OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Gene Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Circulating microvesicles miR139‐3p from bronchopulmonary dysplasia aggravates pulmonary vascular simplification by targeting 4E binding protein 1	39
	33
Reappraising the role of chronic inflammatory burden in heart failure	29
Icariin Facilitates Osteogenic Differentiation and Suppresses Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Enhancing SOST Methylation in Postmenopausal Osteoporosis	21
	20
RETRACTION: Long non‐coding RNA KCNQ1OT1 Promotes the Progression of Gastric Cancer via the miR‐145‐5p/ARF6 Axis	20
Interaction Between YTH Domain‐Containing Family Protein 2 and SET Domain‐Containing Lysine Methyltransferase 7 Suppresses Autophagy in Osteoarthritis Chondrocytes, Exacerbating Cartilage Damage	20
Circular RNA circ_0001588 sponges miR‐211‐5p to facilitate the progression of glioblastoma via up‐regulating YY1 expression	19
Issue Information	19
Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma	18
	18
The CHST11 gene is linked to lung cancer and pulmonary fibrosis	18
Issue Information	18
	17
CRISPR‐Cas9 screening identified lethal genes enriched in necroptosis pathway and of prognosis significance in osteosarcoma	17
	17
Issue Information	16
Targeted gene next‐generation sequencing reveals genomic profile in a cohort of 46 Chinese patients with breast cancer	15
	15
	14
T‐cell exhaustion: A potential target biomarker of the tumour microenvironment affecting oesophageal adenocarcinoma	14
Issue Information	14
Transcriptome and single‐cell sequencing analysis in tumor microenvironment	14
Peroxisome proliferator‐activated receptors signature reveal the head and neck squamous cell carcinoma energy metabolism phenotype and clinical outcome	13
Age‐related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis	13

Cytotoxic T‐lymphocytes in acute myeloid leukemia: Monitoring prognosis and guiding treatment choice	13
Reducing the transcriptional read‐through rate of a lentiviral vector for β‐thalassemia gene therapy	13
Diverse cell death patterns‐related signature for predicting prognosis and drug sensitivity of osteosarcoma patients	13
Metabolic and immune‐related gene signatures: Predictive stratification and prognostic implications in gastric cancer	13
Amino acids and their roles in tumor immunotherapy of breast cancer	12
	12
Issue Information	12
Minicircle‐based expression of vascular endothelial growth factor in mesenchymal stromal cells from diverse human tissues	11
Application of CAR‐T cell technology in autoimmune diseases and human immunodeficiency virus infection treatment	11
Zebrafish in understanding molecular pathophysiology, disease modeling, and developing effective treatments for Rett syndrome	11
A glycosylation signature for predicting the progression and immunotherapeutic response of prostate cancer	11
Lnc00113 promotes triple‐negative breast cancer progression via the NOB‐1/MAPK signaling axis	11
Issue Information	10
M2 macrophage marker CHI3L2 could serve as a potential prognostic and immunological biomarker in glioma by integrated single‐cell and bulk RNA‐Seq analysis	10
The diagnostic significance of circulating lncRNA ADAMTS9‐AS2 tumor biomarker in non‐small cell lung cancer among the Egyptian population	10
A novel compound heterozygous variant linked to hematuria in a family with hereditary factor VII deficiency	10
Function and prognostic value of N6‐methyladenosine‐modified RNAs in lung adenocarcinoma	10
X‐linked BCOR variants identified in Chinese Han patients with congenital heart disease	10
Identification of module genes and functional pathway analysis in septic shock subtypes by integrated bioinformatics analysis	9
Leveraging SEER data through machine learning to predict distant lymph node metastasis and prognosticate outcomes in hepatocellular carcinoma patients	9
Long non‐coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR‐326/PKM2 axis	9
