OOIR: Observatory of International Research

Papers

(The median citation count of Experimental and Molecular Medicine is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3	493
Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation	212
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability	199
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway	195
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	166
Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos	119
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells	101
Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting	95
Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP	78
Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection	76
An unusual nicotinamide derivative, 4-pyridone-3-carboxamide ribonucleoside (4PYR), is a novel endothelial toxin and oncometabolite	76
Dissecting single-cell genomes through the clonal organoid technique	75
Single-cell analysis of salt-induced hypertensive mouse aortae reveals cellular heterogeneity and state changes	72
O-GlcNAcylation in health and neurodegenerative diseases	70
Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease	66
Reduced expression of TAZ inhibits primary cilium formation in renal glomeruli	64
Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion	63
Thrap3 promotes R-loop resolution via interaction with methylated DDX5	61
Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency	61
Exploiting the mechanism of estrogen-induced transcription to fight breast cancer	56
YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior	56
CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia–reperfusion injury	49
Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency	46
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms	44
Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells	44

Disruption of nucleocytoplasmic trafficking as a cellular senescence driver	43
S100A9 in adult asthmatic patients: a biomarker for neutrophilic asthma	42
The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats	39
Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue	39
Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice	39
Senescent tumor cells: an overlooked adversary in the battle against cancer	39
Human kidney organoids reveal the role of glutathione in Fabry disease	37
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions	37
Epigenetic silencing of UBXN8 contributes to leukemogenesis in t(8;21) acute myeloid leukemia	36
TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury	36
Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair	35
ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1	35
Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm	34
Concept and application of circulating proteasomes	32
Hepatocyte organoids and cell transplantation: What the future holds	31
Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis	30
Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production	29
Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1	28
Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer	27
Biobanking of human gut organoids for translational research	26
Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation	25
Oleoylethanolamide induces eosinophilic airway inflammation in bronchial asthma	25
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing	24
Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α	23
BIX01294 inhibits EGFR signaling in EGFR-mutant lung adenocarcinoma cells through a BCKDHA-mediated reduction in the EGFR level	22
Hypothalamic primary cilium: A hub for metabolic homeostasis	22
Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss	22
Genomic and transcriptomic analyses reveal a tandem amplification unit of 11 genes and mutations in mismatch repair genes in methotrexate-resistant HT-29 cells	22