Molecular Cell

Article	Citations
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	772
TADs do not stay in the loop	760
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	517
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	468
Meet the authors: Shouqiao Hou and Daichao Xu	443
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	309
BARBEKO’ing in the lab: Versatile CRISPR screens with barcoded base editors	308
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	303
eIF4G as a switch for heat shock mRNA translation	295
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	291
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	276
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	274
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	273
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	262
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance	246
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	240
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	222
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	218
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	215
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	213
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition	212
Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution	211
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	209
TIGR on the loose: A dual-guide RNA system for DNA targeting	201
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	193

RNA polymerase and ppGpp deliver a one-two punch to antibiotics	192
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication	186
Mitochondria: A “pacemaker” for species-specific development	184
Sister chromatid cohesion halts DNA loop expansion	177
Gene architecture directs splicing outcome in separate nuclear spatial regions	177
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation	175
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	173
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	169
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	168
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	166
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function	158
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	158
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs	155
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	147
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	146
STING: Stay near to STIM(1) neuroprotection	145
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	145
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	142
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	140
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses	139
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	137
Nucleosomes specify co-factor access to p53	137
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	135
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	135
Hydrogen sulfide: A whiff of trouble for cancer cell survival	135
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape	130
Mitochondrial protein transport: Versatility of translocases and mechanisms	130
Introducing new group leaders: Wen Zhou	129
Silent silencers: Leave no trace	126
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	123
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	122
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	121
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	117
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization	117
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	114
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	113
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	112
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	111
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	110
A domain of all trades: The enzymatic versatility of the NiRAN domain	109
Are nanopore technologies ready for the proteomic challenge primetime?	109
Meet the authors: Irene Beusch and Hiten Madhani	108
Meet the authors: Emily R. Feierman and Erica Korb	102
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	101
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	101
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	101
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	99
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma	99
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability	98
The γ-secretase substrate proteome and its role in cell signaling regulation	98

Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	97
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	96
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	96
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	95
VPS4A is the selective receptor for lipophagy in mice and humans	95
The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism	95
Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity	95
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	94
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	93
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	93
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	93
Single-molecule studies reveal branched pathways for activator-dependent assembly of RNA polymerase II pre-initiation complexes	92
Recent technical advances in the study of nucleic acid modifications	92
Heat shock induces premature transcript termination and reconfigures the human transcriptome	91
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	91
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	91
A tRF nucleator for Nucleolin in cancer metastasis	90
Structural basis for product specificities of MLL family methyltransferases	90
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling	90
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	90
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria	88
Universal features of Nsp1-mediated translational shutdown by coronaviruses	88
Mammalian DNA N6-methyladenosine: Challenges and new insights	88
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	87
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	87
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	86
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency	85
Meet the authors: Adam De Jesus and Hossein Ardehali	84
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	84
Emerging mechanisms underlying formaldehyde toxicity and response	84
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	83
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2	83
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	83
Mapping replication forks, one replicon at a time	83
Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich	82
Proton perception and activation of a proton-sensing GPCR	82
Physics meets biology: The joining of two forces to further our understanding of cellular function	81
Parp1 promotes sleep, which enhances DNA repair in neurons	81
Planes, trains, and automobiles: How cells localize their molecules	81
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	80
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states	80
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	79
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	79
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	79
Genome homeostasis defects drive enlarged cells into senescence	78
Basis of gene-specific transcription regulation by the Integrator complex	78
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination	78
The lncRNA ALPHA specifically targets chikungunya virus to control infection	77
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape	77
Sequence and chromatin features guide DNA double-strand break resection initiation	76
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	76
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair	75
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	74
Active DNA damage eviction by HLTF stimulates nucleotide excision repair	74
PEX5 translocation into and out of peroxisomes drives matrix protein import	74
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	73
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	73
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns	73
Exquisite exposure: Formaldehyde as a metabolic regulator	72
Next generation single-molecule techniques: Imaging, labeling, and manipulation in vitro and in cellulo	72
Phosphorylation by JNK switches BRD4 functions	71
Mitochondrial degradation: Mitophagy and beyond	71
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	71
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	70
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	70
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	70
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	69
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	69
AMPK: restoring metabolic homeostasis over space and time	69
RASopathy mutations open new insights into the mechanism of BRAF activation	68
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	68
Exploring patterns in molecular biology	68
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	68
Meet the author: Itay Koren	68
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	68
Too big not to fail: Different paths lead to senescence of enlarged cells	67
Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	66
The Cupid shuffle: Do enhancers prefer specific promoters?	66
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	66
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	66

