OOIR: Observatory of International Research

Papers

(The median citation count of Pediatric Drugs is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Cardioprotective Effect of Nigella sativa in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study	75
Common Selfcare Indications of Pain Medications in Children	58
Impact of Antiseizure Medications on Appetite and Weight in Children	50
Alirocumab: Pediatric First Approval	40
Pharmacokinetics in Critically Ill Children with Acute Kidney Injury	34
Pitolisant: Pediatric First Approval	34
Existing and Emerging Targeted Therapies in Juvenile Psoriatic Arthritis: Challenges and Unmet Needs	33
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update	28
Correction: Enteral and Parenteral Treatment with Caffeine for Preterm Infants in the Delivery Room: A Randomised Trial	28
Comment on: “The Effect of Alfentanil on Emergence Delirium Following General Anesthesia in Children: A Randomized Clinical Trial”	27
Authors’ Reply to Sethuraman’s comment on “The Effect of Alfentanil on Emergence Delirium Following General Anesthesia in Children: A Randomized Clinical Trial”	26
Laboratory Safety from a Randomized 16-Week Phase III Study of Dupilumab in Children Aged 6 Months to 5 Years with Moderate-to-Severe Atopic Dermatitis	25
Diagnosis of Serious Conditions Delayed in Association with Ondansetron Treatment for Vomiting in the Pediatric Emergency Department	25
Pharmacogenetic Aspects of Drug Metabolizing Enzymes and Transporters in Pediatric Medicine: Study Progress, Clinical Practice and Future Perspectives	24
Golimumab in Children with Chronic Recurrent Multifocal Osteomyelitis: A Case Series and Review of the Literature	22
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations	22
Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)	21
A Multi-Center Evaluation of the Pharmacokinetics and Safety of Intravenous Ibuprofen in Infants 1–6 Months of Age	21
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study	20
Pediatric Drugs, Accelerated Approval, and Prospects for Reform	20
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain	17
Treatment Options for Alopecia Areata in Children and Adolescents	16
Developing CAR T-Cell Therapies for Pediatric Solid Tumors	15
Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings	15
Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis	15

Drug Treatment of Heart Failure in Children: Gaps and Opportunities	14
Safety of Ferric Carboxymaltose in Children: Report of a Case Series from Greece and Review of the Literature	14
Navigating the Regulatory Landscape to Develop Pediatric Oncology Drugs: Expert Opinion Recommendations	14
Correction to: Prescribing Patterns and Impact of Factors Associated with Time to Initial Biologic Therapy among Children with Non-systemic Juvenile Idiopathic Arthritis	14
Safety of Quinolones in Children: A Systematic Review and Meta-Analysis	13
Implications of Evolving Disease Classification for Drug Approval in Juvenile Idiopathic Arthritis	13
Diagnosis and Management of Pediatric Chronic Hand Eczema: The PeDRA CACHES Survey	13
Use of Furosemide and Chlorothiazide Combination Continuous Infusion in Furosemide-Refractory Patients in the Pediatric Intensive Care Unit: A Retrospective Cohort Study	13
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies	11
Pharmacotherapy for Cancer Treatment-Related Cardiac Dysfunction and Heart Failure in Childhood Cancer Survivors	11
Effectiveness and Safety of Ustekinumab for Pediatric Inflammatory Bowel Disease: A Systematic Review	11
Developments in the Management of Severe Asthma in Children and Adolescents: Focus on Dupilumab and Tezepelumab	11
Hemodynamic Quality Improvement Bundle to Reduce the Use of Inotropes in Extreme Preterm Neonates	10
Randomized Clinical Trial of Metoclopramide as Prophylaxis of Gastroesophageal Reflux Disease in Preterm Infants	10
Real-Life Use of Biosimilars in Pediatric Inflammatory Bowel Disease: A Nation-Wide Web Survey on Behalf of the SIGENP IBD Working Group	10
Prucalopride for Treatment of Upper Gastrointestinal Symptoms in Children	10
