OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Ginseng Research is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Corrigendum to “Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models” [J Ginseng Res 46 (2022) 426-434]	134
Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway	114
Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1	106
The antitumor effects and apoptotic mechanism of 20(S)-Protopanaxadiol in acute myeloid leukemia	97
The necrotroph Botrytis cinerea promotes disease development in Panax ginseng by manipulating plant defense signals and antifungal metabolites degradation	80
Ginsenoside Rh2 alleviates inflammatory response and enhances motor function recovery in spinal cord injury mice via the ROS/MAPK14 signaling pathway	72
Anti-thrombotic effects of ginsenoside Rk3 by regulating cAMP and PI3K/MAPK pathway on human platelets	69
Integrated LC–HRMS and in silico prediction discovery a hydroxylated protopanaxatriol metabolite in vivo with enhanced anti-inflammatory activity	65
Ginsenoside Rg5, a potent agonist of Nrf2, inhibits HSV-1 infection-induced neuroinflammation by inhibiting oxidative stress and NF-κB activation	62
Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model	60
Inhibitory effect of ginsenglactone A from Panax ginseng on the tube formation of human umbilical vein endothelial cells and migration of human ovarian cancer cells	43
Ginsenoside F2 Restrains Hepatic Steatosis and Inflammation by Altering the Binding Affinity of Liver X Receptor Coregulators	41
Ginseng acetylcholine from various ginsengs and its in vivo physiological effect	40
Ginsenoside Rg5 alleviates radiation-induced acute lung vascular endothelium injury by reducing mitochondrial apoptosis via Sirt1	40
Panaxcerol D from Panax ginseng ameliorates the memory impairment induced by cholinergic blockade or Aβ25–35 peptide in mice	39
Ginsenoside Rg3-enriched Korean Red Ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium	38
Panax ginseng as a microbial ecosystem modulator: implications for systemic health via the gut-organ axes	35
20(S)-protopanaxatriol alleviates gastritis by attenuating oxidative stress and inflammatory responses via inhibition of PI3K/AKT and JAK/STAT3 pathways	35
Protective effects of Panax ginseng berry extract on blue light-induced retinal damage in ARPE-19 cells and mouse retina	34
Optimizing Component Formula Extracted from Ginseng and Salvia Inhibits Lung Cancer Metastasis and EMT via Suppressing AKT/GSK-3β/β-catenin Pathway	33
Ginsenoside Rb1-engineered nanocomposite hydrogel promotes pressure injury repair through SIRT1-AMPK-mediated ferroptosis inhibition and angiogenesis activation	33
Production and characterization of lentivirus vector-based SARS-CoV-2 pseudoviruses with dual reporters: Evaluation of anti-SARS-CoV-2 viral effect of Korean Red Ginseng	32
Targeting the SMG9–Wnt/β-catenin axis: A novel mechanism by which ginsenoside Rh2 suppresses triple-negative breast cancer progression	32
Ginsenoside Rg5 modulates the TLR4 and BCL-2 pathways by inhibiting NOX1, thereby alleviating inflammation, apoptosis and pyroptosis in hyperuricemia nephropathy	31
Targeting mitochondrial quality control: Ginsenoside Rg1 as a therapeutic candidate for neuromuscular diseases	30

Renoprotective mechanisms of bioconverted wild-simulated ginseng: mitigating oxidative stress, inflammation, and apoptosis to protect against ischemic renal injury via Nrf2/HO-1/NF-κB/caspase-3 signal	30
Quantitative description and microscopic mechanism of ginsenosides’ reactions during the thermal-driven processing of Panax ginseng	30
Korean Red Ginseng and Rb1 restore altered social interaction, gene expressions in the medial prefrontal cortex, and gut metabolites under post-weaning social isolation in mice	29
Exploring the potential of ginseng-derived compounds in treating cancer cachexia	29
Corrigendum to “Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2”[J Ginseng Res 45(5) September 202	29
Korean Red Ginseng slows coreceptor switch in HIV-1 infected patients	27
Proteomic profiling reveals the mechanism of ginsenoside synthesis in Panax notoginseng	27
Assessing systemic, developmental, and reproductive toxicity and estrogenicity of Korean red ginseng extract G1899 in juvenile Sprague-Dawley Rats	27
Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway	26
Korean Red Ginseng extract treatment prevents post-antibiotic dysbiosis-induced bone loss in mice	26
Antiplatelet activity of a Korean red ginseng–derived saponin fraction and its inhibition of influenza A virus–induced thrombosis	25
Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD	25
Compound K-enriched Korean red ginseng prevents lung cancer progression by targeting cancer cells and fibroblasts	23
Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway	23
Effects of Korean red ginseng on T-cell repopulation after autologous hematopoietic stem cell transplantation in childhood cancer patients	22
Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy	22
Activation of BMPR1b–SMAD pathway by Ginsenoside F1 restores osteoblast function in ovariectomy-induced osteoporosis	22
Comprehensive metabolomic profiling of Panax quinquefolius: qualitative and quantitative analysis across different habitats, harvesting seasons and parts by UPLC/Triple TOF-MS and UPLC/Qtrap-MS	21
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation	21
Ginsenoside Rg5 alleviates allergic rhinitis in rats by modulating nasal microbiota by inhibiting JAK2/STAT3/BCL-2 and MAPK signaling	21
Effects of Korean red ginseng on the HIV-1 env sequence length and CpG dinucleotides	21
Corrigendum to “Nrf2-mediated activation of HO-1 is required in the blocking effect of compound K, a ginseng saponin metabolite, against oxidative stress damage in ARPE-19 human retinal pigment epithe	21
Long-term administration of red ginseng non-saponin fraction rescues the loss of skeletal muscle mass and strength associated with aging in mice	21