Hyperfunction variant rs708035 of interleukin 1 receptor‐associated kinases 2 gene involved in the predisposition of leprosy infection	9
Novel algorithm for diagnosis of Arrhythmogenic cardiomyopathy and dilated cardiomyopathy: Key gene expression profiling using machine learning	9
The profile of cytokines against bacterial infection in dental pulp	9
NLRC4‐mediated pyroptosis was involved in coagulation disorders of acute pancreatitis	9
	9
VEGF₁₆₅ gene‐modified human umbilical cord blood mesenchymal stem cells protect against acute liver failure in rats	9
Characterization of neutrophil extracellular traps related gene pair for predicting prognosis in hepatocellular carcinoma	9
Autophagy‐related CMTM6 promotes glioblastoma progression by activating Wnt/β‐catenin pathway and acts as an onco‐immunological biomarker	9
Withdrawn: X.Chen, Y.Li, M.Zhang, X.Wu, J.Zhu. Silencing LCK inactivates the NF‐κB pathway to attenuate cartilage injury in osteoarthritis: An in vivo and in vitro study, published in Th	8
Cuproptosis‐related classification and personalized treatment in lower‐grade gliomas to prompt precise oncology	8
Downregulated expression of plakophilin‐2 gene in patients with colon adenocarcinoma predicts an unfavorable prognosis and immune infiltrate	8
Hematopoietic stem cell gene therapy for the treatment of SYNGAP1‐related non‐specific intellectual disability	8
RNA expression profiling in lymphoblastoid cell lines from mutated and non‐mutated amyotrophic lateral sclerosis patients	8
Association of CYP4A22 gene polymorphisms with cerebral stroke risk in the Chinese Han population	8
Decoding dysregulated genes, molecular pathways and microRNAs involved in cervical cancer	8
Bioinformatics‐based analysis of programmed cell death pathway and key prognostic genes in gastric cancer: Implications for the development of therapeutics	8
Withdrawn: Y.Yin, X.Lu, M.Yang, J.Shangguan, Y.Zhang. Inhibition of lncRNA MALAT1 reduces myocardial ischemia–reperfusion injury of rat cardiomyocytes through regulating the miR‐135a‐5p/HIF1AN axis, p	8
Withdrawn: Z.Cui, Q.Sun, W.Yan, Q.Han, G.Wang, Y.Hu. The role of miR‐320a and its target gene GMEB1 in epithelial‐mesenchymal transition and invasion of colorectal cancer, published in The Journal of	8
Haplotype analysis and linkage disequilibrium of ApoB gene polymorphisms and its relationship with hyperlipidemia in patients with acne vulgaris	8
Shikonin potentiates skin wound healing in Sprague–Dawley rats by stimulating fibroblast and endothelial cell proliferation and angiogenesis	7
WES and Transcriptome Analysis Identifies FN1 as a Candidate Gene for Anterior Segment Dysgenesis	7
Identification of novel homozygous missense and deletion mutations manifesting oligospermia infertility in Kashmiri population	7
Investigating the prognostic role of lncRNAs associated with disulfidptosis‐related genes in clear cell renal cell carcinoma	7
Genetic variation in catechol‐O‐methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects	7
Fiber modifications enable fowl adenovirus 4 vectors to transduce human cells	7
Issue Information	7
Long non‐coding DANCR targets miR‐185‐5p to upregulate LIM and SH3 protein 1 promoting prostate cancer via the FAK/PI3K/AKT/GSK3β/snail pathway	7
Expression pattern of long non‐coding RNAs MALAT1 and MEG3 in COVID‐19 patients	7
The long non‐sacoding RNA TMEM147‐AS1/miR‐133b/ZNF587 axis regulates the Warburg effect and promotes prostatic carcinoma invasion and proliferation	7

Long non‐coding RNA KCNQ1OT1 promotes proliferation, migration and invasion via targeting miR‐134 in retinoblastoma	7
Transcriptome mapping of renal clear cell carcinoma revealed by machine learning algorithm based on enhanced computed tomography images	7
Prognosis and therapy in thyroid cancer by gene signatures related to natural killer cells	7
RNA Interference Targeting Small Heat Shock Protein B8 Failed to Improve Distal Hereditary Motor Neuropathy in the Mouse Model	6
RNA sequencing and bioinformatics analysis revealed PACSIN3 as a potential novel biomarker for platinum resistance in epithelial ovarian cancer	6
