OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Gene Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
	61
Issue Information	40
Haplotype analysis and linkage disequilibrium of ApoB gene polymorphisms and its relationship with hyperlipidemia in patients with acne vulgaris	35
WES and Transcriptome Analysis Identifies FN1 as a Candidate Gene for Anterior Segment Dysgenesis	23
Long non‐coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR‐326/PKM2 axis	22
Interaction Between YTH Domain‐Containing Family Protein 2 and SET Domain‐Containing Lysine Methyltransferase 7 Suppresses Autophagy in Osteoarthritis Chondrocytes, Exacerbating Cartilage Damage	22
Withdrawn: X.Chen, Y.Li, M.Zhang, X.Wu, J.Zhu. Silencing LCK inactivates the NF‐κB pathway to attenuate cartilage injury in osteoarthritis: An in vivo and in vitro study, published in Th	22
Identification of module genes and functional pathway analysis in septic shock subtypes by integrated bioinformatics analysis	21
Lnc00113 promotes triple‐negative breast cancer progression via the NOB‐1/MAPK signaling axis	21
Hyperfunction variant rs708035 of interleukin 1 receptor‐associated kinases 2 gene involved in the predisposition of leprosy infection	21
Application of CAR‐T cell technology in autoimmune diseases and human immunodeficiency virus infection treatment	20
Downregulated expression of plakophilin‐2 gene in patients with colon adenocarcinoma predicts an unfavorable prognosis and immune infiltrate	19
Diverse cell death patterns‐related signature for predicting prognosis and drug sensitivity of osteosarcoma patients	18
Issue Information	18
Withdrawn: Z.Cui, Q.Sun, W.Yan, Q.Han, G.Wang, Y.Hu. The role of miR‐320a and its target gene GMEB1 in epithelial‐mesenchymal transition and invasion of colorectal cancer, published in The Journal of	18
Adenovirus VA RNAs impair maturation of primary microRNA	17
Autophagy‐related risk signature based on CDNK2A to facilitate survival prediction of patients with endometrial cancer	17
LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis	17
Integrative analysis of an endoplasmic reticulum stress‐related signature in multiple myeloma	16
Antigen processing and presentation‐related signature‐derived BNIP3 is a novel oncogene and immunotherapy determinant in osteosarcoma based on machine learning and in vitro validation	16
Downregulation of indolethylamine N‐methyltransferase is an early event in the rat hepatocarcinogenesis and is associated with poor prognosis in hepatocellular carcinoma patients	15
Interleukin‐17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression	15
Issue Information	14
Synovial mesenchymal stem cell‐derived extracellular vesicles containing microRN555A‐26a‐5p ameliorate cartilage damage of osteoarthritis	14
Constructing and validating a risk model based on neutrophil‐related genes for evaluating prognosis and guiding immunotherapy in colon cancer	14

Issue Information	13
Studying the mechanism underlying lipid metabolism in osteosarcoma based on transcriptomic RNA sequencing and single‐cell data	12
Integrated mRNA and microRNA profiling in lung tissue and blood from human silicosis	12
Bone marrow overexpression of SNAI1 is an early indicator of intrinsic drug resistance in patients with de novo acute myeloid leukemia	12
Issue Information	12
Pharmacogenomic evaluation of CYP2C19 alleles linking low clopidogrel response and the risk of acute coronary syndrome in Indians	12
Identification of novel homozygous variants in FOXE3 and AP4M1 underlying congenital syndromic anophthalmia and microphthalmia	12
Activation of toll‐like receptor 4/nuclear factor‐kappa B signaling by triggering a receptor expressed on myeloid cells 1 promotes alveolar macrophage M1 polarization and exacerbates septic acute lung	12
Expression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma	11
Anisomycin inhibits the activity of human ovarian cancer stem cells via regulating antisense RNA NCBP2‐AS2/MEK/ERK/STAT3 signaling	11
Association between HLA alleles and Epstein–Barr virus Zta‐IgA serological status in healthy males from southern China	10
A novel anoikis‐related prognostic signature associated with prognosis and immune infiltration landscape in lung adenocarcinoma	10
Issue Information	10
circANKRD28 inhibits cisplatin resistance in non‐small‐cell lung cancer through the miR‐221‐3p/SOCS3 axis	10
lncRNA MALAT1 promotes osteogenic differentiation through the miR‐217/AKT3 axis: A possible strategy to alleviate osteoporosis	10
Comprehensive profiling of endocrine metabolism identifies a novel signature with robust predictive value in ovarian cancer	10
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FOXA3: A Novel Tumor Suppressor in Esophageal Squamous Cell Carcinoma	10
