OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Development and Technology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Development of PLGA-SPC3 functionalized gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: biodistribution and cytotoxicity analysis	89
Insights into tablet sticking: a quantitative case study with an ibuprofen and methocarbamol-based formulation	51
Glycyrrhizic acid assists anti-psoriatic efficacy of a self-deformable curcumin loaded transdermal gel	42
Influence of punch coating surface properties on sticking during the tableting process	36
Facile fabrication of degradable, serrated polyethylene diacrylate microneedles using stereolithography	33
Boron phenyl alanine targeted ionic liquid decorated chitosan nanoparticles for mitoxantrone delivery to glioma cell line	27
Formulation and optimization of a single-layer coat for targeting budesonide pellets to the descending Colon	23
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers	21
Preparation and functional evaluation of electrospun polymeric nanofibers as a new system for sustained topical ocular delivery of itraconazole	20
Comparison study of physicochemical and biopharmaceutics properties of hydrophobic drugs ground by two dry milling processes	20
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS	20
Scale-up in twin-screw wet granulation: impact of formulation properties	19
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin.	18
Preparation, characterization, and antibacterial activity of tigecycline-loaded, ultrasound-activated microbubbles	18
Formulation development, characterization, and evaluation of bedaquiline fumarate – Soluplus ^® – solid dispersion	16
Tabletability and compactibility of α-lactose monohydrate powders of different particle size. I. Experimental comparison	16
Emulgels: a promising topical drug delivery system for arthritis management and care	16
Sustained linagliptin administration: superior glycemic control and less pancreatic injury in diabetic rats	16
Enhancement of the dissolution and in-vitro activity of a new antineoplastic agent	15
Sustained release of curcumin self-emulsifying drug delivery system (SEDDS) from solvent-cast Soluplus^® films	15
Drug-silica-cellulose ternary matrix for the oral delivery of Cyclosporine A: in vitro and in vivo evaluation	15
Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug	15
Intranasal delivery of sulpiride nanostructured lipid carrier to central nervous system; in vitro characterization and in vivo study	14
Permeability of olmesartan medoxomil from lipid based and suspension formulations using an optimized HDM-PAMPA model	14
Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded with shikonin	14

Preparation and anti-tumor activity of paclitaxel silk protein nanoparticles encapsulated by biofilm	13
Development of an enhanced formulation to minimize pharmacokinetic variabilities of a weakly basic drug compound	13
Evaluating the color stability of titanium dioxide-free film coats under environmental and light stress	13
Buccal lidocaine mucoadhesive patches for pediatrics’ teething pain: overcoming possible hazards of oral gels	13
mRNA-based vaccines – global approach, challenges, and could be a promising wayout for future pandemics	13
Preparation of a novel tacrolimus ion sensitive ocular in situ gel and in vivo evaluation of curative effect of immune conjunctivitis	13
Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation	13
Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA)	12
Impact of grinding balls on the size reduction of Aprepitant in wet ball milling procedure	12
Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system	12
Targeted delivery strategy of indocyanine green-mitoxantrone loaded liposomes co-modified with BTP-7 and BR2 for the treatment of glioma	12
Formulation of smokeless tobacco products with a wide range of pH to study nicotine pharmacokinetics and pharmacodynamics	12
Correction	11
Design and evaluation of erucic acid-phytosphingosine structured cationic nanoemulsions as a plasmid DNA delivery system against breast cancer cells	11
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study	11
Acriflavine-loaded solid lipid nanoparticles: preparation, physicochemical characterization, and anti-proliferative properties	11
Microfluidics in drug delivery: review of methods and applications	11
Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation	11
Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples	10
Development and characterization of an amorphous curcumin-Eudragit^®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties	10
Formulation design, optimization and in vivo evaluation of oral co-encapsulated resveratrol-humic acid colloidal polymeric nanocarriers	10
Dual-modified PCL-PEG nanoparticles for improved targeting and therapeutic efficacy of docetaxel against colorectal cancer	10
pH/enzyme dual sensitive and nucleus-targeting dendrimer nanoparticles to enhance the antitumour activity of doxorubicin	10
Thermosensitive gel based on cellulose derivative for topical delivery of propolis in acne treatment	10
Sustained latanoprost release from PEGylated solid lipid nanoparticle-laden soft contact lens to treat glaucoma	9
Extracellular vesicle-based formulation of doxorubicin: drug loading optimization, characterization, and cytotoxicity evaluation in tumor spheroids	9
