OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biotechnology is 118. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
TRGT-ing the dark genome to accurately characterize tandem repeats at scale	2045
The champions of drug development	1833
People	1265
Cancer Moonshot aims at liquid biopsies	1219
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding	789
Integrating medicine, engineering and business to educate early-stage researchers in cardiovascular device development	666
AI’s plastic recycling	642
Fluorescence microscopy resolution increases to near-atomic level	623
Single-cell RNA-seq keeps cells alive	619
Fungal architecture is a thing, and it’s eye-catching	553
Dreaming ideal protein structures	538
Synthetic biologics provide a path to target bHLH transcription factors	502
Author Correction: An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation	501
An optimized toolkit for prime editing	478
Overcoming unpredictability in biotech patents by tailored claiming aligned with genuine enablement	463
Drug pipeline 1Q22 — a raft of new modalities … and clinical blowups	426
Framework for predicting alloreactivity in hematopoietic cell transplants	388
Author Correction: Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion	363
Behind the graduate mental health crisis in science	361
Denmark invests in mucosal vaccines	351
Wireless microelectronic fibers to discover gut and brain pathways	348
People	342
Bite-sized solutions	333
Negative innovation: when patents are bad for patients	328
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope	321

Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism	313
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites	305
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids	301
Predicting transcriptional outcomes of novel multigene perturbations with GEARS	293
Cellular shuttles put mislocalized proteins in their right place	283
Engineered serum markers for non-invasive monitoring of gene expression in the brain	279
Dual SORT LNPs for multi-organ base editing	279
Diffusion model expands RoseTTAFold’s power	274
Biopharma dives into tumor-seeking radioactive drugs	258
Chem-map profiles drug binding to chromatin in cells	256
Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations	251
Democratizing knowledge representation with BioCypher	250
Engineering innate immune cells for cancer immunotherapy	246
Droplet-based transcriptome profiling of individual synapses	244
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice	243
A small and highly sensitive red/far-red optogenetic switch for applications in mammals	239
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome	237
The lysosomal degraders	228
The world’s first CRISPR therapy is approved: who will receive it?	213
Generative models for protein structures and sequences	211
Multi-omics single-cell data integration and regulatory inference with graph-linked embedding	205
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy	202
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition	193
An oncolytic virus–T cell chimera for cancer immunotherapy	191
Variant to function mapping at single-cell resolution through network propagation	187
3Q22 — more malaise in the markets	187
Biotech news from around the world	186
Light-sheet microscopy at high resolution	183
The need for need-finding in medical education	183
Author Correction: The cost of drug patent expiration date errors	178
Live cell imaging of signaling networks using a conventional microscope	174
Single-cell nanobody-based profiles of multiple epigenetic modalities and chromatin velocity	171
Delix Therapeutics : psychedelics without the trip	169
AI predicts cancer relapse from slides	168
Biotech news from around the world	166
Towards the non-invasive imaging of brain networks and functions at high resolution	166
People	165
Cancer diagnostics	165
Next-generation psychedelics: should new agents skip the trip?	164
Who will oversee the ethical limits of human embryo research?	162
Assessing workforce needs for the emerging CAR-T cell therapy industry	161
Nanotechnology offers alternative ways to fight COVID-19 pandemic with antivirals	161
Hallucinating functional protein sequences	160
Precise DNA cleavage using CRISPR-SpRYgests	160
Gains in early-onset dementia with progranulin open new paths for drug discovery	160
Decoding gene regulation with CRISPR perturbations	159
FDA approves first MASH drug	158
Adrestia Therapeutics — Gene networks to the rescue	156
Delivering 3 billion doses of Comirnaty in 2021	153
Slaughter-free meat hits the grocery shelf	152

Prediction of peptide mass spectral libraries with machine learning	152
Orna Therapeutics: circular logic	150
Retraction Note: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN	149
HSV-1’s contribution as a vector for gene therapy	148
Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression	146
Computationally designed enzymes show potent catalytic activity	145
Grand challenges in bioinformatics education and training	143
Engineered pegRNAs improve prime editing efficiency	142
A language model beats alphafold2 on orphans	142
Mapping single-cell data to reference atlases by transfer learning	141
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes	140
Detection of mosaic and population-level structural variants with Sniffles2	139
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice	139
Improving non-viral knock-in with modified single-stranded DNAs and small molecules	139
Top 20 translational researchers of 2020	138
2022 – toughing out the trough	138
Biotech news from around the world	138
Drug pipeline 4Q22 — sticking around	138
Chemigenetic kinase biosensors illuminate cell signaling networks	136
A strategy to load, rethread and read protein sequences through a nanopore	135
Enzymatic synthesis of RNA oligonucleotides	135
Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection	134
CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information	134
Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin	132
Spatial host–microbiome sequencing reveals niches in the mouse gut	130
Biotech news from around the world	129
Lab-made antibody stops malaria	129
100,000 whole-genome sequences’ diagnostic bonus	129
Forum: Boyden and Danzl	129
Synthetic virology: the experts speak	128
Moderna feud with NIH over COVID vaccine	128
COVID vaccine IP waiver agreed	128
Are ecological processes that select beneficial traits in agricultural microbes nature’s intellectual property rights?	125
Growth of biotech clusters over several decades through pioneering, variety and entrepreneurial science	123
The devolution of biosimilars regulations	123
Consternation follows Marks’ FDA departure	123
Baby’s first genome	122
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants	121
Microbiome-friendly phages join the campaign for better antimicrobials	120
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR	120
Platform solutions for commercial challenges to expanding patient access and making gene editing sustainable	119
A circularly permuted CasRx platform for efficient, site-specific RNA editing	118
Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR	118