Interventions for the Management of Pain and Sedation in Newborns Undergoing Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy: A Systematic Review	10
Macitentan: Pediatric First Approval	10
An Update of Pharmacological Management in Children with Functional Constipation	10
Mechanism-Based Pharmacological Treatment for Chronic Non-cancer Pain in Adolescents: Current Approaches and Future Directions	10
Emerging Treatments in Neonatal Fungal Infections: Progress and Prospects	9
Bosutinib: Pediatric First Approval	9
Asparaginase-Associated Pancreatitis in Pediatric Patients with Acute Lymphoblastic Leukemia: Current Perspectives	9
Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature	9
Managing Lupus Nephritis in Children and Adolescents	9
Interventions to Reduce Pediatric Prescribing Errors in Professional Healthcare Settings: A Systematic Review of the Last Decade	8
Correction to: Multidisciplinary Clinical Care in the Management of Patients Receiving Anti‑GD2 Immunotherapy for High‑Risk Neuroblastoma	8
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia	8
Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient	8
Pharmacotherapy of Disruptive Behaviors in Children with Intellectual Disabilities	8
Juvenile Dermatomyositis: Updates in Pathogenesis and Biomarkers, Current Treatment, and Emerging Targeted Therapies	8
Ceftaroline Fosamil for Treatment of Pediatric Complicated Skin and Soft Tissue Infections and Community-Acquired Pneumonia	8
A Mixed-Methods Analysis of Medication Safety Incidents Reported in Neonatal and Children’s Intensive Care	8
Evaluating and Mitigating Risk of Acute Kidney Injury with the Combination of Vancomycin and Piperacillin-Tazobactam in Children	7
Drug Treatment of Low Bone Mass and Other Bone Conditions in Pediatric Patients	7
Perioperative Indications for Gabapentinoids in Pediatrics: A Narrative Review	7
Immunosuppression Regimens for Intestinal Transplantation in Children	7
Intercepting Medication Errors in Pediatric In-patients Using a Prescription Pre-audit Intelligent Decision System: A Single-center Study	7
Innovations in Clinical Development in Rare Diseases of Children and Adults: Small Populations and/or Small Patients	7
What Role for Long-Acting Injectable Antipsychotics in Managing Schizophrenia Spectrum Disorders in Children and Adolescents? A Systematic Review	7
Best Evidence-Based Dosing Recommendations for Dexmedetomidine for Premedication and Procedural Sedation in Pediatrics: Outcome of a Risk-Benefit Analysis By the Dutch Pediatric Formulary	7
Pharmacokinetics of l-Citrulline in Neonates at Risk of Developing Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension	7
Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs	6
Targeted Treatments for Myasthenia Gravis in Children and Adolescents	6
Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy	6
Treatment Options in Pediatric Behçet’s Disease	6
Pharmacokinetics of Commonly Used Antimicrobials in Critically Ill Pediatric Patients During Extracorporeal Membrane Oxygenation: A Systematic Review	6
Preventing Recurrence of Crohn’s Disease Post-Ileocaecal Surgery in Paediatric Patients: A Therapy Guide Based on Systematic Review of the Evidence	6
Clinical Evidence Supporting FDA Approval of Gene and RNA Therapies for Rare Inherited Conditions	6
Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates	6

Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention	6
Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review	6
Perforated Appendicitis in Children: Management, Microbiology, and Antibiotic Stewardship	5
Efficacy and Safety of Proactive Therapy with 2% Crisaborole Ointment in Children with Mild-to-Moderate Atopic Dermatitis: A Randomized Controlled Study	5
Dexmedetomidine for Less Invasive Surfactant Administration: Another Promising Medicine in an Ever-Growing Toolbox?	5
Physiologically Based Pharmacokinetic (PBPK) Model-Informed Dosing Guidelines for Pediatric Clinical Care: A Pragmatic Approach for a Special Population	5
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?	5
Population Pharmacokinetics of Moxifloxacin in Children	5
