OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Development and Technology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Insights into tablet sticking: a quantitative case study with an ibuprofen and methocarbamol-based formulation	117
Facile fabrication of degradable, serrated polyethylene diacrylate microneedles using stereolithography	54
Influence of punch coating surface properties on sticking during the tableting process	47
Formulation and optimization of a single-layer coat for targeting budesonide pellets to the descending Colon	30
Novel vanillic acid-loaded in situ gels: development, characterization, in vitro evaluation for enhanced w	28
Formulation and characterization of a fixed-dose microemulsion containing efavirenz, emtricitabine, and tenofovir	25
Glycyrrhizic acid assists anti-psoriatic efficacy of a self-deformable curcumin loaded transdermal gel	25
Gum tragacanth-based hemostatic sponge for enhanced hemostasis in dental surgery	22
Fabrication and characterization of Coenzyme Q10-loaded nanofibers for potential biomedical applications	21
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers	21
Development of PLGA-SPC3 functionalized gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: biodistribution and cytotoxicity analysis	19
Sustained linagliptin administration: superior glycemic control and less pancreatic injury in diabetic rats	18
Comparison study of physicochemical and biopharmaceutics properties of hydrophobic drugs ground by two dry milling processes	18
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS	17
Formulation development, characterization, and evaluation of bedaquiline fumarate – Soluplus ^® – solid dispersion	17
Scale-up in twin-screw wet granulation: impact of formulation properties	17
Enhancement of the dissolution and in-vitro activity of a new antineoplastic agent	16
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin.	16
Emulgels: a promising topical drug delivery system for arthritis management and care	16
Permeability of olmesartan medoxomil from lipid based and suspension formulations using an optimized HDM-PAMPA model	16
Tabletability and compactibility of α-lactose monohydrate powders of different particle size. I. Experimental comparison	16
Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug	15
Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded with shikonin	15
Preparation and anti-tumor activity of paclitaxel silk protein nanoparticles encapsulated by biofilm	15
Drug-silica-cellulose ternary matrix for the oral delivery of Cyclosporine A: in vitro and in vivo evaluation	15

mRNA-based vaccines – global approach, challenges, and could be a promising wayout for future pandemics	15
Preparation of a novel tacrolimus ion sensitive ocular in situ gel and in vivo evaluation of curative effect of immune conjunctivitis	14
Evaluating the color stability of titanium dioxide-free film coats under environmental and light stress	14
Intranasal delivery of sulpiride nanostructured lipid carrier to central nervous system; in vitro characterization and in vivo study	13
Development of an enhanced formulation to minimize pharmacokinetic variabilities of a weakly basic drug compound	13
Buccal lidocaine mucoadhesive patches for pediatrics’ teething pain: overcoming possible hazards of oral gels	13
Enhanced solubility and controlled release of probucol using electrospun nanofibers prepared with different pharmaceutical polymers	13
Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation	13
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study	12
Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system	12
Correction	12
Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA)	12
Formulation of smokeless tobacco products with a wide range of pH to study nicotine pharmacokinetics and pharmacodynamics	12
Effect of different molecular weight and terminal group PLGA on docetaxel nanoparticles: characterization and cytotoxic activity of castration-resistant prostate cancer cells	11
Targeted delivery strategy of indocyanine green-mitoxantrone loaded liposomes co-modified with BTP-7 and BR2 for the treatment of glioma	11
Design and evaluation of erucic acid-phytosphingosine structured cationic nanoemulsions as a plasmid DNA delivery system against breast cancer cells	11
Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles	11
Formulation and characterization of novel oral pH-sensitive electrospun nanofibers for boosting dissolution and penetration of model class IV drug	11
Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation	11
Thermosensitive gel based on cellulose derivative for topical delivery of propolis in acne treatment	11
Development and characterization of an amorphous curcumin-Eudragit^®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties	11
Design and characterization of quercetin-embedded biocomposite hydrogel for the management of polycystic ovary syndrome: a dual in vitro and	11
Impact of grinding balls on the size reduction of Aprepitant in wet ball milling procedure	11
Microfluidics in drug delivery: review of methods and applications	11
pH/enzyme dual sensitive and nucleus-targeting dendrimer nanoparticles to enhance the antitumour activity of doxorubicin	11
Improvement of liraglutide release from PLGA microspheres by a porous microsphere-gel composite system	10
Sustained latanoprost release from PEGylated solid lipid nanoparticle-laden soft contact lens to treat glaucoma	10
Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC	10
Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples	10
Extracellular vesicle-based formulation of doxorubicin: drug loading optimization, characterization, and cytotoxicity evaluation in tumor spheroids	10
The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines	9
Formulation and evaluation of buccal films loaded with insulin encapsulated in glucose responsive amphiphilic dendrimer micelles	9
Ivermectin: recent approaches in the design of novel veterinary and human medicines	9
Chitosan-biotin topical film: preparation and evaluation of burn wound healing activity	9
Smart microneedle platforms for skin cancer therapy: a review of stimuli-responsive and targeted drug delivery systems	9
An overview of polyallylamine applications in gene delivery	8
Manufacturing classification system (MCS): enabling better understanding of oral solid dosage formulation design	8
In vitro galactose-targeted study of RSPP050-loaded micelles against liver hepatocellular carcinoma	8
Itraconazole-loaded microemulsions: formulation, characterization, and dermal delivery using shed snakeskin as the model membrane	8
Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system class-I drug	8
