Organic Process Research & Development

Article	Citations
Cu-Mediated Ullmann-Type Cross-Coupling and Industrial Applications in Route Design, Process Development, and Scale-up of Pharmaceutical and Agrochemical Processes	94
Continuous Crystallization Processes in Pharmaceutical Manufacturing: A Review	87
Potential Explosion Hazards Associated with the Autocatalytic Thermal Decomposition of Dimethyl Sulfoxide and Its Mixtures	78
Integrated Continuous Pharmaceutical Technologies—A Review	77
Potential for the Formation of N-Nitrosamines during the Manufacture of Active Pharmaceutical Ingredients: An Assessment of the Risk Posed by Trace Nitrite in Water	76
Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply	75
Pathways for N-Nitroso Compound Formation: Secondary Amines and Beyond	67
Heterogeneous Catalysis for Cross-Coupling Reactions: An Underutilized Powerful and Sustainable Tool in the Fine Chemical Industry?	66
Applications of Flow Chemistry in the Pharmaceutical Industry—Highlights of the Recent Patent Literature	57
Potential Safety Hazards Associated with Using N,N-Dimethylformamide in Chemical Reactions	54
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	53
Continuous Production of Five Active Pharmaceutical Ingredients in Flexible Plug-and-Play Modules: A Demonstration Campaign	52
Multikilogram per Hour Continuous Photochemical Benzylic Brominations Applying a Smart Dimensioning Scale-up Strategy	51
Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination	51
Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO)	51
Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir	50
Fully Automated Chemical Synthesis: Toward the Universal Synthesizer	50
A Structured Approach To Cope with Impurities during Industrial Crystallization Development	45
Strategies to Tackle the Waste Water from α-Tocopherol-Derived Surfactant Chemistry	44
Design of a Kilogram Scale, Plug Flow Photoreactor Enabled by High Power LEDs	44
Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor	44
A General Kilogram Scale Protocol for Suzuki–Miyaura Cross-Coupling in Water with TPGS-750-M Surfactant	41
Comparison of the Thermal Stabilities of Diazonium Salts and Their Corresponding Triazenes	40
Optimization of a Decatungstate-Catalyzed C(sp3)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor	39
Progress and Opportunities for Utilizing Seeding Techniques in Crystallization Processes	39

Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction	39
Pilot-Scale Production of Peroxygenase from Agrocybe aegerita	35
Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition	35
Recent Advances in Enzyme Immobilization Utilizing Nanotechnology for Biocatalysis	35
Ranitidine—Investigations into the Root Cause for the Presence of N-Nitroso-N,N-dimethylamine in Ranitidine Hydrochloride Drug Substances and Associated Drug Products	34
Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study	33
Renewable Solvents for Palladium-Catalyzed Carbonylation Reactions	33
Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis	32
Supporting-Electrolyte-Free and Scalable Flow Process for the Electrochemical Synthesis of 3,3′,5,5′-Tetramethyl-2,2′-biphenol	30
A Perspective on the Analytical Challenges Encountered in High-Throughput Experimentation	30
Scale-Up of a Heterogeneous Photocatalytic Degradation Using a Photochemical Rotor–Stator Spinning Disk Reactor	30
Continuous Flow C-Glycosylation via Metal–Halogen Exchange: Process Understanding and Improvements toward Efficient Manufacturing of Remdesivir	29
Recent Advances in Photobiocatalysis for Selective Organic Synthesis	28
The Effect of Dissolved Oxygen on Kinetics during Continuous Biocatalytic Oxidations	28
Toward a Practical, Two-Step Process for Molnupiravir: Direct Hydroxamination of Cytidine Followed by Selective Esterification	28
High-Throughput Electrochemistry: State of the Art, Challenges, and Perspective	28
PAT Implementation on a Mobile Continuous Pharmaceutical Manufacturing System: Real-Time Process Monitoring with In-Line FTIR and Raman Spectroscopy	28
