OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Toxicology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Interference: A Much-Neglected Aspect in High-Throughput Screening of Nanoparticles	25
Mapping the Mitochondrial Regulation of Epigenetic Modifications in Association With Carcinogenic and Noncarcinogenic Polycyclic Aromatic Hydrocarbon Exposure	23
Amended Safety Assessment of Parabens as Used in Cosmetics	23
Safety Assessment of Silk Protein Ingredients as Used in Cosmetics	14
Development and Regulatory Challenges for Peptide Therapeutics	14
Tg.rasH2 Mouse Model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey of Current Practices	14
The Effects of Polymer Coating of Gold Nanoparticles on Oxidative Stress and DNA Damage	14
Nonclinical Development of SRK-181: An Anti-Latent TGFβ1 Monoclonal Antibody for the Treatment of Locally Advanced or Metastatic Solid Tumors	14
Tumor-Inhibitory Effects of Zerumbone Against HT-29 Human Colorectal Cancer Cells	14
Acute Inhalation Toxicity After Inhalation of ZnO Nanoparticles: Lung Surfactant Function Inhibition In Vitro Correlates With Reduced Tidal Volume in Mice	13
Metabolomics as a Truly Translational Tool for Precision Medicine	13
Range of Neurological Signs in Cynomolgus Monkeys After Intrathecal Bolus Administration of Antisense Oligonucleotides	12
Effects of Reverse Transcriptase Inhibitors on Proliferation, Apoptosis, and Migration in Breast Carcinoma Cells	12
Investigating the Impact of OGT Inhibition on Doxorubicin- and Docetaxel-Induced Cytotoxicity in PC-3 and WPMY-1 Cells	11
Exposure and Public Health Effects of Polycyclic Aromatic Hydrocarbon Compounds in Sub-Saharan Africa: A Systematic Review	11
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™	11
Safety Assessment of PEGylated Alkyl Glycerides as Used in Cosmetics	10
Cadmium Chloride Induces Memory Deficits and Hippocampal Damage by Activating the JNK/p⁶⁶Shc/NADPH Oxidase Axis	10
Aflatoxin B1-Induced COX-2 Expression Promotes Mitophagy and Contributes to Lipid Accumulation in Hepatocytes In Vitro and In Vivo	10
Safety Assessment of Lecithin and Other Phosphoglycerides as Used in Cosmetics	10
Exploring Potential Carcinogenic Activity of Per- and Polyfluorinated Alkyl Substances Utilizing High-Throughput Toxicity Screening Data	9
Toxicology Paradise: Sorting Out Adverse and Non-adverse Findings in Animal Toxicity Studies	9
Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm	9
Quantitative Neurotoxicology: An Assessment of the Neurotoxic Profile of Kainic Acid in Sprague Dawley Rats	8
α-Melanocyte-Stimulating Hormone Triggers Melanogenesis Via Activation of the Aryl Hydrocarbon Receptor Pathway in B16F10 Mouse Melanoma Cells	8

Evaluation of Pulmonary Effects of 3-D Printer Emissions From Acrylonitrile Butadiene Styrene Using an Air-Liquid Interface Model of Primary Normal Human-Derived Bronchial Epithelial Cells	8
Toxicology Practice During COVID-19 Pandemic: Experience of the Dammam Poison Control Center-Eastern Province, Saudi Arabia	7
Safety Assessment of Polyaminopropyl Biguanide (Polyhexamethylene Biguanide Hydrochloride) as Used in Cosmetics	7
Genotoxic and Cytotoxic Activities of Lantadene A-Loaded Gold Nanoparticles (LA-AuNPS) in MCF-7 Cell Line: An in vitro Assessment	7
An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation	7
Combined Cardiopulmonary Assessments Using Impedance and Digital Implants in Conscious Freely Moving Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs: Pharmacological Characterization and Socia	6
In VitrotoIn VivoConcordance of Toxicity Using the Human Proximal Tubule Cell Line HK-2	6
Mutagenic, Acute, and Subchronic Toxicity Studies of the Hesperetin-7-Glucoside–β-Cyclodextrin Inclusion Complex	6
Nonclinical Safety Profile of Sotorasib, a KRAS^G12C-Specific Covalent Inhibitor for the Treatment of KRAS p.G12C-Mutated Cancer	6
Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics	6
Nonclinical Safety Assessment of Zanubrutinib: A Novel Irreversible BTK Inhibitor	6
Safety Assessment of AAV2-hGDNF Administered Via Intracerebral Injection in Rats for Treatment of Parkinson's Disease	5
Evaluation of the Effect of Hyaluronic Acid–Based Biomaterial Enriched With Tenascin-C on the Behavior of the Neural Stem Cells	5
