OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Genomics is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Prolonged obesity alters males’ adipose profile: implications for disease?	32
Editorial Board	24
Identification of shared and disease-specific intratumoral microbiome-host gene associations in gastrointestinal tumors	23
Single-cell RNA sequencing reveals genes relevant to periodontal therapy and periodontitis	23
Analysis of a genetic region affecting mouse body weight	21
Assessing the impact of boldine on the gastrocnemius using multiomics profiling at 7 and 28 days post-complete spinal cord injury in young male mice	21
Impact of stress phenotype, elevated temperature, and bacterin exposure on male Atlantic salmon (Salmo salar) growth, stress, and immune biomarker gene expression	19
NR4A2-Driven Metabolic Reprogramming in the Heart: From Adaptive Response to Maladaptive Remodeling	19
Investigative power of genomic informational field theory relative to genome-wide association studies for genotype-phenotype mapping	19
The expression profile of 79 genes from 107 viruses revealed new insights into disease susceptibility in rats, mice, and muskrats	17
Deciphering taxonomic and functional patterns of microbial communities associated with the tiger tail seahorse (Hippocampus comes)	16
A long-term high-fat diet induces differential gene expression changes in spatially distinct adipose tissue of male mice	15
Dose-dependent progression of multiple low-dose streptozotocin-induced diabetes in mice	15
Mapping cardiac electrical abnormalities in rodents	14
Transcriptomic responses of equine skeletal muscle to acute exercise in a hot environment	14
Maternal and fetal mitochondrial gene dysregulation in hypertensive disorders of pregnancy	14
Complementary human gene interaction maps from radiation hybrids and CRISPRi	13
Cardiac biomarker responses following high-intensity interval and continuous exercise: the influence of ACE-I/D gene polymorphism and training status in men	13
Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with Krtcap3	13
Gut microbiome and host interactions in catfish: hybridization structures bacterial communities along catfish intestinal tract	12
Gene expression profile and injury sites in mice treated with Shiga toxin 2 and lipopolysaccharide as a Shiga toxin-associated hemolytic uremic syndrome model	12
MicroRNA-499-5p promotes vascular smooth muscle cell proliferation and migration via inhibiting SOX6	12
Single-cell profiling of the peripheral blood immune landscape during mid- and late-stage pregnancy	11
Physiological, biochemical, and genome-wide expression patterns during graded normobaric hypoxia in healthy individuals	11
Global phosphoproteomic profiling of skeletal muscle in ovarian hormone-deficient mice	10

Transcriptomics and proteomics revealed sex differences in human pulmonary microvascular endothelial cells	10
Off the shelf: Regulation of fish blood pH through ionocyte membrane remodelling and protein translocation without additional synthesis	10
Fecal dysbiosis and inflammation in intestinal-specific Cftr knockout mice on regimens preventing intestinal obstruction	10
Metabolomic pattern associated with physical sequelae in patients presenting with respiratory symptoms validates the aestivation concept in dehydrated patients	10
Knockout of Hsp70 genes significantly affects locomotion speed and gene expression in leg skeletal muscles of Drosophila melanogas	10
Kidney cell response to acute cardiorenal and isolated kidney ischemia-reperfusion injury	10
Gut microbial composition and diversity varies by CREBRF genotype among Samoan infants	9
The microbiome shaping cancer development, progression, and therapeutic response	9
Decoding exercise adaptation through multidimensional biocircuitry	9
Vacuole membrane protein 1 and miRNA-21: are they reliable partners to rescue acute kidney injury?	9
Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer	9
Connecting genes to physiology: the first 25 years of Physiological Genomics	9
Retraction for Huang et al., PEA15-HKII, stabilized by U2AF2, form a molecular switch governing cellular fate after spinal cord injury via MAPK pathway	9
Gut microbiota of wild fish as reporters of compromised aquatic environments sleuthed through machine learning	9
Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy intervention	8
Low carbohydrate availability promotes a distinct circulating microRNA profile 24 h following aerobic exercise	8
The genetic regulation of the gastric transcriptome is associated with metabolic and obesity-related traits and diseases	8
Lost in translation? Evidence for a muted proteomic response to thermal stress in a stenothermal Antarctic fish and possible evolutionary mechanisms	8
