Toxicological Sciences

Article	Citations
Structure-specific variation in per- and polyfluoroalkyl substances toxicity among genetically diverse Caenorhabditis elegans strains	68
Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: a case study examining associations between PFOA a	65
2023–2024 Toxicological Sciences Paper of the Year	61
Haloacetamides exacerbate non-alcoholic fatty liver disease induced by a high-fat diet in C57BL/6J mice	53
Inhaled ozone induces distinct alterations in pulmonary function in models of acute and episodic exposure in female mice	49
Simulated burn pit smoke condensates cause sustained impact on human airway epithelial cells	49
Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system	47
Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity	43
Tributyltin and the Female Hypothalamic-Pituitary-Gonadal Disruption	43
Effects of the Hedgehog Signaling Inhibitor Itraconazole on Developing Rat Ovaries	40
Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents	38
Correction to: Gestational Exposure to Perchlorate in the Rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain	35
2021–2022Toxicological Sciencespaper of the year	35
Erratum to: An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability	34
In Memoriam: Donald J. Reed (1930–2022)	33
Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment	32
The Foam Cell Formation Associated With Imbalanced Cholesterol Homeostasis Due to Airborne Magnetite Nanoparticles Exposure	32
Upregulation of Circ_0035266 Contributes to the Malignant Progression of Inflammation-Associated Malignant Transformed Cells Induced by Tobacco-Specific Carcinogen NNK	32
Early detection of genotoxic hepatocarcinogens in rats using γH2AX and Ki-67: prediction by machine learning	32
Organochlorine Pesticide Dieldrin Suppresses Cellular Interferon-Related Antiviral Gene Expression	32
A Model of Human Small Airway on a Chip for Studies of Subacute Effects of Inhalation Toxicants	32
Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor	31
Metabolic reprograming and increased inflammation by cadmium exposure following early-life respiratory syncytial virus infection: the involvement of protein S-palmitoylation	31
Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes	29
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage	29

Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation	29
Rat deconvolution as knowledge miner for immune cell trafficking from toxicogenomics databases	28
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats	26
Dioxin Disrupts Thyroid Hormone and Glucocorticoid Induction of klf9, a Master Regulator of Frog Metamorphosis	26
Dictyostelium discoideum:An Alternative Nonanimal Model for Developmental Toxicity Testing	26
Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin	24
Liver Toxicity Observed With Lorlatinib When Combined With Strong CYP3A Inducers: Evaluation of Cynomolgus Monkey as a Nonclinical Model for Assessing the Mechanism of Combinational Toxicity	22
Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARγ in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol	22
Demyelination and impaired oligodendrogenesis in the corpus callosum following lead exposure	21
Feature-agnostic metabolomics for determining effective subcytotoxic doses of common pesticides in human cells	21
Comment on: “Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis”	21
Comprehensive Cardiotoxicity Assessment of COVID-19 Treatments Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes	20
Urinary miRNA Profiles in Chronic Kidney Injury—Benefits of Extracellular Vesicle Enrichment and miRNAs as Potential Biomarkers for Renal Fibrosis, Glomerular Injury, and Endothelial Dysfunction	20
Molecular Dosimetry of DNA Adducts in Rats Exposed to Vinyl Acetate Monomer	20
Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor	20
CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury	20
Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection	19
Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats	19
Gestational Exposure to Perchlorate in the Rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain	19
Towards a more effective REACH legislation in protecting human health	18
Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2	18
Investigations into hydrogen sulfide-induced suppression of neuronal activityin vivoand calcium dysregulationin vitro	18
Single-cell insights into mouse testicular toxicity under peripubertal exposure to di(2-ethylhexyl) phthalate	17
Cadmium inhibits calcium activity in hippocampal CA1 neurons of freely moving mice	17
Threshold for increased liver weight is protective of other effects in Peromyscus exposed to PFNA	17
Role of PPARγ in dyslipidemia and altered pulmonary functioning in mice following ozone exposure	17
Fetoplacental disposition and toxicity of cadmium in mice lacking the Bcrp transporter	16
A New Approach Methodology (NAM) Based Assessment of Butylated hydroxytoluene (BHT) for Endocrine Disruption Potential	16