Successful liver transduction by re‐administration of different adeno‐associated virus vector serotypes in mice	10
Sequence variants in the BTD underlying biotinidase deficiency in families of Pakistani origin	9
Identification of SGMS2 as a molecule involved in natural killer cell recruitment and its in‐deep analysis in the liver cancer microenvironment: Evidence from large populations cohort	9
Insights into the heterogeneity of the tumor microenvironment in lung adenocarcinoma and squamous carcinoma through single‐cell transcriptomic analysis: Implications for distinct immunotherapy outcome	9
A combined diagnostic model based on circulating tumor cell in patients with solitary pulmonary nodules	9
Noninvasive detection of fetal genetic variations through polymorphic site sequencing of maternal plasma DNA	9
Genomic instability‐associated two‐miRNA signature as a novel prognostic biomarker in breast cancer	9
Genetically predicted blood metabolites mediate the association between circulating immune cells and pancreatic cancer: A Mendelian randomization study	9
Issue Information	9
Cis‐regulation of antisense non‐coding RNA at the JAZF1 locus in type 2 diabetes	9
Construction and validation of risk model of EMT‐related prognostic genes for kidney renal clear cell carcinoma	9
Non‐coding RNAs are correlated to TGF‐β receptor type 2 in patients with colorectal cancer	9
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Homozygous missense variant in POPDC3 causes recessive limb‐girdle muscular dystrophy type 26	8
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JAM2 is a prognostic biomarker and inhibits proliferation, metastasis and epithelial–mesenchymal transition in lung adenocarcinoma	8
Issue Information	8
A variant in sperm‐specific glycolytic enzyme enolase 4 (ENO4) causes human male infertility	8
Issue Information	8
FPPS Downregulation Attenuates Endoplasmic Reticulum Stress in Pulmonary Epithelial Cells	8
Exploration of YBX1 role in the prognostic value and immune characteristics by single‐cell and bulk sequencing analysis for liver hepatocellular carcinoma	8
Circulating plasma miR222‐3P status and its potential diagnostic performance in prostate cancer	7
Silencing N29 Regulated miR‐193b‐5p/TGFBR2 Axis to Mitigate the Progression of Cardiac Hypertrophy	7
Development of an ubiquitin‐proteasome system signature for predicting prognosis and providing therapeutic guidance for patients with triple‐negative breast cancer	7
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FN1 and cancer‐associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma	7
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Implantation of human urine stem cells promotes neural repair in spinal cord injury rats associated cadeharin‐1 and integrin subunit beta 1 expression	7
Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating the miR‐564/ZIC2 axis	7
Identification of prognostic value of anoikis‐related gene score model combined with tumor microenvironment score models in esophageal squamous cell carcinoma	7
Prenatal diagnosis of Walker–Warburg syndrome due to compound mutations in the B3GALNT2 gene	7
lncRNA IGF2‐AS promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR‐3,126‐5p to upregulate KLK4	7

MicroRNA‐145‐5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma	7
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The profile of cytokines against bacterial infection in dental pulp	6
Issue Information	6
Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma	6
Biocompatible hydroxyapatite‐based nano vehicle bypasses viral transduction and enables sustained silencing of a pluripotency marker gene, demonstrating desired differentiation in mouse embryonic stem	6
Machine learning reveals PANoptosis as a potential reporter and prognostic revealer of tumour microenvironment in lung adenocarcinoma	6
A novel compound heterozygous variant linked to hematuria in a family with hereditary factor VII deficiency	6
Reducing the transcriptional read‐through rate of a lentiviral vector for β‐thalassemia gene therapy	6
Development of the prognostic value in lung adenocarcinoma based on anoikis‐related genes and initial experimental validation	6
A comprehensive study of oxidative stress‐related effects on the prognosis and drug therapy of cervical cancer	6
Reappraising the role of chronic inflammatory burden in heart failure	6
Novel algorithm for diagnosis of Arrhythmogenic cardiomyopathy and dilated cardiomyopathy: Key gene expression profiling using machine learning	6
sRNA21, a novel small RNA, protects Mycobacterium abscessus against oxidative stress	5
Histidine‐enhanced gene delivery systems: The state of the art	5
