Nature Neuroscience

Article	Citations
Reactive astrocyte nomenclature, definitions, and future directions	1112
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19	902
Parameterizing neural power spectra into periodic and aperiodic components	899
Synergy between amyloid-β and tau in Alzheimer’s disease	589
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex	436
Using Bayes factor hypothesis testing in neuroscience to establish evidence of absence	368
Topographic organization of the human subcortex unveiled with functional connectivity gradients	323
The extent and drivers of gender imbalance in neuroscience reference lists	313
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization	302
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice	287
Neuroinflammatory astrocyte subtypes in the mouse brain	286
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques	267
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia	255
Revisiting the neurovascular unit	252
Considering sex as a biological variable will require a global shift in science culture	248
Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease	239
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits	234
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank	225
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level	219
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions	208
Motor learning promotes remyelination via new and surviving oligodendrocytes	205
Long-term maturation of human cortical organoids matches key early postnatal transitions	197
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys	196
Brain capillary pericytes exert a substantial but slow influence on blood flow	186
Microglia phagocytose myelin sheaths to modify developmental myelination	182

A community-based transcriptomics classification and nomenclature of neocortical cell types	175
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo	175
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis	174
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease	172
Edge-centric functional network representations of human cerebral cortex reveal overlapping system-level architecture	170
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain	170
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset	169
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells	168
Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning	166
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice	165
Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons	161
Quantifying behavior to understand the brain	161
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production	158
Interplay between persistent activity and activity-silent dynamics in the prefrontal cortex underlies serial biases in working memory	158
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing	152
Revealing the structure of pharmacobehavioral space through motion sequencing	151
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex	151
Large-scale neural recordings call for new insights to link brain and behavior	146
A genetically encoded sensor for measuring serotonin dynamics	145
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia	143
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans	141
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits	140
Neural mechanisms of aggression across species	139
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis	139
Acute social isolation evokes midbrain craving responses similar to hunger	136
A massive 7T fMRI dataset to bridge cognitive neuroscience and artificial intelligence	135
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction	134
Shared computational principles for language processing in humans and deep language models	133
Active dendritic currents gate descending cortical outputs in perception	125
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration	123
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease	122
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease	121
The claustrum coordinates cortical slow-wave activity	119
Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits	119
Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons	118
Recent advances in neurotechnologies with broad potential for neuroscience research	117
Diversity and dynamism in the cerebellum	117
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics	115
High-fat food biases hypothalamic and mesolimbic expression of consummatory drives	114
Issues and recommendations from the OHBM COBIDAS MEEG committee for reproducible EEG and MEG research	113
Identification of neural oscillations and epileptiform changes in human brain organoids	113
Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex	112
Transcriptomic organization of the human brain in post-traumatic stress disorder	106
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders	105
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges	104
Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit	104
Anatomically segregated basal ganglia pathways allow parallel behavioral modulation	103
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels	103
Wireless multilateral devices for optogenetic studies of individual and social behaviors	103
Prefrontal–amygdala circuits in social decision-making	102

Spatial and cell type transcriptional landscape of human cerebellar development	101
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB	101
Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease	100
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine	100
A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice	99
Brainstem neurons that command mammalian locomotor asymmetries	97
Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression	97
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice	96
Challenges and future directions for representations of functional brain organization	96
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine	96
Rotational dynamics reduce interference between sensory and memory representations	96
General anesthetics activate a potent central pain-suppression circuit in the amygdala	95
A synergistic core for human brain evolution and cognition	94
Single-neuron projectome of mouse prefrontal cortex	94
Microglia contribute to the propagation of Aβ into unaffected brain tissue	93
Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits	93
The neural basis of psychedelic action	93
An investigation across 45 languages and 12 language families reveals a universal language network	93
Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks	92
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble	91
Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition	91
Synaptic vesicles transiently dock to refill release sites	91
Dense neuronal reconstruction through X-ray holographic nano-tomography	91
Circuit and molecular architecture of a ventral hippocampal network	91
Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making	91
Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging	90
Decoding molecular and cellular heterogeneity of mouse nucleus accumbens	90
An amygdala-to-hypothalamus circuit for social reward	90
Mice alternate between discrete strategies during perceptual decision-making	89
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors	89
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders	88
Brain proteome-wide association study implicates novel proteins in depression pathogenesis	88
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies	87
A glycolytic shift in Schwann cells supports injured axons	87
Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia	87
Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain	86
Attractor dynamics gate cortical information flow during decision-making	86
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents	86
RNA transport and local translation in neurodevelopmental and neurodegenerative disease	85
Genetic variants associated with longitudinal changes in brain structure across the lifespan	85
Microglial Gi-dependent dynamics regulate brain network hyperexcitability	85
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states	84
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies	83
The basal ganglia control the detailed kinematics of learned motor skills	83
Gene-based therapies for neurodegenerative diseases	83
The role of population structure in computations through neural dynamics	82
Cortical-like dynamics in recurrent circuits optimized for sampling-based probabilistic inference	82
Modeling behaviorally relevant neural dynamics enabled by preferential subspace identification	81
Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity	80
How to establish robust brain–behavior relationships without thousands of individuals	80
Inferences on a multidimensional social hierarchy use a grid-like code	80
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity	80
Probing neural codes with two-photon holographic optogenetics	79
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology	78
Maternal immune activation in mice disrupts proteostasis in the fetal brain	78
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration	78
The preference for sugar over sweetener depends on a gut sensor cell	75
Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration	75
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis	74
Cortical interneurons in autism	73
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines	72
Periods of synchronized myelin changes shape brain function and plasticity	71
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines	71
Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival	71
Assessing the depth of language processing in patients with disorders of consciousness	71
Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior	70
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing	69
Visual and linguistic semantic representations are aligned at the border of human visual cortex	69
Semantic reconstruction of continuous language from non-invasive brain recordings	69
A role for the cortex in sleep–wake regulation	69
VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error	68
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development	68
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation	67
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice	67
A quantitative reward prediction error signal in the ventral pallidum	66
How to build a cognitive map	66
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury	65
Independent generation of sequence elements by motor cortex	65
Conservation of brain connectivity and wiring across the mammalian class	65
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons	65

Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states	65
Neural fragility as an EEG marker of the seizure onset zone	64
Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior	64
A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging	64
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting	64
Association between real-world experiential diversity and positive affect relates to hippocampal–striatal functional connectivity	63
Posterior amygdala regulates sexual and aggressive behaviors in male mice	62
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function	62
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation	62
Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types	62
Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition	62
Multiple convergent hypothalamus–brainstem circuits drive defensive behavior	62
Targeted photostimulation uncovers circuit motifs supporting short-term memory	61
A cortical circuit for audio-visual predictions	61
A parsimonious description of global functional brain organization in three spatiotemporal patterns	60
Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways	60
Complementary contributions of non-REM and REM sleep to visual learning	60
Circulating miR-181 is a prognostic biomarker for amyotrophic lateral sclerosis	60
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging	60
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections	59
Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model	59
Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit	59
Identification of early neurodegenerative pathways in progressive multiple sclerosis	58
Neurons detect cognitive boundaries to structure episodic memories in humans	57
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior	57
Thalamic subnetworks as units of function	56
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway	56
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice	56
AHR is a Zika virus host factor and a candidate target for antiviral therapy	56
Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective	56
Correlations enhance the behavioral readout of neural population activity in association cortex	55
Genetically identified amygdala–striatal circuits for valence-specific behaviors	55
Membrane potential dynamics underlying context-dependent sensory responses in the hippocampus	55
Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system	54
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations	54
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination	54
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation	53
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans	53
Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics	53
Systematic errors in connectivity inferred from activity in strongly recurrent networks	53
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement	53
Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses	53
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life	53
Causal role for the primate superior colliculus in the computation of evidence for perceptual decisions	53
Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation	52
Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor	52
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice	52
Placental endocrine function shapes cerebellar development and social behavior	51
Reactivation predicts the consolidation of unbiased long-term cognitive maps	51
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease	50
Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning	50
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration	50
Synaptic plasticity as Bayesian inference	50
Episodic memory retrieval success is associated with rapid replay of episode content	50
Dynamic representations in networked neural systems	50
Hippocampal place codes are gated by behavioral engagement	49
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience	49
Baseline brain function in the preadolescents of the ABCD Study	49
Interneuron origin and molecular diversity in the human fetal brain	49
Memory trace interference impairs recall in a mouse model of Alzheimer’s disease	49
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation	48
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia	48
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility	47
Insights into Alzheimer’s disease from single-cell genomic approaches	46
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex	46
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus	46
Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments	46
An emergent neural coactivity code for dynamic memory	46
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits	45
Cerebellar granule cell axons support high-dimensional representations	45
Behavioral origin of sound-evoked activity in mouse visual cortex	45
Experience-dependent contextual codes in the hippocampus	44
Addressing racial and phenotypic bias in human neuroscience methods	44
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia	44
Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical–hippocampal interactions	44
Formalizing planning and information search in naturalistic decision-making	43
Adult-born dentate granule cells promote hippocampal population sparsity	43
Optogenetics at the presynapse	43
Confronting racially exclusionary practices in the acquisition and analyses of neuroimaging data	43
Common and stimulus-type-specific brain representations of negative affect	43
Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells	42
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex	42
Learning is shaped by abrupt changes in neural engagement	42
A thalamo-amygdalar circuit underlying the extinction of remote fear memories	42
Fiber photometry in striatum reflects primarily nonsomatic changes in calcium	42
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis	42
Vector trace cells in the subiculum of the hippocampal formation	41
Glymphatic influx and clearance are accelerated by neurovascular coupling	40
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB	40
Anatomic resolution of neurotransmitter-specific projections to the VTA reveals diversity of GABAergic inputs	40
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity	40
Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes	40
Massively parallel techniques for cataloguing the regulome of the human brain	40
Learning binds new inputs into functional synaptic clusters via spinogenesis	40
Integrating new memories into the hippocampal network activity space	39