Molecular Cell

Article	Citations
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells	1467
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy	465
Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding	388
Ultrastructural Details of Mammalian Chromosome Architecture	358
Redox metabolism: ROS as specific molecular regulators of cell signaling and function	332
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1	286
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting	286
Ferroptosis at the intersection of lipid metabolism and cellular signaling	276
A conceptual framework for understanding phase separation and addressing open questions and challenges	262
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid	250
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions	246
Increased demand for NAD+ relative to ATP drives aerobic glycolysis	236
Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity	205
Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells	194
Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication	193
Cell Death in the Origin and Treatment of Cancer	186
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms	185
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation	184
Molecular mechanisms of early plant pattern-triggered immune signaling	181
From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism	178
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing	178
DNA Damage and Cancer Immunotherapy: A STING in the Tale	165
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA	160
The CRISPR-Cas toolbox and gene editing technologies	159
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis	159

AMPK: restoring metabolic homeostasis over space and time	156
Integrated lncRNA function upon genomic and epigenomic regulation	155
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation	155
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis	154
Biomarker-Guided Development of DNA Repair Inhibitors	154
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA	153
The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2	149
Integrating Old and New Paradigms of G1/S Control	146
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex	144
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression	144
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death	143
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	138
Highly Parallel Profiling of Cas9 Variant Specificity	135
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation	135
Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA	134
Ca2+ Fluxes and Cancer	133
High-resolution structure and strain comparison of infectious mammalian prions	132
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy	131
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity	131
Functional landscape of SARS-CoV-2 cellular restriction	127
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity	126
HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis	126
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation	124
Cytokine-like Roles for Metabolites in Immunity	123
Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment	122
Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control	121
The ASC-1 Complex Disassembles Collided Ribosomes	118
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis	118
Nanopore Sequencing Enables Comprehensive Transposable Element Epigenomic Profiling	117
Structural diversity of the SARS-CoV-2 Omicron spike	117
Structured elements drive extensive circular RNA translation	116
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation	116
Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork	116
Reshaping endoplasmic reticulum quality control through the unfolded protein response	115
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging	115
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists	114
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control	114
A Structure-Based Mechanism for DNA Entry into the Cohesin Ring	113
Hidden codes in mRNA: Control of gene expression by m6A	113
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis	112
Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases	112
Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer	112
ATP-Driven Separation of Liquid Phase Condensates in Bacteria	112
High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq	112
Hallmarks of DNA replication stress	111
Primary Role of the Nucleosome	110
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance	110
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation	109
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence	108
Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis	107

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets	107
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination	106
Deubiquitinases: From mechanisms to their inhibition by small molecules	105
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine	105
Structure of the miniature type V-F CRISPR-Cas effector enzyme	104
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection	103
The SARS-CoV-2 RNA interactome	103
Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity	103
Rational Cancer Treatment Combinations: An Urgent Clinical Need	101
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans	100
Persister cancer cells: Iron addiction and vulnerability to ferroptosis	99
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade	99
Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes	99
Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes	98
The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates	98
Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells	97
Opposing Functions of BRD4 Isoforms in Breast Cancer	96
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP	96
Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription	96
ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains	96
Transcription activation is enhanced by multivalent interactions independent of phase separation	96
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B	95
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release	94
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity	94
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly	94
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing	94
Walking a tightrope: The complex balancing act of R-loops in genome stability	93
ER-directed TREX1 limits cGAS activation at micronuclei	93
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair	92
CRISPR-based genome editing through the lens of DNA repair	92
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells	92
Gene Architecture and Sequence Composition Underpin Selective Dependency of Nuclear Export of Long RNAs on NXF1 and the TREX Complex	91
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication	91
Two-Parameter Mobility Assessments Discriminate Diverse Regulatory Factor Behaviors in Chromatin	89
Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes	89
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation	88
Unbiased spatial proteomics with single-cell resolution in tissues	88
Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin	88
Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change	87
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors	87
The expanding universe of PARP1-mediated molecular and therapeutic mechanisms	86
Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics	86
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps	86
Integrator is a genome-wide attenuator of non-productive transcription	85
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy	85
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	85
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation	85
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer	84
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2	84
Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis	83
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2	83
Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo	82
A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits	82
Stress-induced nuclear condensation of NELF drives transcriptional downregulation	81
Liquid-liquid phase separation: Orchestrating cell signaling through time and space	81
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells	81
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing	80
scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells	80
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa	80
Structure of an activated DNA-PK and its implications for NHEJ	79
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis	78
An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila	78
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis	78
Deciphering the multi-scale, quantitative cis-regulatory code	78
Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms	77
Ribosome states signal RNA quality control	77
Toward Understanding Microbiome-Neuronal Signaling	76
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation	76
The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules	76
Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells	75
Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection	75
Cellular pathways influenced by protein arginine methylation: Implications for cancer	75
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD	74
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate	74
The SARS-CoV-2 subgenome landscape and its novel regulatory features	73
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis	73
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells	73
A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning	73
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases	73
Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA	72

