OOIR: Observatory of International Research

Papers

(The TQCC of Organic Process Research & Development is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	163
Issue Editorial Masthead	85
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	63
Industrial-Scale Organic Solvent Nanofiltration for Dimer Impurity Removal: Enhancing Vitamin D₃ Production	58
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	57
Analytical Control Strategies for Process Chemists	53
Recent Highlights in Micellar Catalysis: An Industrial Outlook	50
Biocatalysis: Improving Enzymatic Processes through Protein and Reaction Engineering	48
Issue Publication Information	48
Green Chemistry Articles of Interest to the Pharmaceutical Industry	47
Synthesis of BACE1 Inhibitors E2609/E2071 via Oxime–Olefin Cycloaddition Following a Process Risk Mitigation Strategy	45
Importance of Thermal Stability Data to Avoid Dangerous Reagents: Temozolomide Case Study	44
OPR&D: An Exceptional Legacy and Exciting Opportunities for the Future of Process Chemistry	43
Issue Editorial Masthead	43
Pd-Catalyzed Miyaura Borylations Mediated by Potassium Pivalate with Alcohol Cosolvents	42
Exploration for Chemical Filter Cartridges that Can Reduce Nitrogen Oxides, a Common Factor in the Formation of Nitrosamines	42
Some Items of Interest to Process R&D Chemists and Engineers	40
Scaling up a C–H Borylation: Addressing the Safety Concerns of an Iridium-Catalyzed Process for Multikilo Scale Manufacture	40
Issue Publication Information	39
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	38
Consolidating and Managing Data for Drug Development within a Pharmaceutical Laboratory: Comparing the Mapping and Reporting Tools from Software Applications	38
Issue Publication Information	37
Issue Publication Information	36
Reduction in the Thermal Stability of Nitro-Containing Compounds due to Cross-Catalyzed Autocatalytic Decomposition Caused by Nitro-Containing Impurities	36
In Support of Early-Career Researchers	36

Quantification of Nitrite in Excipients and Chemicals: A Versatile and Highly Sensitive Method Using Headspace Gas Chromatography Coupled to Mass Spectrometry	35
Implementation of MSMPR Crystallization to Avoid Liquid–Liquid Phase Separation	35
Issue Publication Information	35
Some Items of Interest to Process R&D Chemists and Engineers	35
Issue Editorial Masthead	34
Pinnick Oxidation on Scale: Process Development of a BDK Inhibitor	28
Highly Efficient and Selective Hydrogenation of Sugars Catalyzed by Ru-MACHO-BH: Practical Synthesis of Sugar Alcohols	28
Hydroformylation and Late-Stage Diversification on Densely Functionalized Cores of Influenza Endonuclease Inhibitors	27
Process Safety from Bench to Pilot to Plant	27
Acetonitrile Regeneration from Oligonucleotide Production Waste Streams	27
Issue Editorial Masthead	27
Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594	27
Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A	27
Issue Editorial Masthead	27
A Novel and Practical Synthesis of Mavorixafor	26
Issue Editorial Masthead	26
Simple Methods to Predict Particle Size for Growth-Only Systems Undergoing One or More Temperature Cycles	26
Thermal Safety and Structure-Related Reactivity Investigation of Five-Membered Cyclic Sulfamidates	25
Efficient, Scalable Synthesis of Functionalized Pyrrolo[2,1-f][1,2,4]triazines	25
Regulatory Highlights	24
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	24
Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine	24
Development of New Catalytic Asymmetric Routes toward a Cost-Driving Building Block of Nirmatrelvir	24
Issue Editorial Masthead	24
Issue Editorial Masthead	24
Synthesis of Fingolimod Employing Regioselective Aziridine Ring-Opening Reaction as a Key Step	23
Highly Efficient Production of Optically Active (R)-Tetrahydrothiophene-3-ol in Batch and Continuous Flow by Using Immobilized Ketoreductase	22
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	22
Some Items of Interest to Process R&D Chemists and Engineers	22
Discovery of New Fe(II)/α-Ketoglutarate-Dependent Dioxygenases for Oxidation of l-Proline	22
Some Items of Interest to Process R&D Chemists and Engineers	22
Issue Publication Information	21
Some Items of Interest to Process R&D Chemists and Engineers	21
Corrections to “An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer”	21
Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid	21
