Toxicological Sciences

Article	Citations
Correction to: Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	171
Haloacetamides exacerbate non-alcoholic fatty liver disease induced by a high-fat diet in C57BL/6J mice	145
Effect of third-party components on emissions from a pod style electronic cigarette	122
Quantitative and qualitative concordance between clinical and nonclinical toxicity data	113
Comparative review of human health reference values of the United States	71
Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration	70
Early detection of genotoxic hepatocarcinogens in rats using γH2AX and Ki-67: prediction by machine learning	65
The Foam Cell Formation Associated With Imbalanced Cholesterol Homeostasis Due to Airborne Magnetite Nanoparticles Exposure	60
DNA adducts form in mouse lung and liver after oral naphthalene exposure	51
Comment on: “Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis”	50
Why rat oral cavity tumors should not be the basis of quantitative cancer risk assessment for oral exposure to hexavalent chromium	48
Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats	48
Correction to: Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats	45
Cadmium inhibits calcium activity in hippocampal CA1 neurons of freely moving mice	42
Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents	42
Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection	41
Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury	41
A mixture of organophosphate esters sex-specifically impacts monocyte–macrophages in Sprague-Dawley rats	40
Adapting existing toxicokinetic models to relate perfluoroalkyl and polyfluoroalkyl intake to biomarkers in humans	37
Effects of mixed metal exposure on MRI metrics in basal ganglia	37
Blockade of Voltage-Dependent K+ Channels by Benztropine, a Muscarinic Acetylcholine Receptor Inhibitor, in Coronary Arterial Smooth Muscle Cells	35
Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats	34
Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights	34
Circ_0089282 inhibits carbon black nanoparticle-induced DNA damage by promoting DNA repair protein in the lung	29
Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression	29

The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior	28
Effects of combustible cigarettes and heated tobacco products on immune cell-driven inflammation in chronic obstructive respiratory diseases	26
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury	26
In vitro modeling of the post-ingestion bioaccessibility of per- and polyfluoroalkyl substances sorbed to soil and house dust	26
Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics	26
Evaluation of neurotoxicity and the role of oxidative stress of cobalt nanoparticles, titanium dioxide nanoparticles, and multiwall carbon nanotubes in Caenorhabditis elegans	26
Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry	24
Antiepileptic drugs are endocrine disruptors for the human fetal testisex vivo	23
Adolescent exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) depletes the ovarian reserve, increases ovarian fibrosis, and alters the Hippo pathway in adult female mice	23
Multigenerational Effects of an Environmentally Relevant Phthalate Mixture on Reproductive Parameters and Ovarian miRNA Expression in Female Rats	23
The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury	22
Response to reader comment on: Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing	22
Investigating the replacement of carboxylates with carboxamides to modulate the safety and efficacy of platinum(II) thioether cyanide scavengers	22
Chronic arsenic exposure affects stromal cells and signaling in the small intestine in a sex-specific manner	22
Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors	22
Detection of developmental toxicity of the anti-COVID-19 drug molnupiravir using gastruloid-based in vitro assays	21
Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model	21
A novel constrained drop surfactometer demonstrates inhibition of lung surfactant function by PFAS aerosols in vitro	21
Environmental Exposure to Brominated Flame Retardants: Unraveling Endocrine and Mammary Gland Effects That May Increase Disease Risk	19
MAD2L1 supports MYC-driven liver carcinogenesis in mice and predicts poor prognosis in human hepatocarcinoma	19
Assessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility	18
Advanced cardiotoxicity profiling using field potential imaging with UHD-CMOS-MEA in human iPSC-derived cardiomyocytes	18
Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment	17
Integration of new approach methods for the assessment of data-poor chemicals	17
Caveolin-1 and Its Functional Peptide CSP7 Affect Silica-Induced Pulmonary Fibrosis by Regulating Fibroblast Glutaminolysis	17
Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts	17
Gestational ozone inhalation elicits maternal cardiac dysfunction and transcriptional changes to placental pericytes and endothelial cells	17
Pluripotent stem cells for target organ developmental toxicity testing	17
Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure	16
Bayesian refinement of a physiologically based pharmacokinetic model for ethylbenzene pharmacokinetics in mice, rats, and humans	16
Lead exposure at the feto-maternal interface: a cause for concern for fetal membrane trophoblasts	16
Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow	16
Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator	16
Comparative toxicological assessment of 2 bisphenols using a systems approach: evaluation of the behavioral and transcriptomic responses of Danio rerio to bisphenol A and tetrabromobisphenol A	16
Letter to the editor	16
Trichloroethylene metabolite modulates DNA methylation-dependent gene expression in Th1-polarized CD4+ T cells from autoimmune-prone mice	16
Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS	16
Thank You, ToxSci 2024 Reviewers	16
Long-lasting developmental effects in rat offspring after maternal exposure to acetamiprid in the drinking water during gestation	16
A CRISPR-Cas9 mutation in sox9b long intergenic noncoding RNA (slincR) affects zebrafish development, behavior, and regeneration	15
Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate	15
ToxPoint: The indispensable role of zebrafish as a new approach methodology (NAM) in toxicology	15
Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells	15
Systematic review of potential developmental and reproductive toxicity of microplastics	14
Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusio	14
Perfluorooctane Sulfonic Acid Disrupts Protective Tight Junction Proteins via Protein Kinase D in Airway Epithelial Cells	14
A systems toxicology approach for identification of disruptions in cholesterol homeostasis after aggregated exposure to mixtures of perfluorinated compounds in humans	14
Formaldehyde and the transient receptor potential ankyrin-1 contribute to electronic cigarette aerosol-induced endothelial dysfunction in mice	14
Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Ppara-null mouse livers	14
Particulate threats: aryl hydrocarbon receptor, alveolar epithelium, environmentally persistent free radicals, and endothelial dysfunction	14

NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice	14
Rethinking the Microenvironment’s Role in Chemical-Induced Malignancy	14
CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health	14
Bone morphogenetic protein 4 is involved in cadmium-associated bone damage	14
Statistical analysis of multi-endpoint phenotypic screening increases sensitivity of planarian neurotoxicity testing	13
Health risk assessment of toxic metals and DNA damage in somatic and germ cells by soil and groundwater of a major cement factory in Nigeria	13
Defining VOC signatures of airway epithelial cells with PM2.5 exposure	13
Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa	13
Correction to: 1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice	13
Inhalation of concentrated ambient PM2.5 promotes inactivation of telomerase reverse transcriptase, telomere shortening, and senescence of multiple cell types in mice	13
The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity	13
Wedelolactone inhibits ferroptosis and alleviates hyperoxia-induced acute lung injury via the Nrf2/HO-1 signaling pathway	13
Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture:in vitrodose-dependent release, chemical content, and microRNA signatures involved in liver health	13
Application of a metabolic network-based graph neural network for the identification of toxicant-induced perturbations	13
Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish	13
Parenchymal and Inflammatory Cell Responses to Single and Repeated Ozone Exposure in Healthy and Surfactant Protein-C Mutant Lung	13
E-Cigarette (E-Cig) Liquid Composition and Operational Voltage Define the In Vitro Toxicity of Δ8Tetrahydrocannabinol/Vitamin E Acetate (Δ8THC/VEA) E-Cig Aerosols	13
The association between histopathologic effects and liver weight changes induced in mice and rats by chemical exposures: an analysis of the data from Toxicity Reference Database (ToxRefDB)	13
A perspective review on factors that influence mutagenicity in medicinal plants and their health implications	13
Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice	13
Cadmium-induced stress: a close look at the relationship between autophagy and apoptosis	13
Technical evaluation and standardization of the human thyroid microtissue assay	12
Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells	12
Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity	12
The need for good practice in the application of mechanistic constructs in hazard and risk assessment	12
SETBP1-R54P mutation promotes malignant transformation of cadmium-induced 16HBE cells by down-regulating circ_0007095 expression	12
Azacitidine and cytarabine induce sustained lymphopenia with abnormal differentiation of common lymphoid progenitors and prolonged suppression of Dnmt3a and Dnmt3b expression in mice	12
Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors	12
