International Journal of Toxicology

Article	Citations
Isoflurane Promotes Cell Proliferation, Invasion, and Migration by Regulating BACH1 and miR-375 in Prostate Cancer Cells In Vitro	22
Mink Oil	17
In Utero Exposure to Di-n-butyl Phthalate Causes Modulation in Neurotransmitter System of Wistar Rats: A Multigenerational Assessment	16
Safety Assessment of a Novel Intravenous Diclofenac Sodium Formulation Following 28-Day Repeated Administration in Wistar Rats	15
Isopropyl Lanolate	13
Safety Assessment of Adenosine as Used in Cosmetics	13
Effect of Chronic Consumption of Fluoridated Water on Sciatic Nerve Conduction Velocity in Male Wistar Rats	12
I Wish I Had Known That! Impactful Guidance and Perspectives for a Fulfilling Career in Toxicology	12
Book Title: Neurotoxicity of Solvents, Vol. 14, 1st Edition. In Advances in Neurotoxicology Series AschnerMichaelCostaLucio G. In: ThrielChristoph van Ed. Neurotoxicity of Solvents - Volume 14, 1st Ed	12
Challenges and Opportunities of Cosmeceutical Regulations: A Global Perspective	12
Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics	11
A Characterization of the Nonclinical Pharmacology and Toxicology of Aficamten, a Reversible Allosteric Inhibitor of Cardiac Myosin	10
Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics	10
Inhalation of Particulate-free Diesel Engine Exhaust Induces Pulmonary Histopathological Alterations in Rat Models: Role of TRPV1 Receptors and Oxidative Stress During Sub-acute Exposure	10
Amended Safety Assessment of Synthetically Manufactured Amorphous Silica and Hydrated Silica as Used in Cosmetics	9
The Dog as a Second Species for Toxicology Testing Provides Value to Drug Development	9
Glycol Stearate and Glycol Stearate SE	9
In Silico Human Cardiomyocyte Action Potential Modeling: Exploring Ion Channel Input Combinations	9
Sodium α-Olefin Sulfonates	9
Recent Advances in Analytical Techniques for Antidepressants Determination in Complex Biological Matrices: A Review	9
Novel Finding of Urinary Erythropoietin as an Early Biomarker of Cisplatin-Induced Nephrotoxicity	8
Model Characterization: Total Body Irradiation or Busulfan for Conditioning in Human Cell Therapy Toxicology and Tumorigenicity Studies using NOD/SCID/IL2Rγnull (NSG) Mice	8
Safety Assessment of Hydroxyethyl Urea as Used in Cosmetics	8
Safety Assessment of Soy-Derived Ingredients as Used in Cosmetics	8
Microplastics: A Narrative Review on Modes of Exposure and Impact on Human Health	8

Dose Range-Finding Toxicity Study in Rats With Recombinant Human Lactoferrin Produced in Komagataella phaffii	7
Hepatitis A Virus Infection in Cynomolgus Monkeys Confounds the Safety Evaluation of a Drug Candidate	7
Pre-clinical Safety Assessment of Quercetagetin: Insights From Repeated-Dose Toxicity and Genotoxicity Studies	7
A Commentary on Fasting of Nonclinical Research Animals	7
Safety Assessment of Apple-Derived Ingredients as Used in Cosmetics	7
In vitro Safety Assessment of Extracts and Compounds From Plants as Sunscreen Ingredients	7
Safety Assessment of Hydrogen Peroxide as Used in Cosmetics	6
Lard and Lard-Derived Ingredients	6
Amyl Acetate and Isoamyl Acetate	6
Book Review: Reproductive and Developmental Toxicology Third Edition	6
Comparative Analyses of the Influences of Vehicles on Selected Biological Parameters Following Single-Dose Oral Administration in Sprague-Dawley Rats	6
Polyamino Sugar Condensate	6
Non-Human Primate Husbandry and Impact on Non-Human Primates Health: Outcomes From an IQ DruSafe/3RS Industrial Benchmark Survey	6
