Nature Neuroscience

Article	Citations
Reactive astrocyte nomenclature, definitions, and future directions	1074
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19	883
Parameterizing neural power spectra into periodic and aperiodic components	846
Synergy between amyloid-β and tau in Alzheimer’s disease	574
Disease-associated astrocytes in Alzheimer’s disease and aging	514
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex	412
Using Bayes factor hypothesis testing in neuroscience to establish evidence of absence	356
Topographic organization of the human subcortex unveiled with functional connectivity gradients	304
The extent and drivers of gender imbalance in neuroscience reference lists	304
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization	287
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice	280
Neuroinflammatory astrocyte subtypes in the mouse brain	276
Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons	259
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques	252
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia	245
Revisiting the neurovascular unit	242
Considering sex as a biological variable will require a global shift in science culture	242
Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease	232
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits	226
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank	212
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions	205
Motor learning promotes remyelination via new and surviving oligodendrocytes	204
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level	202
Long-term maturation of human cortical organoids matches key early postnatal transitions	191
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys	183

Brain capillary pericytes exert a substantial but slow influence on blood flow	183
Microglia phagocytose myelin sheaths to modify developmental myelination	172
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo	171
A community-based transcriptomics classification and nomenclature of neocortical cell types	171
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain	165
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis	164
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset	164
Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning	164
Edge-centric functional network representations of human cerebral cortex reveal overlapping system-level architecture	161
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells	160
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice	160
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease	157
Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons	154
Quantifying behavior to understand the brain	152
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production	151
Interplay between persistent activity and activity-silent dynamics in the prefrontal cortex underlies serial biases in working memory	149
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72	147
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing	146
Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury	143
A genetically encoded sensor for measuring serotonin dynamics	142
Revealing the structure of pharmacobehavioral space through motion sequencing	140
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia	139
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits	136
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis	134
Large-scale neural recordings call for new insights to link brain and behavior	133
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans	133
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex	131
Neural mechanisms of aggression across species	129
Acute social isolation evokes midbrain craving responses similar to hunger	129
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction	128
A massive 7T fMRI dataset to bridge cognitive neuroscience and artificial intelligence	127
Active dendritic currents gate descending cortical outputs in perception	121
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration	121
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease	119
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease	118
Shared computational principles for language processing in humans and deep language models	117
The claustrum coordinates cortical slow-wave activity	115
Recent advances in neurotechnologies with broad potential for neuroscience research	114
Diversity and dynamism in the cerebellum	112
High-fat food biases hypothalamic and mesolimbic expression of consummatory drives	111
Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits	110
Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex	109
Issues and recommendations from the OHBM COBIDAS MEEG committee for reproducible EEG and MEG research	108
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics	108
Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons	108
Identification of neural oscillations and epileptiform changes in human brain organoids	107
Transcriptomic organization of the human brain in post-traumatic stress disorder	103
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges	102
Prefrontal–amygdala circuits in social decision-making	101
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders	100

Wireless multilateral devices for optogenetic studies of individual and social behaviors	98
Spatial and cell type transcriptional landscape of human cerebellar development	98
Anatomically segregated basal ganglia pathways allow parallel behavioral modulation	98
Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit	97
A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice	96
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels	96
Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression	95
Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice	95
Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease	94
Challenges and future directions for representations of functional brain organization	94
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice	93
General anesthetics activate a potent central pain-suppression circuit in the amygdala	91
Dense neuronal reconstruction through X-ray holographic nano-tomography	91
Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits	91
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine	91
Brainstem neurons that command mammalian locomotor asymmetries	91
Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks	90
Rotational dynamics reduce interference between sensory and memory representations	90
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble	89
Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition	89
The neural basis of psychedelic action	89
Microglia contribute to the propagation of Aβ into unaffected brain tissue	88
Circuit and molecular architecture of a ventral hippocampal network	87
A glycolytic shift in Schwann cells supports injured axons	87
Single-neuron projectome of mouse prefrontal cortex	87
Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making	87
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB	87
Decoding molecular and cellular heterogeneity of mouse nucleus accumbens	86
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors	86
Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging	85
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies	85
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents	85
Synaptic vesicles transiently dock to refill release sites	85
An amygdala-to-hypothalamus circuit for social reward	85
Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia	84
An investigation across 45 languages and 12 language families reveals a universal language network	84
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine	84
Brain proteome-wide association study implicates novel proteins in depression pathogenesis	83
Microglial Gi-dependent dynamics regulate brain network hyperexcitability	83
Mice alternate between discrete strategies during perceptual decision-making	83
Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain	83
Attractor dynamics gate cortical information flow during decision-making	82
A synergistic core for human brain evolution and cognition	81
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders	81
RNA transport and local translation in neurodevelopmental and neurodegenerative disease	80
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies	80
Probing neural codes with two-photon holographic optogenetics	79
Genetic variants associated with longitudinal changes in brain structure across the lifespan	79
Hippocampal neurons represent events as transferable units of experience	79
Gene-based therapies for neurodegenerative diseases	79
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states	78
Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity	78
Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration	75
The role of population structure in computations through neural dynamics	75
Cortical-like dynamics in recurrent circuits optimized for sampling-based probabilistic inference	75
Maternal immune activation in mice disrupts proteostasis in the fetal brain	75
Within-group synchronization in the prefrontal cortex associates with intergroup conflict	74
How to establish robust brain–behavior relationships without thousands of individuals	74
Modeling behaviorally relevant neural dynamics enabled by preferential subspace identification	73
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity	73
The preference for sugar over sweetener depends on a gut sensor cell	73
Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology	73
The basal ganglia control the detailed kinematics of learned motor skills	72
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration	72
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines	71
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis	71
Assessing the depth of language processing in patients with disorders of consciousness	70
Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival	70
Cortical interneurons in autism	68
A role for the cortex in sleep–wake regulation	68
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing	67
Visual and linguistic semantic representations are aligned at the border of human visual cortex	67
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development	66
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines	66
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice	65
Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior	65
Inferences on a multidimensional social hierarchy use a grid-like code	65
Semantic reconstruction of continuous language from non-invasive brain recordings	64
Conservation of brain connectivity and wiring across the mammalian class	64
VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error	63

Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states	63
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation	63
Periods of synchronized myelin changes shape brain function and plasticity	63
Four core properties of the human brain valuation system demonstrated in intracranial signals	63
Multiple convergent hypothalamus–brainstem circuits drive defensive behavior	62
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting	62
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons	62
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury	61
Neural fragility as an EEG marker of the seizure onset zone	61
Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior	60
Targeted photostimulation uncovers circuit motifs supporting short-term memory	60
Posterior amygdala regulates sexual and aggressive behaviors in male mice	59
Complementary contributions of non-REM and REM sleep to visual learning	59
How to build a cognitive map	59
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function	58
Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types	58
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation	58
Identification of early neurodegenerative pathways in progressive multiple sclerosis	58
Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model	57
Independent generation of sequence elements by motor cortex	57
A quantitative reward prediction error signal in the ventral pallidum	57
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging	57
Circulating miR-181 is a prognostic biomarker for amyotrophic lateral sclerosis	57
Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition	56
Association between real-world experiential diversity and positive affect relates to hippocampal–striatal functional connectivity	56
Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective	55
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior	55
Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways	55
Associative and plastic thalamic signaling to the lateral amygdala controls fear behavior	54
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway	54
Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit	54
Membrane potential dynamics underlying context-dependent sensory responses in the hippocampus	54
A parsimonious description of global functional brain organization in three spatiotemporal patterns	54
Genetically identified amygdala–striatal circuits for valence-specific behaviors	53
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections	53
A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging	53
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination	53
AHR is a Zika virus host factor and a candidate target for antiviral therapy	53
Primate auditory prototype in the evolution of the arcuate fasciculus	52
A cortical circuit for audio-visual predictions	52
Correlations enhance the behavioral readout of neural population activity in association cortex	52
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement	52
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life	51
Neurons detect cognitive boundaries to structure episodic memories in humans	51
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice	51
Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation	51
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation	50
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans	50
Systematic errors in connectivity inferred from activity in strongly recurrent networks	50
Causal role for the primate superior colliculus in the computation of evidence for perceptual decisions	50
Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses	50
Placental endocrine function shapes cerebellar development and social behavior	50
Thalamic subnetworks as units of function	49
Interneuron origin and molecular diversity in the human fetal brain	49
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration	49
Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor	49
Reactivation predicts the consolidation of unbiased long-term cognitive maps	48
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia	48
Episodic memory retrieval success is associated with rapid replay of episode content	48
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice	48
Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning	48
Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics	47
Synaptic plasticity as Bayesian inference	47
Baseline brain function in the preadolescents of the ABCD Study	47
Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system	47
Dynamic representations in networked neural systems	47
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex	46
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation	46
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations	46
Cerebellar granule cell axons support high-dimensional representations	45
Deconstructing the neurobiology of cannabis use disorder	45
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus	45
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia	44
Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical–hippocampal interactions	43
Memory trace interference impairs recall in a mouse model of Alzheimer’s disease	43
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility	42
An emergent neural coactivity code for dynamic memory	42
Insights into Alzheimer’s disease from single-cell genomic approaches	42
Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments	42
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits	42
Formalizing planning and information search in naturalistic decision-making	41
Addressing racial and phenotypic bias in human neuroscience methods	41
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience	41
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease	41
A thalamo-amygdalar circuit underlying the extinction of remote fear memories	41
Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells	40
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB	40
Vector trace cells in the subiculum of the hippocampal formation	40
Experience-dependent contextual codes in the hippocampus	40
Massively parallel techniques for cataloguing the regulome of the human brain	39
Behavioral origin of sound-evoked activity in mouse visual cortex	39
Confronting racially exclusionary practices in the acquisition and analyses of neuroimaging data	39
Common and stimulus-type-specific brain representations of negative affect	38
Anatomic resolution of neurotransmitter-specific projections to the VTA reveals diversity of GABAergic inputs	38
Adult-born dentate granule cells promote hippocampal population sparsity	38