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling	72
RNA m6A methylation across the transcriptome	71
Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms	71
Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B	70
Increasing cell size remodels the proteome and promotes senescence	69
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability	69
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	69
Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex	69
Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity	69
Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors	69
Proteome-wide mapping of short-lived proteins in human cells	68
Hyperosmotic stress alters the RNA polymerase II interactome and induces readthrough transcription despite widespread transcriptional repression	68
Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease	68
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors	68
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression	68
Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates	68
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition	67
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis	67
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	67
MYC Controls the Epstein-Barr Virus Lytic Switch	67
Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compaction	67
The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks	67
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP	67
BR-Bodies Provide Selectively Permeable Condensates that Stimulate mRNA Decay and Prevent Release of Decay Intermediates	66
Pre-termination Transcription Complex: Structure and Function	65
Ribosome-associated quality-control mechanisms from bacteria to humans	64
Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq	64
Identification and functional characterization of transcriptional activators in human cells	64
Single-strand DNA breaks cause replisome disassembly	64
CRISPR-Cas13 Inhibitors Block RNA Editing in Bacteria and Mammalian Cells	64
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells	64
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates	63
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion	63
Simultaneous profiling of multiple chromatin proteins in the same cells	63
DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex	62
Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters	62
Transcription-mediated supercoiling regulates genome folding and loop formation	62
Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor	62
TopBP1 assembles nuclear condensates to switch on ATR signaling	62
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair	61
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination	61
Moonlighting functions of metabolic enzymes and metabolites in cancer	61
A UPR-Induced Soluble ER-Phagy Receptor Acts with VAPs to Confer ER Stress Resistance	60
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization	60
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain	60
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53	60
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS	60
Effector-mediated membrane disruption controls cell death in CBASS antiphage defense	60
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases	60
CARM1 regulates replication fork speed and stress response by stimulating PARP1	60
A unified atlas of CD8 T cell dysfunctional states in cancer and infection	59
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition	59
Spatiotemporal coordination of transcription preinitiation complex assembly in live cells	59
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease	58
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	58
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting	58
Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies	58
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape	57
Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication	57
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity	57
eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health	57
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells	56
Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers	56
The phosphorylation switch that regulates ticking of the circadian clock	56
Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity	56
Structural Basis for pri-miRNA Recognition by Drosha	55
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency	55
Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation	55
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs	55
Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis	55
Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis	55
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs	54
Phase Separation in Cell Division	54
Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels	54
Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins	54
Translation stress and collided ribosomes are co-activators of cGAS	54
ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet	54
To skip or not to skip: choosing repriming to tolerate DNA damage	54
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets	53
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation	53
RNA circles with minimized immunogenicity as potent PKR inhibitors	53
Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy	53
Ferroptosis: A flexible constellation of related biochemical mechanisms	53
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells	53
POINT technology illuminates the processing of polymerase-associated intact nascent transcripts	53
TFIID Enables RNA Polymerase II Promoter-Proximal Pausing	53
Compendium of human transcription factor effector domains	53
Cryo-EM in molecular and cellular biology	53
A Mechanism for microRNA Arm Switching Regulated by Uridylation	52
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo	52
The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA	52
Structures of the human dopamine D3 receptor-Gi complexes	52
Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage	52
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation	52
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons	52