OOIR: Observatory of International Research

Papers

(The TQCC of Biodrugs is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Clinical Features and Drug Retention of TNF Inhibitors in Older Patients with Ankylosing Spondylitis: Results from the KOBIO Registry	286
Targeting Neurological Aspects of Mucopolysaccharidosis Type II: Enzyme Replacement Therapy and Beyond	204
Comparative Safety Profiles of Oncology Biosimilars: A Systematic Review and Network Meta-analysis	98
The Path to Accessible Care: Development and Impact of Eculizumab Biosimilars for Paroxysmal Nocturnal Hemoglobinuria and Atypical Hemolytic Uremic Syndrome	96
New and Emerging Biological Therapies for Myasthenia Gravis: A Focussed Review for Clinical Decision-Making	82
Emerging Therapy in Osteoarthritis: Mesenchymal Stem Cells, Secretomes, and Using Hydrogels to Enhance Efficacy	74
Targeting Amyloid Fibrils by Passive Immunotherapy in Systemic Amyloidosis	72
Modification of Extracellular Vesicle Surfaces: An Approach for Targeted Drug Delivery	60
Critical Analysis of cGMP Large-Scale Expansion Process in Bioreactors of Human Induced Pluripotent Stem Cells in the Framework of Quality by Design	59
Recurring Fatigue After Biologic Administration: Patient-Reported Data from the Dutch Biologic Monitor	57
In Vitro Biological Characterization of Recombinant Insulin Aspart from Biogenomics and Originator Insulin Aspart	48
Antisense Oligonucleotide Therapy: From Design to the Huntington Disease Clinic	46
Historical Overview of Regulatory Approvals and PMDA Assessments for Biosimilar Products in Japan During 2009–2022	42
Acknowledgement to Referees	40
Localised Delivery of Macromolecules to the Large Intestine: Translation to Clinical Trials	36
Switching from One Biosimilar to Another Biosimilar of the Same Reference Biologic: A Systematic Review of Studies	33
A Tale of Two New Targets for Hypertriglyceridaemia: Which Choice of Therapy?	33
CAR-T Cells and the Kidney: Insights from the WHO Safety Database	32
Correction to: Immunotherapy in Gastro-Oesophageal Cancer: Current Practice and the Future of Personalised Therapy	31
Demand- Versus Supply-Side Policies in Market Penetration of Biosimilars: Which is More Effective?	31
The Present and Future of Monoclonal Antibody Therapies for Multiple Sclerosis	30
Correction: Dystrophin- and Utrophin-Based Therapeutic Approaches for Treatment of Duchenne Muscular Dystrophy: A Comparative Review	30
First-Line Treatment of Advanced Non-Small-Cell Lung Cancer with Immune-Checkpoint Inhibitors: New Combinations and Long-Term Data	28
Malaria Vaccines: Progress to Date	27
Do the Outcomes of Clinical Efficacy Trials Matter in Regulatory Decision-Making for Biosimilars?	27

