OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biotechnology is 113. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Forum: Alexandrov and Le	1579
Federation Bio: from single strains to a purely synthetic microbiome	1321
Forum: Optogenetics roundtable with Deisseroth and Gradinaru	1046
Multiplexed mapping of chromatin features at single-cell resolution	926
First Rounders: Jay Keasling	677
Unlocking drug modes of action with multi-dimensional high-throughput metabolic profiling	603
Toward a safer and more secure US bioeconomy	537
Glia-enriched cortical organoids implanted in mice capture astrocyte diversity	531
Making space for spatial biology in the clinic	488
Video game unleashes millions of citizen scientists on microbiome research	465
Synthetic GPCRs for controlling cellular responses	454
Base editors	449
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids	440
Forum: CRISPR screening roundtable with Stegmaier and Doench	411
People	391
Biotech news from around the world	378
Bilateral China–Brazil ties over agbiotech	374
Bluebird’s CALD gene therapy poised for approval	350
Improving the safety of lipid nanoparticle-based DNA delivery for extended gene expression	347
Biotech news from around the world	333
An oncolytic virus–T cell chimera for cancer immunotherapy	329
Variant to function mapping at single-cell resolution through network propagation	311
Bat biotech takes flight	310
Biotech news from around the world	309
Diffusion model expands RoseTTAFold’s power	301

Fungal architecture is a thing, and it’s eye-catching	287
People	286
Engineered Cas13 variants with minimal collateral RNA targeting	286
Linking genetic variants to cellular function and disease	278
Ultra-precision medicine	272
First Rounders: Lita Nelsen	269
Photys Therapeutics: customizing phosphorylation via molecular matchmaking	269
The champions of drug development	261
Biotech news from around the world	254
Women build strength in numbers	254
Synthetic biologics provide a path to target bHLH transcription factors	250
A neural network for long-term super-resolution imaging of live cells with reliable confidence quantification	244
Spatial characterization of single tumor cells by proteomics	241
Increase vigilance against cyberattacks	241
Patents benefit patients and patent reform would spur diagnostic and therapeutic development	240
Biotech news from around the world	239
Vector BioPharma: resurrecting adenoviral gene delivery	239
Multiplex-GAM detects complex chromatin interactions	233
Fluorescence microscopy resolution increases to near-atomic level	228
Eight diseases for gene therapy accelerator	226
People	224
Editor’s pick: Tenpoint Therapeutics	214
Wearable devices	214
Decoding the building blocks of cellular processes from single-cell transcriptomics data	208
Spanish tortillas go vegan	204
A base editor modifies bacterial genes in the guts of living mice	194
HIV drug 100% protective	193
Radical solutions	188
Big pharma craves slice of AI-based RNA drug discovery	185
Monitoring protein proximity with fluorogens	182
Nanopore sequencing	181
Detecting somatic mutations in single-cell data sets	179
Precise intraoperative brain tumor classification	177
Startups probe hidden viruses in the ‘dark genome’ to treat disease	170
An improved organoid model of the human cerebellum	165
Merck enlists trispecific killers	164
Cancer Moonshot aims at liquid biopsies	164
Single-cell multi-omics allows functional characterization of structural variants	161
AI’s plastic recycling	160
FDA okays first cardiac myosin inhibitor	159
Biotech news from around the world	158
Citizen chickpeas	156
Single-cell RNA-seq keeps cells alive	154
Vision–language AI assistance in human pathology	154
100,000 genomes — in Africa, for Africa	152
Biotech news from around the world	152
People	151
Has the PTAB made a difference in drug settlements and generic entry?	150
In vivo CRISPR agent cuts HAE attacks 95%	150
Supercharging T cell therapy with cancer mutations	149

Single-molecule peptide sequencing on semiconductor chips	145
Around the world in a month	144
Exploring tRNAs and their modifications and crosstalk using Nano-tRNAseq	144
Lentiviral vector cleared of causing blood cancer	142
Editor’s pick: Switch Therapeutics	142
Five questions with Weixin Tang	142
T cells	141
Cellular shuttles put mislocalized proteins in their right place	140
An antigen discovery pipeline integrates multi-omics data and informs immunotherapy	139
TRGT-ing the dark genome to accurately characterize tandem repeats at scale	139
Uncovering the global RNA virome	137
Government targets, end-of-year patenting rush and innovative performance in China	136
Industry moves on 3Rs	135
People	133
Organoids and organs on a chip	132
Personalized phosphoproteomics identifies functional signaling	129
Denmark invests in mucosal vaccines	128
Mining extinct proteomes for antimicrobial peptides	127
Capturing and modeling cellular niches from dissociated single-cell and spatial data	126
Generation of programmable splicing factors using RNA-binding proteins that activate exon inclusion	124
Sound healing and beyond	124
People	123
Wireless microelectronic fibers to discover gut and brain pathways	122
Genentech, Sangamo ink Alzheimer’s deal	122
CRISPR therapies march into clinic, but genotoxicity concerns linger	121
Chroma Medicine and Tune Therapeutics: Two companies take up epigenome editing	121
Identification of antimicrobial peptides from the human gut microbiome using deep learning	121
KARR-seq reveals cellular higher-order RNA structures and RNA–RNA interactions	119
Inferring cell–cell communication at single-cell resolution	119
Engineered CRISPR-Cas12a for higher-order combinatorial chromatin perturbations	119
Startup tackles oncogene-rich ecDNA	119
The lysosomal degraders	118
Bite-sized solutions	118
Real-time monitoring of tumor-homing bacteria and tumor cells in vivo using ultrasound	117
scChIX-seq infers dynamic relationships between histone modifications in single cells	116
Writing cellular history in protein chains	115
Drug licensing as evidence of evolution, diffusion and catch-up in East Asia	114
High-throughput retrieval of target sequences from complex clone libraries using CRISPRi	113
Rapid-response manufacturing of adenovirus-vectored vaccines	113
Mapping the patent landscape of medical machine learning	113