Journal of Gene Medicine

Article	Citations
	68
Issue Information	40
Withdrawn: X.Chen, Y.Li, M.Zhang, X.Wu, J.Zhu. Silencing LCK inactivates the NF‐κB pathway to attenuate cartilage injury in osteoarthritis: An in vivo and in vitro study, published in Th	28
Long non‐coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR‐326/PKM2 axis	25
Application of CAR‐T cell technology in autoimmune diseases and human immunodeficiency virus infection treatment	22
Hyperfunction variant rs708035 of interleukin 1 receptor‐associated kinases 2 gene involved in the predisposition of leprosy infection	21
Downregulated expression of plakophilin‐2 gene in patients with colon adenocarcinoma predicts an unfavorable prognosis and immune infiltrate	21
Identification of module genes and functional pathway analysis in septic shock subtypes by integrated bioinformatics analysis	21
Diverse cell death patterns‐related signature for predicting prognosis and drug sensitivity of osteosarcoma patients	20
Lnc00113 promotes triple‐negative breast cancer progression via the NOB‐1/MAPK signaling axis	19
Interaction Between YTH Domain‐Containing Family Protein 2 and SET Domain‐Containing Lysine Methyltransferase 7 Suppresses Autophagy in Osteoarthritis Chondrocytes, Exacerbating Cartilage Damage	18
Autophagy‐related risk signature based on CDNK2A to facilitate survival prediction of patients with endometrial cancer	17
WES and Transcriptome Analysis Identifies FN1 as a Candidate Gene for Anterior Segment Dysgenesis	17
Haplotype analysis and linkage disequilibrium of ApoB gene polymorphisms and its relationship with hyperlipidemia in patients with acne vulgaris	17
Withdrawn: Z.Cui, Q.Sun, W.Yan, Q.Han, G.Wang, Y.Hu. The role of miR‐320a and its target gene GMEB1 in epithelial‐mesenchymal transition and invasion of colorectal cancer, published in The Journal of	17
Antigen processing and presentation‐related signature‐derived BNIP3 is a novel oncogene and immunotherapy determinant in osteosarcoma based on machine learning and in vitro validation	16
Adenovirus VA RNAs impair maturation of primary microRNA	16
Constructing and validating a risk model based on neutrophil‐related genes for evaluating prognosis and guiding immunotherapy in colon cancer	16
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Integrative analysis of an endoplasmic reticulum stress‐related signature in multiple myeloma	16
Interleukin‐17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression	15
Downregulation of indolethylamine N‐methyltransferase is an early event in the rat hepatocarcinogenesis and is associated with poor prognosis in hepatocellular carcinoma patients	14
LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis	14
Integrated mRNA and microRNA profiling in lung tissue and blood from human silicosis	13
Studying the mechanism underlying lipid metabolism in osteosarcoma based on transcriptomic RNA sequencing and single‐cell data	13

Identification of novel homozygous variants in FOXE3 and AP4M1 underlying congenital syndromic anophthalmia and microphthalmia	12
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circANKRD28 inhibits cisplatin resistance in non‐small‐cell lung cancer through the miR‐221‐3p/SOCS3 axis	12
Bone marrow overexpression of SNAI1 is an early indicator of intrinsic drug resistance in patients with de novo acute myeloid leukemia	12
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lncRNA MALAT1 promotes osteogenic differentiation through the miR‐217/AKT3 axis: A possible strategy to alleviate osteoporosis	12
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Activation of toll‐like receptor 4/nuclear factor‐kappa B signaling by triggering a receptor expressed on myeloid cells 1 promotes alveolar macrophage M1 polarization and exacerbates septic acute lung	11
A novel anoikis‐related prognostic signature associated with prognosis and immune infiltration landscape in lung adenocarcinoma	11
Expression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma	11
Anisomycin inhibits the activity of human ovarian cancer stem cells via regulating antisense RNA NCBP2‐AS2/MEK/ERK/STAT3 signaling	11
FOXA3: A Novel Tumor Suppressor in Esophageal Squamous Cell Carcinoma	11
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Cis‐regulation of antisense non‐coding RNA at the JAZF1 locus in type 2 diabetes	10
Pharmacogenomic evaluation of CYP2C19 alleles linking low clopidogrel response and the risk of acute coronary syndrome in Indians	10
Noninvasive detection of fetal genetic variations through polymorphic site sequencing of maternal plasma DNA	10
Successful liver transduction by re‐administration of different adeno‐associated virus vector serotypes in mice	10
Construction and validation of risk model of EMT‐related prognostic genes for kidney renal clear cell carcinoma	9
Identification of SGMS2 as a molecule involved in natural killer cell recruitment and its in‐deep analysis in the liver cancer microenvironment: Evidence from large populations cohort	9
