OOIR: Observatory of International Research

Papers

(The TQCC of Drugs & Aging is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Drug-Related Orthostatic Hypotension: Beyond Anti-Hypertensive Medications	67
Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management	65
Bimatoprost Implant: First Approval	45
Depression in Patients with Parkinson’s Disease: Current Understanding of its Neurobiology and Implications for Treatment	37
Romosozumab: A Review in Postmenopausal Osteoporosis	33
Safety of Janus Kinase Inhibitors in Older Patients: A Focus on the Thromboembolic Risk	31
Problematic Opioid Use Among Older Adults: Epidemiology, Adverse Outcomes and Treatment Considerations	29
Potentially Inappropriate Medications, Drug–Drug Interactions, and Anticholinergic Burden in Elderly Hospitalized Patients: Does an Association Exist with Post-Discharge Health Outcomes?	26
Immune Checkpoint Inhibitors for Patients Aged ≥ 75 Years with Advanced Cancer in First- and Second-Line Settings: A Meta-Analysis	26
Adjunctive Perampanel in Older Patients With Epilepsy: A Multicenter Study of Clinical Practice	25
The FORTA (Fit fOR The Aged) List 2021: Fourth Version of a Validated Clinical Aid for Improved Pharmacotherapy in Older Adults	25
Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models	24
Attitudes Towards Deprescribing Among Older Adults with Limited Life Expectancy and Their Relatives: A Systematic Review	23
Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects	23
Drug–Drug Interactions and Prescription Appropriateness in Patients with COVID-19: A Retrospective Analysis from a Reference Hospital in Northern Italy	22
Pulmonary Tuberculosis in Older Adults: Increased Mortality Related to Tuberculosis Within Two Months of Treatment Initiation	22
A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alz	20
Opioids and Falls Risk in Older Adults: A Narrative Review	19
Current Insights into Treating Vertigo in Older Adults	17
Barriers and Enablers of Healthcare Providers to Deprescribe Cardiometabolic Medication in Older Patients: A Focus Group Study	17
Association Between Potentially Inappropriate Medications and Hospital Encounters Among Older Adults: A Meta-Analysis	16
Effects of Resveratrol Supplementation on the Cognitive Function of Patients with Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials	16
Onychomycosis in Older Adults: Prevalence, Diagnosis, and Management	16
Diagnosis and Management of Pain in Parkinson's Disease: A New Approach	16
Frequency and Acceptance of Clinical Decision Support System-Generated STOPP/START Signals for Hospitalised Older Patients with Polypharmacy and Multimorbidity	16

Efficacy and Safety of Once-Daily Vibegron for Treatment of Overactive Bladder in Patients Aged ≥65 and ≥75 Years: Subpopulation Analysis from the EMPOWUR Randomized, International, Phase III Study	16
Efficacy and Safety of Daridorexant in Older and Younger Adults with Insomnia Disorder: A Secondary Analysis of a Randomised Placebo-Controlled Trial	16
Hormonal Agents for the Treatment of Depression Associated with the Menopause	16
Comparative Safety and Efficacy of Treatments for Overactive Bladder Among Older Adults: A Network Meta-analysis	15
Assessment of Poor Inhaler Technique in Older Patients with Asthma or COPD: A Predictive Tool for Clinical Risk and Inhaler Performance	15
Safety and Tolerability Results from the PILLAR Study: A Phase IV, Double-Blind, Randomized, Placebo-Controlled Study of Mirabegron in Patients ≥ 65 years with Overactive Bladder-Wet	14
Prevalence of Musculoskeletal Pain and Analgesic Treatment Among Community-Dwelling Older Adults: Changes from 1999 to 2019	14
Diagnostic and Management Strategies for Patients with Chronic Prostatitis and Chronic Pelvic Pain Syndrome	14
Pharmacotherapy for Spine-Related Pain in Older Adults	14
Frailty and Potentially Inappropriate Prescribing in Older People with Polypharmacy: A Bi-Directional Relationship?	14
International Validation of the Turkish Inappropriate Medication Use in the Elderly (TIME) Criteria Set: A Delphi Panel Study	14
Factors Affecting Prescriber Implementation of Computer-Generated Medication Recommendations in the SENATOR Trial: A Qualitative Study	13
Safety, Effectiveness, and Immunogenicity 6 Months After BNT162B2 mRNA Vaccine in Frail Nursing Home Residents	13
Overactive Bladder in Frail Older Adults	12
Prevalence and Factors Associated with Potential Drug-Drug Interactions in Older Community-Dwelling Adults: A Prospective Cohort Study	12
Medication Counselling in Older Patients Prior to Hospital Discharge: A Systematic Review	12
Decision Tools and Studies to Improve the Diagnosis of Urinary Tract Infection in Nursing Home Residents: A Narrative Review	12
Ghent Older People’s Prescriptions Community Pharmacy Screening (GheOP3S)-Tool Version 2: Update of a Tool to Detect Drug-Related Problems in Older People in Primary Care	12
Prevention of Chemotherapy-Induced Nausea and Vomiting in the Older Patient: Optimizing Outcomes	11
Predictors of Mortality in the Older Population: The Role of Polypharmacy and Other Medication and Chronic Disease-Related Factors	11
Use and Deprescribing of Potentially Inappropriate Medications in Frail Nursing Home Residents	11
Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011–2022 Update	11
Short-Course Systemic and Topical Non-Steroidal Anti-Inflammatory Drugs: Impact on Adverse Renal Events in Older Adults with Co-Morbid Disease	11
Use of Hormone Therapy in Postmenopausal Women with Alzheimer’s Disease: A Systematic Review	11
Difficult-to-Treat Rheumatoid Arthritis in Older Adults: Implications of Ageing for Managing Patients	11
Management of the Older Patient with Myelodysplastic Syndrome	10
Treatment of Seizures in Older Patients with Dementia	10
What Makes Deprescription of Psychotropic Drugs in Nursing Home Residents with Dementia so Challenging? A Qualitative Systematic Review of Barriers and Facilitators	10
Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team	10
ThinkCascades: A Tool for Identifying Clinically Important Prescribing Cascades Affecting Older People	10
Ulcerative Colitis in Adulthood and in Older Patients: Same Disease, Same Outcome, Same Risks?	10
Current Therapies and Drug Development Pipeline in Lewy Body Dementia: An Update	10
Ethnic Variations in the Quality Use of Medicines in Older Adults: Māori and Non-Māori in Aotearoa New Zealand	10
Safety of Remdesivir for Patients 80 Years of Age or Older with Coronavirus Disease 2019 (COVID-19)	10
Gout Flare Burden, Diagnosis, and Management: Navigating Care in Older Patients with Comorbidity	10
Diabetic Kidney Disease in Older People with Type 2 Diabetes Mellitus: Improving Prevention and Treatment Options	9
Preoperative Comparison of Three Anticholinergic Drug Scales in Older Adult Patients and Development of Postoperative Delirium: A Prospective Observational Study	9
The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of their Potential Efficacy and Suitability	9
Drug Survival, Safety, and Effectiveness of Biologics in Older Patients with Psoriasis: A Comparison with Younger Patients—A BioCAPTURE Registry Study	9
Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker–Loop Diuretic Prescribing Cascade	9
Major Depressive Disorder in Older Patients as an Inflammatory Disorder: Implications for the Pharmacological Management of Geriatric Depression	9
A Structured Literature Review and International Consensus Validation of FORTA Labels of Oral Anticoagulants for Long-Term Treatment of Atrial Fibrillation in Older Patients (OAC-FORTA 2019)	9
Trends in Anticoagulant Use at Nursing Home Admission and Variation by Frailty and Chronic Kidney Disease Among Older Adults with Atrial Fibrillation	9
Safety and Effectiveness of Immune Checkpoint Inhibitors in Older Patients with Cancer: A Systematic Review of 48 Real-World Studies	9
The Cross-Talk between Age, Hypertension and Inflammation in COVID-19 Patients: Therapeutic Targets	9
Attitudes to Drug Use in Residential Aged Care Facilities: A Cross-Sectional Survey of Nurses and Care Staff	8
Differential Diagnoses and Clinical Implications of Medication Nonadherence in Older Patients with Chronic Kidney Disease: A Review	8
Aspiring to Reasonableness in Accelerated Approval: Anticipating and Avoiding the Next Aducanumab	8
Safety and Tolerability of Antimicrobial Agents in the Older Patient	8
Effect of Antihypertensive and Statin Medication Use on Muscle Performance in Community-Dwelling Older Adults Performing Strength Training	8

