OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 42. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Genome-wide CRISPR screening identifies genes in recombinant human embryonic kidney 293 cells for increased ammonia resistance	94
Introduction of acetyl-phosphate bypass and increased culture temperatures enhanced growth-coupled poly-hydroxybutyrate production in the marine cyanobacterium Synechococcus sp. PCC7002	82
Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes	81
Engineering Halomonas bluephagenesis for high-efficiency biosynthesis of pyruvate	79
Engineering sub-organelles of a diploid Saccharomyces cerevisiae to enhance the production of 7-dehydrocholesterol	69
Pan-reactome analysis of Streptomyces strains reveals association and disconnection between primary and secondary metabolism	67
Development of a thermophilic l-arabinose-inducible system in Acetivibrio thermocellus (Clostridium thermocellum)	66
Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability	66
Engineering carbon source division of labor for efficient α-carotene production in Corynebacterium glutamicum	65
Butyrate as a growth factor of Clostridium acetobutylicum	64
Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides	61
Engineering a biosensor based high-throughput screening platform for high-yield caffeic acid production in Escherichia coli	60
Engineering Yarrowia lipolytica for sustainable ricinoleic acid production: A pathway to free fatty acid synthesis	60
Engineering Halomonas bluephagenesis for pilot production of terpolymers containing 3-hydroxybutyrate, 4-hydroxybutyrate and 3-hydroxyvalerate from glucose	58
Metabolic engineering of Escherichia coli for the production of two-carbon primary amines	58
Improved arginine production in Escherichia coli by harnessing the intracellular citrulline	58
Heterologous biosynthesis of betanin triggers metabolic reprogramming in tobacco	58
13C-Metabolic flux analysis of 3T3-L1 adipocytes illuminates its core metabolism under hypoxia	57
Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)	56
Inferring secretory and metabolic pathway activity from omic data with secCellFie	55
Biosynthesis of 12-aminododecanoic acid from biomass sugars	53
Engineering an SspB-mediated degron for novel controllable protein degradation	53
Coordinating caffeic acid and salvianic acid A pathways for efficient production of rosmarinic acid in Escherichia coli	51
Identification of a specific exporter that enables high production of aconitic acid in Aspergillus pseudoterreus	51
De novo 2′-fucosyllactose biosynthesis using glucose as the sole carbon source by multiple engineered Bacillus subtilis	51

Quantifying supply and demand in the pea aphid-Buchnera symbiosis reveals the metabolic Achilles’ heels of this interaction	49
Optimized production of concanamycins using a rational metabolic engineering strategy	48
Development of a Streptomyces-based system for facile thioholgamide library generation and analysis	47
Machine-learning guided elucidation of contribution of individual steps in the mevalonate pathway and construction of a yeast platform strain for terpenoid production	45
Versatile xylose and arabinose genetic switches development for yeasts	45
Disruption of acyl-acyl carrier protein (acyl-ACP) synthetase in cyanobacteria impairs lipid remodeling as revealed by acyl-ACP measurements	44
Engineering diverse fatty acid compositions of phospholipids in Escherichia coli	43
Rethinking 13C-metabolic flux analysis – The Bayesian way of flux inference	43
Silk fibroin production in Escherichia coli is limited by a positive feedback loop between metabolic burden and toxicity stress	43
Systematic study of genomic loci in Escherichia coli B and K12 for genomic integration: application in plasmid-free astaxanthin production	43
Consistent biosynthesis of D-glycerate from variable mixed substrates	43
Metabolic engineering of Escherichia coli for N-methylserotonin biosynthesis	42
Unlocking lager's flavour palette by metabolic engineering of Saccharomyces pastorianus for enhanced ethyl ester production	42
Consolidated bioprocessing for bioethanol production by metabolically engineered cellulolytic fungus Myceliophthora thermophila	42
COSMIC-dFBA: A novel multi-scale hybrid framework for bioprocess modeling	42
Auto-inducible synthetic pathway in E. coli enhanced sustainable indigo production from glucose	42
Deep learning for NAD/NADP cofactor prediction and engineering using transformer attention analysis in enzymes	42