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Comprehensive profiling of endocrine metabolism identifies a novel signature with robust predictive value in ovarian cancer	9
Genomic instability‐associated two‐miRNA signature as a novel prognostic biomarker in breast cancer	9
A combined diagnostic model based on circulating tumor cell in patients with solitary pulmonary nodules	9
Sequence variants in the BTD underlying biotinidase deficiency in families of Pakistani origin	9
FPPS Downregulation Attenuates Endoplasmic Reticulum Stress in Pulmonary Epithelial Cells	9
Non‐coding RNAs are correlated to TGF‐β receptor type 2 in patients with colorectal cancer	9
Issue Information	9
Genetically predicted blood metabolites mediate the association between circulating immune cells and pancreatic cancer: A Mendelian randomization study	9
Homozygous missense variant in POPDC3 causes recessive limb‐girdle muscular dystrophy type 26	9
Development of an ubiquitin‐proteasome system signature for predicting prognosis and providing therapeutic guidance for patients with triple‐negative breast cancer	8
Insights into the heterogeneity of the tumor microenvironment in lung adenocarcinoma and squamous carcinoma through single‐cell transcriptomic analysis: Implications for distinct immunotherapy outcome	8
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Exploration of YBX1 role in the prognostic value and immune characteristics by single‐cell and bulk sequencing analysis for liver hepatocellular carcinoma	8
Implantation of human urine stem cells promotes neural repair in spinal cord injury rats associated cadeharin‐1 and integrin subunit beta 1 expression	8
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A variant in sperm‐specific glycolytic enzyme enolase 4 (ENO4) causes human male infertility	8
Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating the miR‐564/ZIC2 axis	7
Prenatal diagnosis of Walker–Warburg syndrome due to compound mutations in the B3GALNT2 gene	7
Machine learning reveals PANoptosis as a potential reporter and prognostic revealer of tumour microenvironment in lung adenocarcinoma	7
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Insights Into the Dysfunctional Communication Switches Targeting Osteocyte Mechanotransduction and Lacunar–Canalicular Gene Network in Pathogenesis of Osteoarthritis	7
Circulating plasma miR222‐3P status and its potential diagnostic performance in prostate cancer	7
JAM2 is a prognostic biomarker and inhibits proliferation, metastasis and epithelial–mesenchymal transition in lung adenocarcinoma	7
A comprehensive study of oxidative stress‐related effects on the prognosis and drug therapy of cervical cancer	7
Silencing N29 Regulated miR‐193b‐5p/TGFBR2 Axis to Mitigate the Progression of Cardiac Hypertrophy	7
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FN1 and cancer‐associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma	7

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lncRNA OIP5‐AS1 knockdown or miR‐223 overexpression can alleviate LPS‐induced ALI/ARDS by interfering with miR‐223/NLRP3‐mediated pyroptosis	6
Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma	6
Reducing the transcriptional read‐through rate of a lentiviral vector for β‐thalassemia gene therapy	6
Biocompatible hydroxyapatite‐based nano vehicle bypasses viral transduction and enables sustained silencing of a pluripotency marker gene, demonstrating desired differentiation in mouse embryonic stem	6
Development of the prognostic value in lung adenocarcinoma based on anoikis‐related genes and initial experimental validation	6
The profile of cytokines against bacterial infection in dental pulp	6
Novel algorithm for diagnosis of Arrhythmogenic cardiomyopathy and dilated cardiomyopathy: Key gene expression profiling using machine learning	6
Bioinformatics‐based analysis of programmed cell death pathway and key prognostic genes in gastric cancer: Implications for the development of therapeutics	6
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A novel compound heterozygous variant linked to hematuria in a family with hereditary factor VII deficiency	6
Reappraising the role of chronic inflammatory burden in heart failure	6
Identification of prognostic value of anoikis‐related gene score model combined with tumor microenvironment score models in esophageal squamous cell carcinoma	6
A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion	5
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Identification and characterization of RAC1‐related immune and prognostic subtypes of hepatocellular carcinoma	5
Idiopathic Pulmonary Fibrosis Is Associated With Type 1 Diabetes: A Two‐Sample Mendelian Randomization Study	5
Apoptosis pathways and osteoporosis: An approach to genomic analysis	5
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Histidine‐enhanced gene delivery systems: The state of the art	5
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USP18 promotes colon adenocarcinoma progression via targeting the ERK‐MNK signaling pathway	5
