OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biotechnology is 115. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Framework for predicting alloreactivity in hematopoietic cell transplants	1706
TRGT-ing the dark genome to accurately characterize tandem repeats at scale	1664
The champions of drug development	1138
People	1081
Cancer Moonshot aims at liquid biopsies	729
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding	644
Integrating medicine, engineering and business to educate early-stage researchers in cardiovascular device development	585
AI’s plastic recycling	578
Fluorescence microscopy resolution increases to near-atomic level	577
Single-cell RNA-seq keeps cells alive	549
Ultra-precision medicine	499
Diffusion model expands RoseTTAFold’s power	496
Fungal architecture is a thing, and it’s eye-catching	479
Behind the graduate mental health crisis in science	461
Dreaming ideal protein structures	434
Synthetic biologics provide a path to target bHLH transcription factors	399
Author Correction: An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation	398
An optimized toolkit for prime editing	387
Overcoming unpredictability in biotech patents by tailored claiming aligned with genuine enablement	370
Negative innovation: when patents are bad for patients	368
Drug pipeline 1Q22 — a raft of new modalities … and clinical blowups	331
Denmark invests in mucosal vaccines	324
Wireless microelectronic fibers to discover gut and brain pathways	318
People	314
Bite-sized solutions	308

Author Correction: Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion	304
Cellular shuttles put mislocalized proteins in their right place	304
The world’s first CRISPR therapy is approved: who will receive it?	297
The lysosomal degraders	287
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites	276
Chem-map profiles drug binding to chromatin in cells	276
Biopharma dives into tumor-seeking radioactive drugs	274
Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism	267
Democratizing knowledge representation with BioCypher	261
Variant to function mapping at single-cell resolution through network propagation	260
An oncolytic virus–T cell chimera for cancer immunotherapy	255
Engineered serum markers for non-invasive monitoring of gene expression in the brain	254
A small and highly sensitive red/far-red optogenetic switch for applications in mammals	245
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids	245
Engineering innate immune cells for cancer immunotherapy	240
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope	231
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition	223
Ebola as a case study for the patent landscape of medical countermeasures for emerging infectious diseases	222
Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations	221
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice	217
Generative models for protein structures and sequences	214
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy	213
Predicting transcriptional outcomes of novel multigene perturbations with GEARS	203
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome	200
Multi-omics single-cell data integration and regulatory inference with graph-linked embedding	195
Droplet-based transcriptome profiling of individual synapses	195
3Q22 — more malaise in the markets	194
Biotech news from around the world	189
Light-sheet microscopy at high resolution	188
HSV-1’s contribution as a vector for gene therapy	177
Hallucinating functional protein sequences	176
The need for need-finding in medical education	176
Live cell imaging of signaling networks using a conventional microscope	173
Author Correction: The cost of drug patent expiration date errors	173
Single-cell nanobody-based profiles of multiple epigenetic modalities and chromatin velocity	170
Delix Therapeutics : psychedelics without the trip	165
AI predicts cancer relapse from slides	165
Towards the non-invasive imaging of brain networks and functions at high resolution	164
Biotech news from around the world	163
Slaughter-free meat hits the grocery shelf	162
People	162
Adrestia Therapeutics — Gene networks to the rescue	159
Cancer diagnostics	157
Grand challenges in bioinformatics education and training	154
Next-generation psychedelics: should new agents skip the trip?	154
Who will oversee the ethical limits of human embryo research?	153
Gains in early-onset dementia with progranulin open new paths for drug discovery	152
Delivering 3 billion doses of Comirnaty in 2021	152
Decoding gene regulation with CRISPR perturbations	151
Retraction Note: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN	150

Orna Therapeutics: circular logic	150
Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression	149
A language model beats alphafold2 on orphans	149
FDA approves first MASH drug	147
Precise DNA cleavage using CRISPR-SpRYgests	145
Prediction of peptide mass spectral libraries with machine learning	144
Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes	142
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice	142
Mapping single-cell data to reference atlases by transfer learning	141
Nanotechnology offers alternative ways to fight COVID-19 pandemic with antivirals	141
Detection of mosaic and population-level structural variants with Sniffles2	140
Engineered pegRNAs improve prime editing efficiency	139
Assessing workforce needs for the emerging CAR-T cell therapy industry	137
2022 – toughing out the trough	137
Improving non-viral knock-in with modified single-stranded DNAs and small molecules	137
Drug pipeline 4Q22 — sticking around	134
Biotech news from around the world	134
Top 20 translational researchers of 2020	133
CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information	132
Microbiome-friendly phages join the campaign for better antimicrobials	131
Chemigenetic kinase biosensors illuminate cell signaling networks	129
A carte blanche approval in Alzheimer’s	128
Biotech news from around the world	127
100,000 whole-genome sequences’ diagnostic bonus	127
Forum: Boyden and Danzl	127
Microbiomes	127
Synthetic virology: the experts speak	126
Lab-made antibody stops malaria	126
COVID vaccine IP waiver agreed	126
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR	124
Moderna feud with NIH over COVID vaccine	124
Are ecological processes that select beneficial traits in agricultural microbes nature’s intellectual property rights?	124
Growth of biotech clusters over several decades through pioneering, variety and entrepreneurial science	123
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants	123
The devolution of biosimilars regulations	120
A strategy to load, rethread and read protein sequences through a nanopore	119
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors	117
Precision RNA base editing with engineered and endogenous effectors	117
Consternation follows Marks’ FDA departure	115
Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants	115
How will generative AI disrupt data science in drug discovery?	115