Manganese relative oral bioavailability in electric arc furnace steel slag is influenced by high iron content and low bioaccessibility	16
Unraveling the hemolytic toxicity tapestry of peptides using chemical space complex networks	16
Cadmium inhibits differentiation of human trophoblast stem cells into extravillous trophoblasts and disrupts epigenetic changes within the promoter region of the HLA-G gene	16
Development of a physiologically based pharmacokinetic model for flunixin in cattle and swine following dermal exposure	16
Weight of evidence for cross-species conservation of androgen receptor-based biological activity	16
Exploring the interplay between cannabinoids and thymic functions	16
Correction to: Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	16
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin	15
Effects of dopamine agonists on the estradiol-induced prolactin surge in ovariectomized female Wistar Han rats	15
Die hard: cell death mechanisms and their implications in nanotoxicology	15
Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys	15
Tbx2 knockdown alleviated sevoflurane-induced cognitive disorder and neuron damages in aged rats via suppressing oxidative stress and ferroptosis	14
PreS/MD: Predictor of Sensitization Hazard for Chemical Substances Released From Medical Devices	14
Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs	14
Coupling the H295R with ERα and AR U2OS CALUX assays enables simultaneous testing for estrogenic, anti-androgenic and steroidogenic modalities	14
Maternal pre-conceptional glyphosate exposure impacts the offspring hepatic and ovarian proteome	14
Mixtures of phthalates disrupt expression of genes related to lipid metabolism and peroxisome proliferator-activated receptor signaling in mouse granulosa cells	14
Human-relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice	14
Excretion of polybrominated diphenyl ethers and AhR activation in breastmilk among firefighters	14
Signature analysis of high-throughput transcriptomics screening data for mechanistic inference and chemical grouping	14
Reliability of the AR-CALUX®In Vitro Method Used to Detect Chemicals with (Anti)Androgen Activity: Results of an International Ring Trial	13
Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats	13

Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes	13
Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and assoc	13
Associations between per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult National Health and Nutrition Examination Survey 2017 to	13
Kupffer cell expression of macrophage receptor with collagenous structure (MARCO) modulates macrophage gene induction and limits acute liver injury	13
DNA adducts form in mouse lung and liver after oral naphthalene exposure	13
A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity	13
COVID-19 Therapeutics and Vaccines: A Race to Save Lives	13
Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits	12
Transcriptomic analysis in liver spheroids identifies a dog-specific mechanism of hepatotoxicity for amcenestrant	12
Glyphosate toxicity:in vivo, in vitro, and epidemiological evidence	12
Deletion of IL-1β exacerbates acrylamide-induced neurotoxicity in mice	12
Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population	12
Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity	12
Woodsmoke Extracts Cross-Link Proteins and Induce Cornified Envelope Formation without Stimulating Keratinocyte Terminal Differentiation	12
TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells	12
SETBP1-R54P mutation promotes malignant transformation of cadmium-induced 16HBE cells by down-regulating circ_0007095 expression	12
Ferrostatin-1 mitigates cellular damage in a ferroptosis-like environment in Caenorhabditis elegans	12
Effect of third-party components on emissions from a pod style electronic cigarette	12
Gestational and Lactational Exposure to the Emergent Alternative Plasticizer 1,2-Cyclohexane Dicarboxylic Acid Diisononyl Ester (DINCH) Impairs Lipid Metabolism to a Greater Extent Than the Commonly U	12
Anticancer Activity and In Vitro to In Vivo Mechanistic Recapitulation of Novel Ruthenium-Based Metallodrugs in the Zebrafish Model	11
The effect of TiO2 nanoparticles on antral follicles is dependent on the nanoparticle internalization rate	11
Corrigendum to: Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence	11
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis	11
A Novel Computational Machine Learning Pipeline to Quantify Similarities in Three-Dimensional Protein Structures	11
Machine learning and artificial intelligence in physiologically based pharmacokinetic modeling	11
Correction to: Deletion of IL-1β exacerbates acrylamide-induced neurotoxicity in mice	11
Distribution of polybrominated diphenyl ethers (PBDEs) in placental tissues of maternal and fetal origin in exposed Wistar rats and associations with thyroid hormone levels	11
Aflatoxin B1 Induces Gut-Inflammation-Associated Fecal Lipidome Changes in F344 Rats	11
Investigation of urinary miRNA profile changes in amphotericin B-induced nephrotoxicity in C57BL/6 mouse, Sprague–Dawley rats and Beagle dogs	11
Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome—An Examination Using Triclosan and Perfluorohexane Sulfonate	11
Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans	11
Modeling the developing nervous system: a neuroscience perspective on the use of NAMs in DNT testing	11
Diet-induced obesity alters the ovarian chemical biotransformation and oxidative stress response proteins both basally and in response to 7,12-dimethylbenz[a]anthracene exposure	11
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury	11
Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs	11
Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity	11
Chemical Exposure-Induced Developmental Neurotoxicity in Head-Regenerating Schmidtea mediterranea	10
An in vitro and machine learning framework for quantifying serum albumin binding of per- and polyfluoroalkyl substances	10
A Sulfonyl Azide-Based Sulfide Scavenger Rescues Mice from Lethal Hydrogen Sulfide Intoxication	10
The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib	10
Adolescent exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) depletes the ovarian reserve, increases ovarian fibrosis, and alters the Hippo pathway in adult female mice	10
Effects of combustible cigarettes and heated tobacco products on immune cell-driven inflammation in chronic obstructive respiratory diseases	10
Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes	10
Vapor Cannabis Exposure Generationally Affects Male Reproductive Functions in Mice	10
Multigenerational Effects of an Environmentally Relevant Phthalate Mixture on Reproductive Parameters and Ovarian miRNA Expression in Female Rats	10
Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights	10
Toxicity of waterpipe tobacco smoking: the role of flavors, sweeteners, humectants, and charcoal	10
Mechanistic Computational Model for Extrapolating In Vitro Thyroid Peroxidase (TPO) Inhibition Data to Predict Serum Thyroid Hormone Levels in Rats	10
The Challenges of Predicting Drug-Induced QTc Prolongation in Humans	10
Club Cells Are the Primary Target for Permethrin-Induced Mouse Lung Tumor Formation	10
Effects of mixed metal exposure on MRI metrics in basal ganglia	10
Assessing Safety Without Animal Testing: The Road Ahead	10
Deciphering Adverse Drug Reactions:In VitroPriming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01	10
Estimating Hepatotoxic Doses Using High-Content Imaging in Primary Hepatocytes	10
Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated With Chemical Alterations ofIn VitroNeural Network Formation	9
The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats	9
New Approach Methodology for Assessing Inhalation Risks of a Contact Respiratory Cytotoxicant: Computational Fluid Dynamics-Based Aerosol Dosimetry Modeling for Cross-Species and In Vitro Comparisons	9
Blockade of Voltage-Dependent K+ Channels by Benztropine, a Muscarinic Acetylcholine Receptor Inhibitor, in Coronary Arterial Smooth Muscle Cells	9
A systems approach reveals species differences in hepatic stress response capacity	9
Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain	9
Principal Component Analysis of Striatal and Extrastriatal D2 Dopamine Receptor Positron Emission Tomography in Manganese-Exposed Workers	9
Species-Specific Urothelial Toxicity With an Anti-HIV Noncatalytic Site Integrase Inhibitor (NCINI) Is Related to Unusual pH-Dependent Physicochemical Changes	9
Postnatal administration of S-adenosylmethionine restores developmental AHR activation-induced deficits in CD8+ T-cell function during influenza A virus infection	9
Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging	9
Comparative cardiotoxicity assessment of bisphenol chemicals and estradiol using human induced pluripotent stem cell-derived cardiomyocytes	9
Evaluation of neurotoxicity and the role of oxidative stress of cobalt nanoparticles, titanium dioxide nanoparticles, and multiwall carbon nanotubes in Caenorhabditis elegans	9
Fetal and neonatal dioxin exposure causes sex-specific metabolic alterations in mice	9
Impact of Surface Chemistry of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles on Protein Corona Formation and Endothelial Cell Uptake, Toxicity, and Barrier Function	9
Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis	9
Neuroligin-1 Is a Mediator of Methylmercury Neuromuscular Toxicity	9
Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice	9
In vitro modeling of the post-ingestion bioaccessibility of per- and polyfluoroalkyl substances sorbed to soil and house dust	9
Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research	9
Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexyl phthalate	9
Persistent γ-H2AX Formation and Expression of Stem Cell Markers in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Bladder Carcinogenesis in Rats	8
Zoledronic acid and ibandronate-induced nephrotoxicity in 2D and 3D proximal tubule cells derived from human and rat	8
Structure-activity relationship read-across and transcriptomics for branched carboxylic acids	8