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	27
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	27
Scalable Flow Electrochemical Alcohol Oxidation: Maintaining High Stereochemical Fidelity in the Synthesis of Levetiracetam	27
Recent Advances in High-Throughput Automated Powder Dispensing Platforms for Pharmaceutical Applications	27
Manufacturing Process Development for Belzutifan, Part 1: A Concise Synthesis of the Indanone Starting Material	26
Applications of Quantum Chemistry in Pharmaceutical Process Development: Current State and Opportunities	26
Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis	26
Design and Characterization of a Scaled-up Ultrasonic Flow Reactor	26
Seeding Techniques and Optimization of Solution Crystallization Processes	26
Green Chemistry: A Framework for a Sustainable Future	26
Development and Execution of an Ni(II)-Catalyzed Reductive Cross-Coupling of Substituted 2-Chloropyridine and Ethyl 3-Chloropropanoate	26
Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib	25
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 1: CDI-Promoted Amide Bond Formation	25
Improvement of the C-glycosylation Step for the Synthesis of Remdesivir	25
From Bench to Plant: An Opportunity for Transition Metal Paired Electrocatalysis	25
In Situ Imaging Combined with Deep Learning for Crystallization Process Monitoring: Application to Cephalexin Production	25
Simple Synthesis of Amides via Their Acid Chlorides in Aqueous TPGS-750-M	25
Defining the Qualities of High-Quality Palladium on Carbon Catalysts for Hydrogenolysis	25
Flash Chemistry Approach to Organometallic C-Glycosylation for the Synthesis of Remdesivir	25
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview	25
Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic Resolution	24
Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process	24
High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry	24
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and Filtration	23
API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing	23
A Comment on Continuous Flow Technologies within the Agrochemical Industry	23
Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?	23
Predicting Performance of Photochemical Transformations for Scaling Up in Different Platforms by Combining High-Throughput Experimentation with Computational Modeling	23
Minimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions	23
Development and Scale-Up of a Direct Asymmetric Reductive Amination with Ammonia	22
Organosilanes in Metal-Catalyzed, Enantioselective Reductions	22
Unconventional Ethereal Solvents in Organic Chemistry: A Perspective on Applications of 2-Methyltetrahydrofuran, Cyclopentyl Methyl Ether, and 4-Methyltetrahydropyran	22
3D Printed Reactors for Synthesis of Active Pharmaceutical Ingredients in Continuous Flow	22

Insights into Fast Amide Couplings in Aqueous Nanomicelles	21
Development of Scalable Routes to 1-Bicyclo[1.1.1]pentylpyrazoles	21
Recent Advances in Nonprecious Metal Catalysis	21
Process Safety in the Pharmaceutical Industry—Part I: Thermal and Reaction Hazard Evaluation Processes and Techniques	21
Use of High-Throughput Tools for Telescoped Continuous Flow Synthesis of an Alkynylnaphthyridine Anticancer Agent, HSN608	21
Electrochemical Cyclobutane Synthesis in Flow: Scale-Up of a Promising Melt-Castable Energetic Intermediate	21
Commercial-Scale Visible Light Trifluoromethylation of 2-Chlorothiophenol Using CF3I Gas	21
Pd-Catalyzed Cross-Couplings: On the Importance of the Catalyst Quantity Descriptors, mol % and ppm	21
Recent Advances in Nonprecious Metal Catalysis	20
Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor	20
Multigram Synthesis of Pure HMF and BHMF	19
Computer Aided Design of Solvent Blends for Hybrid Cooling and Antisolvent Crystallization of Active Pharmaceutical Ingredients	19
Decarboxylative Bromination of Sterically Hindered Carboxylic Acids with Hypervalent Iodine(III) Reagents	19
