OOIR: Observatory of International Research

Papers

(The TQCC of Drugs & Aging is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Topical Medications for Chronic Itch in Older Patients: Navigating a Pressing Need	84
Association between the Use of Suvorexant and Hip Fracture in Older Adults in Japan Using a Nationwide Administrative Claims Database: A Matched Case–Control Study	70
Real-World Drug Survival of Biologics and Targeted Synthetic Disease-Modifying Anti-rheumatic Drugs Among Patients with Psoriatic Arthritis	57
Seborrheic Dermatitis in Older Adults: Pathogenesis and Treatment Options	55
Metformin: An Old Drug with New Tricks—Promising Role in Vascular Aging and Cardioprotection	45
Perioperative Anticholinergic Medication Use and Incident Dementia among Older Surgical Patients: a Retrospective Cohort Study using Real-World Data	43
Ulcerative Colitis in Adulthood and in Older Patients: Same Disease, Same Outcome, Same Risks?	42
Safety Study of Anticoagulants for Preventing Deep Venous Thrombosis after Intracerebral Hemorrhage: Data from the Chinese Stroke Center Alliance	42
Prevalence of Self-Reported Adverse Effects to Cannabis by Older Canadians: A Cross-Sectional Analysis	39
The Difficulties of Managing Pain in People Living with Frailty: The Potential for Digital Phenotyping	37
Changes in Medication Complexity and Post-Hospitalization Outcomes in Older Adults Hospitalized for Heart Failure	36
Symptoms of Orthostatic Hypotension and Drugs Affecting Autonomic Function are Associated with the Onset of Frailty in Community-Dwelling Persons Aged 80 Years and Above: A Prospective Observational S	34
Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and T	34
Diagnosis and Pharmacological Management of Microscopic Colitis in Geriatric Care	32
The Aging Patient with Cystic Fibrosis	31
Time-Varying Use of Proton Pump Inhibitors and Cognitive Impairment and Dementia: A Real-World Analysis from Germany	30
Evaluation of Renal Function Testing in Older Australian Veterans Dispensed Medicines that Require Renal Function Monitoring	29
Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing	29
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects	29
Psychotropic Medication Prescribing to Patients with Dementia Admitted to Acute Hospitals in Ireland	28
Serum Concentration of Apixaban in Relation to Renal Function in Older Hospitalized Patients	25
Difficult-to-Treat Rheumatoid Arthritis in Older Adults: Implications of Ageing for Managing Patients	24
Utility of Big Data to Explore Medication Adherence in Māori and Non-Māori Community-Dwelling Older Adults with Heart Failure in Aotearoa New Zealand: A Cross-sectional Study	23
Development of a Predictive Model for Potentially Inappropriate Medications in Older Patients with Cardiovascular Disease	22
The PROMISING Project: A Pilot Study to Improve Geriatric Care Through a Pharmacist-Led Psychotropic Stewardship Program	22