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The inflammatory response‐related robust machine learning signature in endometrial cancer: Based on multi‐cohort studies	5
Identification and characterization of RAC1‐related immune and prognostic subtypes of hepatocellular carcinoma	5
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Circular RNA circ_0001588 sponges miR‐211‐5p to facilitate the progression of glioblastoma via up‐regulating YY1 expression	5
Idiopathic Pulmonary Fibrosis Is Associated With Type 1 Diabetes: A Two‐Sample Mendelian Randomization Study	5
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USP18 promotes colon adenocarcinoma progression via targeting the ERK‐MNK signaling pathway	5
Issue Information	5
Integrated transcriptome, proteome and single‐cell sequencing uncover the prognostic and immunological features of colony‐stimulating factor 3 receptor in pan‐cancer	5
Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR‐217	5
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Issue Information	5
Bioinformatics‐based analysis of programmed cell death pathway and key prognostic genes in gastric cancer: Implications for the development of therapeutics	5
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Down‐regulation of circITCH promotes osteosarcoma development and resistance to doxorubicin via the miR‐524/RASSF6 axis	5
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Three molecular subtypes and a five‐gene signature for hepatocellular carcinoma based on m7G‐related classification	5
Leveraging human–mouse studies to advance the genetics of hearing impairment in Africa	5
Issue Information	5
lncRNA OIP5‐AS1 knockdown or miR‐223 overexpression can alleviate LPS‐induced ALI/ARDS by interfering with miR‐223/NLRP3‐mediated pyroptosis	5
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A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion	5
Hsa_circ_0003596 enhances the development of cell renal clear cell carcinoma through the miR‐502‐5p/IGF1/PI3K/AKT axis	4
LINC00852 is associated with poor prognosis in non‐small cell lung cancer patients and its inhibition suppresses cancer cell proliferation and chemoresistance via the hsa‐miR‐145‐5p/KLF4 axis	4
Characterization of Immune Landscape Based on Homologous Recombination Deficiency Associated Signatures and Identification of Knockdown of ERCC6L to Promote Radiosensitivity in Breast Cancer	4
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Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1	4
Intramyocardial adenoviral vascular endothelial growth factor‐D^∆N∆C gene therapy does not induce ventricular arrhythmias	4
Apoptosis pathways and osteoporosis: An approach to genomic analysis	4
Marked increase in tumor transfection with a truncated branched polymer	4
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MYC‐activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR‐584‐3p/ROCK1 axis	4
Issue Information	4
Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF‐β1/Smad3 signaling pathway	4
A signature based on neutrophil extracellular trap‐related genes for the assessment of prognosis, immunoinfiltration, mutation and therapeutic response in hepatocellular carcinoma	4
Association between polymorphisms of ABCB1 and prognosis in esophageal squamous cell carcinoma patients treated with taxane	4
Identification and exploration of aging‐related subtypes and distinctive role of SERPINE1 in heart failure based on single‐cell and bulk RNA sequencing data	4
Issue Information	4
A Treg‐related riskscore model may improve the prognosis evaluation of colorectal cancer	4
Inhibition of HIST1H2AB suppresses the proliferation of lung adenocarcinoma	4
Issue Information	4
Network pharmacology and bioinformatics analysis on the underlying mechanisms of baicalein against oral squamous cell carcinoma	4
Anoikis‐related signature in liver hepatocellular carcinoma defines the YBX1/SPP1 axis by machine learning strategies and valid experiments	4
ANKRD37 inhibits trophoblast migration and invasion by regulating the NF‐κB pathway in preeclampsia	4
Issue Information	4
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Retraction: Bladder cancer‐associated transcript 2 contributes to nephroblastoma progression	4
Long non‐coding RNA linc00659 promotes tumour progression by regulating FZD6/Wnt/β‐catenin signalling pathway in colorectal cancer via m6A reader IGF2BP1	4
Novel molecular insights into pyroptosis in triple‐negative breast cancer prognosis and immunotherapy	4
Metabolism‐related gene vaccines and immune infiltration in ovarian cancer: A novel risk score model of machine learning	4
Homologous recombination repair gene‐based risk model predicts prognosis and immune microenvironment for primary lung cancer after previous malignancies	4