliable Low-Loading Palladium-Catalyzed Monoamination Process for the Large-Scale Synthesis of 3-Bromo-2,5-difluoroaniline	11
Issue Publication Information	11
Stereoselective Construction of 3-(Aminoalkylidene)oxindoles in One Pot: Development of a Novel, Robust, and Scalable Process for the Multigram-Scale Preparation of Nintedanib	11
Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol	11
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	11

Scalable Process for Reduction of Aromatic Carboxylic Acids to Aldehydes via Pinacolborane	11
Process Development of the Novel LpxC Inhibitor T-1228. Part 1: Synthesis of the Diol Fragment	11
Practical One-Pot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis-(2-nitrophenyl)-disulfides	11
Issue Editorial Masthead	11
Practical and Efficient Approach to Scalable Synthesis of Rucaparib	11
Some Items of Interest to Process R&D Chemists and Engineers	10
Regulatory Highlights	10
Correction to “Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts”	10
Process Development and Scale-Up of the Novel β-Lactamase Inhibitor WCK 6395	10
Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod	10
Optimized Method to Achieve 1-Hydroxy-5-aminotetrazole (HAT)	10
Practical and Scalable Synthesis of 1,3-Adamantanediol	10
Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine	10
Continuous Crystallization of Atorvastatin Calcium at a Multitonnage Scale Using Dynamically Mixed Flow Reactors for Target Polymorph Control	10
Robust Analytical Methods for Monitoring the Formation of a Chiral Oxazaborolidine Catalyst	10
Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF₄) and Dialkylamines in Continuous Flow Mode	10
Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up	10
Continuous Manufacturing of Rocuronium Bromide Part 2: Step 2 Process Development	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Green and Low-Cost Synthesis of Thermally Stable Cation-Exchange Resin-Supported Diazonium Salt: An Example of Weakly Basic p-Nitroaniline Diazotization	10
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part III. Assembly of Drug Substance, Salt Formation, and Impurity Control	10
Integrated Flow Emulsion Electrosynthetic System by In Situ Generation of Emulsions, Subsequent Emulsion Electrolysis, and Final Phase Separation	10
Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes	10
Continuous Flow Intensification for the Synthesis of High-Purity Warfarin	10
A Sustainable Approach to ε-Lys Branched GLP-1 Analogs: Integrating Green SPPS, Metal-free Alloc Removal, Waste Minimization and TFA/PFAS-free Resin Cleavage	10
Multigram-Scale Synthesis and Study of Reactivity of Two Difluoromethylating Reagents Based on Sulfoximine Skeletons	10
Overcoming PAT Challenges in Automated Process Validation for Continuous Liquid–Gas Biphasic Processes	9
Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands	9
Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source	9
Reliable Calorimetric Method to Study the Incompatibilities between Hydrazine Hydrate and Metallic Impurities	9
Technology Transfer and Process Development of Danicopan to Enable Process Validation	9
Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactio	9
Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195)	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Quantum Mechanical Methods for Thermal Hazard Risk Assessment in Early Phase Pharmaceutical Development	9
Structure Determination of Synthesized Nitrosamine Drug Substance-Related Impurities (NDSRIs) Using 3D ED/MicroED	9
Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core	9
Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction	9
Continuous Flow Synthesis of Crotonic Acid from Crotonaldehyde	9
Preparation of Impurity-Spiked Good Laboratory Practice Toxicological Batches of Active Pharmaceutical Ingredient Using Resonant Acoustic Mixing	9
Issue Publication Information	9
Continuous Purification of a Conjugated Short Interfering RNA Therapeutic Using Anion Exchange Twin-Column Chromatography (MCSGP)	9
Continuous-Flow Oxidation of Amines Based on Nitrogen-Rich Heterocycles: A Facile and Sustainable Approach for Promising Nitro Derivatives	9
Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative	9
Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Optimization of a Parham Cyclization Aided by In Situ FTIR for an Enabling Synthesis of Tricyclo[6.2.0.0^3,6]deca-1,3(6),7-trien-2-amine	9
A Confined Impinging Jet Reactor for High-Throughput Continuous Flow Mononitration of Salicylic Acid	9
Integrating Process Safety Consideration to Enhance Route Development and Optimization	9
Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination	9
Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition	9
Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis	9
Continuous Manufacturing of Rocuronium Bromide. Part 1: Step 1 Process Development	9
Multigram, Chromatography-Free Synthesis of the Flavonol Morin	9
Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling	9
Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors	9
Issue Editorial Masthead	9
Benchtop NMR-Based In-Line Analysis of Diastereoselective Enzymatic α-Amino Acid Synthesis: Quantification and Validation	8
Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode	8
Process Development of the Pyrazinecarboxamide Component of Gilteritinib, a FLT3 Inhibitor	8
Efficient and Scalable Diastereoselective Synthesis of ((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol Hydrochloride	8
Kilogram-Scale Preparation of the Amino Alcohol Fragment of Selgantolimod by Enzymatic Resolution of an α,α-Disubstituted Amino Ester	8
Issue Editorial Masthead	8
Issue Publication Information	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution	8
Development of a Continuous Flow Synthesis of Lorazepam	8
Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities	8
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	8
Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes	8
Stereoselective Nickel(II)-Catalyzed Addition of Aryl Grignards to Diphenylacetylene in the Synthesis of Zuclomiphene	8
Thermal Safety and Structure-Related Reactivity Investigation of Five-Membered Cyclic Sulfamidates	8
Issue Editorial Masthead	8
Synthesis and Impurity Profiling of a Vital Intermediate in Gabapentin and Bispidine Derivative Pathways by Response Surface Methodology	8
Issue Publication Information	8
Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine	8
Process Safety from Bench to Pilot to Plant	8
Correction to “Development of a Practical Telescoped Process to Prepare (P)-7-(2-Amino-6-fluorophenyl)-4-hydroxy-6-(trifluoromethyl)pyrido[3,4-d]pyrimidin-8(7H)-one: A Key Interme	8
Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A	8
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	8
In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth	8
Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling	8
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223	8
Accurate Quantitation of N -Nitrosodimethylamine in Pharmaceutical Products with High Levels of N ,	8
Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline	8
Issue Editorial Masthead	8
Issue Editorial Masthead	8
Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid	8
Methanol Steam Reforming Controls the Selective Transfer Hydrogenation vs N-Methylation of Nitrobenzene Using a PVP-Stabilized IrO₂ Nanoparticle Catalyst	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling	8
Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode	8