Development and safety of investigational and approved drugs targeting the RAS function regulation in RAS mutant cancers	8
Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary	8
LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun Pathway	8

Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data	8
Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile	8
Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics	8
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy)	8
Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat	8
Chronic exposure to BDE-47 aggravates acute pancreatitis and chronic pancreatitis by promoting acinar cell apoptosis and inflammation	8
Developmental exposure to pesticides that disrupt retinoic acid signaling causes persistent retinoid and behavioral dysfunction in zebrafish	8
Evaluating the impact of anatomical and physiological variability on human equivalent doses using PBPK models	8
Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression	8
Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction	8
Arsenic disrupts extracellular vesicle-mediated signaling in regenerating myofibers	7
Comparisons of PK-Sim and R program for physiologically based pharmacokinetic model development for broiler chickens and laying hens: meloxicam as a case study	7
Evaluation of phenotypic and behavioral toxicity of micro- and nano-plastic polystyrene particles in larval zebrafish (Danio rerio)	7
Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models	7
Firsthand and Secondhand Exposure Levels of Maltol-Flavored Electronic Nicotine Delivery System Vapors Disrupt Amino Acid Metabolism	7
Identifying assessment criteria for in vitro studies: a method and item bank	7
Fine particulate matter and osteoporosis: evidence, mechanisms, and emerging perspectives	7
Mechanistic toxicology in light of genetic compensation	7
The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior	7
Circ_0089282 inhibits carbon black nanoparticle-induced DNA damage by promoting DNA repair protein in the lung	7
Manganese-induced neuronal apoptosis: new insights into the role of endoplasmic reticulum stress in regulating autophagy-related proteins	7
Carbon Nanotube Exposure Triggers a Cerebral Peptidomic Response: Barrier Compromise, Neuroinflammation, and a Hyperexcited State	7
Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure	7
The Importance of Conventional Toxicological Metrics of Aerosol Characterization	7
Dolutegravir Impairs Stem Cell-Based 3D Morphogenesis Models in a Manner Dependent on Dose and Timing of Exposure: An Implication for Its Developmental Toxicity	7
Retraction: Research Article Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell Impairment in Mice	7
Alteration of glycosphingolipid metabolism by ozone is associated with exacerbation of allergic asthma characteristics in mice	7
ToxPoint: Implications of Species Differences in Function and Localization of Transporters at the Blood–Testis Barrier	7
St. John’s Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation	7
An industry perspective on the FDA Modernization Act 2.0/3.0: potential next steps for sponsors to reduce animal use in drug development	7
The brominated flame retardant hexabromocyclododecane causes systemic changes in polyunsaturated fatty acid incorporation in mouse lipids	7
Converging Roles of the Aryl Hydrocarbon Receptor in Early Embryonic Development, Maintenance of Stemness, and Tissue Repair	6
Qualified kidney injury biomarkers demonstrate value during early clinical drug development	6
Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions	6
Regulatory trends of organophosphate and pyrethroid pesticides in cannabis and applications of the Comparative Toxicogenomics Database and Caenorhabditis elegans	6
Gallic acid relieved bortezomib-induced peripheral neurotoxicity by restoring Schwann cell lysosomal activity	6
An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin	6
Cadmium exposure and osteoporosis: epidemiological evidence and mechanisms	6
Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis	6
When the weight of evidence does not weigh enough: EFSA’s draft scientific opinion on BPA	6
Temephos Decreases Sperm Quality and Fertilization Rate and Is Metabolized in Rat Reproductive Tissues at Low-Dose Exposure	6
Correction: Ammonium perchlorate: serum dosimetry, neurotoxicity, and resilience of the neonatal rat thyroid system	6
Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry	6
Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function	6
A Transformative Vision for an Omics-Based Regulatory Chemical Testing Paradigm	6
Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity	6
Iodoacetic Acid, a Water Disinfection Byproduct, Disrupts Hypothalamic, and Pituitary Reproductive Regulatory Factors and Induces Toxicity in the Female Pituitary	6
The Effects of Organophosphate Esters Used as Flame Retardants and Plasticizers on Granulosa, Leydig, and Spermatogonial Cells Analyzed Using High-Content Imaging	6