Preparation and cytotoxicity evaluation of folic acid-modified YF8-OA self-assembled lipid prodrug nanoparticles	9
Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC	9
Effect of different molecular weight and terminal group PLGA on docetaxel nanoparticles: characterization and cytotoxic activity of castration-resistant prostate cancer cells	9
Improved transdermal permeability of tanshinone IIA from cataplasms by loading onto nanocrystals and porous silica	9
An overview of PLGA in-situ forming implants based on solvent exchange technique: effect of formulation components and characterization	8
The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines	8
Improvement of liraglutide release from PLGA microspheres by a porous microsphere-gel composite system	8
Chitosan-biotin topical film: preparation and evaluation of burn wound healing activity	8
Ivermectin: recent approaches in the design of novel veterinary and human medicines	8
Challenges and recent advances in erythropoietin stability	7
Stability of trastuzumab during nanomedicine formulation using SEC-HPLC coupled with polyacrylamide gel electrophoresis	7
Manufacturing classification system (MCS): enabling better understanding of oral solid dosage formulation design	7
Dissolving microneedles loaded with nimodipine for prevention of sleep disorders at a high altitude	7
In vitro galactose-targeted study of RSPP050-loaded micelles against liver hepatocellular carcinoma	7
Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes	7
Itraconazole-loaded microemulsions: formulation, characterization, and dermal delivery using shed snakeskin as the model membrane	7
Nanocarriers with long-term retention in the respiratory system for prolonged drug exposure	7
Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting	6
Pharmaceutical applications and requirements of resins for printing by digital light processing (DLP)	6
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy	6
Controlled release of bioactive IL-2 from visible light photocured biodegradable elastomers for cancer immunotherapy applications	6
An overview of polyallylamine applications in gene delivery	6
Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation	6
The therapeutic efficacy and safety improvements of crizotinib prodrug micelles on breast cancer treatment	6

Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	6
Application of plant-derived exosome-like nanoparticles in drug delivery	6
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer	6
Black seed oil boosts antidiabetic activity of glibenclamide: development of solidified self nanoemulsifying drug delivery system and evaluation in Streptozotocin-Induced diabetic rat model	6
The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer	6
Correction	6
Two-dimensional printing of nanoparticles as a promising therapeutic method for personalized drug administration	6
Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system class-I drug	6
Mannosylation of pH-sensitive liposomes promoted cytoplasmic delivery of protein to macrophages: green fluorescent protein (GFP) performed as an endosomal escape tracer	6
The pioneering impact of artificial intelligence (AI) on pharmaceutical research and drug development (invited editorial)	6
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method	6
The effect of some acrylic polymers on dissolution of celecoxib solid dispersion formulations	5
In-vitro evaluation of dendrimeric formulation of oxaliplatin	5
Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives	5
Porous microneedle arrays as promising tools for the quantification of drugs in the skin: a proof of concept study	5
In vitro evaluation of enteral tube administration of lansoprazole orally disintegrating tablets	5
Nanoparticle-based chewable gels of praziquantel	5
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery	5
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis	5
Drug content determination of low-dosed hot-melt extruded filaments using Raman spectroscopy	5
Mini-tablets as technological strategy for modified release of morphine sulfate	5
Enhanced skin penetration and clinical antifungal activity of eugenol encapsulated in aspasomes	5
Docetaxel liposomes for lung targeted delivery: development and evaluation	5
Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations	5
Atorvastatin-loaded cubosome: a repurposed targeted delivery systems for enhanced targeting against breast cancer	5
Nanocoating and biological evaluation of clindamycin- and rifampicin-loaded nanospheres impregnated silicone tube for antibacterial application	5
Development of stabilized fuzapladib solution for injection: forced degradation study and pharmacokinetic evaluation	5
Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser	5
An overview on the advantages and limitations of 3D printing of microneedles	5
Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain	5
Ten years of the manufacturing classification system: a review of literature applications and an extension of the framework to continuous manufacture	5
Microsponges-mediated targeted topical delivery of rosemary oil for hair growth promotion: optimization and in-vivo studies	5
Self-assembled micelles enhance the oral delivery of curcumin for the management of alcohol-induced tissue injury	5