Alternative splicing of CADM1 is associated with endothelial progenitor cell dysfunction in preeclampsia	8
Correction for Gomez et al., volume 57, 2025, p. 65–79	7
Podocyte cell-specific Npr1 is required for blood pressure and renal homeostasis in male and female mice: role of sex-specific differences	7
The skeletal muscle of aged male mice exhibits sustained growth regulatory transcriptional profile following glucocorticoid exposure compared with young males	7
Epigenetic fluctuations underlie gene expression timescales and variability	7
Lung proinflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones	7
Extracellular vesicle-mediated transfer of lncRNA CLDN10-AS1 aggravates low-density lipoprotein-induced vascular endothelial injury	7
Sex and molecular differences in cardiovascular parameters at peak influenza disease in mice	7
Computational modeling of the synergistic role of GCN2 and the HPA axis in regulating the integrated stress response in the central circadian timing system	7
Differences in the bacterial communities along the intestinal tract of juvenile channel (Ictalurus punctatus) and hybrid (I. punctatus× I. furcatus) catfish	7
Blood pressure and the kidney cortex transcriptome response to high-sodium diet challenge in female nonhuman primates	7
A genetic variant associated with aquaporin 3 expression is correlated to in-hospital death in COVID-19 patients with extracellular hyperosmolality	7
Resistance exercise differentially alters extracellular vesicle size and subpopulation characteristics in healthy men and women: an observational cohort study	7
Rodents exposed to placental ischemia in utero display sex differences in brain miRNA expression, mitochondrial function, and blood pressure in adulthood	6
Myocardial transcriptomic and proteomic landscapes across the menopausal continuum in a murine model of chemically induced accelerated ovarian failure	6
Endothelial to mesenchymal transition in neonatal hyperoxic lung injury: role of sex as a biological variable	6
Embryonic hypoxia alters cardiac gene expression patterns in American alligators, Alligator mississippiensis	6
Systems genomics reveals age- and sex-dependent metabolic dysregulation from Glo1 reduction in mice	6
Knockdown of deoxythymidylate kinase suppresses progression and epithelial-mesenchymal-transition of lung adenocarcinoma via STAT3 signaling	6
METTL3-mediated m6A modification promotes processing and maturation of pri-miRNA-19a to facilitate nasopharyngeal carcinoma cell proliferation and invasion	6
DNA methylation dynamics in the small intestine of egg-selected laying hens along egg production stages	6
Immune and metabolic challenges induce changes in pain sensation and related pathways in the hypothalamus	6
Editorial Board	6
Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium	5
PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm	5
Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat	5
Nf1 in heart development: a potential causative gene for congenital heart disease: a narrative review	5
Multidimensional biocircuitry of exercise adaptation: integrating in vivo and ex vivo phenomics with miRNA mapping	5
Uromodulin in sepsis and severe pneumonia: a two-sample Mendelian randomization study	5
The effect of high-fiber diet based on gut microbiota in patients with chronic heart failure	5
Multidimensional characterization of the tumor microenvironment profiles in lung squamous cell carcinoma	5
White-throated sparrow (Zonotrichia albicollis) liver and pectoralis flight muscle transcriptomic changes in preparation for migration	5

Changes in the fecal gut microbiome of home healthcare patients with disabilities through consumption of malted rice amazake	5
Proteomics of novel induced pluripotent stem cell-derived vascular endothelial cells reveal extensive similarity with an immortalized human endothelial cell line	5
Changes in Liver and Lung antioxidant and mitochondrial biogenesis gene expression in Decompression Sickness resistant rats.	5
Transcriptomics and metabolomics analysis reveal cell subpopulations of trophoblast cells associated with preeclampsia	5
Corrigendum for Medvar et al., Volume 48, 2016, p. 502–512	5
Specific circulating miRNAs are associated with plasma lipids in a healthy American cohort	5
Transcriptome profiling suggests molecular sexual dimorphism in lumbosacral dorsal root ganglia and sex-specific mechanisms underlying visceral pain	5
Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague-Dawley rats	4
Small LDL subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids	4
Integrated analysis of methylome and transcriptome responses to exercise training in children with overweight/obesity	4
