Toxicological Sciences

Article	Citations
Erratum to: An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability	136
Correction to: Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	125
Haloacetamides exacerbate non-alcoholic fatty liver disease induced by a high-fat diet in C57BL/6J mice	105
Effect of third-party components on emissions from a pod style electronic cigarette	103
Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats	67
Comment on: “Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis”	63
Quantitative and qualitative concordance between clinical and nonclinical toxicity data	58
The Foam Cell Formation Associated With Imbalanced Cholesterol Homeostasis Due to Airborne Magnetite Nanoparticles Exposure	55
Comparative review of human health reference values of the United States	52
Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration	49
Early detection of genotoxic hepatocarcinogens in rats using γH2AX and Ki-67: prediction by machine learning	48
Correction to: Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats	46
Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury	45
Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection	43
Cadmium inhibits calcium activity in hippocampal CA1 neurons of freely moving mice	43
Why rat oral cavity tumors should not be the basis of quantitative cancer risk assessment for oral exposure to hexavalent chromium	42
Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents	41
DNA adducts form in mouse lung and liver after oral naphthalene exposure	41
Effects of combustible cigarettes and heated tobacco products on immune cell-driven inflammation in chronic obstructive respiratory diseases	40
The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior	38
Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics	36
A mixture of organophosphate esters sex-specifically impacts monocyte–macrophages in Sprague-Dawley rats	35
Adapting existing toxicokinetic models to relate perfluoroalkyl and polyfluoroalkyl intake to biomarkers in humans	34
Effects of mixed metal exposure on MRI metrics in basal ganglia	33
Blockade of Voltage-Dependent K+ Channels by Benztropine, a Muscarinic Acetylcholine Receptor Inhibitor, in Coronary Arterial Smooth Muscle Cells	33

In vitro modeling of the post-ingestion bioaccessibility of per- and polyfluoroalkyl substances sorbed to soil and house dust	32
Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats	32
Adolescent exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) depletes the ovarian reserve, increases ovarian fibrosis, and alters the Hippo pathway in adult female mice	31
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury	31
Evaluation of neurotoxicity and the role of oxidative stress of cobalt nanoparticles, titanium dioxide nanoparticles, and multiwall carbon nanotubes in Caenorhabditis elegans	29
Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression	27
Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights	26
Multigenerational Effects of an Environmentally Relevant Phthalate Mixture on Reproductive Parameters and Ovarian miRNA Expression in Female Rats	26
Circ_0089282 inhibits carbon black nanoparticle-induced DNA damage by promoting DNA repair protein in the lung	25
Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity	24
Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry	24
Response to reader comment on: Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing	23
Gestational ozone inhalation elicits maternal cardiac dysfunction and transcriptional changes to placental pericytes and endothelial cells	22
Antiepileptic drugs are endocrine disruptors for the human fetal testisex vivo	22
Environmental Exposure to Brominated Flame Retardants: Unraveling Endocrine and Mammary Gland Effects That May Increase Disease Risk	21
Detection of developmental toxicity of the anti-COVID-19 drug molnupiravir using gastruloid-based in vitro assays	21
Investigating the replacement of carboxylates with carboxamides to modulate the safety and efficacy of platinum(II) thioether cyanide scavengers	21
Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors	21
MAD2L1 supports MYC-driven liver carcinogenesis in mice and predicts poor prognosis in human hepatocarcinoma	21
The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury	20
Comparative toxicological assessment of 2 bisphenols using a systems approach: evaluation of the behavioral and transcriptomic responses of Danio rerio to bisphenol A and tetrabromobisphenol A	20
Caveolin-1 and Its Functional Peptide CSP7 Affect Silica-Induced Pulmonary Fibrosis by Regulating Fibroblast Glutaminolysis	20
Advanced cardiotoxicity profiling using field potential imaging with UHD-CMOS-MEA in human iPSC-derived cardiomyocytes	19
Pluripotent stem cells for target organ developmental toxicity testing	19
Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model	19
Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts	19
Chronic arsenic exposure affects stromal cells and signaling in the small intestine in a sex-specific manner	18
Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow	18
Assessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility	17
Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment	17
Integration of new approach methods for the assessment of data-poor chemicals	16
ToxPoint: The indispensable role of zebrafish as a new approach methodology (NAM) in toxicology	16
Thank You, ToxSci 2024 Reviewers	16
Letter to the editor	15
Bone morphogenetic protein 4 is involved in cadmium-associated bone damage	15
Bayesian refinement of a physiologically based pharmacokinetic model for ethylbenzene pharmacokinetics in mice, rats, and humans	15
Trichloroethylene metabolite modulates DNA methylation-dependent gene expression in Th1-polarized CD4+ T cells from autoimmune-prone mice	15
Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Ppara-null mouse livers	15
Lead exposure at the feto-maternal interface: a cause for concern for fetal membrane trophoblasts	15
Long-lasting developmental effects in rat offspring after maternal exposure to acetamiprid in the drinking water during gestation	15
Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure	15
Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator	14
Tox-GAN: An Artificial Intelligence Approach Alternative to Animal Studies—A Case Study With Toxicogenomics	14
CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health	14
Systematic review of potential developmental and reproductive toxicity of microplastics	14
Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate	14
Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusio	14
A CRISPR-Cas9 mutation in sox9b long intergenic noncoding RNA (slincR) affects zebrafish development, behavior, and regeneration	14
Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells	14
Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS	14

Perfluorooctane Sulfonic Acid Disrupts Protective Tight Junction Proteins via Protein Kinase D in Airway Epithelial Cells	14
Parenchymal and Inflammatory Cell Responses to Single and Repeated Ozone Exposure in Healthy and Surfactant Protein-C Mutant Lung	13
Formaldehyde and the transient receptor potential ankyrin-1 contribute to electronic cigarette aerosol-induced endothelial dysfunction in mice	13
Particulate threats: aryl hydrocarbon receptor, alveolar epithelium, environmentally persistent free radicals, and endothelial dysfunction	13
Application of a metabolic network-based graph neural network for the identification of toxicant-induced perturbations	13
A systems toxicology approach for identification of disruptions in cholesterol homeostasis after aggregated exposure to mixtures of perfluorinated compounds in humans	13
Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa	13
Statistical analysis of multi-endpoint phenotypic screening increases sensitivity of planarian neurotoxicity testing	13
Correction to: 1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice	13
NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice	13
Technical evaluation and standardization of the human thyroid microtissue assay	13
The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity	12
Health risk assessment of toxic metals and DNA damage in somatic and germ cells by soil and groundwater of a major cement factory in Nigeria	12
The association between histopathologic effects and liver weight changes induced in mice and rats by chemical exposures: an analysis of the data from Toxicity Reference Database (ToxRefDB)	12
ToxPoint: Copper Is the New Showstopper	12
Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice	12
Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors	12
Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish	12
Defining VOC signatures of airway epithelial cells with PM2.5 exposure	12
A perspective review on factors that influence mutagenicity in medicinal plants and their health implications	12
Cadmium-induced stress: a close look at the relationship between autophagy and apoptosis	12
ToxPoint: Waste incineration management of plastic materials—an issue of increasing global public health importance	12
Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture:in vitrodose-dependent release, chemical content, and microRNA signatures involved in liver health	12
E-Cigarette (E-Cig) Liquid Composition and Operational Voltage Define the In Vitro Toxicity of Δ8Tetrahydrocannabinol/Vitamin E Acetate (Δ8THC/VEA) E-Cig Aerosols	12
Inhalation of concentrated ambient PM2.5 promotes inactivation of telomerase reverse transcriptase, telomere shortening, and senescence of multiple cell types in mice	12
Wedelolactone inhibits ferroptosis and alleviates hyperoxia-induced acute lung injury via the Nrf2/HO-1 signaling pathway	12
Azacitidine and cytarabine induce sustained lymphopenia with abnormal differentiation of common lymphoid progenitors and prolonged suppression of Dnmt3a and Dnmt3b expression in mice	12
Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity	12
