OOIR: Observatory of International Research

Papers

(The H4-Index of Metabolic Engineering is 41. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Editorial Board	211
Editorial Board	127
Introduction of acetyl-phosphate bypass and increased culture temperatures enhanced growth-coupled poly-hydroxybutyrate production in the marine cyanobacterium Synechococcus sp. PCC7002	107
Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides	106
Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes	100
Microbial synthesis of wax esters	93
Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A–dependent bioproduction in rewired Pseudomonas putida	85
Computational design and analysis of modular cells for large libraries of exchangeable product synthesis modules	68
Engineering Escherichia coli for production of geraniol by systematic synthetic biology approaches and laboratory-evolved fusion tags	67
Portable bacterial CRISPR transcriptional activation enables metabolic engineering in Pseudomonas putida	65
Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability	65
Synthetic metabolic pathways for conversion of CO2 into secreted short-to medium-chain hydrocarbons using cyanobacteria	61
In-planta production of the biodegradable polyester precursor 2-pyrone-4,6-dicarboxylic acid (PDC): Stacking reduced biomass recalcitrance with value-added co-product	61
A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes	59
Heterologous biosynthesis of betanin triggers metabolic reprogramming in tobacco	57
Butyrate as a growth factor of Clostridium acetobutylicum	55
Engineering sub-organelles of a diploid Saccharomyces cerevisiae to enhance the production of 7-dehydrocholesterol	54
Engineering Yarrowia lipolytica for sustainable ricinoleic acid production: A pathway to free fatty acid synthesis	54
Biosensor-informed engineering of Cupriavidus necator H16 for autotrophic D-mannitol production	53
A “push-pull-restrain” strategy to improve citronellol production in Saccharomyces cerevisiae	51
Engineering carbon source division of labor for efficient α-carotene production in Corynebacterium glutamicum	51
The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity	51
Optimized production of concanamycins using a rational metabolic engineering strategy	50
Multi-level rebalancing of the naringenin pathway using riboswitch-guided high-throughput screening	50
13C-Metabolic flux analysis of 3T3-L1 adipocytes illuminates its core metabolism under hypoxia	50

Biosynthesis of 12-aminododecanoic acid from biomass sugars	50
Development of a Streptomyces-based system for facile thioholgamide library generation and analysis	49
Engineering an SspB-mediated degron for novel controllable protein degradation	47
Inferring secretory and metabolic pathway activity from omic data with secCellFie	47
Identification of a specific exporter that enables high production of aconitic acid in Aspergillus pseudoterreus	46
Integrating metabolome dynamics and process data to guide cell line selection in biopharmaceutical process development	46
Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)	46
Versatile xylose and arabinose genetic switches development for yeasts	44
Integrated knowledge mining, genome-scale modeling, and machine learning for predicting Yarrowia lipolytica bioproduction	44
Machine-learning guided elucidation of contribution of individual steps in the mevalonate pathway and construction of a yeast platform strain for terpenoid production	44
Highly efficient production of L-homoserine in Escherichia coli by engineering a redox balance route	44
Enhanced targeted DNA methylation of the CMV and endogenous promoters with dCas9-DNMT3A3L entails distinct subsequent histone modification changes in CHO cells	43
Metabolic engineering of the oleaginous alga Nannochloropsis for enriching eicosapentaenoic acid in triacylglycerol by combined pulling and pushing strategies	42
Glycoengineering of Aspergillus nidulans to produce precursors for humanized N-glycan structures	42
De novo 2′-fucosyllactose biosynthesis using glucose as the sole carbon source by multiple engineered Bacillus subtilis	41
High-yield production of (R)-acetoin in Saccharomyces cerevisiae by deleting genes for NAD(P)H-dependent ketone reductases producing meso-2,3-butanediol and 2,3-dimethylglycerate	41
Coordinating caffeic acid and salvianic acid A pathways for efficient production of rosmarinic acid in Escherichia coli	41
Cascaded valorization of brown seaweed to produce l-lysine and value-added products using Corynebacterium glutamicum streamlined by systems metabolic engineering	41
Synergistic experimental and computational approach identifies novel strategies for polyhydroxybutyrate overproduction	41