Intrapyloric Botulinum Toxin A Injection for Gastroparesis and Functional Upper Gastrointestinal Symptoms in Children: Mayo Clinic Experience, Review of the Literature, and Meta-analysis	5
Managing Patient Pressure to Prescribe Antibiotics in the Clinic	5
Secukinumab: A Review in Moderate to Severe Pediatric Plaque Psoriasis	5
Treatment of Langerhans Cell Histiocytosis and Histiocytic Disorders: A Focus on MAPK Pathway Inhibitors	5
Ganaxolone: A Review in Epileptic Seizures Associated with Cyclin-Dependent Kinase-Like 5 Deficiency Disorder	5
Meningococcal Vaccination in the United States: Past, Present, And Future	5
Acknowledgement to Referees	5
Medical Management of Infantile Hemangiomas: An Update	5
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making	5
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System	5
Slower Recovery with Early Lopinavir/Ritonavir use in Pediatric COVID-19 Patients: A Retrospective Observational Study	4
Commercial Versus Compounded Preparations in Pediatric Ophthalmology	4
Pediatric Bipolar Disorder: Challenges in Diagnosis and Treatment	4
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study	4
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System	4
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review	4
Optimizing Pediatric Sedation: Evaluating Remimazolam and Dexmedetomidine for Safety and Efficacy in Clinical Practice	4
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN	4
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial	4
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review	4
Intranasal Analgesia in Preterm and Term Neonates	4
Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma	3
An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus	3
Prevalence and Temporal Trends of Attention Deficit Hyperactivity Disorder Medication Fills During Pregnancy and Breastfeeding in Denmark	3
Thromboprophylaxis for Coagulopathy Related to COVID-19 in Pediatrics: A Narrative Review	3
Adverse Drug Reactions in Children: Comparison of Reports Collected in a Pharmacovigilance Project Versus Spontaneously Collected ADR Reports	3
Correction to: Secukinumab: A Review in Moderate to Severe Pediatric Plaque Psoriasis	3
Paediatric Drug Development in China: Current Status and Future Prospects	3
Tyrosine Kinase Inhibitors and Beyond for Chronic Myeloid Leukemia in Children	3
An Update on CFTR Modulators as New Therapies for Cystic Fibrosis	3
A Retrospective Review of Baclofen Treatment for Children with Rumination Syndrome at a Single Center	3
Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms	3
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways	3
Efficacy of Secukinumab Across Subgroups and Overall Safety in Pediatric Patients with Moderate to Severe Plaque Psoriasis: Week 52 Results from a Phase III Randomized Study	3
Efficacy and Safety of Tacrolimus in the Treatment of Pediatric Henoch–Schönlein Purpura Nephritis	3
The Role of Pharmacotherapeutic Agents in Children with Desmoid Tumors	3
Benefits and Risks of Antidepressant Drugs During Pregnancy: A Systematic Review of Meta-analyses	3
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review	3
Targeted Therapy in Pediatric AML: An Evolving Landscape	3
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option	3
Managing Antiphospholipid Syndrome in Children and Adolescents: Current and Future Prospects	3
Management of IgA Vasculitis with Nephritis	3
Management of Central Diabetes Insipidus in Disabled Children with Diluted Oral Desmopressin Lyophilisate Formulation Administered Through Nasogastric Tube: A Retrospective Case Series	3
Multidisciplinary Clinical Care in the Management of Patients Receiving Anti-GD2 Immunotherapy for High-Risk Neuroblastoma	3
Insulin Glargine 300 U/mL Therapy in Children and Adolescents with Type 1 Diabetes	3
Emerging Treatments for Childhood Interstitial Lung Disease	3
Management of Hospitalized Respiratory Syncytial Virus Bronchiolitis in the Pediatric Ward in Spain: Assessing the Impact of a New Clinical Practice Protocol	3
Dual-Targeted Therapy in Pediatric Inflammatory Bowel Disease: A Comprehensive Review	3