Stability of trastuzumab during nanomedicine formulation using SEC-HPLC coupled with polyacrylamide gel electrophoresis	8
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	7
Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance	7
Application of plant-derived exosome-like nanoparticles in drug delivery	7
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy	7
Challenges and recent advances in erythropoietin stability	7
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer	7
Development and optimization of cilostazol loaded transethosomal gel for improved performance	7
Nanocarriers with long-term retention in the respiratory system for prolonged drug exposure	7
Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes	7

Self-assembled mumio-stabilized bioactive gel systems for topical therapeutics of rheumatoid arthritis: structural, rheological, cytocompatibility, and antimicrobial properties	7
Chylomicron-mimicking supramolecular nano emulsion for oral luteolin delivery against hyperuricemia	7
Dissolving microneedles loaded with nimodipine for prevention of sleep disorders at a high altitude	7
Two-dimensional printing of nanoparticles as a promising therapeutic method for personalized drug administration	7
Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting	6
The pioneering impact of artificial intelligence (AI) on pharmaceutical research and drug development (invited editorial)	6
Fabrication and optimization of verapamil-loaded PEGylated nanoparticles for management of traumatic brain injury: a comparative evaluation	6
Porous microneedle arrays as promising tools for the quantification of drugs in the skin: a proof of concept study	6
Drug content determination of low-dosed hot-melt extruded filaments using Raman spectroscopy	6
The therapeutic efficacy and safety improvements of crizotinib prodrug micelles on breast cancer treatment	6
Pharmaceutical applications and requirements of resins for printing by digital light processing (DLP)	6
Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation	6
Stability assessment of a novel 3D-printed oral dosage form of Mexiletine Hydrochloride: a six-month shelf-life study	6
Development of stabilized fuzapladib solution for injection: forced degradation study and pharmacokinetic evaluation	6
Preparation, characterization and drug release properties of 5-(p-carboxyphenoxy) valeric anhydride microspheres loaded with nimodipine	6
HPMCAS-solidified supersaturated baicalin self-nanoemulsifying drug delivery systems: development and anti-colitis evaluation	6
Black seed oil boosts antidiabetic activity of glibenclamide: development of solidified self nanoemulsifying drug delivery system and evaluation in Streptozotocin-Induced diabetic rat model	6
The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer	6
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method	6
Thermosensitive hydrogel with nanostructured lipid carriers (NLC) for the topical administration of curcuminoids, resveratrol, and piperine intended for the treatment of psoriasis	6
Nanocoating and biological evaluation of clindamycin- and rifampicin-loaded nanospheres impregnated silicone tube for antibacterial application	6
Perspective on the influence of suspension manufacturing unit operations on bioburden viability and selection of sampling points at the pilot scale	5
Engineering orally disintegrating tablets for buccal delivery of cilostazol with enhanced dissolution and bioavailability: a novel dual porogenic approach, in vitro char	5
Formulation and characterization of transfersomes for ocular delivery of tonabersat	5
Recent advances and persistent challenges in the design of freeze-drying process for monoclonal antibodies	5
Ten years of the manufacturing classification system: a review of literature applications and an extension of the framework to continuous manufacture	5
Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells	5
Docetaxel liposomes for lung targeted delivery: development and evaluation	5
Atorvastatin-loaded cubosome: a repurposed targeted delivery systems for enhanced targeting against breast cancer	5
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis	5
An injectable ropivacaine and lornoxicam sustained-release gel regulated by low molecular weight poly(ortho esters)	5
Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain	5
Preparation, characterization and in vivo studies of amorphous solid dispersion of gambogic acid with meglumine	5
Co-crystallization of Hesperidin with different co-formers to enhance solubility, antioxidant and anti-inflammatory activities	5
Formulation and evaluation of carrier-based dry powders containing budesonide and arformoterol for inhalation therapy	5
Caspofungin formulations for buccal and sublingual mucosae anti-fungal infections: physicochemical characterization, rheological analysis, release and ex vivo permeabili	5
Revolutionizing treatment for topical fungal infections: evaluating penetration-enhancer-containing vesicles as a fluconazole delivery system: Ex-vivo and	5
Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations	5
Ivermectin-based therapeutics: modern dosage forms and drug delivery innovations	5
Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser	5
Quality by design (QbD) development of a Soluplus/TPGS-based ternary amorphous solid dispersion for enhanced oral bioavailability of acacetin	5
Nanoparticle-based chewable gels of praziquantel	5
Microsponges-mediated targeted topical delivery of rosemary oil for hair growth promotion: optimization and in-vivo studies	5
Surface Modification of lactose carrier particles using a fluid bed coater to improve fine particle fraction for dry powder inhalers	5
Advancing darunavir delivery: nanoformulation strategies and innovations in HIV therapy	5
Fast dissolving microneedle patch for pronounced systemic delivery of an antihyperlipidemic drug	5
Transdermal drug delivery of rizatriptan using microneedles array patch: preparation, characterization and ex-vivo/in-vivo study	5
Preparation and characterization of duloxetine-loaded nanofiber scaffold composed of polyvinyl alcohol and chitosan as wound healing agent, fabricated by electrospinning method	5
Using chitosan-coated magnetite nanoparticles as a drug carrier for opioid delivery against breast cancer	5
Enhanced skin penetration and clinical antifungal activity of eugenol encapsulated in aspasomes	5
Mini-tablets as technological strategy for modified release of morphine sulfate	5
Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives	5
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery	5
AI-guided real-time detection of flow irregularities and bottlenecks in pharmaceutical vial filling lines using vision-based models	5
Characterization and ex vivo evaluation of curcumin nanoethosomes for melanoma treatment	5