Correction to “Multigram Synthesis of Tetrasubstituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow”	21
Issue Publication Information	21
Some Items of Interest to Process R&D Chemists and Engineers	21
Method to Rapidly Identify Potential Solvent Systems for Crystallization of Cocrystals	20
Strategy to Assess and Control Nitrosamine Formation in API during Storage: A Sitagliptin Case Study	20
Application of an Interdisciplinary Approach to Form Selection in Drug Development	20
High-Throughput Experimentation Enabling Rapid Process Optimization of an RSV Drug Candidate	20
Stereoselective Nickel(II)-Catalyzed Addition of Aryl Grignards to Diphenylacetylene in the Synthesis of Zuclomiphene	20
Issue Editorial Masthead	20
Side-Chain Unprotected Fmoc-Arg/His/Tyr-OH Couplings and Their Application in Solid-Phase Peptide Synthesis through a Minimal-Protection/Green Chemistry Strategy	20
Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture	20
Some Items of Interest to Process R&D Chemists and Engineers	20
High-Throughput Crystallization Screening Technique with Transmission PXRD Analysis	19
Issue Publication Information	19
Oligonucleotide Purification by Ion Exchange Chromatography: A Step-by-Step Guide to Process Understanding, Modeling, and Simulation	19

pH-Switchable Phase-Transfer Agents for Host Cell Protein Rejection in the Cascaded Biocatalytic Synthesis of an Active Pharmaceutical Ingredient	19
Application of a Statistical Approach to Process Development of Futibatinib by Employing Quality-by-Design Principles. Part 1: Identification of Critical Process Parameters for Impurities	19
Application of Continuous Flow in Tazobactam Synthesis	18
Improved Purification of GalNAc-Conjugated Antisense Oligonucleotides Using Boronic Acids	18
Some Items of Interest to Process R&D Chemists and Engineers	18
Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO) III: Investigations Regarding the Main Decomposition	18
Optimized Process and Quality Evaluation for Ketamine Hydrochloride	18
Platform Strategies for Synthetic Oligonucleotide Drug Substances	18
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	17
First Multikilogram Synthesis of the Next-Generation Oral Selective ERα Degrader Camizestrant	17
Early Process Development of CH7057288, a Benzofuran-Containing Selective NTRK Inhibitor	17
Atom-Economical and Environmentally Friendly Bts-Based Purine PNA Monomers without Base-Protecting Groups	17
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	17
Robust Liquid Chromatography–Mass Spectrometry Determination of Deuterium Isotopologues for Quality Control of Deucravacitinib Using Nominal Mass Instrumentation	17
Issue Editorial Masthead	16
Process Development for the Manufacture of a Topical Pan-Trk Inhibitor Incorporating Decarboxylative sp²–sp³ Cross-Coupling	16
Efficient and Scalable Diastereoselective Synthesis of ((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol Hydrochloride	16
Development of a Scalable Method for the Synthesis of Ethoxy(pentafluoro)cyclotriphosphazene	16
Opportunities for Machine Learning and Artificial Intelligence to Advance Synthetic Drug Substance Process Development	16
Improving Solid-State Properties of the Side-Chain Peptide Building Blocks for the Synthesis of GLP-1 Analogs through Their Complexation with Metal Cations	16
Issue Publication Information	16
Comprehensive Synthetic Route Redesign of AZD5991: A High-Complexity Atropisomeric Macrocycle	16
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	16
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	15
Scalable Synthesis of ABBV-105 Enabled by Suzuki Coupling with Low Pd Loading, Ru-Catalyzed Asymmetric Hydrogenation, and Acylation Using Impinging Jet	15
How to Develop Organometallic Catalytic Reactions in the Pharmaceutical Industry	15
Thermal Risk Assessment and Optimization of Hazard Ranking for Aromatic Nitro Compounds: Multiparameterization and Quantitative Structure–Property Relationship Modeling	15
Synthesis of N-Bromo and N-Iodo Imides: A Rapid Redox-Neutral and Bench Stable Process	15
Thermal Runaway Inhibition of Adipic Acid Green Synthesis Based on a Radical Chain Reaction Mechanism	15
Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272	15
Proprietary Synthesis of the C27–C35 Fragment of Eribulin and Its Elaboration toward the C14–C35 Subunit	15