Weight of Evidence: Is an Animal Study Warranted? Assessments for Carcinogenicity, Drug Abuse Liability, and Pediatric Safety	6
Assessment of Global DNA Methylation in SH-SY5Y Cells Exposed to the Neonicotinoid Insecticides Imidacloprid and Thiamethoxam	5
AAV2-hAADC (Eladocagene Exuparvovec) Biodistribution and Expression: Superiority of Intraputaminal versus Intracerebroventricular and Intrathecal (Lumbar) Routes of Administration	5
Safety Assessment of Carica papaya (Papaya)—Derived Ingredients as Used in Cosmetics	5
A Randomized, Double-Blind, Controlled Trial to Assess the Effects of Lactoferrin at Two Doses vs. Active Control on Immunological and Safety Parameters in Healthy Adults	5
Thank you to our ad hoc reviewers!	5
Mutagenic, Acute, and Subchronic Toxicity Studies of the Hesperetin-7-Glucoside–β-Cyclodextrin Inclusion Complex	5
Safety Assessment of Methylxanthines as Used in Cosmetics	5
Effects of Solvent Dimethyl Sulfoxide Invites a Rethink of Its Application in Amyloid Beta Cytotoxicity	5
Ayahuasca and Dimethyltryptamine Adverse Events and Toxicity Analysis: A Systematic Thematic Review	5
Predictive Modeling of Pharmacokinetic Drug–Drug and Herb–Drug Interactions in Oncology: Insights From PBPK Studies	5
Toxicology Certification: The Need, the Value, and an Evolving Landscape	5
Incidence of Neoplasms and Selected Non-Neoplastic Findings in Control and Positive Control Groups in CByB6F1-Tg(HRAS)2Jic Hemizygous (rasH2 TM ) Mou	5
Nonclinical Safety Assessment of Lipid Nanoparticle-and Emulsion-Based Self-Amplifying mRNA Vaccines in Rats	5
Safety Assessment of Fatty Ethers as Used in Cosmetics	5
Book Review: Haschek and Rousseaux’s Handbook of Toxicologic Pathology	5
NRX-101, a Rapid-Acting Anti-Depressant, Does Not Cause Neurotoxicity Following Ketamine Administration in Preclinical Models	4
Book Review: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals	4
Mitochondria: Key Mediator for Environmental Toxicant–Induced Neurodegeneration	4
An Industry Perspective on Key Considerations for the ICH S13 Guidance: Nonclinical Safety Evaluations of Oligonucleotide-Based Therapeutics	4
Re-Review Summary of PEG Stearates as Used in Cosmetics	4
Re-Review Summary of VA/Crotonates Copolymer as Used in Cosmetics	4
Non-Clinical Cell Therapy Development Using the NCG Mouse Model as a Test System	4
Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes	4
Are Repeat-Dose Toxicity Studies Informative for Safety Assessment of Vaccine Candidates? A Survey of Vaccine Developers	4
Safety Assessment of Mannitol, Sorbitol, and Xylitol as Used in Cosmetics	3
Safety Assessment of Alkyl Amide MIPA Ingredients as Used in Cosmetics	3
Quaternium-18 and Quaternium-18 Bentonite	3
Alternatives to Monkey Reproductive Toxicology Testing for Biotherapeutics	3
Recent Advances in Drug Discovery Toxicology	3
Safety Assessment of Barley-Derived Ingredients as Used in Cosmetics	3
Editor’s note	3
In Vitro Evaluation of Vancomycin-Induced Toxicity in Human Primary Knee Chondrocytes	3
Evaluation of the Carcinogenic Potential of Enarodustat (JTZ-951), a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor, in 26-Week Tg.rasH2 Mouse Study and 2-Year Sprague-Dawley Rat Study	3
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics	3
The Non-Human Primate in Safety Assessment of a Bifunctional Long-Acting Insulin Analogue	3
Safety Assessment of Levulinic Acid and Sodium Levulinate as Used in Cosmetics	3

Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™	3
Safety Assessment of Eucalyptus globulus (Eucalyptus)-Derived Ingredients as Used in Cosmetics	3
Safety Assessment of Palm-Derived Ingredients as Used in Cosmetics	3
Thank you to our ad hoc reviewers!	3
Evaluation of Developmental and Reproductive Toxicity in Rabbits for MB-102, a Fluorescent Tracer Agent Designed for Real-Time Measurement of Glomerular Filtration Rate	3
Book Reviews	3
Ozone Preexposure Exacerbates Septic Lung Injury Through ADAR1 Modulation and Pyroptosis Activation	3
Safety Assessment of Basic Yellow 57 as Used in Cosmetics	3
Recovery Animals in Toxicology Studies: An Innovation and Quality Consortium Perspective on Best Practices With Case Study Examples	3
Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics	3
Safety Assessment of Polyquaternium-6 as Used in Cosmetics	3
Eleventh Triennial Toxicology Salary Survey	3
Shp2 in Alveolar Macrophages Regulates Macrophage I Phenotype in Acute Lung Injury	3
The Nonclinical Safety Assessment of a Novel Anti-CEACAM5 Antibody Exatecan Conjugate Predicts a Low Risk for Interstitial Lung Disease (ILD) in Patients—The Putative Mechanism Behind ILD	3
Re-Review Summary of Sodium Sesquicarbonate, Sodium Carbonate, and Sodium Bicarbonate as Used in Cosmetics	2
Pathology as a Core Discipline in the Biological Evaluation of Medical Devices	2
Safety Assessment of Salvia officinalis (Sage)-Derived Ingredients as Used in Cosmetics	2
Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study,	2
BHT – Butylated Hydroxytoluene	2
Phytantriol	2
MicroRNA-9-5p Is Involved in Lipopolysaccharide-Induced Acute Lung Injury Via the Regulation of Macrophage Polarization	2
An Evaluation of Zebrafish, an Emerging Model Analyzing the Effects of Toxicants on Cognitive and Neuromuscular Function	2
Identifying and Understanding Seizure Liability in Drug Development	2
Safety Assessment of Ascorbyl Glucoside and Sodium Ascorbyl Glucoside as Used in Cosmetics	2
Harihara M. Mehendale: A Life Dedicated to Mentoring and Research	2
Safety Assessment of Scutellaria baicalensis -Derived Ingredients as Used in Cosmetics	2
Safety Assessment of Zingiber officinale (Ginger) – Derived Ingredients as Used in Cosmetics	2
Biotin	2
A Retrospective Comparison of Electrocardiographic Parameters in Ketamine and Tiletamine-Zolazepam Anesthetized Indian Rhesus Monkeys (Macaca mulatta)	2
Co-Culturing Rat Dorsal Root Ganglion Neurons With Rat Schwann Cells Protects Them Against the Cytotoxic Effects of Silver and Gold Nanoparticles	2
Safety Assessment of Diacetone Alcohol as Used in Cosmetics	2
Safety Evaluation of a Prototypical Diazirine-Based Covalent Crosslinker and Molecular Adhesive	2
Sodium Lauryl Sulfoacetate	2
Translational Challenges From Nonclinical to Clinical Program: Case Study Examples	2
Isobutane, Isopentane, Butane, and Propane	2
Editor’s note	2
Safety Assessment of Dodecanedioic Acid (Dodecanedioic Acid Disodium Salt) Using Genotoxicity and Repeated 28-day Oral Toxicological Evaluation	2
An Industry Perspective on the Use of Novel Excipients in Lipid Nanoparticles—Nonclinical Considerations	2
Mutagenesis and Carcinogenesis Risk Evaluation for AAV and Lentiviral Gene Therapies	2
Thank you to our ad hoc reviewers!	2
Evaluation of Pulmonary Effects of 3-D Printer Emissions From Acrylonitrile Butadiene Styrene Using an Air-Liquid Interface Model of Primary Normal Human-Derived Bronchial Epithelial Cells	2
Assessing the Safety of MA-[D-Leu-4]-OB3, a Synthetic Peptide Leptin Mimetic: Two Pre-Clinical Toxicity Studies in Male and Female C57BL/6 Mice	2