Drug–Drug Interactions and Prescription Appropriateness at Hospital Discharge: Experience with COVID-19 Patients	8
Primary-Care Prescribers’ Perspectives on Deprescribing Opioids and Benzodiazepines in Older Adults	8
Impact of Fall Risk and Direct Oral Anticoagulant Treatment on Quality-Adjusted Life-Years in Older Adults with Atrial Fibrillation: A Markov Decision Analysis	8
Next-Generation Androgen Receptor-Signaling Inhibitors for Prostate Cancer: Considerations for Older Patients	8
Safety and Tolerability of Natural and Synthetic Cannabinoids in Older Adults: A Systematic Review and Meta-Analysis of Open-Label Trials and Observational Studies	8
Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels	7
Age-Related Lymphocyte Output During Disease-Modifying Therapies for Multiple Sclerosis	7
A Cohort Study on Influenza Vaccine and All-Cause Mortality in Older Adults: Methodological Concerns and Public Health Implications	7
Pharmacological Treatment in the Management of Glenohumeral Osteoarthritis	7
Efficacy, Safety, and Accuracy of Intra-articular Therapies for Hand Osteoarthritis: Current Evidence	7
Safety of Pyrazinamide for the Treatment of Tuberculosis in Older Patients Over 75 Years of Age: A Retrospective Monocentric Cohort Study	7
Use of Antibiotics in Chronic Obstructive Pulmonary Disease: What is Their Current Role in Older Patients?	7
Deprescribing Medications that Increase the Risk of Falls in Older People: Exploring Doctors' Perspectives Using the Theoretical Domains Framework (TDF)	7
Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia – A Narrative Review	7
Safety and Effectiveness of Biologic Disease-Modifying Antirheumatic Drugs in Older Patients with Rheumatoid Arthritis: A Prospective Cohort Study	7
Scoping Review of Studies Evaluating Frailty and Its Association with Medication Harm	7
MediQuit, an Electronic Deprescribing Tool for Patients on Polypharmacy: Results of a Feasibility Study in German General Practice	7
Management of Hypertension in the Elderly and Frail Patient	7
Antipsychotics and Lorazepam During Delirium: Are We Harming Older Patients? A Real-Life Data Study	7
Psychotropic Drug Prescription in Nursing Homes During the COVID-19 Pandemic	7
Anticholinergic Burden and Fractures: A Systematic Review with Methodological Appraisal	7
Fibromyalgia in Older Individuals	7
Efficacy and Safety of the Association of Nimodipine and Choline Alphoscerate in the Treatment of Cognitive Impairment in Patients with Cerebral Small Vessel Disease. The CONIVaD Trial	7
The EURO-FORTA (Fit fOR The Aged) List Version 2: Consensus Validation of a Clinical Tool for Improved Pharmacotherapy in Older Adults	7