OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Toxicology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Editor’s Response to Jorge A. García-Valenzuela and Martha R. Baez-Gaxiola	19
In Utero Exposure to Di-n-butyl Phthalate Causes Modulation in Neurotransmitter System of Wistar Rats: A Multigenerational Assessment	19
Phytantriol	17
Mutagenicity Assessment of Homologous Series of Methyl Ester Sulphonates (MES) Using the Bacterial Reverse Mutation (Ames) Test	13
Preclinical Safety Evaluation of Etripamil Nasal Spray in Cynomolgus Macaques (Macaca fascicularis) to Assess for Safety in Patients With Paroxysmal Supraventricular Tachycardia	12
Safety Assessment of Adenosine as Used in Cosmetics	10
5-Lipoxygenase Contributes to Benzo[a]pyrene-Induced Cytotoxicity and DNA Damage in Human Bronchial Epithelial Cells	8
Thank you to our ad hoc reviewers!	8
Aluminum Starch Octenylsuccinate	8
NEW: Haschek and Rousseaux’s Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology, 4th Edition - 2021	8
Safety Assessment of Alkyl Amide MIPA Ingredients as Used in Cosmetics	8
Mink Oil	8
Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics	8
I Wish I Had Known That! Impactful Guidance and Perspectives for a Fulfilling Career in Toxicology	7
The Non-Human Primate in Safety Assessment of a Bifunctional Long-Acting Insulin Analogue	7
Effect of Chronic Consumption of Fluoridated Water on Sciatic Nerve Conduction Velocity in Male Wistar Rats	7
Erythorbic Acid and Sodium Erythorbate	7
Isopropyl Lanolate	7
Assessing the Safety of MA-[D-Leu-4]-OB3, a Synthetic Peptide Leptin Mimetic: Two Pre-Clinical Toxicity Studies in Male and Female C57BL/6 Mice	7
So…….You Want to be a Peer Reviewer?	6
Normal Neurodevelopment and Fertility in Juvenile Male Rats Exposed to Polyethylene Glycol Following Dosing With PEGylated rFIX (Nonacog Beta Pegol, N9-GP): Evidence from a 10-Week Repeat-Dose Toxicit	6
Quaternium-18 and Quaternium-18 Bentonite	6
Increasing the Reuse of Protein Non-Naïve Nonhuman Primates in Pharmaceutical Drug Discovery and Development: An Overview and Industry Position on the Challenges and Benefits	6
Drug-Induced Seizures: Considerations for Underlying Molecular Mechanisms	6
Four-Week GLP Immunotoxicity Assessment of Lactoferrin Alpha Produced by Komagataella phaffii in Sprague-Dawley Rats	6

Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle	6
Safety Assessment of a Novel Intravenous Diclofenac Sodium Formulation Following 28-Day Repeated Administration in Wistar Rats	6
Review of the Hazards and Contraindications of Etomidate	6
Updating the Standards of Professional Competence in the Field of Toxicology: The Second Generation of Best Practice	6
Telomere Length and Arsenic: Improving Animal Models of Toxicity by Choosing Mice With Shorter Telomeres	6
Liquiritigenin Blocks Breast Cancer Progression by Inhibiting Connective Tissue Growth Factor Expression via Up-Regulating miR-383-5p	5
Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics	5
Safety Assessment of Polyol Phosphates as Used in Cosmetics	5
Recovery Animals in Toxicology Studies: An Innovation and Quality Consortium Perspective on Best Practices With Case Study Examples	5
A Characterization of the Nonclinical Pharmacology and Toxicology of Aficamten, a Reversible Allosteric Inhibitor of Cardiac Myosin	5
Isoflurane Promotes Cell Proliferation, Invasion, and Migration by Regulating BACH1 and miR-375 in Prostate Cancer Cells In Vitro	5
Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s	5
Chromium [Cr(VI)] Exposure Causes Cytotoxicity of Human Bronchial Epithelial Cells (16-HBE) and Proteomic Alterations	4
13-Week Repeated Oral Toxicity and Toxicokinetic Studies of Rabeprazole Sodium and Sodium Bicarbonate Combination in Dogs	4
Corrigendum to “Mutagenic, Acute, and Subchronic Toxicity Studies of the Hesperetin-7-Glucoside–β-Cyclodextrin Inclusion Complex”	4
PPG-11 and PPG-15 Stearyl Ether	4
Editor’s Note	4
Alternatives to Monkey Reproductive Toxicology Testing for Biotherapeutics	4
Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics	4
Toxicological Implications of Biological Heterogeneity	4
