OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 42. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Editorial Board	125
Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides	84
Butyrate as a growth factor of Clostridium acetobutylicum	81
Editorial Board	77
Development of a thermophilic l-arabinose-inducible system in Acetivibrio thermocellus (Clostridium thermocellum)	73
Pan-reactome analysis of Streptomyces strains reveals association and disconnection between primary and secondary metabolism	72
Heterologous biosynthesis of betanin triggers metabolic reprogramming in tobacco	66
Engineering Yarrowia lipolytica for sustainable ricinoleic acid production: A pathway to free fatty acid synthesis	65
Genome-wide CRISPR screening identifies genes in recombinant human embryonic kidney 293 cells for increased ammonia resistance	64
Improved arginine production in Escherichia coli by harnessing the intracellular citrulline	63
Engineering carbon source division of labor for efficient α-carotene production in Corynebacterium glutamicum	62
Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability	61
Engineering Halomonas bluephagenesis for pilot production of terpolymers containing 3-hydroxybutyrate, 4-hydroxybutyrate and 3-hydroxyvalerate from glucose	61
Synthetic metabolic pathways for conversion of CO2 into secreted short-to medium-chain hydrocarbons using cyanobacteria	60
Introduction of acetyl-phosphate bypass and increased culture temperatures enhanced growth-coupled poly-hydroxybutyrate production in the marine cyanobacterium Synechococcus sp. PCC7002	57
Biosensor-informed engineering of Cupriavidus necator H16 for autotrophic D-mannitol production	57
Engineering sub-organelles of a diploid Saccharomyces cerevisiae to enhance the production of 7-dehydrocholesterol	56
Engineering a biosensor based high-throughput screening platform for high-yield caffeic acid production in Escherichia coli	53
The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity	53
Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes	53
Quantifying supply and demand in the pea aphid-Buchnera symbiosis reveals the metabolic Achilles’ heels of this interaction	53
13C-Metabolic flux analysis of 3T3-L1 adipocytes illuminates its core metabolism under hypoxia	52
Optimized production of concanamycins using a rational metabolic engineering strategy	52
Engineering an SspB-mediated degron for novel controllable protein degradation	51
Development of a Streptomyces-based system for facile thioholgamide library generation and analysis	51

De novo 2′-fucosyllactose biosynthesis using glucose as the sole carbon source by multiple engineered Bacillus subtilis	50
Identification of a specific exporter that enables high production of aconitic acid in Aspergillus pseudoterreus	49
Coordinating caffeic acid and salvianic acid A pathways for efficient production of rosmarinic acid in Escherichia coli	49
Metabolic engineering of the oleaginous alga Nannochloropsis for enriching eicosapentaenoic acid in triacylglycerol by combined pulling and pushing strategies	48
Inferring secretory and metabolic pathway activity from omic data with secCellFie	48
Integrating metabolome dynamics and process data to guide cell line selection in biopharmaceutical process development	47
Consistent biosynthesis of D-glycerate from variable mixed substrates	47
Machine-learning guided elucidation of contribution of individual steps in the mevalonate pathway and construction of a yeast platform strain for terpenoid production	47
Biosynthesis of 12-aminododecanoic acid from biomass sugars	47
Versatile xylose and arabinose genetic switches development for yeasts	47
Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)	47
CelloSelect – A synthetic cellobiose metabolic pathway for selection of stable transgenic CHO cell lines	45
Unlocking lager's flavour palette by metabolic engineering of Saccharomyces pastorianus for enhanced ethyl ester production	45
Consolidated bioprocessing for bioethanol production by metabolically engineered cellulolytic fungus Myceliophthora thermophila	44
COSMIC-dFBA: A novel multi-scale hybrid framework for bioprocess modeling	44
Engineering diverse fatty acid compositions of phospholipids in Escherichia coli	43
Advances in systems metabolic engineering of autotrophic carbon oxide-fixing biocatalysts towards a circular economy	43
Metabolic engineering of Escherichia coli for N-methylserotonin biosynthesis	42
Rethinking 13C-metabolic flux analysis – The Bayesian way of flux inference	42