OOIR: Observatory of International Research

Papers

(The median citation count of Cancer Genomics & Proteomics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Pharmacogenetics of Toxicities Related to Endocrine Treatment in Breast Cancer: A Systematic Review and Meta-analysis	24
Myb Repression Mediates Stat5b-knockdown-induced Apoptosis and Inhibits Proliferation of Glioblastoma Stem Cells	21
Combination of Urinary MiR-501 and MiR-335 With Current Clinical Diagnostic Parameters as Potential Predictive Factors of Prostate Biopsy Outcome	20
CircRNAs as New Therapeutic Entities and Tools for Target Identification in Acute Myeloid Leukemia	19
Development and Validation of Potential Molecular Subtypes and Signatures of Thyroid Carcinoma Based on Aging-related Gene Analysis	19
Noncoding RNAs and Their Response Predictive Value in Azacitidine-treated Patients With Myelodysplastic Syndrome and Acute Myeloid Leukemia With Myelodysplasia-related Changes	18
Irradiated Cell-derived Exosomes Enhance Cell Proliferation and Radioresistanceviathe MAPK/Erk Pathway	18
Terrein Exhibits Anti-tumor Activity by Suppressing Angiogenin Expression in Malignant Melanoma Cells	13
Nuclear Respiratory Factor 1 Overexpression Inhibits Proliferation and Migration of PC3 Prostate Cancer Cells	12
Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Analyses of Clinicopathological, Molecular, and Prognostic Characteristics With Retrospective Review of 237 Endometrial Carcinoma C	11
HLA-E and HLA-F Are Overexpressed in Glioblastoma and HLA-E Increased After Exposure to Ionizing Radiation	11
Association of Matrix Metalloproteinase-2 Promoter Genotypes With Leiomyoma Risk	10
High-throughput Proteomic Profiling of Male Breast Cancer Tissue	10
Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by γ-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells	10
FN1 and VEGFA Are Potential Therapeutic Targets in Glioblastoma as Determined by Bioinformatics Analysis	10
The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression ofC-MY	10
Disruption of Lipid Raft Microdomains, Regulation of CD38, TP53, and MYC Signaling, and Induction of Apoptosis by Lomitapide in Multiple Myeloma Cells	10
MiR-575 in Exosomes of Vaginal Discharge Is Downregulated in Ovarian Cancer Patients	9
The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk	9
CXCL10Expression in Human Colorectal Cancer Tissue and its Correlation With Serum Levels of CXCL10	9
Contribution of Cyclin Dependent Kinase Inhibitor 1A Genotypes to Childhood Acute Lymphocytic Leukemia Risk in Taiwan	9
Artesunate-induced Cellular Effects Are Mediated by Specific EPH Receptors and Ephrin Ligands in Breast Carcinoma Cells	9
An miRNA Signature Predicts Grading of Pancreatic Neuroendocrine Neoplasms	9
Risk Stratification by TissueGAD1Expression Level in Curatively Resected Esophageal Squamous Cell Carcinoma	9
Mapping Proteome Changes in Microsatellite Stable, Recurrent Colon Cancer Reveals a Significant Immune System Signature	9

Loss of F-Box and Leucine Rich Repeat Protein 5 (FBXL5) Expression Is Associated With Poor Survival in Patients With Hepatocellular Carcinoma After Curative Resection: A Two-institute Study	8
Significant Association of Matrix Metalloproteinase-9 Polymorphisms With Triple Negative Breast Cancer Risk	8
GULP1 as a Downstream Effector of the Estrogen Receptor-β Modulates Cisplatin Sensitivity in Bladder Cancer	8
C1orf50 Drives Malignant Melanoma Progression Through the Regulation of Stemness	8
Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction	7
Next Generation Sequencing Analysis and its Benefit for Targeted Therapy of Lung Adenocarcinoma	7
DNA Methylation in Recurrent Glioblastomas: Increased TEM8 Expression Activates the Src/PI3K/AKT/GSK-3β/B-Catenin Pathway	7
Recurrent Fusion of the Genes for High-mobility Group AT-hook 2 (HMGA2) and Nuclear Receptor Co-repressor 2 (NCOR2) in Osteoclastic Giant Cell-rich Tumors of Bone	7
Accumulating Genetic Mutations from Primary to Secondary Biliary Tract Cancers: Analysis of Four Patients With Metachronous Biliary Tract Cancer Using Comprehensive Genomic Profiling	7
Acute Undifferentiated Leukemia With a Balanced t(5;10)(q35;p12) Resulting in Fusion ofHNRNPH1WithMLLT10	7
Preoperative ctDNA Levels Are Associated With Poor Overall Survival in Patients With Ovarian Cancer	7
Expression of DNA Mismatch Repair Proteins, PD1 and PDL1 in Barrett’s Neoplasia	6
Knockdown of G Protein-coupled Estrogen Receptor 1 (GPER1) Enhances Tumor-supportive Properties in Cervical Carcinoma Cells	6
Methionine Restriction Increases Exosome Production and Secretion in Breast Cancer Cells	6
Expression of “Hallmarks of Cancer” Genes in Cervical Carcinoma Is Differentially Affected by GPER1 Overexpression Depending on Histologic Entity	6
A Novel Cryptic t(2;3)(p21;q25) Translocation Fuses theWWTR1andPRKCEGenes in Uterine Leiomyoma With 3q- as the Sole Visible Chromosome Abnormality	6
Biomarker Expression Profiling in Cervix Carcinoma Biopsies Unravels WT1 as a Target of Artesunate	6
Mesonephric-like Carcinosarcoma of the Uterine Corpus: Clinicopathological, Molecular and Prognostic Characteristics in Comparison With Uterine Mesonephric-like Adenocarcinoma and Conventional Endomet	6
Bioinformatic Prediction of Novel Signaling Pathways of Apoptosis-inducing Factor, Mitochondrion-associated 3 (AIFM3) and Their Roles in Metastasis of Cholangiocarcinoma Cells	6
Cordycepin Activates Autophagy to Suppress FGF9-induced TM3 Mouse Leydig Progenitor Cell Proliferation	6
Circular RNA in Non-small Cell Lung Carcinoma: Identification of Targets and New Treatment Modalities	6
Inhibition of Increased Invasiveness of Breast Cancer Cells With Acquired Tamoxifen Resistance by Suppression of CYR61	6
Targeting Autophagy With the Synergistic Combination of Chloroquine and Rapamycin as a Novel Effective Treatment for Well-differentiated Liposarcoma	5
Suppressing Expression of SERPINE1/PAI1 Through Activation of GPER1 Reduces Progression of Vulvar Carcinoma	5
A Multiplex Biomarker Assay Improves the Prediction of Survival in Epithelial Ovarian Cancer	5
The Role of ER Stress and the Unfolded Protein Response in Cancer	5
Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer	5
Prediction of Angiopoietin-like Protein 4-related Signaling Pathways in Cholangiocarcinoma Cells	5
FAM32ASuppression Decreases 5-Fluorouracil-induced Apoptosis and Is Associated With Poor Prognosis in Gastric Cancer	5
PIK3CA Mutated Colorectal Cancers Without KRAS, NRAS and BRAF Mutations Possess Common and Potentially Targetable Mutations in Epigenetic Modifiers and DNA Damage Response Genes	5
Exploring Current Challenges and Perspectives for Automatic Reconstruction of Clonal Evolution	5
Whole-genome Sequencing Analysis of Bile Tract Cancer Reveals Mutation Characteristics and Potential Biomarkers	5
High Frequency of Juxtamembrane DomainERBB2Mutation in Gastric Cancer	5
Induction of the DNA-Repair Gene POLQ only in BRCA1-mutant Breast-Cancer Cells by Methionine Restriction	5