Association of SNP-SNP interactions of surfactant protein genes with severity of respiratory syncytial virus infection in children	4
The uterine secretory cycle: recurring physiology of endometrial outputs that setup the uterine luminal microenvironment	4
Complementary yet divergent effects of exercise and an exercise mimetic on microbiome in high-fat diet-induced obesity	4
mRatBN7.2: familiar and unfamiliar features of a new rat genome reference assembly	4
A novel locus and HbA1c: tracing pathophysiological links beyond diabetes	4
Transcriptional dynamics of sleep deprivation and subsequent recovery sleep in the male mouse cortex	4
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer	4
Genome-wide comparative analyses highlight selection signatures underlying saline adaptation in Chilika buffalo	4
Single-cell transcriptomic heterogeneity between conduit and resistance mesenteric arteries in rats	4
Detecting metabolic stress signals to optimize intense military training: a focus on extracellular vesicle cargo as a promising strategy	4
Echocardiography phenotyping in murine genetic reference population of BXD strains reveals significant QTLs associated with cardiac function and morphology	4
Differential expression of miRNAs in slow and fast muscle fibers isolated from GFP-Myh7 mice	4
Genetic and environmental factors associated with lactose digestion in African populations	4
Emerging roles for estrogen in regulating skeletal muscle physiology	4
Melanocortin MC₄R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain	4
Genome-wide association study of exercise-induced skeletal muscle hypertrophy and the construction of predictive model	4
A better way to assess developmental competence of mammalian early embryos?	4
Human endogenous retroviruses: our genomic fossils and companions	4
Pregnancy-specific shifts in the maternal microbiome and metabolome in the BPH/5 mouse model of superimposed preeclampsia	4
Local and systemic transcriptomic responses from acute exercise induced muscle damage of the human knee extensors	4
Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies	3
Vitamin D regulates microflora and ameliorates LPS-induced placental inflammation in rats	3
Gonadal sex and chromosome complement influence the gut microbiome in a mouse model of allergic airway inflammation	3
Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat	3
Early fibrotic gene activation precedes structural remodeling in the heart of cardiac myosin binding protein-C knockout mice	3
Biological sex: why we should listen to genetics and lessons from race to guide precision medicine	3
Parental cardiorespiratory fitness influences early life energetics and metabolic health	3
Temporal shifts to the gut microbiome associated with cognitive dysfunction following high-fat diet consumption in a juvenile model of traumatic brain injury	3
Differences in gut microbiota and metabolites between wrestlers with varying precompetition weight control effect	3
Whole blood transcriptome characterization of young female triathlon athletes following an endurance exercise: a pilot study	3
Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder	3
Genetic connection of carotid atherosclerosis with coat color and body weight in an intercross between hyperlipidemic mouse strains	3
Is the time to task failure during severe-intensity exercise associated with muscle, blood, and respiratory changes?	3
Optimization of mouse kidney digestion protocols for single-cell applications	3
Colorectal cancer subtyping and prognostic model construction based on interleukin-related genes	3
Polycystin-2-dependent transcriptome reveals early response of autosomal dominant polycystic kidney disease	3
Changes in the saliva metabolome occur very rapidly in response to acute physical stress	3
Cross talk between obesogenic diet and estrogen drives distinct microbiota profiles in ovariectomized mice	3
Chamber-specific transcriptomic insight into cardiac development using guinea pig and human heart tissue	3
Pectic polysaccharides derived from Hainan Rauwolfia ameliorate NLR family pyrin domain-containing 3-mediated colonic epithelial cell pyroptosis in ulcerative colitis	3
Integrated genomics approaches identify transcriptional mediators and epigenetic responses to Afghan desert particulate matter in small airway epithelial cells	3
Dissecting the interplay between estrogen- and diet-induced obesity on the gut microbiota	3
Can abnormal chromatin folding cause high-penetrance cancer predisposition?	3
A first complete catalog of highly expressed genes in eight chicken tissues reveals uncharacterized gene families specific for the chicken testis	3