OOIR: Observatory of International Research

Papers

(The median citation count of Experimental and Molecular Medicine is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3	454
Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy	228
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability	225
Genomic and transcriptomic analyses reveal a tandem amplification unit of 11 genes and mutations in mismatch repair genes in methotrexate-resistant HT-29 cells	190
BIX01294 inhibits EGFR signaling in EGFR-mutant lung adenocarcinoma cells through a BCKDHA-mediated reduction in the EGFR level	181
MD2 blockade prevents modified LDL-induced retinal injury in diabetes by suppressing NADPH oxidase-4 interaction with Toll-like receptor-4	179
The arachidonic acid metabolite 11,12-epoxyeicosatrienoic acid alleviates pulmonary fibrosis	173
Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation	171
Exploiting the mechanism of estrogen-induced transcription to fight breast cancer	168
Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss	153
Methods in organoids: a model that goes beyond our imagination	151
Plasma extracellular vesicle delivery of miR-210-3p by targeting ATG7 to promote sepsis-induced acute lung injury by regulating autophagy and activating inflammation	148
Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response	136
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway	108
Hypothalamic primary cilium: A hub for metabolic homeostasis	91
Fibrinolytic nanocages dissolve clots in the tumor microenvironment, improving the distribution and therapeutic efficacy of anticancer drugs	89
Neuroendocrine control of appetite and metabolism	86
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis	73
Protein arginine methyltransferases: promising targets for cancer therapy	72
Type I and III interferon responses in SARS-CoV-2 infection	72
Roles of circadian clocks in cancer pathogenesis and treatment	71
Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis	70
TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury	64
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	64
Aurora kinase A, a synthetic lethal target for precision cancer medicine	62

Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss	60
The impact of fine particulate matter (PM) on various beneficial functions of human endometrial stem cells through its key regulator SERPINB2	59
The p53-caspase-2 axis in the cell cycle and DNA damage response	57
Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells	55
The clinical use of blood-test factors for Alzheimer’s disease: improving the prediction of cerebral amyloid deposition by the QPLEXTM Alz plus assay kit	55
MicroRNA-26a/b-5p promotes myocardial infarction-induced cell death by downregulating cytochrome c oxidase 5a	51
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells	49
LncRNA HSPA7 in human atherosclerotic plaques sponges miR-223 and promotes the proinflammatory vascular smooth muscle cell transition	45
Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair	44
Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis	44
ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1	43
Epigenetic silencing of UBXN8 contributes to leukemogenesis in t(8;21) acute myeloid leukemia	42
REDD1 is a determinant of low-dose metronomic doxorubicin-elicited endothelial cell dysfunction through downregulation of VEGFR-2/3 expression	41
Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity	41
Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos	39
Application of QPLEXTM biomarkers in cognitively normal individuals across a broad age range and diverse regions with cerebral amyloid deposition	39
Editorial Expression of Concern: Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species producti	38
On the origin and evolution of SARS-CoV-2	38
Organoids in image-based phenotypic chemical screens	37
circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3	36
Organoids as host models for infection biology – a review of methods	36
CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia–reperfusion injury	34
Emerging and re-emerging fatal viral diseases	33
PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis	33
Retraction Note: Downregulation of the long noncoding RNA MBNL1-AS1 protects sevoflurane-pretreated mice against ischemia-reperfusion injury by targeting KCNMA1	32
The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death	32
Gastrointestinal cancer organoids—applications in basic and translational cancer research	32
Concept and application of circulating proteasomes	32
Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting	31
The role of exosomal lncRNAs in cancer biology and clinical management	30
Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2	29
Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency	29
WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling	28
Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm	27
Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP	27
Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection	25
IL-30† (IL-27A): a familiar stranger in immunity, inflammation, and cancer	25
The interplay of microRNAs and transcription factors in autophagy regulation in nonalcoholic fatty liver disease	24
Hepatocyte organoids and cell transplantation: What the future holds	24
Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer	23
Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa	21
Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy	21
Tumor microenvironment and radioresistance	21
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms	20
The evolution and future of influenza pandemic preparedness	20
2′-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice	20
Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease	20
Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase α1	20
Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis	20