Optimized Synthesis of the Key Intermediate of Telmisartan via the Cyclization of 2-Bromoarylamine with n-Butyronitrile	15
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	15
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	15
Process Intensification via End-to-End Continuous Manufacturing of Atorvastatin Calcium Using an Integrated, Modular Reaction-Crystallization-Spherical Agglomeration-Filtration-Drying Process	14
A Journey through Process Development Enhanced by Kinetic Modeling: An Efficient Manufacturing Route to Balcinrenone	14
Development of the Late-Phase Manufacturing Process of ZPL389: Control of Process Impurities by Enhanced Process Knowledge	14
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	14
Process Development of the Pyrazinecarboxamide Component of Gilteritinib, a FLT3 Inhibitor	14
Understanding and Controlling the Formation of an N-Alkyl Impurity in Olmesartan Medoxomil: A Derivative via Michael-Type Addition between Tetrazole and Mesityl Oxide In Situ Generated from Ace	14
Development of a Cryogenic Flow Reactor to Optimize Glycosylation Reactions Based on the Active Donor Intermediate	14
Synthesis and Impurity Profiling of a Vital Intermediate in Gabapentin and Bispidine Derivative Pathways by Response Surface Methodology	14
Insights into Large-Scale Synthesis of Benfotiamine	14
Synthesis of Rovafovir Etalafenamide (Part IV): Evolution of the Synthetic Process to the Fluorinated Nucleoside Fragment	13
Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir	13
Catalyst-Free and Scalable Process for Synthesis of Novel MAP4K4 Inhibitor DMX-5804 and Its Glyco-Conjugates	13
Development of a Practical and Scalable Synthetic Route for the Adenosine Monophosphate-Activated Protein Kinase Activator, ASP4132	13
Pilot-Scale Production of Peroxygenase from Agrocybe aegerita	13
Scalable Process for Making 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid Using Methylene as the Protecting Group	13
Deracemization via Periodic and Non-periodic Temperature Cycles: Rationalization and Experimental Validation of a Simplified Process Design Approach	13
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	13
Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates	13
Six-Step Gram-Scale Synthesis of the Human Immunodeficiency Virus Integrase Inhibitor Dolutegravir Sodium	13
On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Development of a Highly Efficient Synthesis for Ciprofloxacin	13
Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B₁	13
Binary Solvent Swap Processing in a Bubble Column in Batch and Continuous Modes	13
Some Items of Interest to Process R&D Chemists and Engineers	13
Preparation of Enantiopure 3-Aminopiperidine and 3-Aminoazepane Derivatives from Ornithine and Lysine. Consecutive Syntheses of Pharmacologically Active Analogs, Such as Besifloxacin	12
Risk Assessment of the Leachables’ Profile for Small-Molecule Pharmaceutical Drug Substances	12
An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer	12
Development of a Continuous Flow Synthesis of Lorazepam	12
Development of Scalable Processes with Underutilized Biocatalyst Classes	12
Identification of Kinetics and Autocatalytic Behavior in Acetic Anhydride Hydrolysis Reaction via Reaction Calorimetry	12
Optimized Synthesis of a Key Intermediate of Nirmatrelvir	12
Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut Reaction	12
Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture	12
Continuous-Flow Synthesis of syn-2-Amino-1,3-diol via Catalytic Hydrogenation: A Vital Intermediate of (+)-Thiamphenicol and (+)-Florfenicol	12
Scalable and Safe Transformation of 3-Hydroxypropionitrile to Its Amidoxime	12
Refractive Index to Monitor Solid-Phase Oligonucleotide Synthesis	12
Rapid Enantiomeric Excess Measurements of Enantioisotopomers by Molecular Rotational Resonance Spectroscopy	12
Photocatalytic and Photoinduced Phosphonylation of Aryl Iodides: A Batch and Flow Study	12
Continuous Crystallization Kinetics of Cefradine in a Mixed Suspension Mixed Product Removal System	11
High-Yielding Process for the Synthesis of Hydroxychloroquine under Concentrated Conditions: Nucleophilic Amination of Chloropyridines Promoted by Dimethyl Sulfoxide or Catalyzed by 3,5-Bis(trifluorom	11
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	11
Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183	11