The differential toxicity of three different oxidized nickel compound nanoparticles and the effects of particle surface ligands in mouse alveolar macrophages	11
Molecular Dosimetry of DNA Adducts in Rats Exposed to Vinyl Acetate Monomer	11
Exploration of oxidative stress-mediated genetic toxicology modes of action using a pathway analysis, Connectivity Mapping, and transcriptional benchmark dosing-based framework	11
Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population	11
The need for good practice in the application of mechanistic constructs in hazard and risk assessment	11
Identification of an adverse outcome pathway (AOP) for chemical-induced craniofacial anomalies using the transgenic zebrafish model	11
Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells	11
SETBP1-R54P mutation promotes malignant transformation of cadmium-induced 16HBE cells by down-regulating circ_0007095 expression	11
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin	11
Die hard: cell death mechanisms and their implications in nanotoxicology	11
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats	11
Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation	11
Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach	11
Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity	11
Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity	11
Associations between per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult National Health and Nutrition Examination Survey 2017 to	11
The Importance of Conventional Toxicological Metrics of Aerosol Characterization	11
Weight of evidence for cross-species conservation of androgen receptor-based biological activity	11
Unraveling the hemolytic toxicity tapestry of peptides using chemical space complex networks	11
Potential Biomarker Identification by RNA-Seq Analysis in Antibiotic-Related Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Pilot Study	11
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway	11
Development of a physiologically based pharmacokinetic model for flunixin in cattle and swine following dermal exposure	11
Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats	11
St. John’s Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation	10
Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data	10
Assessing Safety Without Animal Testing: The Road Ahead	10
Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary	10
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy)	10
Diet-induced obesity alters the ovarian chemical biotransformation and oxidative stress response proteins both basally and in response to 7,12-dimethylbenz[a]anthracene exposure	10
Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction	10
Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans	10
The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats	10
Structure-activity relationship read-across and transcriptomics for branched carboxylic acids	10
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice	9
An open-source interactive physiologically based pharmacokinetic model of tylosin in broiler chickens and laying hens	9
A mixture parameterized biologically based dosimetry model to predict body burdens of polycyclic aromatic hydrocarbons in developmental zebrafish toxicity assays	9
Chronic exposure to BDE-47 aggravates acute pancreatitis and chronic pancreatitis by promoting acinar cell apoptosis and inflammation	9
Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis	9
LC3B-regulated autophagy mitigates zinc oxide nanoparticle-induced epithelial cell dysfunction and acute lung injury	9
Mast cells are key mediators in the pulmonary inflammatory response to formaldehyde exposure	9
Developmental immunotoxicity study of tris(chloropropyl) phosphate in Hsd:Sprague Dawley SD rats exposed through dosed feed	9
Pulmonary immune response regulation, genotoxicity, and metabolic reprogramming by menthol- and tobacco-flavored e-cigarette exposures in mice	9
Distribution of polybrominated diphenyl ethers (PBDEs) in placental tissues of maternal and fetal origin in exposed Wistar rats and associations with thyroid hormone levels	9
Correction: Ammonium perchlorate: serum dosimetry, neurotoxicity, and resilience of the neonatal rat thyroid system	9
Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model	9
Exposure to the Organophosphate Pesticide Fenitrothion Directly Induced Defects in Mouse Embryonic External Genitalia	9
Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage	9
A computational framework to in silico screen for drug-induced hepatocellular toxicity	9
Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice	9
Behavior and brain size of larval zebrafish exposed to environmentally relevant concentrations of beta-methylamino-l-alanine	9
Incorporating Metabolic Competence into High-Throughput Profiling Assays	8
Single-cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a proinflammatory metabolic signature in male mice at late adulthood	8

An environmentally relevant mixture of per- and polyfluoroalkyl substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells	8
