OOIR: Observatory of International Research

Papers

(The TQCC of Korean Journal of Physiology & Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis	18
Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe	18
Phytochemicals as promising agents in Axl-targeted cancer treatment	16
Drug repositioning of regorafenib for renal cell carcinoma identifies DDR2 ‑associated sensitivity in ACHN models	16
Chios gum mastic enhance the proliferation and odontogenic differentiation of human dental pulp stem cells	16
Differential expression of ORAI channels and STIM proteins in renal cell carcinoma subtypes: implications for metastasis and therapeutic targeting	15
Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart	15
Effects of gas signaling molecule SO₂ in cardiac functions of hyperthyroid rats	14
Hyaluronan-mediated motility receptor-mediated aerobic glycolysis enhances stem-like properties and chemoresistance in lung adenocarcinoma	13
Cell-cell contacts via N-cadherin induce a regulatory renin secretory phenotype in As4.1 cells	13
Effects of in vivo treatment with K_v7.4 activator, URO-K10, on the impaired relaxation of pulmonary arteries in the monocrotaline-induced pulmonary hypertensive rats	13
Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice	13
Protective effect of 6′-Sialyllactose on LPS-induced macrophage inflammation via regulating Nrf2-mediated oxidative stress and inflammatory signaling pathways	12
Chelidonine inhibits melanoma cell malignancy by inactivating TLR4/NF-κB and PI3K/AKT signaling pathways	12
Relation between heart rate variability and spectral analysis of electroencephalogram in chronic neuropathic pain patients	12
Circular RNA circAtxn10 regulates skeletal muscle cell differentiation by targeting miR-143-3p and Chrna1	11
Amorfrutin A ameliorates cerebral ischemia/reperfsion injury in vivo and in vitro via modulating Nrf2/HO-1 signaling pathway	11
Sweroside plays a role in mitigating high glucose-induced damage in human renal tubular epithelial HK-2 cells by regulating the SIRT1/NF-κB signaling pathway	11
Ferroptosis and its role in gastric and colorectal cancers	10
Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca²⁺-spikes and cell death in cultured rat hippocampal neurons	10
Antitumor effects of valdecoxib on hypopharyngeal squamous carcinoma cells	10
Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migration	10
Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina	10
Thermotherapy as an alternative to exercise for metabolic health in obese postmenopausal women: focus on circulating irisin level	9
Chemopreventive potential of goniothalamin in diethylnitrosamine-induced hepatocellular carcinoma through the suppression of P13K/AKT signalling pathway	9

Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells	9
Emerging role of circular RNAs in diabetic retinopathy	9
Corrigendum to: Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells	9
Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression	8
The transformative impact of large language models on medical writing and publishing: current applications, challenges and future directions	8
Evaluation of the effects of disulfiram, an alcohol-aversive agent with anti-cancer activity, on mouse bone marrow cells	8
Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ	8
The impact of CYP2D6 on donepezil concentration and its lack of effect on the treatment response and adverse effect in Korean patients with Alzheimer's disease	7
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells	7
Somatodendritic organization of pacemaker activity in midbrain dopamine neurons	7
Profiling of endogenous metabolites and changes in intestinal microbiota distribution after GEN-001 (Lactococcus lactis) administration	7
Microglial galectin-3 increases with aging in the mouse hippocampus	7
The role of sestrin2 in skeletal muscle regeneration after injury	7
Differential expression of the enzymes regulating myosin light chain phosphorylation are responsible for the slower relaxation of pulmonary artery than mesenteric artery in rats	7
OAC1 improves mitofusin 2 expression to alleviate neuronal injury following experimental ischemic stroke	7
Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells	7
The WNT/Ca²⁺ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling	7
Ca²⁺ entry through reverse Na+/Ca²⁺ exchanger in NCI-H716, glucagon-like peptide-1 secreting cells	6
Hemin attenuates bleomycin-induced lung fibrosis in mice by regulating the TGF-β1/MAPK and AMPK/SIRT1/PGC-1α/HO-1/NF-κB pathways	6
Retraction to: Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression	6
Hyperbaric oxygenation applied before or after mild or hard stress: effects on the redox state in the muscle tissue	6
Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis	6
Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway	6
Gaseous signal molecule SO₂ regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes	6
Roles of metabotropic glutamate receptor 5 in low [Mg²⁺]_o-induced interictal epileptiform activity in rat hippocampal slices	6
Decrease of glycogen synthase kinase 3β phosphorylation in the rat nucleus accumbens shell is necessary for amphetamineinduced conditioned locomotor activity	6
Astragalus polysaccharide ameliorates diabetic retinopathy by inhibiting the SHH-Gli1-AQP1 signaling pathway in streptozotocin-induced type 2 diabetic rats	5
Age-dependent expression of ion channel genes in rat	5
Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression	5
Norepinephrine triggers glutamatergic long-term potentiation in hypothalamic paraventricular nucleus magnocellular neuroendocrine cells through postsynaptic β1-AR/PKA signaling pathway in vitro	5
Vericiguat reduces pyroptosis in rats with coronary microembolization by inhibiting the AMPK/Nrf2/NLRP3 signaling pathway	5
RNA polymerase I subunit D activated by Yin Yang 1 transcription promote cell proliferation and angiogenesis of colorectal cancer cells	5
New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta	5
Novel artesunate-metformin conjugate inhibits bladder cancer cell growth associated with Clusterin/SREBP1/FASN signaling pathway	5
Organoid-based modeling and regenerative strategies for salivary gland dysfunction	5
Identification of novel molecular subtypes in ovarian cancer via zinc homeostasis-related genes and their prognostic and immune landscape implications	5
Tricyclic antidepressants dose-dependently modulate the biphasic activity of the TRPC5 channel through opioid receptors	5
Effects of β-adrenoceptor antagonist and 5-HT_1A and 5-HT_1B receptor antagonist alprenolol on human Kv1.3 currents	5