Molecular Cell

Article	Citations
Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants	894
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	567
STING: Stay near to STIM(1) neuroprotection	537
Meet the authors: Shouqiao Hou and Daichao Xu	503
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance	340
Nucleosomes specify co-factor access to p53	316
Hydrogen sulfide: A whiff of trouble for cancer cell survival	306
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	305
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	286
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	283
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	244
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	235
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function	231
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication	229
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses	221
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	217
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	198
Sister chromatid cohesion halts DNA loop expansion	198
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape	193
The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens	192
Sticky business: Rationalizing CRBN’s zinc-finger targeting by molecular glues	192
eIF4G as a switch for heat shock mRNA translation	190
TIGR on the loose: A dual-guide RNA system for DNA targeting	186
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	185
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	183

The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	174
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	172
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	169
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	165
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	160
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	159
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	159
Mitochondria: A “pacemaker” for species-specific development	154
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	152
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	148
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	146
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	142
Gene architecture directs splicing outcome in separate nuclear spatial regions	136
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	135
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	134
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	134
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	133
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	133
TADs do not stay in the loop	128
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition	124
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	124
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	122
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	120
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs	116
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	116
Mitochondrial protein transport: Versatility of translocases and mechanisms	115
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	115
Silent silencers: Leave no trace	112
Using SPIDRs to map the RNA-protein web	111
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	110
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	110
Meet the authors: Emily R. Feierman and Erica Korb	110
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization	110
Targeted citrullination enables p53 binding to non-canonical sites	107
The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism	107
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria	106
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	106
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	106
Structural basis for product specificities of MLL family methyltransferases	105
Cryo-EM reveals open and closed Asgard chromatin assemblies	105
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	104
Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity	104
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	104
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	102
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	102
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	100
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	100
Tuning insulin receptor signaling using de novo-designed agonists	99
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	99
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	98

Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	98
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	98
Are nanopore technologies ready for the proteomic challenge primetime?	97
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	96
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	96
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	95
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	94
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	94
Meet the authors: Irene Beusch and Hiten Madhani	92
A domain of all trades: The enzymatic versatility of the NiRAN domain	91
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	91
Introducing new group leaders: Wen Zhou	91
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	90
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	90
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma	89
Universal features of Nsp1-mediated translational shutdown by coronaviruses	89
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	89
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	88
A tRF nucleator for Nucleolin in cancer metastasis	88
Mammalian DNA N6-methyladenosine: Challenges and new insights	87
Heat shock induces premature transcript termination and reconfigures the human transcriptome	86
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability	86
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	86
The γ-secretase substrate proteome and its role in cell signaling regulation	86
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	85
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling	84
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	84
VPS4A is the selective receptor for lipophagy in mice and humans	84
Next generation single-molecule techniques: Imaging, labeling, and manipulation in vitro and in cellulo	83
Active DNA damage eviction by HLTF stimulates nucleotide excision repair	83
Sequence and chromatin features guide DNA double-strand break resection initiation	83
Phosphorylation by JNK switches BRD4 functions	83
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	83
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	82
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	82
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	81
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	81
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states	81
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	79
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	78
Basis of gene-specific transcription regulation by the Integrator complex	78
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns	77
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2	77
Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich	77
Planes, trains, and automobiles: How cells localize their molecules	76
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	76
Meet the authors: Adam De Jesus and Hossein Ardehali	76
Mapping replication forks, one replicon at a time	75
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination	75
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	75
The lncRNA ALPHA specifically targets chikungunya virus to control infection	74
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	74
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	74
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	73
Exquisite exposure: Formaldehyde as a metabolic regulator	73
Transcription-replication conflict resolution by nuclear RNA interference	72
Parp1 promotes sleep, which enhances DNA repair in neurons	72
PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed	72
Genome homeostasis defects drive enlarged cells into senescence	70
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape	70
Mitochondrial degradation: Mitophagy and beyond	70
Proton perception and activation of a proton-sensing GPCR	70
Emerging mechanisms underlying formaldehyde toxicity and response	70
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	70
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	70
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	69
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	69
PEX5 translocation into and out of peroxisomes drives matrix protein import	69
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	69
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	68
Exploring patterns in molecular biology	68
Cellular metabolite sensors: Arginine? It’s in the bag!	68
Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	68
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	68
The picky mTORC1 in metabolic enzyme degradation	68
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex	67
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	67
N6-methyladenosine in 5′ UTR does not promote translation initiation	67
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	66
On the covalent nature of lysine polyphosphorylation	66