Disposition of glycolic acid into the embryo following oral administration of ethylene glycol during placentation in the rat and rabbit	8
Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors	8
Is statistical re-evaluation of hemolymphoreticular neoplasms from aspartame studies valid?	8
Corrigendum to: Children with Amalgam Dental Restorations Have Significantly Elevated Blood and Urine Mercury Levels	8
Cell Painting in HepaRG Cells: An Interlaboratory Reproducibility Study	8
Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice	8
Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts	8
The imprinted geneZac1regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease	8
Pulmonary and neurological health effects associated with exposure to representative composite manufacturing emissions and corresponding alterations in circulating metabolite profiles	8
Immunotoxicity of N-butylbenzenesulfonamide: impacts on immune function in adult mice and developmentally exposed rats	8
A transcriptomic biomarker predictive of cell proliferation for use in adverse outcome pathway-informed testing and assessment	8
Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer’s disease-like neuropathology in the AppNL-G-F knock-in mouse model	8
TGx-DDI (toxicogenomic DNA damage-inducing) biomarker validation: multi-site ring trial supporting regulatory use	8
Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions	8
Preimplantational ethanol exposure causes disturbances in gene expression and abnormalities in cerebral cortex morphogenesis and behavior	8
Long-term exposure to silica nanoparticles induces cardiac hypertrophy through the pyroptosis pathway	8
Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver	8
Impact of artificial sunlight aging on the respiratory effects of polyethylene terephthalate microplastics through degradation-mediated terephthalic acid release in male mice	7
Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing	7
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies	7
Public health evaluation of PFAS exposures and breastfeeding: a systematic literature review	7
Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats	7
Corrigendum to: Polychlorinated Biphenyl–Induced Reduction of Dopamine Transporter Expression as a Precursor to Parkinson's Disease–Associated Dopamine Toxicity	7
Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model	7
Naturally occurring autoimmune disease in (NZB × NZW) F1 mice is correlated with suppression of MZ B-cell development due to aberrant B-cell receptor (BCR) signaling, which is exacerbated by exposure	7
Evaluation of the Uptake, Metabolism, and Secretion of Toxicants by Zebrafish Larvae	7
A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment	7
Considering developmental neurotoxicityin vitrodata for human health risk assessment using physiologically-based kinetic modeling: deltamethrin case study	7
Evidence evaluated by European Food Safety Authority does not support lowering the temporary tolerable daily intake for bisphenol A	7
AIVIVE: a novel AI framework for enhanced in vitro to in vivo extrapolation (IVIVE) of toxicogenomics data	7
Peripubertal exposure to oxyfluorfen, a diphenyl herbicide, delays pubertal development in the male rat by antagonizing androgen receptor activity	7
The dose disrupts the pathway: application of Paracelsus principle to mechanistic toxicology	7
Preclinical Toxicological Assessment of A Novel siRNA, SLN360, Targeting Elevated Lipoprotein (a) in Cardiovascular Disease	7
Alternative Flavored Inhalable Products—A New Respiratory Hazard?	7
Perfluorooctane sulfonate exposure and alcohol-associated liver disease severity in a mouse chronic-binge ethanol feeding model	7
High-content toxicological profiling of 87 compounds using a 3D mouse mini-testis model: a New Approach Methodology (NAM) for prioritizing male reproductive toxicants	7
Arsenic Induces GSK3β-Dependent p-Tau, Neuronal Apoptosis, and Cognitive Impairment via an Interdependent Hippocampal ERα and IL-1/IL-1R1 Mechanism in Female Rats	7
The aryl hydrocarbon receptor differentially modulates the expression profile of antibody isotypes in a human B-cell line	7
Maternal PBDE exposure disrupts gut microbiome and promotes hepatic proinflammatory signaling in humanized PXR-transgenic mouse offspring over time	7
Exploring the Influence of Experimental Design on Toxicity Outcomes in Zebrafish Embryo Tests	7
Increased Renal Expression of Complement Components in Patients With Liver Diseases: Nonalcoholic Steatohepatitis, Alcohol-Associated, Viral Hepatitis, and Alcohol-Viral Combination	7
Targeted Intracellular Demethylation of Methylmercury Enhances Elimination Kinetics and Reduces Developmental Toxicity in TransgenicDrosophila	7
Thank you, ToxSci 2023 reviewers	7
DNA Damage and Repair and Epigenetic Modification in the Role of Oxoguanine Glycosylase 1 in Brain Development	7