Gene Expression Profiling Regulated by lncRNA H19 Using Bioinformatic Analyses in Glioma Cell Lines	5
Potential Common Molecular Mechanisms Between Periodontitis and Hepatocellular Carcinoma: A Bioinformatic Analysis and Validation	4
Genetic Analyses of Primary Liver Cancer Cell Lines: Correspondence With Morphological Features of Original Tumors	4
Using Comparative Proteomics to Identify Protein Signatures in Clear Cell Renal Cell Carcinoma	4
Up-regulated Circular RNAs in Colorectal Cancer: New Entities for Therapy and Tools for Identification of Therapeutic Targets	4
Noggin Promotes Cell Proliferation Through Up-regulating EGFR/HER2 in Pancreatic Cancer Cells	4
Regulation and Function of CCL2 and N-Myc in Retinoic Acid-treated Neuroblastoma Cells	4
Transcriptomic Analysis of Metastatic Uveal Melanoma and Differences in Male and Female Patients	4
Melatonin Inhibits Chemical Carcinogen-mediated Malignant Transformation of Urothelial Cells:In VitroEvidence	4
CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma	4
Identification of a Gene Expression Signature to Predict the Risk of Early Recurrence and the Degree of Immune Cell Infiltration in Triple-negative Breast Cancer	4
Identification of a Novel Long Non-coding RNA,lnc-ATMIN-4:2, and its Clinicopathological and Prognostic Significance in Advanced Gastric Cancer	4
CRISPR/Cas9-mediated Knockout ofLYVE1In Human Tongue Cancer Cells Reveals Transcriptomic Changes in Metastasis-associated Pathways	4
Impact of Tumor Grade Distribution on Genetic Alterations in Clear Cell Renal Cell Carcinoma and Prostate Cancer	4
Analysis of Protein–Protein Interactions Identifies NECTIN2 as a Target ofN,N-Bis(5-Ethyl-2-hydroxybenzyl) Methylamine for Inhibition of Lung Cancer Metastasis	4
Hepatocellular Carcinoma: Up-regulated Circular RNAs Which Mediate Efficacy in PreclinicalIn VivoModels	4

The WASP/WAVE Protein Family in Breast Cancer and Their Role in the Metastatic Cascade	4
Circular RNAs With Efficacy in PreclinicalIn VitroandIn VivoModels of Esophageal Squamous Cell Carcinoma	3
Characterization of the Neoantigen Profile in a Tumor Mutation Burden-high Melanoma Patient With Multiple Metastases	3
Long Non-coding RNAs WithIn VitroandIn VivoEfficacy in Preclinical Models of Esophageal Squamous Cell Carcinoma Which Act by a Non-microRNA Sponging Mechanism	3
Engineering of an EPHA2-Targeted Monobody for the Detection of Colorectal Cancer	3
Effects of GSK-J4 on JMJD3 Histone Demethylase in Mouse Prostate Cancer Xenografts	3
Molecular Analysis of Luminal Androgen Receptor Reveals Activated Pathways and Potential Therapeutic Targets in Breast Cancer	3
Kinase D-interacting Substrate of 220 kDa Is Overexpressed in Gastric Cancer and Associated With Local Invasion	3
Molecular Genetics and Targeted Therapies for Paediatric High-grade Glioma	3
Particulate Matter 2.5 Induces FGFR1-mediated Integrin Switch to Promote Non-small Cell Lung Cancer Metastasis	3
Similar Allele Frequencies of Two PathogenicNF2variants in Each of Nine Sporadic Vestibular Schwannomas	3
P53 Status Influences the Anti-proliferative Effect Induced by IFITM1 Inhibition in Estrogen Receptor-positive Breast Cancer Cells	3
Oncogenes and Methionine Addiction of Cancer: Role ofc-MYC	3
Concurrent Reduced Expression of ContiguousPKD1, TSC2andNTHL1Leading to Kidney Diseases and Multiple Diverse Renal Cancers	3
Oral Installation of Recombinant Methioninase-producingEscherichia coliinto the Microbiome Inhibits Colon-cancer Growth in a Syngeneic Mouse Model	3