The Dog as a Second Species for Toxicology Testing Provides Value to Drug Development	4
Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics	4
Polysorbate 80-Induced Anaphylactoid Reaction and the Effects on Cardiovascular Function: Dose Threshold and Species Comparison	4
Juvenile Bone Toxicity: Study Considerations, Regulations, and Techniques for Assessment	4
High-Throughput Drug Screen for Potential Combinations With Venetoclax Guides the Treatment of Transformed Follicular Lymphoma	4
In Silico Human Cardiomyocyte Action Potential Modeling: Exploring Ion Channel Input Combinations	4
Safety Assessment of Streptococcus salivarius UBSS-01 in Rats and Double-Blind Placebo-Controlled Study in Healthy Individuals	4
Corrigendum to “Eleventh Triennial Toxicology Salary Survey”	3
Thank You to Our Ad Hoc Reviewers!	3
Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics	3
Safety Assessment of Triphenyl Phosphate as Used in Cosmetics	3
Preclinical Safety Assessment and Toxicokinetics of Apitegromab, an Antibody Targeting Proforms of Myostatin for the Treatment of Muscle-Atrophying Disease	3
Evaluation of the Carcinogenic Potential of Enarodustat (JTZ-951), a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor, in 26-Week Tg.rasH2 Mouse Study and 2-Year Sprague-Dawley Rat Study	3
Preclinical Safety Evaluation of the Human-Identical Milk Oligosaccharide Lacto-N-Triose II	3
Safety Assessment of Wheat-Derived Ingredients as Used in Cosmetics	3
Safety Assessment of Cocos nucifera (Coconut)-Derived Ingredients as Used in Cosmetics	3
Practical Considerations in Determining Adversity and the No-Observed-Adverse-Effect-Level (NOAEL) in Nonclinical Safety Studies: Challenges, Perspectives and Case Studies	3
American College of Toxicology	3
The Nonclinical Assessment of Trans-1,3,3,3-tetrafluoropropene (HFO-1234ze (E)), a Near Zero Global Warming Potential Propellant for Use in Metered Dose Inhalation Products	2
Glycol Stearate and Glycol Stearate SE	2
Safety Assessment of Mannitol, Sorbitol, and Xylitol as Used in Cosmetics	2
Safety Assessment of Vinylpyrrolidone Polymers as Used in Cosmetics	2
The Nonclinical Safety Assessment of a Novel Anti-CEACAM5 Antibody Exatecan Conjugate Predicts a Low Risk for Interstitial Lung Disease (ILD) in Patients—The Putative Mechanism Behind ILD	2
HC Yellow 5	2
Enhanced Prenatal and Postnatal Development Study in Marmoset Monkeys Following Administration of Felzartamab	2
Recent Advances in Analytical Techniques for Antidepressants Determination in Complex Biological Matrices: A Review	2
Safety Evaluation of KP-10 (Metastin 45–54) Following once Daily Intravenous Administration for 14 Days in Dog	2
Safety Assessment of Alkane Diols as Used in Cosmetics	2
Evaluation of Pharmaceuticals for DNA Damage in the Chicken Egg Genotoxicity Assay (CEGA)	2
Safety Assessment of Eucalyptus globulus (Eucalyptus)-Derived Ingredients as Used in Cosmetics	2

Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™	2
Sodium α-Olefin Sulfonates	2
Evaluation of Developmental and Reproductive Toxicity in Rabbits for MB-102, a Fluorescent Tracer Agent Designed for Real-Time Measurement of Glomerular Filtration Rate	2
Book Reviews	2
Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Exacerbates Methamphetamine-Induced Activation of Microglia and Neuroinflammation	2
Phosphatidylinositol 3-Kinase δ-Specific Inhibitor-Induced Changes in the Ovary and Testis in the Sprague Dawley Rat and Cynomolgus Monkey	2
EDTA and Salts	2
Shp2 in Alveolar Macrophages Regulates Macrophage I Phenotype in Acute Lung Injury	2
Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics	2
Zinc Phenolsulfonate	2
Pharmaceutical Industry Perspective on the Non-Clinical Evaluation of Novel Excipients: Results From an Industry Survey Conducted by the IQ Novel Excipient Working Group	2
American College of Toxicology	2
Amended Safety Assessment of Mentha piperita (Peppermint)–Derived Ingredients as Used in Cosmetics	2
A Health Intersection of Toxicology and Clinical Medicine	2
Sodium Dehydroacetate and Dehydroacetic Acid	2
Mitochondrial Impact of Organophosphate Pesticide-Induced Cardiotoxicity: An In Silico and In Vitro Study	2