OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology and Bioprocess Engineering is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Development of a glucose enzyme fuel cell based on thin film electrode using biocatalysts	39
Homotaurine exhibits contrasting effects of DRD1-mediated thermogenesis-related regulators in C2C12 myoblasts and 3T3−L1 white adipocytes	34
Elucidation of the Mechanism and Kinetics of Ultrasonic Extraction of Paclitaxel from Plant Cell Cultures of Taxus chinensis	31
Improved enzyme-linked immunosorbent assay using surface-adhesive antibody-oriented immobilizing biolinker: a proof-of-concept study	29
Inhibition of Cyclopropane Fatty Acid Synthesis in the Membrane of Halophilic Halomonas socia CKY01 by Kanamycin	28
Improvement of menopausal symptoms by oat hull extracts in ovariectomized animal model	26
The latest techniques for inducing macrophage differentiation	24
Advanced Whole-cell Conversion for D-allulose Production Using an Engineered Corynebacterium glutamicum	22
Bioprocess Challenges in Purification of Therapeutic Protein Charge Variants	20
MiR-1297 and MiR-26a-5p Inhibit Cell Progression of Keratinocytes in Cholesteatoma Depending on the Regulation of BMI1	19
Convolution Neural Network Approaches for Cancer Cell Image Classification	18
A comparison of metabolic engineering strategies applied in Yarrowia lipolytica for β-carotene production	17
CircBRMS1L Participates in Lipopolysaccharide-induced Chondrocyte Injury via the TLR4/NF-κB Pathway through Serving as a miR-142-5p Decoy	17
Mechanistic Insight into Phenolic Compounds Toxicity and State-of-the-art Strategies for Enhancing the Tolerance of Escherichia coli to Phenolic Compounds	15
Regulated in Development and DNA Damage Response 1 Protects Hepatocytes Against Palmitate-induced Lipotoxicity	15
C13-apocarotenoids biosynthesis with engineered microbes	14
The Enzymatic Process of Macroalgae for Conversion into High-tech Bioproducts	14
Effect of reduced atmospheric pressures on the morphology and astaxanthin biosynthesis of microalga Haematococcus lacustris	14
Novel Synthesis of Ca2+-Doped MgAl2O3-G-SiO2 Mesoporous Nanospheres toward Sensing Effects for Selective Electrochemical Performance of Azithromycin	14
Impact of the Synthetic Scaffold Strategy on the Metabolic Pathway Engineering	14
3D microcapsules for human bone marrow-derived mesenchymal stem cell biomanufacturing in a vertical-wheel bioreactor	13
Recent Progress in Microalgal Squalene Production and Its Cosmetic Application	13
Albumin: A Multi-talented Clinical and Pharmaceutical Player	13
Multi-bioinspired Sprayable Nanotherapeutics for Tumor-Specific Focal Cancer Therapy	13
Efficient production of 1,3-propanediol from glycerol by a newly isolated soil bacterium using fed-batch fermentation	12

Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells	12
Assessment of Damnacanthus major Siebold & Zucc callus for antioxidative and moisturizing capacities using an artificial skin alternative	12
Improving the Thermostability of α-Glucosidase from Xanthomonas campestris through Proline Substitutions Guided by Semi-rational Design	12
Recent Advances in the Utilization of Brown Macroalgae as Feedstock for Microbial Biorefinery	12
Erratum to: Optimization of Vacuum Frying Process for Sweet Potato Chip Manufacturing Using Response Surface Methodology and Artificial Neural Network Model	12
Production of Tagatose by Whole-cell Bioconversion from Fructose Using Corynebacterium glutamicum	12
Cyclic AMP Responsive Element Binding Protein 3-like 4/AarF Domain Containing Kinase 5 Axis Facilitates Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells by Modulating the TGFβ Pathwa	12
L-Dihydroxyphenylalanine (L-Dopa) Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via Activation of Dopaminergic and β3-adrenergic Receptors	12
Current Updates on COVID-19 Vaccines and Therapeutics: As of June 2022	12
Fabrication of folic acid–cysteamine-modified silver nanoparticles as promising contrast agent for computed tomography imaging	11
Automatic cancer nuclei segmentation on histological images: comparison study of deep learning methods	11
Nanostructure Materials: Efficient Strategies for Circulating Tumor Cells Capture, Release, and Detection	11
A Review of Microbial Molecular Profiling during Biomass Valorization	11
Metallic Vessel with Mesh Culture Surface Fabricated Using Three-dimensional Printing Engineers Tissue Culture Environment	11
Structural Study on the Impact of S239D/I332E Mutations in the Binding of Fc and FcγRIIIa	11