Patient-Centric Approach for the Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease in Older People	21
Correction: Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options	21
Classifying Polypharmacy According to Pharmacotherapeutic and Clinical Risks in Older Adults: A Latent Class Analysis in Quebec, Canada	19
Exploring Sex, Gender, and Gender-Related Sociocultural Factors in Clinical Decision-Making for Older Adults Using a Prescribing Cascade Vignette: A Transnational Qualitative Study	19
Associations Between Midlife Anticholinergic Medication Use and Subsequent Cognitive Decline: A British Birth Cohort Study	17
Prescription and Non-prescription Medication Pill Burdens and Their Associations with Health-Related Quality of Life in Older Adults: A Cross-Sectional Study	17
Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer’s Disease	17
International Deprescribing Guidelines Did Not Impact Actual Practice in Deprescribing of Potentially Inappropriate Medications for Nursing Home Residents: An Interrupted Time Series Analysis	17
Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study	16
The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of Dementia	16
Methodological Considerations for Describing Medication Changes in Relation to Clinical Events and Death: An Applied Example in Patients with Type 2 Diabetes and Cancer	15
Trends in Drug Duplications in Swedish Older Adults: A Nationwide Register Study from 2006 to 2021	15
Clinical Safety Considerations of Integrase Strand Transfer Inhibitors in the Older Population Living with HIV	15
New Migraine Drugs for Older Adults	15
Correction to: Assessment of Comorbidity Burden and Treatment Response: Reanalysis of the SCD-HEFT Trial	14
Frailty and Potentially Inappropriate Prescribing in Older People with Polypharmacy: A Bi-Directional Relationship?	14
Exploring Hyperkalemia Risk in Frail Older Patients Using RAAS Inhibitors	14
Management of the Older Patient with Myelodysplastic Syndrome	13
Antihypertensive Drugs and Risk of Bone Fractures	13
The Current Landscape of Pharmacotherapies for Sarcopenia	13
Rosacea in Older Adults and Pharmacologic Treatments	13
How Should Clinicians Discuss Deprescribing with Caregivers of Older Adults Living with Dementia? A Qualitative Study	13
Modifiable Determinants of Satisfaction with Intravitreal Treatment in Patients with Neovascular Age-Related Macular Degeneration	13
Incident Functional Limitations Among Community-Dwelling Adults Using Opioids: A Retrospective Cohort Study Using a Propensity Analysis with the Health and Retirement Study	12
Exploring Transplant Medication-Taking Behaviours in Older Adult Kidney Transplant Recipients: A Qualitative Study of Semi-Structured Interviews	12
Comment on “The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of	12
Authors’ Reply to Langford et al.: “Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing”	12
Optimizing Reversal of Neuromuscular Block in Older Adults: Sugammadex or Neostigmine	12
Effect of Information Intervention on Prescribing Practice for Neuropathic Pain in Older Patients: A Nationwide Register-Based Study	12
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees	11
Antidepressants to Manage Osteoarthritic Pain: The Value of Pain Phenotyping	11
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study	11
Renal Function, Cardiovascular Diseases, Appropriateness of Drug Prescription and Outcomes in Hospitalized Older Patients	11
Association Between Gabapentinoid Use and Changes in Claims-Based Frailty Among Long-Term Opioid Users	10
Benzodiazepine Receptor Agonists Use and Cessation Among Multimorbid Older Adults with Polypharmacy: Secondary Analysis from the OPERAM Trial	10
Elevating Safe Use of Over-The-Counter Medications in Older Adults: A Narrative Review of Pharmacy Involved Interventions and Recommendations for Improvement	10
Fall-Risk-Increasing Drugs and Gait Performance in Community-Dwelling Older Adults: Exploratory Results from the Gait and Brain Study	10
The Prognostic Utility of Anticholinergic Burden Scales: An Integrative Review and Gap Analysis	10
Pain in Osteoporosis: Current and Future Strategies	10
Unlocking Deprescribing Potential in Nursing Homes: Insights from a Focus Group Study with Healthcare Professionals	10
Prescription Opioid Use in Older Adults: Trends and Changes in New and Long-Term Use in the United States, 2013–2020	9
From Drugs to Dry Mouth: A Systematic Review Exploring Oral and Psychological Health Conditions Associated with Dry Mouth in Older Adults with Polypharmacy	9
Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects	9
Rho Kinase Inhibitors: Strategies in Glaucoma Treatment in Older Adults	9
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults	9
Do Proton Pump Inhibitors Reduce Upper Gastrointestinal Bleeding in Older Patients with Atrial Fibrillation Treated with Oral Anticoagulants? A Nationwide Cohort Study in France	9
A Motivational Interviewing Intervention to Improve Adherence to ACEIs/ARBs among Nonadherent Older Adults with Comorbid Hypertension and Diabetes	8
Deprescribing Medications that Increase the Risk of Falls in Older People: Exploring Doctors' Perspectives Using the Theoretical Domains Framework (TDF)	8
Anticholinergic Burden and Associated Healthcare Resource Utilization in Older Adults with Overactive Bladder	8
Toxicity in Older Patients with Cancer Receiving Immunotherapy: An Observational Study	8

Secular Trends in Central Nervous System-Active Polypharmacy Among Serial Cross-Sections of US Adults, 2009–2020	8
Associated Factors to Efficacy and Tolerance of Immunotherapy in Older Patients with Cancer Aged 70 Years and Over: Impact of Coprescriptions	8
Pharmacological Treatments for Presbyopia	8
Aging in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: From Pathophysiology to Clinical Management	8
Factors Influencing Hospital Physicians’ Recognition of Prescribing Cascades: A Qualitative Interview Study	8
A Proactive Approach to Prevent Hematopoietic Exhaustion During Cancer Chemotherapy in Older Patients: Temporary Cell-Cycle Arrest	8
Management of Scleritis in Older Adults	8
The Prevalence of Adverse Drug Reactions and Adverse Drug Events from Heart Failure Medications in Frail Older Adults: A Systematic Review	7
Benefit–Risk Assessment of Psychotropic Drugs in Older Patients with Chronic Obstructive Pulmonary Disease	7
Pharmacological Risk Assessment Among Older Patients with Polypharmacy Using the Clinical Decision Support System Janusmed Risk Profile: A Cross-Sectional Register Study	7
Problematic Opioid Use Among Older Adults: Epidemiology, Adverse Outcomes and Treatment Considerations	7
NSAIDs for Pain Control During the Peri-Operative Period of Hip Fracture Surgery: A Systematic Review	7
Treating Hypercholesterolemia in Older Adults for Primary Prevention of Cardiovascular Events	7
A 12-Year Retrospective Study of the Prevalence of Anticholinergic Polypharmacy and Associated Outcomes Among Medicare Patients with Overactive Bladder in the USA	7
Drugs and Healthy Aging	7
Comparison of Anticholinergic Burden Scales and Their Association with Cognitive and Functional Impairment in Older Adults: A Cross-Sectional Study Using the REPOSI Database	7
Current Pharmacological Therapies for the Management of Spondyloarthritis: Special Considerations in Older Patients	7
Ageing with HIV: Medicine Optimisation Challenges and Support Needs for Older People Living with HIV: A Systematic Review	7
Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: The GeroCovid Vax Study	7
Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model	7
Influenza and Aging: Clinical Manifestations, Complications, and Treatment Approaches in Older Adults	7
Prospective Observational Study Evaluating the Prognostic Value of the G8 Screening Tool for Extensive-Stage Small Cell Lung Cancer Patients Who Received Programmed Death-Ligand 1 Inhibitor plus Plati	7
Correction to: Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross‑sectional study	7
Hypotension Under Antihypertensive Treatment and Incident Hospitalizations of Nursing Home Residents	7