Manufacturing Process Development for Belzutifan, Part 6: Ensuring Scalability for a Deoxyfluorination Reaction	19
Antibody–Drug Conjugate Synthesis Using Continuous Flow Microreactor Technology	19
On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Implementation and In Situ Control of Downstream Production	19
Recent Advances in Nonprecious Metal Catalysis	18
Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow	18
Taming Troublesome Suzuki–Miyaura Reactions in Water Solution of Surfactants by the Use of Lecithin: A Step beyond the Micellar Model	18
Heterogeneous Crystallization as a Process Intensification Technology in an Integrated Continuous Manufacturing Process for Pharmaceuticals	18
Evaluation and Screening of Spherical Pd/C for Use as a Catalyst in Pharmaceutical-Scale Continuous Hydrogenations	18
A Review on Synthetic Advances toward the Synthesis of Apremilast, an Anti-inflammatory Drug	18
Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib	18
Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation Control	18
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 2: Enone Synthesis via a Barbier-Type Grignard Process	18
Drug Development through Modification of Small Molecular Drugs with Monodisperse Poly(ethylene glycol)s	18
Preparation of Mono- and Diisocyanates in Flow from Renewable Carboxylic Acids	18
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19	17
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	17
Collaboration as a Key to Advance Capabilities for Earth-Abundant Metal Catalysis	17
Novel Si(II)+ and Ge(II)+ Compounds as Efficient Catalysts in Organosilicon Chemistry: Siloxane Coupling Reaction	17
Integrating Continuous-Flow Electrochemistry and Photochemistry for the Synthesis of Acridinium Photocatalysts Via Site-Selective C–H Alkylation	17
Controlling a Cohort: Use of Mirabilis-Based Purge Calculations to Understand Nitrosamine-Related Risk and Control Strategy Options	17
Synthesis of a Crizotinib Intermediate via Highly Efficient Catalytic Hydrogenation in Continuous Flow	16
Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective	16
Ruthenium-Catalyzed Ester Reductions Applied to Pharmaceutical Intermediates	16
Continuous Industrial-Scale Centrifugal Partition Chromatography with Automatic Solvent System Handling: Concept and Instrumentation	16
Toward a Scalable Synthesis and Process for EMA401, Part III: Using an Engineered Phenylalanine Ammonia Lyase Enzyme to Synthesize a Non-natural Phenylalanine Derivative	16
Explosive Hazard Identification in Pharmaceutical Process Development: A Novel Screening Method and Workflow for Shipping Potentially Explosive Materials	16
A Continuous-Flow Electrochemical Taylor Vortex Reactor: A Laboratory-Scale High-Throughput Flow Reactor with Enhanced Mixing for Scalable Electrosynthesis	16
Manufacturing Process Development for Belzutifan, Part 3: Completing a Streamlined Through-Process with a Safe and Scalable Oxidation	16
Rapid Model-Based Optimization of a Two-Enzyme System for Continuous Reductive Amination in Flow	16
Development of a Commercial Manufacturing Route to 2-Fluoroadenine, The Key Unnatural Nucleobase of Islatravir	16
Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib	16
Biocompatible Catalysts for Lactide Polymerization—Catalyst Activity, Racemization Effect, and Optimization of the Polymerization Based On Design of Experiments	16
Ketone Reductase Biocatalysis in the Synthesis of Chiral Intermediates Toward Generic Active Pharmaceutical Ingredients	16
High-Throughput Classical Chiral Resolution Screening of Synthetic Intermediates: Effects of Resolving Agents, Crystallization Solvents, and Other Factors	16
Scale-Up of Ozonolysis using Inherently Safer Technology in Continuous Flow under Pressure: Case Study on β-Pinene	15
Continuous and Selective Hydrogenation of Heterocyclic Nitroaromatics in a Micropacked Bed Reactor	15
Cost-Effective Flow Peptide Synthesis: Metamorphosis of HPLC	15
