Experimental and Molecular Medicine

Article	Citations
Glutamine reliance in cell metabolism	405
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity	306
Single-cell multiomics: technologies and data analysis methods	289
The mechanism of HMGB1 secretion and release	246
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development	222
Type I and III interferon responses in SARS-CoV-2 infection	191
On the origin and evolution of SARS-CoV-2	184
Zebrafish as an animal model for biomedical research	183
Autophagy as a decisive process for cell death	165
Hepatocellular carcinoma: old friends and new tricks	158
The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells	150
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies	149
Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury	146
Single-cell sequencing techniques from individual to multiomics analyses	139
Stress and the dopaminergic reward system	137
Innate immune sensing of coronavirus and viral evasion strategies	133
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms	123
Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR	123
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling	117
Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission	117
The M-CSF receptor in osteoclasts and beyond	111
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment	111
Single-cell transcriptomics in cancer: computational challenges and opportunities	110
Tailoring photosensitive ROS for advanced photodynamic therapy	110
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	107

Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer	107
Protein arginine methyltransferases: promising targets for cancer therapy	107
Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children	105
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators	104
Function of γδ T cells in tumor immunology and their application to cancer therapy	97
Live biotherapeutic products: the importance of a defined regulatory framework	97
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis	94
Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance	93
The evolution and future of influenza pandemic preparedness	92
Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics	90
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions	87
The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies	84
LSD1: more than demethylation of histone lysine residues	84
Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy	82
METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner	78
Heterochromatin: an epigenetic point of view in aging	78
Single-cell network biology for resolving cellular heterogeneity in human diseases	75
Small but mighty: the causes and consequences of micronucleus rupture	75
DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells	74
Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats	73
Insulin receptor endocytosis in the pathophysiology of insulin resistance	72
Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway	69
Bystander CD4+ T cells: crossroads between innate and adaptive immunity	69
Tumor microenvironment and radioresistance	59
The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders	58
Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases	57
O-GlcNAcylation in health and neurodegenerative diseases	57
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway	57
Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis	56
Understanding paraxial mesoderm development and sclerotome specification for skeletal repair	56
LncRNA DANCR and miR-320a suppressed osteogenic differentiation in osteoporosis by directly inhibiting the Wnt/β-catenin signaling pathway	56
RUNX2-modifying enzymes: therapeutic targets for bone diseases	54
Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer	53
Roles of circadian clocks in cancer pathogenesis and treatment	53
Organoids in image-based phenotypic chemical screens	52
Aurora kinase A, a synthetic lethal target for precision cancer medicine	51
Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion	50
The cellular function of SCAP in metabolic signaling	49
Mitochondrial quality control in intervertebral disc degeneration	48
Liver progenitor cell-driven liver regeneration	48
Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy	48
Endothelial-to-mesenchymal transition in anticancer therapy and normal tissue damage	47
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion	46
The role of natural killer cells in Parkinson’s disease	46
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis	45
The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology	45
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability	42
Analysis of the human breast milk microbiome and bacterial extracellular vesicles in healthy mothers	42
Interactions between tumor-derived proteins and Toll-like receptors	42
Organoids as host models for infection biology – a review of methods	41

Senescent tumor cells: an overlooked adversary in the battle against cancer	41
Oncogenic super-enhancer formation in tumorigenesis and its molecular mechanisms	41
Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice	40
Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases	40
Advances in transcriptome analysis of human brain aging	39
Diverse molecular functions of m6A mRNA modification in cancer	37
Regulation of common neurological disorders by gut microbial metabolites	37
Emerging role of extracellular vesicles in the respiratory system	37
Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease	36
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing	36
m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis	36
Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease	35
S100A9 in adult asthmatic patients: a biomarker for neutrophilic asthma	35
Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis	35
GSK3B induces autophagy by phosphorylating ULK1	34
Immunomodulatory functional foods and their molecular mechanisms	34
Mutational spectrum of SARS-CoV-2 during the global pandemic	31
Histone acylation marks respond to metabolic perturbations and enable cellular adaptation	31
Maintenance of genome integrity and active homologous recombination in embryonic stem cells	31
miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway	31
The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ	30
Current trends in gene recovery mediated by the CRISPR-Cas system	30
The p53-caspase-2 axis in the cell cycle and DNA damage response	30
Dynamic modules of the coactivator SAGA in eukaryotic transcription	30
Neuroendocrine control of appetite and metabolism	30
Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice	29
TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury	29
Stat2 stability regulation: an intersection between immunity and carcinogenesis	28
Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma	28
Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol	28
Formyl peptide receptors in the mucosal immune system	28
Senescence and impaired DNA damage responses in alpha-synucleinopathy models	27
Protective role of estrogen against excessive erythrocytosis in Monge’s disease	27
Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis	27
Autophagy regulation by acetylation—implications for neurodegenerative diseases	26
Relapse of pathological angiogenesis: functional role of the basement membrane and potential treatment strategies	26
Dexmedetomidine promotes the progression of hepatocellular carcinoma through hepatic stellate cell activation	26
Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer	25
Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment	25
Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice	25
Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency	25
Stomach microbiota, Helicobacter pylori, and group 2 innate lymphoid cells	24
Hepatocyte organoids and cell transplantation: What the future holds	24
EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide	24
Eukaryotic clamp loaders and unloaders in the maintenance of genome stability	24
The impact of endotrophin on the progression of chronic liver disease	24
Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage	24
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells	24
The role of exosomal lncRNAs in cancer biology and clinical management	23
Plasma extracellular vesicle delivery of miR-210-3p by targeting ATG7 to promote sepsis-induced acute lung injury by regulating autophagy and activating inflammation	23
Shaping of the 3D genome by the ATPase machine cohesin	23
Human kidney organoids reveal the role of glutathione in Fabry disease	22
SUMO and cellular adaptive mechanisms	22
Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis	22
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β	22
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers	22
Human Cell Atlas and cell-type authentication for regenerative medicine	22
Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells	22
Biobanking of human gut organoids for translational research	22
Gα12/13 signaling in metabolic diseases	22
Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP	21
Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α	21
Comparison of thrombus, gut, and oral microbiomes in Korean patients with ST-elevation myocardial infarction: a case–control study	21
Similar sequences but dissimilar biological functions of GDF11 and myostatin	21
Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells	20
Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats	20
Strategies for genetic manipulation of adult stem cell-derived organoids	19
Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer	19
Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa	19
Disruption of nucleocytoplasmic trafficking as a cellular senescence driver	19
The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses	18
Transplantation of Wnt5a-modified NSCs promotes tissue repair and locomotor functional recovery after spinal cord injury	18
Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN(381–397 a.a.) competing for TGF-β1 activation	18
microRNA-25 as a novel modulator of circadian Period2 gene oscillation	18
Emerging and re-emerging fatal viral diseases	18
Thrap3 promotes R-loop resolution via interaction with methylated DDX5	18
MiR-144-3p is associated with pathological inflammation in patients infected with Mycobacteroides abscessus	18
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease	18
The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats	17
Gastrointestinal cancer organoids—applications in basic and translational cancer research	17

The arachidonic acid metabolite 11,12-epoxyeicosatrienoic acid alleviates pulmonary fibrosis	17
Deciphering the star codings: astrocyte manipulation alters mouse behavior	17
Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-β1 signaling pathway	17
LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways	17
Hypothalamic primary cilium: A hub for metabolic homeostasis	17