Solvent Switching in Continuous Multistep Chemoenzymatic Synthesis: Telescoping Enzymatic Synthesis of Chiral, Pyridine-Containing Amines with Cross-Coupling as a Case Study	11
Energetic Material Synthesis: Scale-up Using a Novel Modular Microflow Reactor Setup	11
Practical Synthesis of Tenofovir Alafenamide Fumarate Inspired by New Retrosynthetic Disconnection Featuring a Novel Carbon–Phosphorus Bond Construction Methodology	11
Continuous Flow Synthesis of tert-Butyl Nitrite and Its Applications as Nitrating Agent	11
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	11

Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline	11
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	11
Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow	11
Issue Editorial Masthead	10
Development of a Scalable Process for the Synthesis of Cyclopropyl-Methyl-Proline with Complex Stereochemistry: A Key Building Block of Factor D Inhibitors	10
Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation	10
Development of a Telescoped Alkylation/Reduction Reaction Sequence and an Asymmetric Hydrogenation to Enable the Kilogram Synthesis of ABBV-3748	10
Development of a Commercial Process for Odalasvir	10
When Safety Data Sheets are a Safety Hazard	10
Synthetic Process Development of (R)-(+)-1,2-Epoxy-5-hexene: An Important Chiral Building Block	10
Recommendations for Effective and Defendable Implementation of Quality by Design	10
Issue Publication Information	10
Regulatory Highlights	10
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	10
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	10
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	10
PAT Implementation on a Mobile Continuous Pharmaceutical Manufacturing System: Real-Time Process Monitoring with In-Line FTIR and Raman Spectroscopy	10
Catalytic Activity of Triphenylphosphine for Electrophilic Aromatic Bromination Using N-Bromosuccinimide and Process Safety Evaluation	10
Recent Advances in Nonprecious Metal Catalysis	10
Use of Bayesian Modeling for Risk Assessment and Robustness Evaluation	10
Process Development for the First GMP Synthesis of SGD-9501-TFA, Part 2: Synthesis of the Payload, Linker, and Drug Linker	10
Synthesis of 5-Substituted Tetrazoles: Reaction of Azide Salts with Organonitriles Catalyzed by Trialkylammonium Salts in Non-polar Media	10
Co-immobilized Multienzyme System for the Cofactor-Driven Cascade Synthesis of (R)-2-Amino-3-(2-bromophenyl)propanoic Acid: A Model Reaction	10
Removal of Alkyl Sulfonates Using DABCO	10
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	10
Development of a Scalable Synthetic Route to BMS-986251, Part 2: Synthesis of the Tricyclic Core and the API	9
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	9
Development of an Optimized Synthetic Process for an Antiobesity Drug Candidate (S-234462) Featuring Mild Chlorination of Benzoxazolone and In Situ IR Monitoring of a Mitsunobu Reaction	9
A Review on Synthetic Advances toward the Synthesis of Apremilast, an Anti-inflammatory Drug	9
Determining Phase Separation Dynamics with an Automated Image Processing Algorithm	9
Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379	9
Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis	9
Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations	9
Scalable Synthesis of CVN424, an Inverse Agonist of the GPR6 Receptor	9
Practical Synthesis of (+)-Biotin Key Intermediate by Calcium Borohydride Reduction and Temperature-Dependent Purity Upgrade during Crystallization	9
Issue Publication Information	9
Analysis of the Change in Molecular Complexity of Reaction Products in Process Development Activities at AstraZeneca Over Time	9
Advances and Opportunities Concerning Nucleation Measurement and Control Technology in Crystallization	9
Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)	9
Antibody–Drug Conjugate Synthesis Using Continuous Flow Microreactor Technology	9
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	9
Improved Synthetic Process of Baloxavir Marboxil Intermediate 3-Benzyloxy-4-oxo-4H-pyran-2-carboxylic Acid	9
Continuous Flow Chemistry with Solids: A Review	9
Temperature-Controlled Photoreactors and ChemBeads as Key Technologies for Robust and Practical Photochemical HTE	9
Pd-Catalyzed Cyanation of a Bromoaryl Carboxylate En Route to Etrumadenant: Robust Process with Low Catalyst Loading Enabled by Preactivation	9
Predicting the Fire and Explosion Properties of Early-Phase Active Pharmaceutical Ingredients	9
