OOIR: Observatory of International Research

Papers

(The median citation count of Pediatric Drugs is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
Alirocumab: Pediatric First Approval	81
Safety of Ferric Carboxymaltose in Children: Report of a Case Series from Greece and Review of the Literature	59
Diagnosis of Serious Conditions Delayed in Association with Ondansetron Treatment for Vomiting in the Pediatric Emergency Department	43
Pharmacogenetic Aspects of Drug Metabolizing Enzymes and Transporters in Pediatric Medicine: Study Progress, Clinical Practice and Future Perspectives	39
Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy	35
Treatment Options for Alopecia Areata in Children and Adolescents	35
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?	34
Perioperative Indications for Gabapentinoids in Pediatrics: A Narrative Review	31
Managing Lupus Nephritis in Children and Adolescents	27
Efficacy of Secukinumab Across Subgroups and Overall Safety in Pediatric Patients with Moderate to Severe Plaque Psoriasis: Week 52 Results from a Phase III Randomized Study	27
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways	27
Acknowledgement to Referees	25
Prevalence and Temporal Trends of Attention Deficit Hyperactivity Disorder Medication Fills During Pregnancy and Breastfeeding in Denmark	22
Intranasal Analgesia in Preterm and Term Neonates	22
New Information on Old Medicinal Products: A Cross-Sectional Analysis of Guidance for Paediatric Use for Substances on the European Priority List of Off-Patent Medicinal Products	21
Commercial Versus Compounded Preparations in Pediatric Ophthalmology	21
Low-Dose Remifentanil in Preterm Cesarean Section with General Anesthesia: A Randomized Controlled Trial	20
Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents	16
Management of Drug-Induced Epidermal Necrolysis (DEN) in Pediatric Patients: Moving from Drug-Induced Stevens–Johnson Syndrome, Overlap and Toxic Epidermal Necrolysis to a Single Unifying Diagnosis of	16
Real-World Data on the Use of Sirolimus in Asian Children with Vascular Malformations	16
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice	16
Methotrexate Intolerance in Juvenile Idiopathic Arthritis: Definition, Risks, and Management	16
Analysis of Risk Factors for Chloral Hydrate Sedative Failure with Initial Dose in Pediatric Patients: a Retrospective Analysis	16
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis	15
Letermovir for Prophylaxis and Pre-emptive Therapy of Cytomegalovirus Infection in Paediatric Allogeneic Haematopoietic Cell Transplant Patients	15

Pharmacokinetics and Safety of Endotracheal Lidocaine for Endotracheal Intubation in Critically Ill Children	15
Subgroup Analysis of Crisaborole for Mild-to-Moderate Atopic Dermatitis in Children Aged 2 to < 18 Years	15
Pediatric Treatment-Resistant Obsessive Compulsive Disorder: Treatment Options and Challenges	14
Dose Rationale of Nasal Glucagon in Japanese Pediatric Patients with Diabetes Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation	13
Inotuzumab Ozogamicin: First Pediatric Approval	13
Learning-Based Models for Predicting IVIG Resistance and Coronary Artery Lesions in Kawasaki Disease: A Review of Technical Aspects and Study Features	13
An Update of Pharmacological Management in Children with Functional Constipation	12
Immunotherapies for Pediatric Solid Tumors: A Targeted Update	12
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations	12
Diagnosis and Management of Non-Infectious Uveitis in Pediatric Patients	12
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date	12
Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature	11
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia	11
Treatment of Langerhans Cell Histiocytosis and Histiocytic Disorders: A Focus on MAPK Pathway Inhibitors	10
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System	10
Insulin Glargine 300 U/mL Therapy in Children and Adolescents with Type 1 Diabetes	10
Best Evidence-Based Dosing Recommendations for Dexmedetomidine for Premedication and Procedural Sedation in Pediatrics: Outcome of a Risk-Benefit Analysis By the Dutch Pediatric Formulary	10