ToxPoint: Waste incineration management of plastic materials—an issue of increasing global public health importance	12
Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity	12
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway	12
ToxPoint: Copper Is the New Showstopper	12
Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity	12
Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach	12
Identification of an adverse outcome pathway (AOP) for chemical-induced craniofacial anomalies using the transgenic zebrafish model	12
Potential Biomarker Identification by RNA-Seq Analysis in Antibiotic-Related Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Pilot Study	12
Associations between per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult National Health and Nutrition Examination Survey 2017 to	12
Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population	11
Unraveling the hemolytic toxicity tapestry of peptides using chemical space complex networks	11
Development of a physiologically based pharmacokinetic model for flunixin in cattle and swine following dermal exposure	11
Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation	11
The differential toxicity of three different oxidized nickel compound nanoparticles and the effects of particle surface ligands in mouse alveolar macrophages	11
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats	11
Die hard: cell death mechanisms and their implications in nanotoxicology	11
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin	11
Exploration of oxidative stress-mediated genetic toxicology modes of action using a pathway analysis, Connectivity Mapping, and transcriptional benchmark dosing-based framework	11
Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats	11
Weight of evidence for cross-species conservation of androgen receptor-based biological activity	11
Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction	10
Structure-activity relationship read-across and transcriptomics for branched carboxylic acids	10
Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary	10
St. John’s Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation	10
Chronic exposure to BDE-47 aggravates acute pancreatitis and chronic pancreatitis by promoting acinar cell apoptosis and inflammation	10
Distribution of polybrominated diphenyl ethers (PBDEs) in placental tissues of maternal and fetal origin in exposed Wistar rats and associations with thyroid hormone levels	10
The Importance of Conventional Toxicological Metrics of Aerosol Characterization	10
Lung injury, oxidative stress and impaired functioning in a model of prolonged ozone exposure in female mice are associated with macrophage proinflammatory and profibrotic activation and altered bioen	10
Assessing Safety Without Animal Testing: The Road Ahead	10
Maternal exposure to iopanoic acid disrupts thyroid hormone metabolism and impairs development of the rodent brain	10
Deoxynivalenol disrupts male mice reproduction through gut–testis axis dysregulation and metabolic alterations	10
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy)	10
Diet-induced obesity alters the ovarian chemical biotransformation and oxidative stress response proteins both basally and in response to 7,12-dimethylbenz[a]anthracene exposure	10
Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data	10
Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice	10
Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis	10
Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model	9
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice	9
A computational framework to in silico screen for drug-induced hepatocellular toxicity	9
Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans	9
Developmental immunotoxicity study of tris(chloropropyl) phosphate in Hsd:Sprague Dawley SD rats exposed through dosed feed	9
Incorporating Metabolic Competence into High-Throughput Profiling Assays	9
Single-cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a proinflammatory metabolic signature in male mice at late adulthood	9
Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions	9
Exposure to the Organophosphate Pesticide Fenitrothion Directly Induced Defects in Mouse Embryonic External Genitalia	9
LC3B-regulated autophagy mitigates zinc oxide nanoparticle-induced epithelial cell dysfunction and acute lung injury	9
An open-source interactive physiologically based pharmacokinetic model of tylosin in broiler chickens and laying hens	9
Cell painting in HepaRG cells: an interlaboratory reproducibility study	9
Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network	9
An environmentally relevant mixture of per- and polyfluoroalkyl substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells	9
Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer’s disease-like neuropathology in the AppNL-G-F knock-in mouse model	9
Mast cells are key mediators in the pulmonary inflammatory response to formaldehyde exposure	9

The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats	9
Correction: Ammonium perchlorate: serum dosimetry, neurotoxicity, and resilience of the neonatal rat thyroid system	9