Photoimmunotherapy of HER2-expressing Breast Cancer Cells	3
SH003 Causes ER Stress-mediated Apoptosis of Breast Cancer CellsviaIntracellular ROS Production	3
Serum Starvation-induced ROS Production Activates the ERK-AP-1-TfR1 Pathway to Up-regulate Survivin to Support Nasopharyngeal Carcinoma Cell Viability	3
Two DifferentNF1Pathogenic Variants in a Family With Neurofibromatosis Type 1	3
Genetic Characterization of Pediatric Mixed Phenotype Acute Leukemia (MPAL)	3
High Expression ofPKCζAndCTNNBIP1Is Associated With Poor Prognosis in Luminal B Breast Cancer	3
Genome-wide Detection of Chimeric Transcripts in Early-stage Non-small Cell Lung Cancer	3
Replication Factor C Subunit 4 Plays a Role in Human Breast Cancer Cell Progression	3
Bioinformatics Analysis of Novel Targets for Treating Cervical Cancer by Immunotherapy Based on Immune Escape	2
KRTA6AandFA2HAre Hub Genes Associated With Cgas-STING-related Immunogenic Cell Death in Lung Adenocarcinoma	2
MDM2Knockdown Reduces the Oncogenic Activities and Enhances NIS Protein Abundance in Papillary Thyroid Cancer	2
Identification ofTTC21Aas a Potential Prognostic Marker in Head and Neck Squamous Cell Carcinoma:In SilicoAnalysis	2
Combination of Circulating Tumour DNA and¹⁸F-FDG PET/CT for Precision Monitoring of Therapy Response in Patients With Advanced Non-small Cell Lung Cancer: A Prospective Study	2
In VivoEffects of Conditioned Medium from Human Uterine Cervical Stem Cells in an Ovarian Cancer Xenograft Mouse Model	2
POLD1 Is Required for Cell Cycle Progression by Overcoming DNA Damage in Malignant Pleural Mesothelioma	2
Clinicopathological and Prognostic Values of Telomerase Reverse Transcriptase (TERT) Promoter Mutations in Ovarian Clear Cell Carcinoma for Predicting Tumor Recurrence, Platinum Resistance and	2
Correlation of GD2 Biosynthesis Enzymes With Cancer Stem Cell Markers in Human Breast Cancer	2
SF3B4 Regulates Cellular Senescence and Suppresses Therapy-induced Senescence of Cancer Cells	2
NovelTPR::ROS1Fusion Gene Activates MAPK, PI3K and JAK/STAT Signaling in an Infant-type Pediatric Glioma	2
Bayesian Approaches in Exploring Gene-environment and Gene-gene Interactions: A Comprehensive Review	2
Cytomorphology and Gene Expression Signatures of Anchorage-independent Aggregations of Oral Cancer Cells	2
Serum Exosomes Expressing CD9, CD63 and HER2 From Breast-Cancer Patients Decreased After Surgery of the Primary Tumor: A Potential Biomarker of Tumor Burden	2
Chromosomal Translocation t(5;12)(p13;q14) Leading to Fusion of High-mobility Group AT-hook 2 Gene With Intergenic Sequences From Chromosome Sub-Band 5p13.2 in Benign Myoid Neoplasms of the Breast: A	2
Engineered Methioninase-expressing Tumor-targetingSalmonella typhimuriumA1-R Inhibits Syngeneic-Cancer Mouse Models by Depleting Tumor Methionine	2
Fucoxanthin Inhibits Development of Sigmoid Colorectal Cancer in a PDX Model With Alterations of Growth, Adhesion, and Cell Cycle Signals	2
Localization ofEGFRMutations in Non-small-cell Lung Cancer Tissues Using Mutation-specific PNA-DNA Probes	2
CEACAM6 Promotes Lung MetastasisviaEnhancing Proliferation, Migration and Suppressing Apoptosis of Prostate Cancer Cells	2
Novel Contribution of Long Non-coding RNAMEG3Genotype to Prediction of Childhood Leukemia Risk	2
Implementation of Oxygen Enhanced Magnetic Resonance Imaging (OE-MRI) and a Pilot Genomic Study of Hypoxia in Bladder Cancer Xenografts	2