OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 42. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Editorial Board	139
Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes	115
Microbial synthesis of wax esters	110
Computational design and analysis of modular cells for large libraries of exchangeable product synthesis modules	105
Editorial Board	96
Butyrate as a growth factor of Clostridium acetobutylicum	89
Engineering carbon source division of labor for efficient α-carotene production in Corynebacterium glutamicum	73
Synthetic metabolic pathways for conversion of CO2 into secreted short-to medium-chain hydrocarbons using cyanobacteria	72
Heterologous biosynthesis of betanin triggers metabolic reprogramming in tobacco	71
Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability	67
Biosensor-informed engineering of Cupriavidus necator H16 for autotrophic D-mannitol production	63
Introduction of acetyl-phosphate bypass and increased culture temperatures enhanced growth-coupled poly-hydroxybutyrate production in the marine cyanobacterium Synechococcus sp. PCC7002	62
Engineering sub-organelles of a diploid Saccharomyces cerevisiae to enhance the production of 7-dehydrocholesterol	61
Engineering Halomonas bluephagenesis for pilot production of terpolymers containing 3-hydroxybutyrate, 4-hydroxybutyrate and 3-hydroxyvalerate from glucose	60
Engineering Yarrowia lipolytica for sustainable ricinoleic acid production: A pathway to free fatty acid synthesis	59
Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides	58
Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A–dependent bioproduction in rewired Pseudomonas putida	57
The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity	56
Biosynthesis of 12-aminododecanoic acid from biomass sugars	56
Optimized production of concanamycins using a rational metabolic engineering strategy	55
Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)	54
Coordinating caffeic acid and salvianic acid A pathways for efficient production of rosmarinic acid in Escherichia coli	53
Machine-learning guided elucidation of contribution of individual steps in the mevalonate pathway and construction of a yeast platform strain for terpenoid production	53
Identification of a specific exporter that enables high production of aconitic acid in Aspergillus pseudoterreus	53
Inferring secretory and metabolic pathway activity from omic data with secCellFie	51

Metabolic engineering of the oleaginous alga Nannochloropsis for enriching eicosapentaenoic acid in triacylglycerol by combined pulling and pushing strategies	50
13C-Metabolic flux analysis of 3T3-L1 adipocytes illuminates its core metabolism under hypoxia	50
Synergistic experimental and computational approach identifies novel strategies for polyhydroxybutyrate overproduction	49
Versatile xylose and arabinose genetic switches development for yeasts	49
Development of a Streptomyces-based system for facile thioholgamide library generation and analysis	48
Multi-level rebalancing of the naringenin pathway using riboswitch-guided high-throughput screening	46
Engineering an SspB-mediated degron for novel controllable protein degradation	46
Highly efficient production of L-homoserine in Escherichia coli by engineering a redox balance route	45
Integrated knowledge mining, genome-scale modeling, and machine learning for predicting Yarrowia lipolytica bioproduction	45
Quantifying supply and demand in the pea aphid-Buchnera symbiosis reveals the metabolic Achilles’ heels of this interaction	45
Integrating metabolome dynamics and process data to guide cell line selection in biopharmaceutical process development	45
Glycoengineering of Aspergillus nidulans to produce precursors for humanized N-glycan structures	45
De novo 2′-fucosyllactose biosynthesis using glucose as the sole carbon source by multiple engineered Bacillus subtilis	45
Consistent biosynthesis of D-glycerate from variable mixed substrates	44
Rethinking 13C-metabolic flux analysis – The Bayesian way of flux inference	44
Metabolic engineering of Escherichia coli for N-methylserotonin biosynthesis	44
Integrating thermodynamic and enzymatic constraints into genome-scale metabolic models	44
Coupling cell growth and biochemical pathway induction in Saccharomyces cerevisiae for production of (+)-valencene and its chemical conversion to (+)-nootkatone	42
COSMIC-dFBA: A novel multi-scale hybrid framework for bioprocess modeling	42
Cascaded valorization of brown seaweed to produce l-lysine and value-added products using Corynebacterium glutamicum streamlined by systems metabolic engineering	42