Rat and dog quad-culture liver chip models: characterization and use to interrogate a potential flavin-containing monooxygenase-mediated, species-specific toxicity of a histamine receptor antagonist	7
In Vitro Pain Assay Using Human iPSC-Derived Sensory Neurons and Microelectrode Array	7
Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development inXenopus laevisUsing Iopanoic Acid	7
A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets	7
Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities	6
Development and safety of investigational and approved drugs targeting the RAS function regulation in RAS mutant cancers	6
Exposure to phthalates enhances estrogen and beta-catenin signaling pathways, leading to endometrial hyperplasia in mice	6
Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated With Chemical Alterations ofIn VitroNeural Network Formation	6
In vitro seizure risk assessment using a microelectrode array and comparison with an in vivo rat study	6
Dual inhibition of TGFβ2,3 is severely toxic, whereas selective inhibition of TGFβ1, 2, or 3 and dual inhibition of TGFβ1,2 is generally tolerated in mouse and cynomolgus monkey toxicology studies	6
Threshold for increased liver weight is protective of other effects in Peromyscus exposed to PFNA	6
In Memoriam: Donald J. Reed (1930–2022)	6
Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor	6
De-risking seizure liability: integrating adverse outcome pathways (AOPs), new approach methodologies (NAMs), and in silico approaches while highlighting knowledge gaps	6
Metabolic reprograming and increased inflammation by cadmium exposure following early-life respiratory syncytial virus infection: the involvement of protein S-palmitoylation	6
Emissions from plastic incineration induce inflammation, oxidative stress, and impaired bioenergetics in primary human respiratory epithelial cells	6
Reader comment on: Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing	6
Environmental exposome meets muscle wasting: unraveling the VOC-sarcopenia nexus through urinary metabolomics, inflammatory mediation, and network pharmacology in the NHANES cohort	6
Retraction: Research Article Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell Impairment in Mice	6
Human-relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice	6
The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure	6
Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways	6
Effects of urban PM2.5 on primary sinonasal epithelial cells in individuals with chronic rhinosinusitis	6
Excretion of polybrominated diphenyl ethers and AhR activation in breastmilk among firefighters	6
CardioMotion: identification of functional and structural cardiotoxic liabilities in small molecules through brightfield kinetic imaging	6
Refining high-throughput in vitro–in vivo extrapolation modeling through incorporation of intestinal toxicokinetics	6
Myclobutanil-mediated alteration of liver-gut FXR signaling in mice	6
Single-cell insights into mouse testicular toxicity under peripubertal exposure to di(2-ethylhexyl) phthalate	6
Effects of dopamine agonists on the estradiol-induced prolactin surge in ovariectomized female Wistar Han rats	6
An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin	6
Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile	6
Ferrostatin-1 mitigates cellular damage in a ferroptosis-like environment in Caenorhabditis elegans	6
Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys	6
TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells	6
Dioxin Disrupts Thyroid Hormone and Glucocorticoid Induction of klf9, a Master Regulator of Frog Metamorphosis	6
Profiling mechanisms that drive acute oral toxicity in mammals and its prediction via machine learning	6
Arsenic causes distinct gene expression changes in macrophages polarizedin vitrowith either interferon-γ or interleukin-4	6
Benzene metabolites increase vascular permeability by activating heat shock proteins and Rho GTPases	6
Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice	5
Impact of exposure to a mixture of organophosphate esters on the adrenal glands of Sprague Dawley rats	5
Environmental pro-oxidants induce altered envelope protein profiles in human keratinocytes	5
Insights into brominated flame retardant neurotoxicity: mechanisms of hippocampal neural cell death and brain region-specific transcriptomic shifts in mice	5
Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids	5
The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice	5
Quantitative label-free proteomic analysis of mouse ovarian antral follicles following oral exposure to a human-relevant mixture of three phthalates	5
Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis	5
Drug-induced impairment of mitochondrial fatty acid oxidation and steatosis: assessment of causal relationship with 45 pharmaceuticals	5
Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants	5
Chronic exposure to a mixture of phthalates shifts the white and brown adipose tissue phenotypes in female mice	5
Qualified kidney injury biomarkers demonstrate value during early clinical drug development	5