Progress and Challenges in the Treatment of Fabry Disease	27
Multispecific Antibodies Targeting PD-1/PD-L1 in Cancer	27
Characterization of Biosimilar Monoclonal Antibodies and Their Reference Products Approved in Japan to Reveal the Quality Characteristics in Post-approval Phase	27
Pharmacokinetics, Safety, and Immunogenicity of a Biosimilar of Nivolumab (LY01015): A Randomized, Double-Blind, Parallel-Controlled Phase I Clinical Trial in Healthy Chinese Male Subjects	26
Biochemical Amenability in Fabry Patients Under Chaperone Therapy—How and When to Test?	25
Real-World Evidence on the Effectiveness and Safety of Spesolimab in the Treatment of Generalized Pustular Psoriasis Flares: A Case Series	23
Defining a Framework for Sustainable Global Biosimilars Markets Using Findings from a Targeted Literature Review	23
Extracellular Vesicles Derived from Mesenchymal Stem Cells: A Potential Biodrug for Acute Respiratory Distress Syndrome Treatment	21
Enhancing the Response Rate to Recombinant Uricases in Patients with Gout	21
Non-small Cell Lung Cancer with EGFR or HER2 Exon 20 Insertion Mutations: Diagnosis and Treatment Options	21
Interleukin-23 versus Interleukin-17 Inhibitors in Preventing Incidental Psoriatic Arthritis in Patients with Psoriasis: A Real-World Comparison From the TriNetX US Collaborative Network	21
Interleukin-17 Inhibitors in the Treatment of Hidradenitis Suppurativa	20
Analytical Data and Single-Dose PK are Sufficient to Conclude Comparable Immunogenicity for Biosimilars: An Ustekinumab Case Study	20
Regulatory Evaluation of Biosimilars: Refinement of Principles Based on the Scientific Evidence and Clinical Experience	20
Exploring the Use of Monoclonal Antibodies and Antiviral Therapies for Early Treatment of COVID-19 Outpatients in a Real-World Setting: A Nationwide Study from England and Italy	20
Novel Migraine Therapies May Reduce Public and Personal Disadvantages for People with Migraine	19
Islet Cell Replacement and Regeneration for Type 1 Diabetes: Current Developments and Future Prospects	18
Interleukin-1 Antagonists for the Treatment of Recurrent Pericarditis	17
Efficacy and Safety of Candidate Biosimilar CT-P43 Versus Originator Ustekinumab in Moderate to Severe Plaque Psoriasis: 28-Week Results of a Randomised, Active-Controlled, Double-Blind, Phase III Stu	17
Understanding IgM Structure and Biology to Engineer New Antibody Therapeutics	17
Long-Term Safety and Effectiveness of PF-05280014 (a Trastuzumab Biosimilar) Treatment in Patients with HER2-Positive Metastatic Breast Cancer: Updated Results of a Randomized, Double-Blind Study	17
Use of Semaglutide (Wegovy) in Adults in France: A Nationwide Drug Utilization Study	16
Targeted Gene Insertion: The Cutting Edge of CRISPR Drug Development with Hemophilia as a Highlight	16
HLX11, a Proposed Pertuzumab Biosimilar: Pharmacokinetics, Immunogenicity, and Safety Profiles Compared to Three Reference Biologic Products (US-, EU-, and CN-Approved Pertuzumab) Administered to Heal	16
The Use of Biologics for Thyroid Eye Disease	16
TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review	16
Tolerability and Reactogenicity Profile of mRNA SARS-Cov-2 Vaccines from a Mass Vaccination Campaign in a Tertiary Hospital: Between-Vaccine and Between-Population Prospective Observational Study (Vig	16
Bioanalytical Methods and Strategic Perspectives Addressing the Rising Complexity of Novel Bioconjugates and Delivery Routes for Biotherapeutics	15
Acute Kidney Injury from Intravitreal Anti-vascular Endothelial Growth Factor Drugs: A Systematic Review and Meta-analysis of Randomized Controlled Trials	15
Impact of Introducing Infliximab Biosimilars on Total Infliximab Consumption and Originator Infliximab Prices in Eight Regions: An Interrupted Time-Series Analysis	15
Safety of Biological Therapies for Severe Asthma: An Analysis of Suspected Adverse Reactions Reported in the WHO Pharmacovigilance Database	14
Next-Generation Anti-TNFα Agents: The Example of Ozoralizumab	14
Extracellular Vesicles and Immune Activation in Solid Organ Transplantation: The Impact of Immunosuppression	14
Recurrent Clostridioides difficile Infection: Current Clinical Management and Microbiome-Based Therapies	14
Impact of Early Access Reform on Oncology Innovation in France: Approvals, Patients, and Costs	13
Assessing Immunogenicity of Biologic Drugs in Inflammatory Joint Diseases: Progress Towards Personalized Medicine	13
Going Beyond Host Defence Peptides: Horizons of Chemically Engineered Peptides for Multidrug-Resistant Bacteria	13
Monoclonal Antibody Generation Using Single B Cell Screening for Treating Infectious Diseases	13