Emerging Treatments in Neonatal Fungal Infections: Progress and Prospects	10
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System	10
Targeted Treatments for Myasthenia Gravis in Children and Adolescents	10
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial	10
Correction to: Secukinumab: A Review in Moderate to Severe Pediatric Plaque Psoriasis	10
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN	9
Medical Management of Infantile Hemangiomas: An Update	9
Dual-Targeted Therapy in Pediatric Inflammatory Bowel Disease: A Comprehensive Review	9
Emerging Treatments for Childhood Interstitial Lung Disease	9
Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma	9
An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus	9
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review	9
Safety and Efficacy of Ledipasvir/Sofosbuvir in the Treatment of Chronic Hepatitis C Virus Infection in Treatment-Naïve Children without and with Comorbidities	8
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review	8
Dabigatran Etexilate: A Review in Pediatric Venous Thromboembolism	8
Prevalence and Perinatal Outcomes Following In Utero Exposure to Prehospital Emergency Methoxyflurane: A 17-Year Retrospective Cohort Study	8
Acute Tolerability of Methylphenidate in Treatment-Naïve Children with ADHD: An Analysis of Naturalistically Collected Data from Clinical Practice	8
Phentermine/Topiramate: Pediatric First Approval	8
The Effect of Alfentanil on Emergence Delirium Following General Anesthesia in Children: A Randomized Clinical Trial	8
Neuroimaging as a Tool for Advancing Pediatric Psychopharmacology	8
Prescription Trends for Primary Headache in Children and Adolescents in China During 2019–2023: A Retrospective Study	8
Current and Emerging Therapies for Prevention and Treatment of Bronchopulmonary Dysplasia in Preterm Infants	8
Executive Function Outcome of Treatment with Viloxazine Extended-Release Capsules in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Post-Hoc Analysis of Four Randomized Clin	8
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis	7
Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians	7
A Multi-Center Evaluation of the Pharmacokinetics and Safety of Intravenous Ibuprofen in Infants 1–6 Months of Age	7
Macitentan in the Young—Mid-term Outcomes of Patients with Pulmonary Hypertensive Vascular Disease treated in a Pediatric Tertiary Care Center	7
Diagnosis and Management of Pediatric Chronic Hand Eczema: The PeDRA CACHES Survey	7
Drug Treatment of Heart Failure in Children: Gaps and Opportunities	7
Treatment Options for Juvenile Pityriasis Rubra Pilaris	7
Optimising Paediatric HIV Treatment: Recent Developments and Future Directions	7
Use of Furosemide and Chlorothiazide Combination Continuous Infusion in Furosemide-Refractory Patients in the Pediatric Intensive Care Unit: A Retrospective Cohort Study	7
Real-Life Use of Biosimilars in Pediatric Inflammatory Bowel Disease: A Nation-Wide Web Survey on Behalf of the SIGENP IBD Working Group	6

Drug Treatment of Low Bone Mass and Other Bone Conditions in Pediatric Patients	6
Cardioprotective Effect of Nigella sativa in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study	6
Developing CAR T-Cell Therapies for Pediatric Solid Tumors	6
Macitentan: Pediatric First Approval	6
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies	6
What Role for Long-Acting Injectable Antipsychotics in Managing Schizophrenia Spectrum Disorders in Children and Adolescents? A Systematic Review	6
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update	6
Treatment Options in Pediatric Behçet’s Disease	5
Ganaxolone: A Review in Epileptic Seizures Associated with Cyclin-Dependent Kinase-Like 5 Deficiency Disorder	5
Paediatric Drug Development in China: Current Status and Future Prospects	5
Deferred Consent in Pediatric Drug Trials: Moving from Why to How	5
Secukinumab: A Review in Moderate to Severe Pediatric Plaque Psoriasis	5
Efficacy and Safety of Wound Catheter Infusion with Ropivacaine After Abdominal Surgery in Children Aged < 1 Year: A Randomized Controlled Trial	5
Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity	5
Efficacy and Safety of the Adjuvant Use of Probiotic Bacillus clausii Strains in Pediatric Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study	5
Efficacy and Safety of Proactive Therapy with 2% Crisaborole Ointment in Children with Mild-to-Moderate Atopic Dermatitis: A Randomized Controlled Study	5
Juvenile Dermatomyositis: Updates in Pathogenesis and Biomarkers, Current Treatment, and Emerging Targeted Therapies	5
A Retrospective Review of Baclofen Treatment for Children with Rumination Syndrome at a Single Center	5
Management of Hospitalized Respiratory Syncytial Virus Bronchiolitis in the Pediatric Ward in Spain: Assessing the Impact of a New Clinical Practice Protocol	5
Correction to: Viloxazine: Pediatric First Approval	5
Impact of Dexmedetomidine Infusion on Opioid and Benzodiazepine Doses in Ventilated Pediatric Patients in the Cardiac Intensive Care Unit	4
Authors’ Reply to Reed and Colleagues’ Comment on “Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review”	4
Enteral and Parenteral Treatment with Caffeine for Preterm Infants in the Delivery Room: A Randomised Trial	4
Therapeutic Drug Monitoring of Antimicrobial Drugs in Children with Cancer: A New Tool for Personalized Medicine	4
Ibrutinib: Pediatric First Approval	4
Antiretroviral Options and Treatment Decisions During Pregnancy	4
A Review of Histamine-2 Receptor Antagonist and Proton Pump Inhibitor Therapy for Gastroesophageal Reflux Disease in Neonates and Infants	4
Intravenous Golimumab in Patients with Polyarticular Juvenile Idiopathic Arthritis and Juvenile Psoriatic Arthritis and Subcutaneous Ustekinumab in Patients with Juvenile Psoriatic Arthritis: Extrapol	4
The Future of Advanced Therapies for Pediatric Crohn’s Disease	4
Deferred Consent in Neonatal Clinical Research: Why, When, How?	4
Acknowledgement to Referees	4
Potential Antibiotics for the Treatment of Neonatal Sepsis Caused by Multidrug-Resistant Bacteria	4
Therapeutic Drug Monitoring of Voriconazole in Critically Ill Pediatric Patients: A Single-Center Retrospective Study	4
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?	4
Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)	3
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain	3
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data	3
Antibiotics for Paediatric Community-Acquired Pneumonia: What is the Optimal Course Duration?	3
Clinical Evidence Supporting FDA Approval of Gene and RNA Therapies for Rare Inherited Conditions	3
Dexmedetomidine for Less Invasive Surfactant Administration: Another Promising Medicine in an Ever-Growing Toolbox?	3
Hemodynamic Quality Improvement Bundle to Reduce the Use of Inotropes in Extreme Preterm Neonates	3
Asparaginase-Associated Pancreatitis in Pediatric Patients with Acute Lymphoblastic Leukemia: Current Perspectives	3
Impact of Antiseizure Medications on Appetite and Weight in Children	3
Pediatric Drugs, Accelerated Approval, and Prospects for Reform	3
Ceftazidime/Avibactam for the Treatment of Infections in Children: A Case Series of Real-World Use	3
Pharmacotherapy for Cancer Treatment-Related Cardiac Dysfunction and Heart Failure in Childhood Cancer Survivors	3
Pharmacokinetics of l-Citrulline in Neonates at Risk of Developing Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension	3
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study	3
Pharmacotherapy of Disruptive Behaviors in Children with Intellectual Disabilities	3
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making	3
Pharmacokinetics in Critically Ill Children with Acute Kidney Injury	3
Golimumab in Children with Chronic Recurrent Multifocal Osteomyelitis: A Case Series and Review of the Literature	3
Medication and Fluid Management of Pediatric Sepsis and Septic Shock	3
Safety of Quinolones in Children: A Systematic Review and Meta-Analysis	3
Pediatric Bipolar Disorder: Challenges in Diagnosis and Treatment	3
The Role of Pharmacotherapeutic Agents in Children with Desmoid Tumors	3
Correction to: Multidisciplinary Clinical Care in the Management of Patients Receiving Anti‑GD2 Immunotherapy for High‑Risk Neuroblastoma	3