The Cupid shuffle: Do enhancers prefer specific promoters?	65
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	65
RASopathy mutations open new insights into the mechanism of BRAF activation	65
A journey from phosphotyrosine to phosphohistidine and beyond	65
Meet the author: Itay Koren	65
Structural mechanism of LIN28B nucleosome targeting by OCT4	64
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	64
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	64
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	64
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	64
Proteasome resides in and dismantles plant heat stress granules constitutively	64
A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells	64
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function	63
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	62
Synaptic activity causes minute-scale changes in BAF complex composition and function	62
The hidden bacterial microproteome	61
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	61
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	61
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	61
Structural and functional basis of mammalian microRNA biogenesis by Dicer	61
Compendium of human transcription factor effector domains	60
Structure of a backtracked hexasomal intermediate of nucleosome transcription	60
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	60
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	59
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	59
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates	59
Too big not to fail: Different paths lead to senescence of enlarged cells	59
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	59
Chaperones in concert: Orchestrating co-translational protein folding in the cell	58
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	58
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	58
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	58
Modulation of protein activity by small RNA base pairing internal to coding sequences	58
SPT5 stabilization of promoter-proximal RNA polymerase II	57
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy	57
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	57
Identification and functional characterization of transcriptional activators in human cells	57
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	57
LDB1 establishes multi-enhancer networks to regulate gene expression	57
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	57
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	57
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	57
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity	57
Tracking the folding of RNA at its birth	56
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	56
Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation	56
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation	56
Poly(m6A) tails stabilize transcripts	55
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation	55
RETRACTED: A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells	55
Allosteric interactions prime androgen receptor dimerization and activation	55
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	55
Reducing the stress of revisions: A chat with Scott W. Hiebert	55
Endogenous ligand recognition and structural transition of a human PTH receptor	55
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	55
Lactate fuels mitosis	54
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	54
Meet the author: Kavitha Sarma	54
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	54
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	54
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	54
SnapShot: Chromosome organization	54
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	54
An NADH-controlled gatekeeper of ATP synthase	54
Condensin II activation by M18BP1	53
The RIG-I-like receptor family of immune proteins	53
Three-step mechanism of promoter escape by RNA polymerase II	53
Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance	53
Detection of alternative DNA structures and its implications for human disease	53
A breathless brake on ferroptosis	53
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma	53
Deciphering the multi-scale, quantitative cis-regulatory code	52
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	52
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance	52
Functional coordination between transcription factor clustering and gene activity	52
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	51
Translation—A tug of war during viral infection	51
A little protein makes big news in translation initiation	51
Phages gain the upper hand in the metabolic arms race for NAD+	51
Proteome-wide discovery of phage anti-defense proteins by Alphafold2	50
Oncogene-dependent sloppiness in mRNA translation	50
Phosphorylation-dependent charge blocks regulate the relaxation of nuclear speckle networks	50
Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms	50
Transcription dynamics and genome organization in the mammalian nucleus: Recent advances	50
Structural basis for OAS2 regulation and its antiviral function	50
Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment	50
Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations	50
Two HUSH complexes connect a direct LINE to innate immunity	49
Reshaping endoplasmic reticulum quality control through the unfolded protein response	49
A small molecule that reshapes the chromatin dynamics of FOXA1	49
Internal mRNA 2′-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer	49
RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages	49
Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes	49
Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria	48
Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB	48