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis	15
Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics	15
Peroxygenase-Driven Ethylbenzene Hydroxylation in a Rotating Bed Reactor	15
Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate	15
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor	15
High-Yield Synthesis of Enantiopure 1,2-Amino Alcohols from l-Phenylalanine via Linear and Divergent Enzymatic Cascades	15
Styrene Oxide Isomerase Catalyzed Meinwald Rearrangement Reaction: Discovery and Application in Single-Step and One-Pot Cascade Reactions	15
An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines	15
Reaction Calorimetry in Continuous Flow Mode: A New Approach for the Thermal Characterization of High Energetic and Fast Reactions	14
Synthesis Development of the Selective Estrogen Receptor Degrader (SERD) LSZ102 from a Suzuki Coupling to a C–H Activation Strategy	14
Recent Advances in Nonprecious Metal Catalysis	14
Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki–Miyaura Reactions of Pharmaceutically Relevant Heterocycles	14
Development of a Commercial Process for Deucravacitinib, a Deuterated API for TYK2 Inhibition	14
On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Development of a Highly Efficient Synthesis for Ciprofloxacin	14
Effective Control of Crystal Size via an Integrated Crystallization, Wet Milling, and Annealing Recirculation System	14
Investigation of On-Resin Disulfide Formation for Large-Scale Manufacturing of Cyclic Peptides: A Case Study	14
Diethanolamine Boronic Esters: Development of a Simple and Standard Process for Boronic Ester Synthesis	14
Quest for a Cure: Potential Small-Molecule Treatments for COVID-19, Part 2	14
Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction	14
Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts	14
Development and Scale-Up of a Novel Photochemical C–N Oxidative Coupling	14
High-Throughput Salt Screening of Synthetic Intermediates: Effects of Solvents, Counterions, and Counterion Solubility	14
A Scalable Membrane Pervaporation Approach for Continuous Flow Olefin Metathesis	14
Two Scalable Syntheses of 3-(Trifluoromethyl)cyclobutane-1-carboxylic Acid	14
A Novel Integrated Workflow for Isolation Solvent Selection Using Prediction and Modeling	13
Recent Advances in Non-Precious Metal Catalysis	13
Recent Advances in Nonprecious Metal Catalysis	13
Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates	13
Selective Oxidation of Benzylic sp3 C–H Bonds using Molecular Oxygen in a Continuous-Flow Microreactor	13
Photoredox Iridium–Nickel Dual Catalyzed Cross-Electrophile Coupling: From a Batch to a Continuous Stirred-Tank Reactor via an Automated Segmented Flow Reactor	13

Development of a Large-Scale Route to Glecaprevir: Synthesis of the Side Chain and Final Assembly	13
Recent Advances in Nonprecious Metal Catalysis	13
Accelerated Development of a Scalable Ring-Closing Metathesis to Manufacture AMG 176 Using a Combined High-Throughput Experimentation and Computational Modeling Approach	13
Kinetics of Polycondensation of Citric Acid with Glycerol Based on a Genetic Algorithm	13
Synthesis and Applications of Periodate for Fine Chemicals and Important Pharmaceuticals	13
Mini-Monoplant Technology for Pharmaceutical Manufacturing	13
Solvent Selection for Mitsunobu Reaction Driven by an Active Learning Surrogate Model	13
Heat Loss in Accelerating Rate Calorimetry Analysis and Thermal Lag for High Self-Heat Rates	13
Application of the New 400 MHz High-Temperature Superconducting (HTS) Power-Driven Magnet NMR Technology for Online Reaction Monitoring: Proof of Concept with a Ring-Closing Metathesis (RCM) Reaction	13
Merging Biocatalysis, Flow, and Surfactant Chemistry: Innovative Synthesis of an FXI (Factor XI) Inhibitor	13
Process Intensification for Obtaining a Cannabidiol Intermediate by Photo-oxygenation of Limonene under Continuous-Flow Conditions	13
Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRASG12C Inhibitors	12
