OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 42. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides	122
Synthetic metabolic pathways for conversion of CO2 into secreted short-to medium-chain hydrocarbons using cyanobacteria	117
Engineering Yarrowia lipolytica for sustainable ricinoleic acid production: A pathway to free fatty acid synthesis	109
Pan-reactome analysis of Streptomyces strains reveals association and disconnection between primary and secondary metabolism	78
Butyrate as a growth factor of Clostridium acetobutylicum	78
Editorial Board	72
Heterologous biosynthesis of betanin triggers metabolic reprogramming in tobacco	70
Engineering carbon source division of labor for efficient α-carotene production in Corynebacterium glutamicum	67
Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability	64
Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes	63
Editorial Board	62
Biosensor-informed engineering of Cupriavidus necator H16 for autotrophic D-mannitol production	58
Engineering sub-organelles of a diploid Saccharomyces cerevisiae to enhance the production of 7-dehydrocholesterol	57
Introduction of acetyl-phosphate bypass and increased culture temperatures enhanced growth-coupled poly-hydroxybutyrate production in the marine cyanobacterium Synechococcus sp. PCC7002	57
Engineering Halomonas bluephagenesis for pilot production of terpolymers containing 3-hydroxybutyrate, 4-hydroxybutyrate and 3-hydroxyvalerate from glucose	56
Quantifying supply and demand in the pea aphid-Buchnera symbiosis reveals the metabolic Achilles’ heels of this interaction	56
Optimized production of concanamycins using a rational metabolic engineering strategy	55
Biosynthesis of 12-aminododecanoic acid from biomass sugars	54
Identification of a specific exporter that enables high production of aconitic acid in Aspergillus pseudoterreus	52
Development of a Streptomyces-based system for facile thioholgamide library generation and analysis	52
Integrating metabolome dynamics and process data to guide cell line selection in biopharmaceutical process development	51
13C-Metabolic flux analysis of 3T3-L1 adipocytes illuminates its core metabolism under hypoxia	50
Versatile xylose and arabinose genetic switches development for yeasts	50
The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity	49
Engineering an SspB-mediated degron for novel controllable protein degradation	49

Metabolic engineering of the oleaginous alga Nannochloropsis for enriching eicosapentaenoic acid in triacylglycerol by combined pulling and pushing strategies	48
Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)	47
De novo 2′-fucosyllactose biosynthesis using glucose as the sole carbon source by multiple engineered Bacillus subtilis	47
Inferring secretory and metabolic pathway activity from omic data with secCellFie	47
Machine-learning guided elucidation of contribution of individual steps in the mevalonate pathway and construction of a yeast platform strain for terpenoid production	46
Synergistic experimental and computational approach identifies novel strategies for polyhydroxybutyrate overproduction	46
Coupling cell growth and biochemical pathway induction in Saccharomyces cerevisiae for production of (+)-valencene and its chemical conversion to (+)-nootkatone	46
Consistent biosynthesis of D-glycerate from variable mixed substrates	46
Coordinating caffeic acid and salvianic acid A pathways for efficient production of rosmarinic acid in Escherichia coli	46
Advances in systems metabolic engineering of autotrophic carbon oxide-fixing biocatalysts towards a circular economy	45
Metabolic engineering of Escherichia coli for N-methylserotonin biosynthesis	44
Consolidated bioprocessing for bioethanol production by metabolically engineered cellulolytic fungus Myceliophthora thermophila	44
Rethinking 13C-metabolic flux analysis – The Bayesian way of flux inference	44
Auto-inducible synthetic pathway in E. coli enhanced sustainable indigo production from glucose	44
Unlocking lager's flavour palette by metabolic engineering of Saccharomyces pastorianus for enhanced ethyl ester production	44
CelloSelect – A synthetic cellobiose metabolic pathway for selection of stable transgenic CHO cell lines	43
Engineering diverse fatty acid compositions of phospholipids in Escherichia coli	43
A Pseudomonas taiwanensis malonyl-CoA platform strain for polyketide synthesis	42
Silk fibroin production in Escherichia coli is limited by a positive feedback loop between metabolic burden and toxicity stress	42
Metabolic engineering of commensal bacteria for gut butyrate delivery and dissection of host-microbe interaction	42
COSMIC-dFBA: A novel multi-scale hybrid framework for bioprocess modeling	42
A reactive species reactions module for integration into genome-scale metabolic models for improved insights: Application to cancer	42