TGx-DDI (toxicogenomic DNA damage-inducing) biomarker validation: multi-site ring trial supporting regulatory use	9
Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage	8
A mixture parameterized biologically based dosimetry model to predict body burdens of polycyclic aromatic hydrocarbons in developmental zebrafish toxicity assays	8
Long-term exposure to silica nanoparticles induces cardiac hypertrophy through the pyroptosis pathway	8
Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors	8
Pulmonary and neurological health effects associated with exposure to representative composite manufacturing emissions and corresponding alterations in circulating metabolite profiles	8
Disposition of glycolic acid into the embryo following oral administration of ethylene glycol during placentation in the rat and rabbit	8
Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts	8
In Memoriam: James E. Gibson (1941–2025)	8
Pulmonary immune response regulation, genotoxicity, and metabolic reprogramming by menthol- and tobacco-flavored e-cigarette exposures in mice	8
Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice	8
Preimplantational ethanol exposure causes disturbances in gene expression and abnormalities in cerebral cortex morphogenesis and behavior	8
Arsenic Induces GSK3β-Dependent p-Tau, Neuronal Apoptosis, and Cognitive Impairment via an Interdependent Hippocampal ERα and IL-1/IL-1R1 Mechanism in Female Rats	8
A transcriptomic biomarker predictive of cell proliferation for use in adverse outcome pathway-informed testing and assessment	8
Behavior and brain size of larval zebrafish exposed to environmentally relevant concentrations of beta-methylamino-l-alanine	8
Corrigendum to: Children with Amalgam Dental Restorations Have Significantly Elevated Blood and Urine Mercury Levels	8
Immunotoxicity of N-butylbenzenesulfonamide: impacts on immune function in adult mice and developmentally exposed rats	8
A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets	8
Evaluation of the Uptake, Metabolism, and Secretion of Toxicants by Zebrafish Larvae	8
Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model	7
Benzene metabolites increase vascular permeability by activating heat shock proteins and Rho GTPases	7
Targeted Intracellular Demethylation of Methylmercury Enhances Elimination Kinetics and Reduces Developmental Toxicity in TransgenicDrosophila	7
Arsenic causes distinct gene expression changes in macrophages polarizedin vitrowith either interferon-γ or interleukin-4	7
Perfluorooctane sulfonate exposure and alcohol-associated liver disease severity in a mouse chronic-binge ethanol feeding model	7
AIVIVE: a novel AI framework for enhanced in vitro to in vivo extrapolation (IVIVE) of toxicogenomics data	7
Naturally occurring autoimmune disease in (NZB × NZW) F1 mice is correlated with suppression of MZ B-cell development due to aberrant B-cell receptor (BCR) signaling, which is exacerbated by exposure	7
Impact of Neonatal Activation of Nuclear Receptor CAR ( Nr 1 i 3) on Cyp2	7
Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development inXenopus laevisUsing Iopanoic Acid	7
Impact of artificial sunlight aging on the respiratory effects of polyethylene terephthalate microplastics through degradation-mediated terephthalic acid release in male mice	7
Exploring the Influence of Experimental Design on Toxicity Outcomes in Zebrafish Embryo Tests	7
Peripubertal exposure to oxyfluorfen, a diphenyl herbicide, delays pubertal development in the male rat by antagonizing androgen receptor activity	7
The dose disrupts the pathway: application of Paracelsus principle to mechanistic toxicology	7
Corrigendum to: Polychlorinated Biphenyl–Induced Reduction of Dopamine Transporter Expression as a Precursor to Parkinson's Disease–Associated Dopamine Toxicity	7
Considering developmental neurotoxicityin vitrodata for human health risk assessment using physiologically-based kinetic modeling: deltamethrin case study	7
Alternative Flavored Inhalable Products—A New Respiratory Hazard?	7
The aryl hydrocarbon receptor differentially modulates the expression profile of antibody isotypes in a human B-cell line	7
Is statistical re-evaluation of hemolymphoreticular neoplasms from aspartame studies valid?	7
The imprinted geneZac1regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease	7
A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment	7
Maternal PBDE exposure disrupts gut microbiome and promotes hepatic proinflammatory signaling in humanized PXR-transgenic mouse offspring over time	7
Refining high-throughput in vitro–in vivo extrapolation modeling through incorporation of intestinal toxicokinetics	7
Preclinical Toxicological Assessment of A Novel siRNA, SLN360, Targeting Elevated Lipoprotein (a) in Cardiovascular Disease	7
Evidence evaluated by European Food Safety Authority does not support lowering the temporary tolerable daily intake for bisphenol A	7
Thank you, ToxSci 2023 reviewers	7