An Aligned Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Scaffold Fixed with Fibronectin to Enhance the Attachment and Growth of Human Endothelial Progenitor Cells	11
Drug-eluting Microneedles Embedded with Nanoparticles for Anti-inflammatory Purposes	10
Continuous cell recycling in methylotrophic yeast Pichia pastoris to enhance product yields: a case study with Yarrowia lipolytica lipase Lip2	10
Plant Platforms for Efficient Heterologous Protein Production	10
Sodium-potassium Adenosine Triphosphatase α2 Subunit (ATP1A2) Negatively Regulates UCP1-dependent and UCP1-independent Thermogenesis in 3T3-L1 Adipocytes	10
Agarwood Pill Enhances Immune Function in Cyclophosphamide-induced Immunosuppressed Mice	10
Ceramide’s Role and Biosynthesis: A Brief Review	10
Cell-free Biosynthesis of Peptidomimetics	10
Bioreducible polysorbate-based micelles encapsulating mitochondria-targeting sonosensitizers for efficient chemo-sonodynamic cancer therapy	10
Bioimprinted Aspergillus niger Lipase Combined with Adsorption Immobilization by Resin and Its Experiment in Catalytic Synthesis of Sucrose-6-acetate	10
Inhibiting angiogenesis and osteogenesis by targeted regulation of KLK4 via the exosomal MiR-422a derived from bone mesenchymal stem cells	10
Zero-valent Iron Enhances Acetate and Butyrate Production from Carbon Monoxide by Fonticella tunisiensis HN43	10
Lentiviral Surface Engineering via Tris(2-Carboxyethyl)Phosphine-mediated HEK-293T Cell Modification	9
Sensitive detection of SARS-CoV2 spike antibodies by a paper-based polypyrrole/reduced graphene oxide sensor	9
Selective Extraction of Chlorophyll a/Photosystem Polypeptides from Spirulina maxima Using Aqueous Two Phase Extraction	9
Green synthesis of gold nanoparticles using Acorus calamus leaf extract and study on their anti-alzheimer potential	9
Renal Protective Effects of Sparstolonin B in a Mouse Model of Sepsis	9
The Inhibitory Effect of Corni Fructus against Oxidative Stress-induced Cellular Damage in C2C12 Murine Myoblasts	9
Ultrasound- and Negative Pressure-assisted Fractional Precipitation of Paclitaxel from Taxus chinensis	9
A study on the relationship between MDR1 mutation and ex vivo drug sensitivities of canine lymphomas	9
Improvement of Tol2 Transposon System Enabling Efficient Protein Production in CHO Cells	9
Erratum to: Impact of the Synthetic Scaffold Strategy on the Metabolic Pathway Engineering	9
Investigation of β-phenylethanol production by a wild-type Pichia kudriavzevii isolated from jiuqu of rice-flavor baijiu	9
Recycle of sugarcane molasses by Aurantiochytrium sp. for high-value docosahexaenoic acid	8
Candida rugosa Lipase Immobilization on Fe3O4 Coated Carboxyl Functionalised Multiwalled Carbon Nanotubes for Production of Food Flavour Esters	8
Anti-obesity Potential of Lactobacillus spp. Isolated from Infant Feces	8
Identification Process and Physiological Properties of Transporters of Carboxylic Acids in Escherichia coli	8
Adsorption of Lithium on Cell Surface as Nanoparticles through Lithium Binding Peptide Display in Recombinant Escherichia coli	8
Enhancing the Thermostability of Cellulase from Clostridium thermocellum via Salt Bridge Interactions	8
Interaction Between Hepatocytes and Proximal Tubular Epithelial Cells in Hypoxia-induced Lipotoxicity	8
Redox switch protein Hsp33 has a novel zinc-dependent DNA binding function under cold stress in Escherichia coli	8
Hyaluronic Acid-based Biomimetic Hydrogels for Tissue Engineering and Medical Applications	8
Osteostimulating Ability of β-tricalcium Phosphate/collagen Composite as a Practical Bone-grafting Substitute: In vitro and in vivo Comparison Study with Commercial One	8
Evaluation of hair growth-promoting, anti-inflammatory, and 5α-reductase inhibitory effects of Spirulina extract using in vitro and in vivo models	8
Publisher Erratum to: Effects of gltA and arcA Mutations on Biomass and 1,3-Propanediol Production in Klebsiella pneumoniae	8

Schisandrae Fructus Ameliorates Topical Particulate Matter 2.5-induced Keratoconjunctivitis Sicca That Are Accompanied by Retinal and Lipid Metabolism Disorders	8
Metabolic modeling of microorganisms involved in anaerobic digestion	8
Metabolic Engineering of Bacillus megaterium for the Production of β-alanine	7
Introduction of an AU-rich Element into the 5’ UTR of mRNAs Enhances Protein Expression in Escherichia coli by S1 Protein and Hfq Protein	7
Cre/Lox-based RMCE for Site-specific Integration in CHO Cells	7
Engineering of the Substrate Pocket of α-ketoglutaric Semialdehyde Dehydrogenase for Improving the Activity toward 3-hydroxypropanal	7