Leveraging human–mouse studies to advance the genetics of hearing impairment in Africa	5
Three molecular subtypes and a five‐gene signature for hepatocellular carcinoma based on m7G‐related classification	5
A Treg‐related riskscore model may improve the prognosis evaluation of colorectal cancer	5
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sRNA21, a novel small RNA, protects Mycobacterium abscessus against oxidative stress	5
Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR‐217	5
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Metabolism‐related gene vaccines and immune infiltration in ovarian cancer: A novel risk score model of machine learning	5
Hsa_circ_0003596 enhances the development of cell renal clear cell carcinoma through the miR‐502‐5p/IGF1/PI3K/AKT axis	5
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Characterization of Immune Landscape Based on Homologous Recombination Deficiency Associated Signatures and Identification of Knockdown of ERCC6L to Promote Radiosensitivity in Breast Cancer	4
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MYC‐activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR‐584‐3p/ROCK1 axis	4
Novel molecular insights into pyroptosis in triple‐negative breast cancer prognosis and immunotherapy	4
Marked increase in tumor transfection with a truncated branched polymer	4
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Association between polymorphisms of ABCB1 and prognosis in esophageal squamous cell carcinoma patients treated with taxane	4
Intramyocardial adenoviral vascular endothelial growth factor‐D∆N∆C gene therapy does not induce ventricular arrhythmias	4
Enhancement of adeno‐associated virus serotype 6 transduction into T cells with cell‐penetrating peptides	4
Early distribution of18 F‐labeled AAV9 vectors in the cerebrospinal fluid after intracerebroventricular or intracisternal magna infusion in non‐human primates	4
Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF‐β1/Smad3 signaling pathway	4
A signature based on neutrophil extracellular trap‐related genes for the assessment of prognosis, immunoinfiltration, mutation and therapeutic response in hepatocellular carcinoma	4
miR‐4286 promotes prostate cancer progression by targeting the expression of SALL1	4
Retraction: Bladder cancer‐associated transcript 2 contributes to nephroblastoma progression	4
Long non‐coding RNA linc00659 promotes tumour progression by regulating FZD6/Wnt/β‐catenin signalling pathway in colorectal cancer via m6A reader IGF2BP1	4
Integrated transcriptome, proteome and single‐cell sequencing uncover the prognostic and immunological features of colony‐stimulating factor 3 receptor in pan‐cancer	4
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Network pharmacology and bioinformatics analysis on the underlying mechanisms of baicalein against oral squamous cell carcinoma	4
Identification and exploration of aging‐related subtypes and distinctive role of SERPINE1 in heart failure based on single‐cell and bulk RNA sequencing data	4
OMICRON: Virology, immunopathogenesis, and laboratory diagnosis	4
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In Silico Analysis of Novel circRNA‐miRNA‐mRNA Axis in BRAFV600E Melanoma: Implications for Primary to Metastasis Transformation and TIME Modulation	4
Extracellular vesicles from bone marrow mesenchymal stem cells alleviate acute rejection injury after liver transplantation by carrying miR‐22‐3p and inducing M2 polarization of Kupffer cells	4
Anoikis‐related signature in liver hepatocellular carcinoma defines the YBX1/SPP1 axis by machine learning strategies and valid experiments	4
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Homologous recombination repair gene‐based risk model predicts prognosis and immune microenvironment for primary lung cancer after previous malignancies	4
Inhibition of HIST1H2AB suppresses the proliferation of lung adenocarcinoma	4
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The inflammatory response‐related robust machine learning signature in endometrial cancer: Based on multi‐cohort studies	4
Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1	4
ANKRD37 inhibits trophoblast migration and invasion by regulating the NF‐κB pathway in preeclampsia	4
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Single‐cell sequencing reveals the correlation of aggrephagy signaling and multiple myeloma immune microenvironment composition	3
Leveraging SEER data through machine learning to predict distant lymph node metastasis and prognosticate outcomes in hepatocellular carcinoma patients	3
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Viral and non‐viral gene therapy using 3D (bio)printing	3
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M2 macrophage marker CHI3L2 could serve as a potential prognostic and immunological biomarker in glioma by integrated single‐cell and bulk RNA‐Seq analysis	3
AKT/FOXM1/STMN1 signaling pathway activation by SMC1A promotes tumor growth in breast cancer	3
