Molecular Cell

Article	Citations
Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis	981
Meet the authors: Shouqiao Hou and Daichao Xu	603
Meet the authors: Meiling Wang, Wenjing Li, and Weixing Zhao	585
TADs do not stay in the loop	546
A DNA helicase remodeling proteins: How DNA-protein crosslink repair unfolds via FANCJ	365
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt	340
You shall not pass! Unveiling the barriers for cohesin-mediated loop extrusion	326
Mitochondria: A “pacemaker” for species-specific development	324
Hydrogen sulfide: A whiff of trouble for cancer cell survival	311
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance	300
Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants	274
The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens	258
eIF4G as a switch for heat shock mRNA translation	252
STING: Stay near to STIM(1) neuroprotection	248
Gene architecture directs splicing outcome in separate nuclear spatial regions	240
Sticky business: Rationalizing CRBN’s zinc-finger targeting by molecular glues	212
TIGR on the loose: A dual-guide RNA system for DNA targeting	207
RNA polymerase and ppGpp deliver a one-two punch to antibiotics	205
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics	205
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs	201
Nucleosomes specify co-factor access to p53	200
HSP90 buffers deleterious genetic variations in BRCA1	189
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition	189
Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers	186
POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps	182

Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID	182
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses	174
SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate	167
Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease	166
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication	165
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain	164
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB	158
Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function	156
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns	153
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions	146
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP	146
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation	145
The molecular basis of tRNA selectivity by human pseudouridine synthase 3	142
SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis	142
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin	140
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha	136
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production	135
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses	130
Sister chromatid cohesion halts DNA loop expansion	129
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II	126
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules	121
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition	121
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function	120
Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes	120
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape	119
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release	119
Mitochondrial protein transport: Versatility of translocases and mechanisms	119
Silent silencers: Leave no trace	118
The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism	118
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination	116
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability	116
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate	114
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation	113
Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin	113
Targeted citrullination enables p53 binding to non-canonical sites	112
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway	111
Mammalian DNA N6-methyladenosine: Challenges and new insights	111
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome	111
UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance	110
VPS4A is the selective receptor for lipophagy in mice and humans	108
Filament formation activates protease and ring nuclease activities of CRISPR Lon-SAVED	108
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress	106
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei	106
Structural basis for product specificities of MLL family methyltransferases	106
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells	106
Using SPIDRs to map the RNA-protein web	105
A domain of all trades: The enzymatic versatility of the NiRAN domain	105
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade	103
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2	103
Meet the authors: Emily R. Feierman and Erica Korb	99

A new horizon unfolding for insulin signaling in health and disease	98
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress	97
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria	97
Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance	96
Bacterial ligases reveal fundamental principles of polyubiquitin specificity	96
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization	96
Are nanopore technologies ready for the proteomic challenge primetime?	94
A new chromatin flavor to cap chromosomes: Where structure, function, and evolution meet	94
Meet the authors: Irene Beusch and Hiten Madhani	93
Introducing new group leaders: Wen Zhou	92
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma	92
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function	91
The γ-secretase substrate proteome and its role in cell signaling regulation	91
An orphan no more: SLC25A45 controls mitochondrial import of methylated amino acids	90
A new UCP1-independent thermogenic mechanism in peroxisomes	90
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms	89
Cryo-EM reveals open and closed Asgard chromatin assemblies	89
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR	89
A tRF nucleator for Nucleolin in cancer metastasis	89
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells	89
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype	88
IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance	87
Universal features of Nsp1-mediated translational shutdown by coronaviruses	86
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis	85
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag	85
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling	85
RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria	85
Tuning insulin receptor signaling using de novo-designed agonists	85
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest	84
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains	84
Mechanical forces regulate the composition and fate of stalled nascent chains	84
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex	83
The lncRNA ALPHA specifically targets chikungunya virus to control infection	82
Heat shock induces premature transcript termination and reconfigures the human transcriptome	82
Sequence and chromatin features guide DNA double-strand break resection initiation	82
PEX5 translocation into and out of peroxisomes drives matrix protein import	80
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas	78
Transcription-replication conflict resolution by nuclear RNA interference	78
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation	78
Basis of gene-specific transcription regulation by the Integrator complex	77
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns	77
Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells	77
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion	76
Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich	76
Planes, trains, and automobiles: How cells localize their molecules	74
Mapping replication forks, one replicon at a time	74
Meet the authors: Adam De Jesus and Hossein Ardehali	74
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability	74
Emerging mechanisms underlying formaldehyde toxicity and response	73
A nucleotide regulates NR4A1 status in gastric cancer	73
DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection	73
PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed	72
Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT	72
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors	72
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression	72
Exquisite exposure: Formaldehyde as a metabolic regulator	72
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination	72
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING	71
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states	71
Mitochondrial degradation: Mitophagy and beyond	71
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination	71
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression	71
Phosphorylation by JNK switches BRD4 functions	70
Proton perception and activation of a proton-sensing GPCR	70
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III	70
Active DNA damage eviction by HLTF stimulates nucleotide excision repair	70
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer	70
Genome homeostasis defects drive enlarged cells into senescence	69
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response	69
Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching	69
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules	69
Next generation single-molecule techniques: Imaging, labeling, and manipulation in vitro and in cellulo	69
Exploring patterns in molecular biology	68
The Cupid shuffle: Do enhancers prefer specific promoters?	67
Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology	67
RASopathy mutations open new insights into the mechanism of BRAF activation	67
Unlocking the EGFR-mediated epitranscriptome: A pathway to novel therapies	67
Meet the author: Itay Koren	67
Meet the authors: Yu Zhou, Ting Shan, and Feiyan Liu	65
Cellular metabolite sensors: Arginine? It’s in the bag!	65

