OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 41. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides	134
Improved arginine production in Escherichia coli by harnessing the intracellular citrulline	91
Heterologous biosynthesis of betanin triggers metabolic reprogramming in tobacco	85
Pan-reactome analysis of Streptomyces strains reveals association and disconnection between primary and secondary metabolism	83
Development of a thermophilic l-arabinose-inducible system in Acetivibrio thermocellus (Clostridium thermocellum)	78
Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes	74
Engineering a biosensor based high-throughput screening platform for high-yield caffeic acid production in Escherichia coli	71
Engineering Halomonas bluephagenesis for pilot production of terpolymers containing 3-hydroxybutyrate, 4-hydroxybutyrate and 3-hydroxyvalerate from glucose	69
Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability	68
Biosensor-informed engineering of Cupriavidus necator H16 for autotrophic D-mannitol production	64
Editorial Board	63
Genome-wide CRISPR screening identifies genes in recombinant human embryonic kidney 293 cells for increased ammonia resistance	61
Introduction of acetyl-phosphate bypass and increased culture temperatures enhanced growth-coupled poly-hydroxybutyrate production in the marine cyanobacterium Synechococcus sp. PCC7002	59
Engineering carbon source division of labor for efficient α-carotene production in Corynebacterium glutamicum	58
Metabolic engineering of Escherichia coli for the production of two-carbon primary amines	57
Synthetic metabolic pathways for conversion of CO2 into secreted short-to medium-chain hydrocarbons using cyanobacteria	56
Engineering Halomonas bluephagenesis for high-efficiency biosynthesis of pyruvate	56
Butyrate as a growth factor of Clostridium acetobutylicum	56
Engineering sub-organelles of a diploid Saccharomyces cerevisiae to enhance the production of 7-dehydrocholesterol	56
Biosynthesis of 12-aminododecanoic acid from biomass sugars	55
Engineering Yarrowia lipolytica for sustainable ricinoleic acid production: A pathway to free fatty acid synthesis	55
Engineering an SspB-mediated degron for novel controllable protein degradation	54
Identification of a specific exporter that enables high production of aconitic acid in Aspergillus pseudoterreus	53
De novo 2′-fucosyllactose biosynthesis using glucose as the sole carbon source by multiple engineered Bacillus subtilis	53
Inferring secretory and metabolic pathway activity from omic data with secCellFie	53

Integrating metabolome dynamics and process data to guide cell line selection in biopharmaceutical process development	52
13C-Metabolic flux analysis of 3T3-L1 adipocytes illuminates its core metabolism under hypoxia	51
Quantifying supply and demand in the pea aphid-Buchnera symbiosis reveals the metabolic Achilles’ heels of this interaction	50
The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity	49
Coordinating caffeic acid and salvianic acid A pathways for efficient production of rosmarinic acid in Escherichia coli	48
Development of a Streptomyces-based system for facile thioholgamide library generation and analysis	48
Optimized production of concanamycins using a rational metabolic engineering strategy	48
Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)	47
Machine-learning guided elucidation of contribution of individual steps in the mevalonate pathway and construction of a yeast platform strain for terpenoid production	47
Consistent biosynthesis of D-glycerate from variable mixed substrates	45
Versatile xylose and arabinose genetic switches development for yeasts	45
Rethinking 13C-metabolic flux analysis – The Bayesian way of flux inference	45
Engineering diverse fatty acid compositions of phospholipids in Escherichia coli	44
Disruption of acyl-acyl carrier protein (acyl-ACP) synthetase in cyanobacteria impairs lipid remodeling as revealed by acyl-ACP measurements	43
Silk fibroin production in Escherichia coli is limited by a positive feedback loop between metabolic burden and toxicity stress	43
Metabolic engineering of Escherichia coli for N-methylserotonin biosynthesis	41