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MEG3 shuttled by exosomes released from human bone marrow mesenchymal stem cells promotes TP53 stability to regulate MCM5 transcription in keloid fibroblasts	3
Long non‐coding RNA LGALS8‐AS1 facilitates PLAGL2‐mediated malignant phenotypes in gastric cancer	3
Potentially functional genetic variants of the notch signaling pathway genes predict survival of Chinese patients with esophageal squamous cell carcinoma	3
Sp2 Transcription Factor Alleviates Chondrocyte Loss in Osteoarthritis by Repressing the DVL1‐Dependent Wnt/β‐Catenin Signaling Pathway	3
Genome wide analysis of dexamethasone stimulated mineralization in human dental pulp cells by RNA sequencing	3
Withdrawn: L.Xuan, Z.Sun, J.Wang, S.Gao. Long non‐coding RNA SNHG8 promotes ovarian cancer progression through serving as a sponge for miR‐1270 to regulate S100A11 expression, published in The Journal	3
Necrotizing apoptosis‐related genes prognosis and treatment effect analysis of osteosarcoma in children	3
Function and prognostic value of N6‐methyladenosine‐modified RNAs in lung adenocarcinoma	3
Cytotoxic T‐lymphocytes in acute myeloid leukemia: Monitoring prognosis and guiding treatment choice	3
RNA sequencing and bioinformatics analysis revealed PACSIN3 as a potential novel biomarker for platinum resistance in epithelial ovarian cancer	3
Metabolic and immune‐related gene signatures: Predictive stratification and prognostic implications in gastric cancer	3
Peroxisome proliferator‐activated receptors signature reveal the head and neck squamous cell carcinoma energy metabolism phenotype and clinical outcome	3
Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylation	3
Impact of ABCB1, ABCC1, ABCC2, and ABCG2 variants in predicting prognosis and clinical outcomes of north Indian lung cancer patients undergoing platinum‐based doublet chemo	3
Prognostic analysis and validation of lncRNAs in bladder cancer on the basis of neutrophil extracellular traps	3
Impact of inflammatory cytokine and adipokine gene variations in the development of HIV‐associated lipodystrophy	3
CSRP3, p.Arg122*, is responsible for hypertrophic cardiomyopathy in a Chinese family	3
Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO‐1 Pathways	3
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Dipeptidyl peptidase 4: A predictor of ferroptosis in ulcerative colitis	3
Methyltransferase‐like 3 modulates osteogenic differentiation of adipose‐derived stem cells in osteoporotic rats	3
Comprehensive transcriptomic analysis and machine learning reveal unique gene expression profiles in patients with immune‐mediated necrotizing myopathy	3
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Age‐related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis	3
Zebrafish in understanding molecular pathophysiology, disease modeling, and developing effective treatments for Rett syndrome	3
Combination therapy with chitosan/siRNA nanoplexes targeting PDGF‐D and PDGFR‐β reveals anticancer effect in breast cancer	3
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Icariside II in NSCLC and COVID‐19: Network pharmacology and molecular docking study	3
Novel polymorphism of the HMGCR gene related to the risk of diabetes in premature triple‐vessel disease patients	3
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Strategic deactivation of mRNA COVID‐19 vaccines: New applications for siRNA therapy and RIBOTACs	2
Comparison of immune‐related gene signatures and immune infiltration features in early‐ and late‐onset preeclampsia	2
Circ_0073228 serves as a competitive endogenous ribonucleic acid to facilitate proliferation and inhibit apoptosis of hepatocellular carcinoma cells by the miR‐139‐5p/deoxyribonuclease II axis	2
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Adoptive Transfer of T Cells as a Potential Therapeutic Approach in the Bleomycin‐Injured Mouse Lung	2
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The suppression of OTUD7B by miR‐491‐5p enhances the ubiquitination of VEGFA to suppress vascular mimicry in non‐small cell lung cancer	2
The role of ABCB1 gene polymorphisms in steroid‐resistant nephrotic syndrome: Evidence from a meta‐analysis of steroid‐receiving patients	2
Integrative Analysis Identifies NSUN2 as an Essential Coordinator for Glioma Malignancy and Glucose Metabolism	2
Single‐cell analysis of Crohn's disease: Unveiling heterogeneity and evaluating ustekinumab outcomes	2
GRIK1‐AS1 deficiency accelerates endometriosis progression by boosting DNMT1‐dependent SFRP1 promoter methylation in endometrial stromal cells	2
Functional analysis of hepatic long non‐coding ribonucleic acids during liver transplantation in humans	2
X‐linked BCOR variants identified in Chinese Han patients with congenital heart disease	2
Autophagy‐related CMTM6 promotes glioblastoma progression by activating Wnt/β‐catenin pathway and acts as an onco‐immunological biomarker	2
Identification of the shared gene signatures and molecular pathways in systemic lupus erythematosus and diffuse large B‐cell lymphoma	2