Evaluation of Pretreatment and GABA Production Using Levilactobacillus brevis Fermentation of the Seaweed Saccharina japonica	7
Effect of Epidermal Growth Factor on the Colony-formation Ability of Porcine Spermatogonial Germ Cells	7
Photothermal heating of cell-free reactions for on-site production of recombinant proteins	7
Enhanced 2,3-butanediol recovery from fermentation broth: a study on isobutanol/sodium chloride aqueous two-phase systems	7
Alpha-tocopherol-incorporating liposomes as efficient protectors from skin cell damages by single infrared-A irradiation with cold stress	7
Development, physico-chemical characterization, and in vivo stability of a novel aglycosylated monoclonal antibody targeting FAM19A5	7
In vitro and in silico study on glucosylation of caprylyl glycol	7
Tuning the Assembly of Bispecific Antibodies by Playing on Differential Polypeptide Chain Molar Ratios	7
Anti-cancer Effect of Hyoscyamus muticus Extract via Its Activation of Fas/FasL-ASK1-p38 Pathway	7
Efficient biodegradation of low-density polyethylene by Pseudomonas plecoglossicida SYp2123 was observed through FT-IR and FE-SEM analysis	7
Development of Orthogonal Aminoacyl tRNA Synthetase Mutant with Enhanced Incorporation Ability with Para-azido-L-phenylalanine	7
Isolation and characterization of two halophilic bacteria producing polyhydroxybutyrate from high-salt environment	7
Single Cell Analysis of Microalgae and Associated Bacteria Flora by Using Flow Cytometry	7
Methane Based Continuous Culture of Methylosinus trichosporium for Production of Poly-3-hydroxybutyrate Using Membrane Recycle System	7
Lessons from Clostridial Genetics: Toward Engineering Acetogenic Bacteria	7
Development of Auxotrophic Agrobacterium tumefaciens AGL1 by Tn5 Transposon for Rice (Oryza sativa L.) Transformation	7
Effects of Acid-fermented Food Wastewater in Microwave-based Direct Lipid Extraction from Wet Microalgae	7
Tumor Homing Peptides as Fusion Partners of Therapeutic Proteins for Efficient Delivery to Cancer Cells	7
Colorimetric detection of milk spoilage at low temperatures: a novel PDA/ZnO@NC membrane for pH-based freshness monitoring	6
Transcriptional Characterization of the Effects of Macrophages on Inflammation-Induced Reconstructed Human Skin Equivalents	6
An ultrasound–negative pressure cavitation adsorption method for the recovery of paclitaxel from cell-free culture supernatants of Taxus chinensis	6
Hyaluronic Acid Stimulated Enterocytic Differentiation of Intestinal Stem Cells and Enhanced Enteroid Grafting on Scaffolds	6
Engineering potyvirus-like particles to display multiple copies of tuberculosis antigens	6
Quantitative Methods for Metabolite Analysis in Metabolic Engineering	6
Curcumin Stimulates UCP1-independent Thermogenesis in 3T3-L1 White Adipocytes but Suppresses in C2C12 Muscle Cells	6
Antioxidant and Anticancer Effects of Epsilon-Poly-L-lysine Produced by Two Novel Strains of Paenibacillus polymyxa HS6 and Stenotrophomonas maltophilia YS8	6
Production of chitosan from Aspergillus niger and quantitative evaluation of the process using adapted analytical tools	6
In silico screening and validation of different dehydrogenases to produce 2,3-butanediol in Bacillus subtilis	6
Ginkgolide B Suppresses TPA-induced Metastatic Potential in MCF-7 Human Breast Cancer Cells by Inhibiting MAPK/AP-1 Signaling	6
An Overview on Wound Dressings and Sutures Fabricated by Electrospinning	6
Efficient isoprenol production in Escherichia coli via acetyl-CoA redirection	6
High-Throughput Production of Microcapsules for Human Bone Marrow Derived Mesenchymal Stem Cell Biomanufacturing in a Vertical-Wheel Bioreactor	6
An integrated in silico reverse vaccinology approach for multi-epitope vaccine designing against Shigellosis caused by Shigella flexneri serotype X	6
Stability Enhancement of Target Enzymes via Tyrosinase-Mediated Site-Specific Polysaccharide Coating	6
Optimization of enzymatic extraction of astaxanthin from Xanthophyllomyces dendrorhous using a recombinant cellulase	6
Strategies to Enhance the Biosynthesis of Monounsaturated Fatty Acids in Escherichia coli	6
Co-utilization of Maltose and Sodium Acetate via Engineered Corynebacterium glutamicum for Improved Itaconic Acid Production	6
Improving the Microbial Production of Amino Acids: From Conventional Approaches to Recent Trends	6
Bioactive Peptides and Its Alternative Processes: A Review	6
An Algicidal Agent against Harmful Algae Using Novel N1-benzyl-N3, N3-diethylpropane-1,3-diamine Derivatives	6
Enhanced cytotoxicity of natural killer cells with Zn-alginate hydrogel microspheres	6
Advancing biofoundry development: strategies and challenges	6