Corrigendum to: Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Si	6
Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors	6
Effects of PFAS on human liver transporters: implications for health outcomes	6
Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids	6
Mono-n-Butyl Phthalate Distributes to the Mouse Ovary and Liver and Alters the Expression of Phthalate-Metabolizing Enzymes in Both Tissues	6
Cadmium Suppresses Bone Marrow Thrombopoietin Production and Impairs Megakaryocytopoiesis in Mice	6
APAP-Induced IκBβ/NFκB Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation	5
Toxicological mechanisms and potencies of organophosphate esters in KGN human ovarian granulosa cells as revealed by high-throughput transcriptomics	5
Caveolin-1 and Its Functional Peptide CSP7 Affect Silica-Induced Pulmonary Fibrosis by Regulating Fibroblast Glutaminolysis	5
Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model	5
Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment	5
Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species	5
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice	5
Critical Evaluation of Low-Molecular Weight Respiratory Sensitizers and Their Protein Reactivity Potential Toward Lysine Residues	5
2020–2021 Toxicological Sciences Paper of the Year	5
Developmental toxicity of pyriproxyfen induces changes in the ultrastructure of neural cells and in the process of skull ossification	5
Drug-induced impairment of mitochondrial fatty acid oxidation and steatosis: assessment of causal relationship with 45 pharmaceuticals	5
Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts	5
Environmental Exposure to Brominated Flame Retardants: Unraveling Endocrine and Mammary Gland Effects That May Increase Disease Risk	5
Sodium Tanshinone IIA Sulfonate Attenuates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Alveolar Epithelial Cells by Enhancing SIRT1 Pathway	5
Epigenetic programming of TBX2/CX43 mediates lower sperm quality in male offspring induced by prenatal dexamethasone exposure	5
The Role of Diversity, Equity, and Inclusion in the Future of Toxicology	5
Integrating Data FromIn VitroNew Approach Methodologies for Developmental Neurotoxicity	5
Mentoring the next generation of ToxSci authors—I Spy ToxSci	5
Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish- and mammalian-based assays	5
Pulmonary immune response regulation, genotoxicity, and metabolic reprogramming by menthol- and tobacco-flavored e-cigarette exposures in mice	5
Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction	5
Advances in Assessing Hazard and Risk to Emerging Threats and Emergency Response: Comparing and Contrasting Efforts of 3 Federal Agencies	5
The role of small GTPases in bisphenol AF-induced multinucleation in comparison with dibutyl phthalate in the male germ cells	5
Corticosteroids alter kidney development and increase glomerular filtration rate in larval zebrafish (Danio rerio)	4
Comparative Toxicogenomics of Glyphosate and Roundup Herbicides by Mammalian Stem Cell-Based Genotoxicity Assays and Molecular Profiling in Sprague-Dawley Rats	4
House dust-derived mixtures of organophosphate esters alter the phenotype, function, transcriptome, and lipidome of KGN human ovarian granulosa cells	4
QuantitativeIn Vitro-to-In VivoExtrapolation for Mixtures: A Case Study of Superfund Priority List Pesticides	4
Ammonium perchlorate: serum dosimetry, neurotoxicity, and resilience of the neonatal rat thyroid system	4
Investigating the replacement of carboxylates with carboxamides to modulate the safety and efficacy of platinum(II) thioether cyanide scavengers	4
Microvesicle-Derived miRNAs Regulate Proinflammatory Macrophage Activation in the Lung Following Ozone Exposure	4
Delineating the Effects of Passaging and Exposure in a Longitudinal Study of Arsenic-Induced Squamous Cell Carcinoma in a HaCaT Cell Line Model	4
Chronic exposure to a mixture of phthalates shifts the white and brown adipose tissue phenotypes in female mice	4
Gestational ozone inhalation elicits maternal cardiac dysfunction and transcriptional changes to placental pericytes and endothelial cells	4
Development of a human liver microphysiological coculture system for higher throughput chemical safety assessment	4
14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats	4
A computational framework to in silico screen for drug-induced hepatocellular toxicity	4
Comparative toxicological assessment of 2 bisphenols using a systems approach: evaluation of the behavioral and transcriptomic responses of Danio rerio to bisphenol A and tetrabromobisphenol A	4
Response to comment on: Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis	4
A mode of action-based probabilistic framework of dose-response assessment for nonmutagenic liver carcinogens: a case study of PCB-126	4
Behavior and brain size of larval zebrafish exposed to environmentally relevant concentrations of beta-methylamino-l-alanine	4
Targeted and Nontargeted Detection and Characterization of Trace Organic Chemicals in Human Serum and Plasma Using QuEChERS Extraction	4