Molecular Cell

Article	Citations
Meet the authors: Grazia Pellicanò and Rodrigo Bermejo	710
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	680
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	485
TADs do not stay in the loop	417
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	391
Protease-mediated processing of Argonaute proteins controls small RNA association	293
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	289
Meet the authors: Shouqiao Hou and Daichao Xu	279
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	273
BARBEKO’ing in the lab: Versatile CRISPR screens with barcoded base editors	267
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	261
Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution	253
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	245
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	241
Sister chromatid cohesion halts DNA loop expansion	229
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation	221
eIF4G as a switch for heat shock mRNA translation	211
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	208
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	206
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	203
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs	199
TIGR on the loose: A dual-guide RNA system for DNA targeting	196
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	194
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	184
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	178

Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	170
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	169
Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication	167
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	163
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	163
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	163
Stochastic initiation of DNA replication across the human genome	162
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape	158
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication	157
Hydrogen sulfide: A whiff of trouble for cancer cell survival	157
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	155
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	150
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	150
Mitochondrial protein transport: Versatility of translocases and mechanisms	147
Mitochondria: A “pacemaker” for species-specific development	145
STING: Stay near to STIM(1) neuroprotection	142
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	140
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses	139
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	136
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition	134
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	133
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	133
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	133
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function	131
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	131
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	130
Gene architecture directs splicing outcome in separate nuclear spatial regions	127
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	126
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	125
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	125
A tRF nucleator for Nucleolin in cancer metastasis	124
Introducing new group leaders: Wen Zhou	123
Silent silencers: Leave no trace	121
Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity	120
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	119
Structural basis for product specificities of MLL family methyltransferases	112
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	112
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	111
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	111
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	109
A domain of all trades: The enzymatic versatility of the NiRAN domain	105
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	105
Are nanopore technologies ready for the proteomic challenge primetime?	103
Meet the authors: Emily R. Feierman and Erica Korb	102
Meet the authors: Irene Beusch and Hiten Madhani	102
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	100
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	99
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	98
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	97
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	96

ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	95
VPS4A is the selective receptor for lipophagy in mice and humans	94
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	93
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	92
The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism	91
Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation	91
Alternative splicing is a developmental switch for hTERT expression	91
Single-molecule studies reveal branched pathways for activator-dependent assembly of RNA polymerase II pre-initiation complexes	90
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	90
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	90
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	90
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	90
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	89
The γ-secretase substrate proteome and its role in cell signaling regulation	89
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	89
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	89
Heat shock induces premature transcript termination and reconfigures the human transcriptome	88
Recent technical advances in the study of nucleic acid modifications	88
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization	87
The SARS-CoV-2 RNA interactome	87
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	87
Universal features of Nsp1-mediated translational shutdown by coronaviruses	87
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	87
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	87
Mammalian DNA N6-methyladenosine: Challenges and new insights	87
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency	87
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	86
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling	86
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability	84
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	84
Mapping replication forks, one replicon at a time	83
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	83
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	83
Meet the authors: Adam De Jesus and Hossein Ardehali	83
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	81
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	80
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	80
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	79
Active DNA damage eviction by HLTF stimulates nucleotide excision repair	79
Proton perception and activation of a proton-sensing GPCR	79
Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich	79
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	78
The lncRNA ALPHA specifically targets chikungunya virus to control infection	78
Meet the authors: Mirjana Lilic and Elizabeth Campbell	78
Physics meets biology: The joining of two forces to further our understanding of cellular function	78
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	78
Planes, trains, and automobiles: How cells localize their molecules	78
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2	78
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	75
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states	75
Phosphorylation by JNK switches BRD4 functions	75
Genome homeostasis defects drive enlarged cells into senescence	75
Parp1 promotes sleep, which enhances DNA repair in neurons	74
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	74
PEX5 translocation into and out of peroxisomes drives matrix protein import	74
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	74
Sequence and chromatin features guide DNA double-strand break resection initiation	73
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	73
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	73
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	73
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair	73
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape	72
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	71
Basis of gene-specific transcription regulation by the Integrator complex	71
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns	70
Exquisite exposure: Formaldehyde as a metabolic regulator	70
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination	70
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	69
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	69
AMPK: restoring metabolic homeostasis over space and time	69
The picky mTORC1 in metabolic enzyme degradation	68
Mitochondrial degradation: Mitophagy and beyond	68
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	68
Next generation single-molecule techniques: Imaging, labeling, and manipulation in vitro and in cellulo	68
Exploring patterns in molecular biology	68
Meet the author: Itay Koren	68
Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	67
RASopathy mutations open new insights into the mechanism of BRAF activation	67
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	66
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	66