Methylglyoxal Aggregates α-Synuclein by Inhibiting SIRT1-Hif-1α in Intestinal Enteroendocrine Cells	2
Hexamidine and Hexamidine Diisethionate	2
Assessing the Neurotoxicity of Bisphenol A Using Network Toxicology, Molecular Docking, and Molecular Dynamics Simulation	1
Titanium Complexes as Used in Cosmetics	1
Safety Assessment of Cocos nucifera (Coconut)-Derived Ingredients as Used in Cosmetics	1
The Spontaneous Incidence of Neurological Clinical Signs in Preclinical Species Using Cage-side Observations or High-definition Video Monitoring: A Retrospective Analysis	1
Safety Assessment of Soy Proteins and Peptides as Used in Cosmetics	1
Safety Assessment of Alkanoyl Lactyl Lactate Salts as Used in Cosmetics	1
The Effects of Nanoplastics on the Dopamine System of Cerebrocortical Neurons	1
Amended Safety Assessment of Mentha piperita (Peppermint)–Derived Ingredients as Used in Cosmetics	1
Glyoxal	1
Safety Assessment of Alkane Diols as Used in Cosmetics	1
Preclinical Safety Evaluation of BB106, a Novel Ketamine–Sulfobutylether-Beta-Cyclodextrin Salt, Following Subcutaneous Administration in Rats and Göttingen Minipigs	1
Integrin αvβ3 Antagonist Ameliorates Atherosclerotic Progression by Reducing Platelet Hyperactivation	1
Corrigendum to “Mutagenic, Acute, and Subchronic Toxicity Studies of the Hesperetin-7-Glucoside–β-Cyclodextrin Inclusion Complex”	1
PPG-11 and PPG-15 Stearyl Ether	1
Four-Week GLP Immunotoxicity Assessment of Lactoferrin Alpha Produced by Komagataella phaffii in Sprague-Dawley Rats	1
Safety Assessment of Vanilla as Used in Cosmetics	1
Re-Review Summary of Cholesterol as Used in Cosmetics	1
Safety Assessment of Glucosamine Ingredients as Used in Cosmetics	1
Safety Assessment of Honey-Derived Ingredients as Used in Cosmetics	1
Book Review: Drug Safety Evaluation, Fourth Edition	1
Sodium Naphthalenesulfonate and Sodium Polynaphthalenesulfonate	1
Acetyl Trialkyl Citrates	1
Safety Assessment of Starch Phosphates as Used in Cosmetics	1
Advanced Glycation End Products Induce Cuproptosis and Then Promote the Activation and Migration of Cardiac Fibroblasts	1
Amended Safety Assessment of Triglycerides as Used in Cosmetics	1
The Nonclinical Assessment of Trans-1,3,3,3-tetrafluoropropene (HFO-1234ze (E)), a Near Zero Global Warming Potential Propellant for Use in Metered Dose Inhalation Products	1
Juvenile Bone Toxicity: Study Considerations, Regulations, and Techniques for Assessment	1
Mutagenicity Assessment of Homologous Series of Methyl Ester Sulphonates (MES) Using the Bacterial Reverse Mutation (Ames) Test	1
Erythorbic Acid and Sodium Erythorbate	1
Dioscorea Villosa (Wild Yam) Root Extract	1
Sub-Cytotoxic Mitochondrial Stress in Cardiomyocytes and Whole-Organism Toxicity in C. elegans Induced by Molnupiravir	1
Methacrylate Ester Monomers	1
Putting a Face on Research	1
Book Review: Hayes’ Principles and Methods of Toxicology	1
Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics	1
An Overview of Gene Editing Modalities and Related Non-clinical Testing Considerations	1

Sodium Dehydroacetate and Dehydroacetic Acid	1
Safety and Toxicological Evaluation of Subunit Keyhole Limpet Hemocyanin-Loaded Lipid–PLGA Hybrid Nanoparticles (sKLH-hNPs) as a Nanocarrier for an Opioid Use Disorder Vaccine	1
Triacetin	1
Corrigendum to “Eleventh Triennial Toxicology Salary Survey”	1
Re-Review Summary of Ricinus Communis (Castor) Seed Oil and Ricinoleates as Used in Cosmetics	1