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	66
Structure of a backtracked hexasomal intermediate of nucleosome transcription	66
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	66
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	66
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	65
The picky mTORC1 in metabolic enzyme degradation	65
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	65
Cellular metabolite sensors: Arginine? It’s in the bag!	65
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	65
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	65
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates	65
Building a complex for destruction	64
Synaptic activity causes minute-scale changes in BAF complex composition and function	64
N6-methyladenosine in 5′ UTR does not promote translation initiation	64
The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state	64
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	64
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	64
Structural and functional basis of mammalian microRNA biogenesis by Dicer	64
Compendium of human transcription factor effector domains	63
Proteasome resides in and dismantles plant heat stress granules constitutively	63
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex	63
On the covalent nature of lysine polyphosphorylation	62
A journey from phosphotyrosine to phosphohistidine and beyond	62
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function	62
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	62
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	62
A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells	62
Structural mechanism of LIN28B nucleosome targeting by OCT4	62
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	62
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	61
The hidden bacterial microproteome	61
Poly(m6A) tails stabilize transcripts	61
Meet the author: Kavitha Sarma	61
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	60
Lactate fuels mitosis	60
Reducing the stress of revisions: A chat with Scott W. Hiebert	60
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	60
Supply and demand: Cellular nutrient uptake and exchange in cancer	60
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	59
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	58
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	58
Allosteric interactions prime androgen receptor dimerization and activation	58
RETRACTED: A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells	58
Identification and functional characterization of transcriptional activators in human cells	57
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	57
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	57
Functional coordination between transcription factor clustering and gene activity	57
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy	57
Three-step mechanism of promoter escape by RNA polymerase II	57
Translation—A tug of war during viral infection	56
(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains	56
SPT5 stabilization of promoter-proximal RNA polymerase II	56
Simple oligonucleotide-based multiplexing of single-cell chromatin accessibility	55
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation	55
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	55
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	55
A novel redox cycle diverts cells from oncogene-induced senescence into cancer	55
Endogenous ligand recognition and structural transition of a human PTH receptor	54
Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation	54
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma	54
Condensin II activation by M18BP1	54
Tracking the folding of RNA at its birth	54
An NADH-controlled gatekeeper of ATP synthase	54
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	54
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	54
SnapShot: Chromosome organization	53
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	53
Detection of alternative DNA structures and its implications for human disease	53
Chaperones in concert: Orchestrating co-translational protein folding in the cell	53
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity	53
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation	53
Modulation of protein activity by small RNA base pairing internal to coding sequences	52
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	52
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	52
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	52
Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance	52
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance	52
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	52
LDB1 establishes multi-enhancer networks to regulate gene expression	51
Integrating the response to stressed mitochondria	51
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation	51
Phages gain the upper hand in the metabolic arms race for NAD+	51
Deciphering the multi-scale, quantitative cis-regulatory code	51
Type III CRISPR-mediated flexible RNA excision with engineered guide RNAs	51
What repeat expansion disorders can teach us about the Central Dogma	50
Proteome-wide discovery of phage anti-defense proteins by Alphafold2	50
Assembly mechanism of Integrator’s RNA cleavage module	50
Metabolism-driven chromatin dynamics: Molecular principles and technological advances	50
The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense	50
Structural basis for OAS2 regulation and its antiviral function	50
Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain	50
A small molecule that reshapes the chromatin dynamics of FOXA1	50
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	50
Internal mRNA 2′-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer	50
The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo	49