Rat and dog quad-culture liver chip models: characterization and use to interrogate a potential flavin-containing monooxygenase-mediated, species-specific toxicity of a histamine receptor antagonist	7
In Vitro Pain Assay Using Human iPSC-Derived Sensory Neurons and Microelectrode Array	7
High-content toxicological profiling of 87 compounds using a 3D mouse mini-testis model: a New Approach Methodology (NAM) for prioritizing male reproductive toxicants	7
DNA Damage and Repair and Epigenetic Modification in the Role of Oxoguanine Glycosylase 1 in Brain Development	7
Dual inhibition of TGFβ2,3 is severely toxic, whereas selective inhibition of TGFβ1, 2, or 3 and dual inhibition of TGFβ1,2 is generally tolerated in mouse and cynomolgus monkey toxicology studies	6
An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin	6
Development and safety of investigational and approved drugs targeting the RAS function regulation in RAS mutant cancers	6
High-content imaging and transcriptomic analyses of the effects of bisphenol S and alternative color developers on KGN granulosa cells	6
TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells	6
Reader comment on: Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing	6
The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure	6
Effects of urban PM2.5 on primary sinonasal epithelial cells in individuals with chronic rhinosinusitis	6
Myclobutanil-mediated alteration of liver-gut FXR signaling in mice	6
De-risking seizure liability: integrating adverse outcome pathways (AOPs), new approach methodologies (NAMs), and in silico approaches while highlighting knowledge gaps	6
Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing	6
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies	6
Effects of dopamine agonists on the estradiol-induced prolactin surge in ovariectomized female Wistar Han rats	6
Dioxin Disrupts Thyroid Hormone and Glucocorticoid Induction of klf9 , a Master Regulator of Frog Metamorphosis	6
Gallic acid relieved bortezomib-induced peripheral neurotoxicity by restoring Schwann cell lysosomal activity	6
Environmental exposome meets muscle wasting: unraveling the VOC-sarcopenia nexus through urinary metabolomics, inflammatory mediation, and network pharmacology in the NHANES cohort	6
Metabolic reprograming and increased inflammation by cadmium exposure following early-life respiratory syncytial virus infection: the involvement of protein S-palmitoylation	6
In vitro seizure risk assessment using a microelectrode array and comparison with an in vivo rat study	6
Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys	6
In Memoriam: Donald J. Reed (1930–2022)	6
Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor	6
Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats	6
Emissions from plastic incineration induce inflammation, oxidative stress, and impaired bioenergetics in primary human respiratory epithelial cells	6
Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways	6
Increased Renal Expression of Complement Components in Patients With Liver Diseases: Nonalcoholic Steatohepatitis, Alcohol-Associated, Viral Hepatitis, and Alcohol-Viral Combination	6
Public health evaluation of PFAS exposures and breastfeeding: a systematic literature review	6
Toxicity of waterpipe tobacco smoking: the role of flavors, sweeteners, humectants, and charcoal	6
Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research	6
Retraction: Research Article Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell Impairment in Mice	6
Ferrostatin-1 mitigates cellular damage in a ferroptosis-like environment in Caenorhabditis elegans	6
Human-relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice	6
Single-cell insights into mouse testicular toxicity under peripubertal exposure to di(2-ethylhexyl) phthalate	6
Excretion of polybrominated diphenyl ethers and AhR activation in breastmilk among firefighters	6
Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile	6
CardioMotion: identification of functional and structural cardiotoxic liabilities in small molecules through brightfield kinetic imaging	6
Threshold for increased liver weight is protective of other effects in Peromyscus exposed to PFNA	6
Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities	6
Profiling mechanisms that drive acute oral toxicity in mammals and its prediction via machine learning	6
Comparison of physiologically based pharmacokinetic modeling platforms for developmental neurotoxicity in vitro to in vivo extrapolation	5
Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants	5
Effects of PFAS on human liver transporters: implications for health outcomes	5
Quantitative label-free proteomic analysis of mouse ovarian antral follicles following oral exposure to a human-relevant mixture of three phthalates	5
Oral exposure to di(2-ethylhexyl) phthalate alters the expression of GATA6, OCT4, and CDX2 in blastocysts and decreases the rate of implantation in a mouse model	5
Environmental pro-oxidants induce altered envelope protein profiles in human keratinocytes	5
Impact of exposure to a mixture of organophosphate esters on the adrenal glands of Sprague Dawley rats	5