New Bench-Scale Method To Elucidate Active Pharmaceutical Ingredient Drying Mechanisms	9
Scalable Flow Electrochemical Alcohol Oxidation: Maintaining High Stereochemical Fidelity in the Synthesis of Levetiracetam	9
A Consideration of the Extent That Tertiary Amines Can Form N-Nitroso Dialkylamines in Pharmaceutical Products	9
Early Process Development of Two Vanin-1 Inhibitors: Solid Form Challenges and Control of Ambident Reactivity	9
Unconventional Ethereal Solvents in Organic Chemistry: A Perspective on Applications of 2-Methyltetrahydrofuran, Cyclopentyl Methyl Ether, and 4-Methyltetrahydropyran	9
Kilogram-Scale Preparation of the Amino Alcohol Fragment of Selgantolimod by Enzymatic Resolution of an α,α-Disubstituted Amino Ester	9
Efficient Synthesis of (S)-Nornicotine using Co-Immobilized IRED and GDH in Batch and Continuous Flow Reaction Systems	9
Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?	9
Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution	9
Practical Manufacturing Process for Baloxavir Marboxil: Efficient Route to a Tricyclic Triazinanone Scaffold	9
Novel Analytical Approach to Quantify Reactive Potentially Mutagenic Sulfonate Ester Impurities in Pharmaceutical Compounds and Its Application in the Development of a Control Strategy for Nonaflate I	9
Issue Editorial Masthead	9
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl₂-BINOL	9
Novel, Practical, and Scalable Approach for the Synthesis of Eldecalcitol	9
A Scalable Solution to Constant-Potential Flow Electrochemistry	9
Flash Thermal Racemization of Chiral Amine in Continuous Flow: An Exploration of Reaction Space Using DoE and Multivariate Transient Flow	8
Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and N^α-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid A	8
Issue Publication Information	8
Therapeutic Peptides Control Strategy: Perspective on Current Industry Practices	8
Continuous Synthesis of 1,3,2-Dioxathiolane 2,2-Dioxide (DTD) by Hydrogen Peroxide with Titanium Silicalite-1 Catalyst Using a Fixed-Bed Reactor	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 6─Development of a Nucleophilic Aromatic Substitution in Water	8
Correction to “Effective Phosphorylation of 2,2′-Methylene-bis(4,6-di-tert-butyl) Phenol in Continuous Flow Reactors”	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Recent Advances in Nonprecious Metal Catalysis	8
Issue Publication Information	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Development of an Intrinsically Safer Methanolysis/Aromatic Nitro Group Reduction for Step 1 and 2 of Talazoparib Tosylate	8
Rediscovery of an Old Named Reaction: From Micellar Catalysis to Unusual Schotten–Baumann Conditions	8
Development of a Directed Ketal Hydrogenation for the Synthesis of a Key Intermediate of Lanabecestat	8
Alternative Approach to the Large-Scale Synthesis of the Densely Functionalized Pyrrolidone BMT-415200	8
Development of a Scalable Asymmetric Process for the Synthesis of Selective PDE4B Inhibitor Nerandomilast (BI 1015550)	8
Issue Publication Information	8
Application of Taylor Vortex Flow Reactor Enabling Precise Control of Nucleation in Reactive Crystallization	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	8
The ReactALL Platform: Experimental Data and Case Studies	8
Thermal Stability, OREOS+ Explosive Hazard Assessment, and Maximum Safe Storage Temperature of Cyclic Hypervalent Iodine (λ-3-Iodane)-Based Reagents	8
Issue Publication Information	8
Efficient and Improved Solution-Phase Synthesis of Modified RNA Dinucleotides: Versatile Synthons in Cap 1 mRNA Therapeutics	8
The Identification of Naloxone-Related Drug Product Degradants	8
Development of a High-Throughput Kinetics Protocol and Application to an Aza-Michael Reaction	7
Development and Process Intensification of an Efficient Flow–Cascade Reaction Sequence in the Synthesis of Afizagabar	7
Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991	7
A Scalable Synthesis of Roxadustat (FG-4592)	7
Efficient Total Synthesis of Bilirubin IXα from Butyrolactone	7
Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO) II: Analysis of Intermediate Substances Obtained in the Induction Period and Investigations Regarding Formic Acid	7
Harnessing the Power of Catalysis for the Synthesis of CRTH2 Antagonist MK-1029	7
Safety Assessments Supporting Scale-up of Chemistry Involving Hydrogen	7