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BRIX1 promotes ribosome synthesis and enhances glycolysis by selected translation of GLUT1 in colorectal cancer	2
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Unveiling Anoikis‐related genes: A breakthrough in the prognosis of bladder cancer	2
Long noncoding RNA 02027 inhibits proliferation, migration and invasion of hepatocellular carcinoma via miR‐625‐3p/PDLIM5 pathway	2
From cancer big data to treatment: Artificial intelligence in cancer research	2
Prognostic evaluation of the novel blueprint of DNA methylation sites by integrating bulk RNA‐sequencing and methylation modification data in endometrial cancer	2
Integrative analysis of cuproptosis‐associated genes for predicting immunotherapy response in single‐cell and multi‐cohort studies	2
Single‐cell RNA‐sequencing analysis reveals divergent transcriptome events between platinum‐sensitive and platinum‐resistant high‐grade serous ovarian carcinoma	2
Maternal ApoE genotype and risk of recurrent pregnancy loss: An updated systematic review and meta‐analysis	2
Hypoxia‐Inducible Factor HIF1α Regulates the Expression of SLC7A1 to Mediate Erastin‐Induced Ferroptosis in Cervical Cancer Cells	2
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T‐cell exhaustion: A potential target biomarker of the tumour microenvironment affecting oesophageal adenocarcinoma	2
Genome‐wide polygenic risk score for rheumatoid arthritis prediction in postmenopausal women	2
TaqI polymorphism T/t genotypes at the vitamin D receptor gene (VDR) are associated with increased serum vitamin D levels in mild and moderate psoriasis vulgaris: A pilot study	2
Pericarpium Trichosanthis Inhibits TGF‐β1‐Smad3 Pathway‐Induced Cardiac Fibrosis in Heart Failure Rats via Upregulation of microRNA‐29b	2
SYNGR2 serves as a prognostic biomarker and correlates with immune infiltrates in esophageal squamous cell carcinoma	2
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Single‐cell transcriptome analysis reveals heterogeneity of neutrophils in non‐small cell lung cancer	2
Exploring the interplay between bisphenol A exposure, the immune microenvironment and hepatocellular carcinoma progression	2
Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR‐214	2
Development of a novel prognostic signature based on single‐cell combined bulk RNA analysis in breast cancer	2
Exploration of s new biomarker in osteosarcoma and association with clinical outcomes: TOP2A+cancer associated fibroblasts	2
Clinical and prognostic significance analysis of glycolysis‐related genes in HNSCC	2
RETRACTION: Long non‐coding RNA KCNQ1OT1 Promotes the Progression of Gastric Cancer via the miR‐145‐5p/ARF6 Axis	2
Overexpression of multidrug resistance‐associated protein 1 protects against cardiotoxicity by augmenting the doxorubicin efflux from cardiomyocytes	1
Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy	1
Identification of immunogenic cell death‐associated subtypes and characterization of the tumor microenvironment in endometrial cancer	1
Knockdown of AK142426 suppresses M2 macrophage polarization and inflammation in peritoneal fibrosis via binding to c‐Jun	1
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Human leukocyte antigen class I association with occult hepatitis B virus infection in the Shaanxi Han group: Analysis at the haplotype level	1
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Association between gut microbiota and seven gastrointestinal diseases: A Mendelian randomized study	1
ANGPTL4—A protein involved in glucose metabolism, lipid metabolism, and tumor development	1
Natural Products as Modulators of miRNA in Hepatocellular Carcinoma: A Therapeutic Perspective	1
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METTL13 promotes nasopharyngeal carcinoma progression through regulating the ZEB1/TPT1 axis	1
Dysregulated cholesterol regulatory genes as a diagnostic biomarker for cancer	1
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Comprehensive analysis of the exosomal circRNA‐miRNA‐mRNA network in breast cancer	1
New molecular insights into ferroptosis in lung adenocarcinoma progression and pharmacological compounds for targeted therapy	1
The Mechanisms, Research Status, and Future Prospects of m6A Modification in Breast Cancer	1
The mechanism of lovastatin in suppressing the proliferation of esophageal squamous cell carcinoma based on proteomics	1
Successful AAV8 readministration: Suppression of capsid‐specific neutralizing antibodies by a combination treatment of bortezomib and CD20 mAb in a mouse model of Pompe disease	1
Identification of novel factors that affect the onset of idiopathic chronic pancreatitis: The role for microRNA‐323b‐5p	1
The Role of MiRNAs in Moyamoya Disease: Vascular Remodeling and Stroke Risk	1
Association of IRGM gene promoter polymorphisms with hepatitis B virus infection	1
Mutation pattern of cancer suppressor p53 gene in factory workers exposed to polypropylene and impact on their reproductive hormones	1