Nonclinical Safety Assessment of Lipid Nanoparticle-and Emulsion-Based Self-Amplifying mRNA Vaccines in Rats	5
Evaluating Skin Sensitization Via Soft and Hard Multivariate Modeling	5
Safety Assessment of Ceramides as Used in Cosmetics	5
Influences of Unmodified and Carboxylated Carbon Nanotubes on Lipid Profiles in THP-1 Macrophages: A Lipidomics Study	5
Repeated Dose Toxicity Study and Developmental and Reproductive Toxicology Studies of a Respiratory Syncytial Virus Candidate Vaccine in Rabbits and Rats	5
Drug-Induced Seizures: Considerations for Underlying Molecular Mechanisms	5
Survivin Promoter-Driven DFF40 Gene Expression Sensitizes Melanoma Cancer Cells to Chemotherapy	5
Safety Assessment of Monoglyceryl Monoesters as Used in Cosmetics	5
Safety Assessment of L-β-Aminoisobutyric Acid (L-BAIBA): Subchronic Toxicity Study in Sprague Dawley Rats	5
Liquiritigenin Blocks Breast Cancer Progression by Inhibiting Connective Tissue Growth Factor Expression via Up-Regulating miR-383-5p	5
Safety Assessment of Saccharide Esters as Used in Cosmetics	4
Comparison of Illicit Drug Seizures Products of Natural Origin Using a Molecular Networking Approach	4
Using Evidence Integration Techniques in the Development of Health-Based Occupational Exposure Levels	4
miR-185-5p Represses Cells Growth and Metastasis of Osteosarcoma via Targeting Cathepsin E	4
Assessment of Statin Interactions With the Human NTCP Transporter Using a Novel Fluorescence Assay	4
Practical Considerations in Determining Adversity and the No-Observed-Adverse-Effect-Level (NOAEL) in Nonclinical Safety Studies: Challenges, Perspectives and Case Studies	4
Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics	4
The Utility of Novel Urinary Biomarkers in Mice for Drug Development Studies	4
Threshold for Anaphylactoid Reaction to Polysorbate 80 in Canines	4
Evaluation of the Expression Profile of Antibiotic-Induced Thrombocytopenia Using the Japanese Adverse Drug Event Report Database	4
Preclinical Safety Assessment and Toxicokinetics of Apitegromab, an Antibody Targeting Proforms of Myostatin for the Treatment of Muscle-Atrophying Disease	4
Protein-Ligand Identification andIn VitroInhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s	4
Four-Week Repeated Intravenous Dose Toxicity of Self-Assembled-Micelle Inhibitory RNA-Targeting Amphiregulin in Mice	4
Behavioral, Histopathologic, and Molecular Biological Responses of Nanoparticle- and Solution-Based Formulations of Vincristine in Mice	3
Wood Smoke Extract Promotes Extracellular Matrix Remodeling in Normal Human Lung Fibroblasts	3
Permitted Daily Exposure Values: Application Considerations in Toxicological Risk Assessments	3
Genotoxicity of Glyphosate on Cultured Human Lymphocytes	3
Recent Advances in Drug Discovery Toxicology	3
Increasing the Reuse of Protein Non-Naïve Nonhuman Primates in Pharmaceutical Drug Discovery and Development: An Overview and Industry Position on the Challenges and Benefits	3
Effects of Vanadium Inhalation and Sweetened Beverage Ingestion in Mice: Morphological and Biochemical Changes in the Liver	3
Proposal to Eliminate Urethane-Treated Positive Control Dose Groups in 26-Week Tg.rasH2 Carcinogenicity Studies	3
Tumorigenicity Assessment of Human Cancer Cell Lines Xenografted on Immunodeficient Mice as Positive Controls of Tumorigenicity Testing	3
Exploring the Definition of “Similar Toxicities”: Case Studies Illustrating Industry and Regulatory Interpretation of ICH S6(R1) for Long-Term Toxicity Studies in One or Two Species	3
Polysorbate 80-Induced Anaphylactoid Reaction and the Effects on Cardiovascular Function: Dose Threshold and Species Comparison	3
Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin	3
Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys	3
Effects of Chronic Exposure to Microcystin-LR on the Gut Microbiota of Male Mice	3

Chromium [Cr(VI)] Exposure Causes Cytotoxicity of Human Bronchial Epithelial Cells (16-HBE) and Proteomic Alterations	3
Nonclinical Development of Biologics: Integrating Safety, Pharmacokinetics, and Pharmacodynamics to Create Smarter and More Flexible Nonclinical Safety Programs Optimizing Animal Use	3