OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Cell is 96. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells	1467
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy	465
Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding	388
Ultrastructural Details of Mammalian Chromosome Architecture	358
Redox metabolism: ROS as specific molecular regulators of cell signaling and function	332
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1	286
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting	286
Ferroptosis at the intersection of lipid metabolism and cellular signaling	276
A conceptual framework for understanding phase separation and addressing open questions and challenges	262
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid	250
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions	246
Increased demand for NAD+ relative to ATP drives aerobic glycolysis	236
Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity	205
Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells	194
Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication	193
Cell Death in the Origin and Treatment of Cancer	186
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms	185
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation	184
Molecular mechanisms of early plant pattern-triggered immune signaling	181
From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism	178
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing	178
DNA Damage and Cancer Immunotherapy: A STING in the Tale	165
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA	160
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis	159
The CRISPR-Cas toolbox and gene editing technologies	159

AMPK: restoring metabolic homeostasis over space and time	156
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation	155
Integrated lncRNA function upon genomic and epigenomic regulation	155
Biomarker-Guided Development of DNA Repair Inhibitors	154
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis	154
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA	153
The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2	149
Integrating Old and New Paradigms of G1/S Control	146
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex	144
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression	144
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death	143
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	138
Highly Parallel Profiling of Cas9 Variant Specificity	135
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation	135
Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA	134
Ca2+ Fluxes and Cancer	133
High-resolution structure and strain comparison of infectious mammalian prions	132
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy	131
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity	131
Functional landscape of SARS-CoV-2 cellular restriction	127
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity	126
HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis	126
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation	124
Cytokine-like Roles for Metabolites in Immunity	123
Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment	122
Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control	121
The ASC-1 Complex Disassembles Collided Ribosomes	118
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis	118
Nanopore Sequencing Enables Comprehensive Transposable Element Epigenomic Profiling	117
Structural diversity of the SARS-CoV-2 Omicron spike	117
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation	116
Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork	116
Structured elements drive extensive circular RNA translation	116
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging	115
Reshaping endoplasmic reticulum quality control through the unfolded protein response	115
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control	114
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists	114
A Structure-Based Mechanism for DNA Entry into the Cohesin Ring	113
Hidden codes in mRNA: Control of gene expression by m6A	113
Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases	112
Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer	112
ATP-Driven Separation of Liquid Phase Condensates in Bacteria	112
High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq	112
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis	112
Hallmarks of DNA replication stress	111
Primary Role of the Nucleosome	110
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance	110
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation	109
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence	108
Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis	107

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets	107
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination	106
Deubiquitinases: From mechanisms to their inhibition by small molecules	105
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine	105
Structure of the miniature type V-F CRISPR-Cas effector enzyme	104
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection	103
The SARS-CoV-2 RNA interactome	103
Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity	103
Rational Cancer Treatment Combinations: An Urgent Clinical Need	101
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans	100
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade	99
Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes	99
Persister cancer cells: Iron addiction and vulnerability to ferroptosis	99
Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes	98
The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates	98
Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells	97
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP	96
Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription	96
ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains	96
Transcription activation is enhanced by multivalent interactions independent of phase separation	96
Opposing Functions of BRD4 Isoforms in Breast Cancer	96