OOIR: Observatory of International Research

Papers

(The TQCC of Experimental and Molecular Medicine is 39. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Glutamine reliance in cell metabolism	389
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity	302
Single-cell multiomics: technologies and data analysis methods	282
The mechanism of HMGB1 secretion and release	228
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development	214
Type I and III interferon responses in SARS-CoV-2 infection	183
On the origin and evolution of SARS-CoV-2	176
Zebrafish as an animal model for biomedical research	172
Autophagy as a decisive process for cell death	157
Hepatocellular carcinoma: old friends and new tricks	151
The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells	148
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies	143
Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury	142
Single-cell sequencing techniques from individual to multiomics analyses	133
Innate immune sensing of coronavirus and viral evasion strategies	130
Stress and the dopaminergic reward system	129
Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR	121
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms	118
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling	117
The force awakens: metastatic dormant cancer cells	117
Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission	113
Tailoring photosensitive ROS for advanced photodynamic therapy	106
The M-CSF receptor in osteoclasts and beyond	106
Single-cell transcriptomics in cancer: computational challenges and opportunities	106
Protein arginine methyltransferases: promising targets for cancer therapy	105

Targeting focal adhesion kinase in cancer cells and the tumor microenvironment	103
Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children	101
Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer	99
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators	97
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis	95
Live biotherapeutic products: the importance of a defined regulatory framework	95
Function of γδ T cells in tumor immunology and their application to cancer therapy	94
Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance	91
The evolution and future of influenza pandemic preparedness	88
Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics	86
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis	85
LSD1: more than demethylation of histone lysine residues	81
The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies	80
Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy	78
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions	78
METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner	77
Heterochromatin: an epigenetic point of view in aging	77
Single-cell network biology for resolving cellular heterogeneity in human diseases	73
DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells	72
β-hydroxybutyrate and its metabolic effects on age-associated pathology	71
Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats	71
Small but mighty: the causes and consequences of micronucleus rupture	70
Insulin receptor endocytosis in the pathophysiology of insulin resistance	70
Bystander CD4+ T cells: crossroads between innate and adaptive immunity	68
Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway	67
The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels	58
New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer’s disease	56
Tumor microenvironment and radioresistance	54
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway	54
O-GlcNAcylation in health and neurodegenerative diseases	54
Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis	53
RUNX2-modifying enzymes: therapeutic targets for bone diseases	52
LncRNA DANCR and miR-320a suppressed osteogenic differentiation in osteoporosis by directly inhibiting the Wnt/β-catenin signaling pathway	52
Understanding paraxial mesoderm development and sclerotome specification for skeletal repair	52
Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases	52
The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders	52
Organoids in image-based phenotypic chemical screens	51
Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer	51
Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion	50
Roles of circadian clocks in cancer pathogenesis and treatment	49
Liver progenitor cell-driven liver regeneration	48
The cellular function of SCAP in metabolic signaling	47
Endothelial-to-mesenchymal transition in anticancer therapy and normal tissue damage	47
Mitochondrial quality control in intervertebral disc degeneration	46
Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy	46
Aurora kinase A, a synthetic lethal target for precision cancer medicine	46
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion	45
The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology	44
The role of natural killer cells in Parkinson’s disease	43
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis	42

Interactions between tumor-derived proteins and Toll-like receptors	41
Analysis of the human breast milk microbiome and bacterial extracellular vesicles in healthy mothers	41
Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases	40
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability	39
Advances in transcriptome analysis of human brain aging	39
Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice	39