The Cupid shuffle: Do enhancers prefer specific promoters?	65
The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state	65
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	65
Too big not to fail: Different paths lead to senescence of enlarged cells	65
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	64
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	64
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	64
On the covalent nature of lysine polyphosphorylation	64
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	64
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	64
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	64
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	63
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	63
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	63
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	63
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates	63
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion	62
Structural mechanism of LIN28B nucleosome targeting by OCT4	62
N6-methyladenosine in 5′ UTR does not promote translation initiation	62
Building a complex for destruction	61
The hidden bacterial microproteome	61
Structural and functional basis of mammalian microRNA biogenesis by Dicer	61
Structure of a backtracked hexasomal intermediate of nucleosome transcription	61
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	61
Proteasome resides in and dismantles plant heat stress granules constitutively	61
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	61
Compendium of human transcription factor effector domains	60
DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network	60
Poly(m6A) tails stabilize transcripts	60
Lactate fuels mitosis	60
A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells	60
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex	60
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	60
A journey from phosphotyrosine to phosphohistidine and beyond	60
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	60
Meet the author: Kavitha Sarma	60
Allosteric interactions prime androgen receptor dimerization and activation	60
Chaperones in concert: Orchestrating co-translational protein folding in the cell	59
A novel redox cycle diverts cells from oncogene-induced senescence into cancer	59
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	59
Reducing the stress of revisions: A chat with Scott W. Hiebert	59
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	59
RETRACTED: A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells	59
Tracking the folding of RNA at its birth	58
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance	58
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	58
Three-step mechanism of promoter escape by RNA polymerase II	57
Simple oligonucleotide-based multiplexing of single-cell chromatin accessibility	56
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity	56
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	56
Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance	56
Modulation of protein activity by small RNA base pairing internal to coding sequences	56
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	55
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets	55
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	55
Supply and demand: Cellular nutrient uptake and exchange in cancer	54
Identification and functional characterization of transcriptional activators in human cells	54
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	54
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	54
Endogenous ligand recognition and structural transition of a human PTH receptor	54
Translation—A tug of war during viral infection	54
(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains	54
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	53
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation	53
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy	53
LDB1 establishes multi-enhancer networks to regulate gene expression	53
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	53
The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability	53
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	52
The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1	52
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	52
SnapShot: Chromosome organization	52
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	52
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	52
SPT5 stabilization of promoter-proximal RNA polymerase II	52
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	52
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	52
Detection of alternative DNA structures and its implications for human disease	52
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma	52
Functional coordination between transcription factor clustering and gene activity	51
Integrating the response to stressed mitochondria	51
Phages gain the upper hand in the metabolic arms race for NAD+	51
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation	51
What repeat expansion disorders can teach us about the Central Dogma	51
The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense	51
Deciphering the multi-scale, quantitative cis-regulatory code	51
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation	51
Two HUSH complexes connect a direct LINE to innate immunity	51
Type III CRISPR-mediated flexible RNA excision with engineered guide RNAs	51
A small molecule that reshapes the chromatin dynamics of FOXA1	50
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	50
DNA-directed termination of RNA polymerase II transcription	50
Proteome-wide discovery of phage anti-defense proteins by Alphafold2	49
Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse	49
Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2	49