Engineering a Transaminase for the Efficient Synthesis of a Key Intermediate for Rimegepant	12
Seeking for Selectivity and Efficiency: New Approaches in the Synthesis of Raltegravir	12
Harnessing the Power of Catalysis for the Synthesis of CRTH2 Antagonist MK-1029	12
Development of a Practical, Biocatalytic Synthesis of tert-Butyl (R)-3-Hydroxyl-5-hexenoate: A Key Intermediate to the Statin Side Chain	12
Kinetic Investigations To Enable Development of a Robust Radical Benzylic Bromination for Commercial Manufacturing of AMG 423 Dihydrochloride Hydrate	12
Scale-Up and Development of Synthesis 2-Ethylhexyl Nitrate in Microreactor Using the Box–Behnken Design	12
Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream	12
Identification and Screening of Potential Organic Solvents for the Liquid–Liquid Extraction of Aromatics	12
High-Productivity Single-Pass Electrochemical Birch Reduction of Naphthalenes in a Continuous Flow Electrochemical Taylor Vortex Reactor	12
Advances in Continuous Flow Calorimetry	12
Continuous-Flow Hofmann Rearrangement Using Trichloroisocyanuric Acid for the Preparation of 2-Benzoxazolinone	12
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process	12
Development of a Scalable Enantioselective Synthesis of JAK Inhibitor Upadacitinib	12
Implementing Continuous Manufacturing for the Final Methylation Step in the AMG 397 Process to Deliver Key Quality Attributes	12
Catalytic Static Mixer-Enabled Hydrogenation of a Key Fenebrutinib Intermediate: Real-Time Analysis for a Stable and Scalable Process	12
Nitrosamine Reactivity: A Survey of Reactions and Purge Processes	12
Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro[4.5]decan-3-amine	12
Two-Phase Flow in a Coiled Flow Inverter: Process Development from Batch to Continuous Flow	12
Characterization of a Modular Continuous Vacuum Screw Filter for Small-Scale Solid–Liquid Separation of Suspensions	12
Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation	12
Highly Productive α-Alkylation of Ketones with Alcohols Mediated by an Ir–Oxalamidato/Solid Base Catalyst System	12
Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions	12
Investigation of Lithium Acetyl Phosphate Synthesis Using Process Analytical Technology	11
Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis	11
Understanding API Static Drying with Hot Gas Flow: Design and Test of a Drying Rig Prototype and Drying Modeling Development	11
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	11
Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU)2Zn(CF2H)2] and Improved Synthesis of the ICHF2 Precursor	11
New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones	11
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation–Cyclization as a Flow–Batch Process Leads to Significant Improvements in Process Mass	11
Polymer-Supported Chiral Cis-Disubstituted Pyrrolidine Catalysts and Their Application to Batch and Continuous-Flow Systems	11
Recent Advances in the Solid- and Solution-Phase Synthesis of Peptides and Proteins Using Microflow Technology	11
Application of C–H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib	11
Highlights of the Recent Patent Literature─Focus on Biocatalysis Innovation	11
Developing a Multistep Continuous Manufacturing Process for (1R,2R)-2-Amino-1-methylcyclopentan-1-ol	11
Air-Stable Iron-Based Precatalysts for Suzuki–Miyaura Cross-Coupling Reactions between Alkyl Halides and Aryl Boronic Esters	11
Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate	11
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	11
Performance Analysis and Model-Free Design of Deracemization via Temperature Cycles	10
Large-Scale Production of C9 Aromatic Hydrocarbon Resin from the Cracked-Petroleum-Derived C9 Fraction: Chemistry, Scalability, and Techno-economic Analysis	10
Application of Continuous Flow in Tazobactam Synthesis	10
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	10
“One-Pot” Synthesis of Molnupiravir from Cytidine	10