Hsa_circ_0040809 regulates colorectal cancer development by upregulating methyltransferase DNMT1 via targeting miR‐515‐5p	6
AKT/FOXM1/STMN1 signaling pathway activation by SMC1A promotes tumor growth in breast cancer	6
	6
lncRNA OIP5‐AS1 knockdown or miR‐223 overexpression can alleviate LPS‐induced ALI/ARDS by interfering with miR‐223/NLRP3‐mediated pyroptosis	6
Global analysis of urinary extracellular vesicle small RNAs in autosomal dominant polycystic kidney disease	6
Icariside II in NSCLC and COVID‐19: Network pharmacology and molecular docking study	5
Potentially functional genetic variants of the notch signaling pathway genes predict survival of Chinese patients with esophageal squamous cell carcinoma	5
Vitamin D receptor gene polymorphismTaqI(rs731236) and its association with the susceptibility to coronary artery disease among Pakistani population	5
Genome wide analysis of dexamethasone stimulated mineralization in human dental pulp cells by RNA sequencing	5
Hsa_circRNA_102229 facilitates the progression of triple‐negative breast cancer via regulating the miR‐152‐3p/PFTK1 pathway	5
Leveraging human–mouse studies to advance the genetics of hearing impairment in Africa	5
Dissecting the molecular profiling and tumor immune microenvironment of three subtypes of esophageal cancer	5
USP31 serves as a potential biomarker for predicting prognosis and immune responses for clear cell renal cell carcinoma via single‐cell and bulk RNA‐sequencing	5
Design of a new cell penetrating peptide for DNA, siRNA and mRNA delivery	5
Extracellular vesicle‐packaged miR‐181c‐5p from epithelial ovarian cancer cells promotes M2 polarization of tumor‐associated macrophages via the KAT2B/HOXA10 axis	5
Safety of intravitreally delivered AAV2 vector‐mediated multi‐characteristic opsin genetic construct in wild type beagle dogs	5
Single‐cell sequencing reveals the correlation of aggrephagy signaling and multiple myeloma immune microenvironment composition	5
Adenovirus VA RNAs impair maturation of primary microRNA	5
Global brain delivery of neuroligin 2 gene ameliorates seizures in a mouse model of epilepsy	5
Antigen processing and presentation‐related signature‐derived BNIP3 is a novel oncogene and immunotherapy determinant in osteosarcoma based on machine learning and in vitro validation	5
Issue Information	5
USP18 promotes colon adenocarcinoma progression via targeting the ERK‐MNK signaling pathway	5
Identification and characterization of RAC1‐related immune and prognostic subtypes of hepatocellular carcinoma	5
	4
A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion	4
Issue Information	4
Issue Information	4
LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis	4
Exploring the mechanism underlying the therapeutic effects of butein in colorectal cancer using network pharmacology and single‐cell RNA sequencing data	4
	4
	4
Issue Information	4
Antisense lncRNA‐RP11‐498C9.13 promotes bladder cancer progression by enhancing reactive oxygen species‐induced mitophagy	4
Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to bortezomib via miR‐874‐3p/HDAC1 axis	4
Natural killer cell‐based signature: Prognostic analysis in head and neck squamous cell carcinoma	4
Dysregulated ceRNA network modulated by copy number variation‐driven lncRNAs in breast cancer: A comprehensive analysis	4
Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO‐1 Pathways	4
Issue Information	4
A novel PPRC1 point mutation in a Chinese family with premature ovarian failure: A case study	4
Issue Information	4
Identification and functional analysis of genetic variants of ISL1 gene promoter in human atrial septal defects	4
	4
	4
	4
Comprehensive analysis of histone acetylation‐related genes in glioblastoma and lower‐grade gliomas: Insights into drug sensitivity, molecular subtypes, immune infiltration, and prognosis	4
Causal effects of female reproductive features on nonalcoholic fatty liver disease: A mendelian randomization study	4
Issue Information	4