The picky mTORC1 in metabolic enzyme degradation	65
On the covalent nature of lysine polyphosphorylation	64
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex	64
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation	64
Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors	64
Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation	64
Structural and functional basis of mammalian microRNA biogenesis by Dicer	64
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A	64
N6-methyladenosine in 5′ UTR does not promote translation initiation	64
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function	64
Synaptic activity causes minute-scale changes in BAF complex composition and function	63
Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer	63
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles	63
Compendium of human transcription factor effector domains	63
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops	63
A journey from phosphotyrosine to phosphohistidine and beyond	63
The hidden bacterial microproteome	62
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting	62
Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation	62
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana	62
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis	62
Modulation of fungal phosphate homeostasis by the plant hormone strigolactone	62
GCN2 monitors mRNA translation termination	61
Proteasome resides in and dismantles plant heat stress granules constitutively	61
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee	61
Structural mechanism of LIN28B nucleosome targeting by OCT4	61
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation	60
Structure of a backtracked hexasomal intermediate of nucleosome transcription	60
A breathless brake on ferroptosis	59
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates	59
Too big not to fail: Different paths lead to senescence of enlarged cells	59
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA	59
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	59
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition	59
Modulation of protein activity by small RNA base pairing internal to coding sequences	58
RETRACTED: A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells	58
Chaperones in concert: Orchestrating co-translational protein folding in the cell	58
Disordered protein regions partner up the cBAF remodeler for a chromatin dance	58
Tracking the folding of RNA at its birth	58
Meet the authors: Lizhen Chen, Shasha Chong, and Zhijie “Jason” Liu	57
Poly(m6A) tails stabilize transcripts	57
Lactate fuels mitosis	57
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis	57
Reducing the stress of revisions: A chat with Scott W. Hiebert	57
SnapShot: Chromosome organization	57
Meet the author: Kavitha Sarma	57
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting	56
Allosteric interactions prime androgen receptor dimerization and activation	56
Detection of alternative DNA structures and its implications for human disease	56
Identification and functional characterization of transcriptional activators in human cells	56
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome	56
Endogenous ligand recognition and structural transition of a human PTH receptor	56
The RIG-I-like receptor family of immune proteins	56
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis	56
Functional coordination between transcription factor clustering and gene activity	56
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals	56
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks	55
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation	55
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries	55
Translation—A tug of war during viral infection	55
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding	55
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance	55
Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation	55
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames	55
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles	55
LDB1 establishes multi-enhancer networks to regulate gene expression	55
Three-step mechanism of promoter escape by RNA polymerase II	54
Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination	54
Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance	54
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity	54
Deciphering the multi-scale, quantitative cis-regulatory code	54
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation	54
Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy	53
An NADH-controlled gatekeeper of ATP synthase	53
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia	53
Condensin II activation by M18BP1	53
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells	53
Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes	52
Internal mRNA 2′-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer	52
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery	52
Metabolism-driven chromatin dynamics: Molecular principles and technological advances	52
Proteome-wide discovery of phage anti-defense proteins by Alphafold2	51
Right on target: Chromatin jets arise from targeted cohesin loading in wild-type cells	51
Two HUSH complexes connect a direct LINE to innate immunity	51
A little protein makes big news in translation initiation	50
β-catenin functions as a molecular adapter for disordered cBAF interactions	50
Integrating the response to stressed mitochondria	50
What repeat expansion disorders can teach us about the Central Dogma	50
Phages gain the upper hand in the metabolic arms race for NAD+	50
Systematic conformation-to-phenotype mapping via limited deep sequencing of proteins	49
Structural atlas of human primary microRNAs generated by SHAPE-MaP	49
The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense	49
Assembly mechanism of Integrator’s RNA cleavage module	49
Type III CRISPR-mediated flexible RNA excision with engineered guide RNAs	49
A small molecule that reshapes the chromatin dynamics of FOXA1	49