High-Throughput Synthesis of (S)-α-Phellandrene through Three-Step Sequential Continuous-Flow Reactions	10
Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19	10
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimidine Core	10
Multigram Synthesis of BMS-929075, an Allosteric, Palm Site Inhibitor of HCV NS5B Replicase, Involving the Synthesis of a Highly Functionalized Benzofuran through a Telescoped Process	10
Process Development of a Sonogashira Cross-Coupling Reaction as the Key Step of Tirasemtiv Synthesis Using Design of Experiments	10
Development of an Operationally Simple, Scalable, and HCN-Free Transfer Hydrocyanation Protocol Using an Air-Stable Nickel Precatalyst	10
Automation Technologies to Enable Data-Rich Experimentation: Beyond Design of Experiments for Process Modeling in Late-Stage Process Development	10
The Nitrosamine “Saga”: Lessons Learned from Five Years of Scrutiny	10
Synthesis of Thiomorpholine via a Telescoped Photochemical Thiol–Ene/Cyclization Sequence in Continuous Flow	10
Semicontinuous Process for GMP Manufacture of a Carbapenem Intermediate via Carbene Insertion Using an Immobilized Rhodium Catalyst	10
Development of a Continuous Photochemical Bromination/Alkylation Sequence En Route to AMG 423	10
Multigram Synthesis of Trioxanes Enabled by a Supercritical CO2 Integrated Flow Process	10
Metal Catalyst and Hydrogen Gas-Free Selective Reduction of Biomass-Derived Substituted Furfuraldehyde to Alkyl Furan as a Key Biofuel Additive	10
Enzymatic Cascade in a Simultaneous, One-Pot Approach with In Situ Product Separation for the Asymmetric Production of (4S,5S)-Octanediol	10
Flow Photocleavage for Automated Glycan Assembly (AGA)	10
Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations	10
Highlights of the Recent Patent Literature: Focus on Asymmetric Organocatalysis	10
Exploring the Role of Anti-solvent Effects during Washing on Active Pharmaceutical Ingredient Purity	10
Prediction of N-Nitrosamine Partition Coefficients for Derisking Drug Substance Manufacturing Processes	10
Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification	10
Kinetics of Polycondensation of Sebacic Acid with Glycerol	10
Continuous Flow Process for the Synthesis of Betahistine via Aza-Michael-Type Reaction in Water	10
Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene	10
Use of Lithium Diisopropylamide in Flow: Operability and Safety Challenges Encountered on a Multigram Scale	9
Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging	9
Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1	9
Six-Step Gram-Scale Synthesis of the Human Immunodeficiency Virus Integrase Inhibitor Dolutegravir Sodium	9
A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry	9
Scalable, Telescoped Hydrogenolysis–Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)-α-Heteroaryl Propionic Acids	9
Development and Scale-Up of a Continuous Manufacturing Process for a Hydrazine Condensation Reaction	9
Highly Efficient Production of Optically Active (R)-Tetrahydrothiophene-3-ol in Batch and Continuous Flow by Using Immobilized Ketoreductase	9
Development of a Commercial Process for Odalasvir	9
Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor	9
Large-Scale Synthesis of Eldecalcitol	9
Asymmetric Organocatalysis and Continuous Chemistry for an Efficient and Cost-Competitive Process to Pregabalin	9
tert-Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPure	9
Formation of Dialkyl-N-nitrosamines in Aqueous Solution: An Experimental Validation of a Conservative Predictive Model and a Comparison of the Rates of Dialkyl and Trialkylamine Nitrosation	9
Discovery of New Fe(II)/α-Ketoglutarate-Dependent Dioxygenases for Oxidation of l-Proline	9
The Impact of Solvent Quality on the Heck Reaction: Detection of Hydroperoxide in 1-Methyl-2-pyrrolidinone (NMP)	9
Stirring Peptide Synthesis to a New Level of Efficiency	9
Synthesis of Rovafovir Etalafenamide (Part I): Active Pharmaceutical Ingredient Process Development, Scale-Up, and Impurity Control Strategy	9