Antiviral effects of Korean Red Ginseng on human coronavirus OC43	21
Cytogenomic profiling of Panax ginseng cultivars and in vitro root cultures through multi-color PLOP-FISH and flow cytometry reveals somaclonal variations	21
Corrigendum to “GinDB-AI: An integrated database of Panax-derived compounds and an AI-driven platform for multidimensional information and biological activity prediction” [J Ginseng Res 50/3 (2026) 10	20
Ginsenoside Re prevents 3-methyladenine-induced catagen phase acceleration by regulating Wnt/β-catenin signaling in human dermal papilla cells	20
Ginseng root-derived exosome-like nanoparticles protect skin from UV irradiation and oxidative stress by suppressing activator protein-1 signaling and limiting the generation of reactive oxygen specie	20
Ginsenoside Rh7 ameliorates myocardial injury in diabetic cardiomyopathy by promoting M2 polarization of macrophages via SIRT1/FOXO1/β-catenin	20
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3	20
A review of pharmacological properties and pharmacokinetic of 20(S)-protopanaxadiol	20
Contemporary perceptions of ginseng among individuals with health needs: A nationwide questionnaire survey	20
Corrigendum to ‘Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner’	19
Protopanaxatriol enhances mucin expression in intestinal epithelial cells and mice	19
Ginsenoside Rc prevents dexamethasone-induced muscle atrophy and enhances muscle strength and motor function	19
Editorial Board	19
Ginsenoside Re inhibits myocardial fibrosis by regulating miR-489/myd88/NF-κB pathway	18
Effect of diabetes on the efficacy and safety of Panax notoginseng saponins in ischemic stroke: a prespecified analysis of the PANDA trial	18
Korean red ginseng extract inhibits microplastic translocation via the gut−liver axis by ameliorating alcohol-induced intestinal disruption	18
Ginseng nonsaponins: New insights into their pharmacological potentials in inflammasome-driven inflammation and immunopathology	17
Sustainable production of natural products using synthetic biology: Ginsenosides	17
Ginsenoside Rg2 attenuates TGF-β1/Smad-mediated fibrotic remodeling in aged male mice with sarcopenia	17
Maltol, a compound in Korean Red Ginseng, attenuates the Staphylococcus aureus–induced inflammasome activation in the skin	17
Direct targeting of ORAI1 by ginsenoside Rg3 modulates calcium signaling and senescence-associated AMPK-NRF2 activation	17
Corrigendum to “Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury”[J Ginseng Res 48(6), November 2024, 592–602]	17
Valorizing ginseng residues using dimethyl ether: Recovering functional lipids and ginsenosides	17
Comprehensive understanding and underlying molecular mechanisms of the adaptogenic effects of Panax ginseng	17
Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome	17
Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability	16
Microbiome-mediated pharmacology of ginseng: Mechanistic insights into metabolic regulation and therapeutic potential	16

Protective effects of Korean Red Ginseng against toxicity of endocrine-disrupting chemicals	16
Ginsenosides exhibit potential therapeutic potential in photoaging by regulating keratinocyte ferroptosis	16
Panax ginseng alleviates diabetic peripheral neuropathy by suppressing mitochondrial dysfunction and oxidative stress via modulation of the RAGE, NF-κB, and Nrf2 pathways	16
Effects of Panax species and their bioactive components on allergic airway diseases	16
Total saponins from Panax ginseng delay aging and cellular senescence via PI3K-AKT pathway in a rapid dual-system screening model of aging	16
Anti-skin aging effects of black ginseng extracts through regulating inflammatory factors and the CLOCK–ERK pathway in mice	15
Rg3-enriched red ginseng extracts enhance apoptosis in CoCl2-stimulated breast cancer cells by suppressing autophagy	15
Biodistribution and pharmacokinetic evaluation of Korean Red Ginseng components using radioisotopes in a rat model	15
The role of ginseng and ginsenosides in ROS and cardiovascular disease	15
Ginsenoside Re promotes osteogenic differentiation via BMP2/p38 pathway in vivo and in vitro	15
Structural analysis, anti-inflammatory activity of the main water-soluble acidic polysaccharides (AGBP-A3) from Panax quinquefolius L berry	15
Editorial Board	15
Comment on antiviral activities of ginseng and putative benefits against monkeypox virus	15
20(S)-ginsenoside Rg3 exerts anti-fibrotic effect after myocardial infarction by alleviation of fibroblasts proliferation and collagen deposition through TGFBR1 signaling pathways	15
Red ginseng-mediated modulation of the NLRP3 Inflammasome in neuroinflammatory-related cognitive impairments	14
The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.	14
Effects of Korean red ginseng on auditory, cognitive, and liver functions in a naturally aged mouse model	14
Korean red ginseng mitigates pulmonary injury and enhances antiviral immunity in a low-dose pseudo-type SARS-CoV-2 infection model	14
Multi-omics and compositional analysis of bidirectional solid fermentation products from Cordyceps militaris and Panax quinquefolius L	14
Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC–CN–NFAT1 signaling in T2DM mice	14
Gintonin upregulates cytokine production and expression of NKp30, NKp44 and NKp44 related to natural killer cell activity on immunosuppressive rat	14
Microbiota, co-metabolites, and network pharmacology reveal the alteration of the ginsenoside fraction on inflammatory bowel disease	14
Editorial Board	14
Antiviral activities of ginseng and its potential and putative benefits against monkeypox virus: A mini review	13
Corrigendum to “Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2” [J. Ginseng Res. 47 (1) (January	13
Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing	13
Compositional changes and physiological activities of fresh ginseng extracts prepared at various temperatures in subcritical water	13
Impact of HIV-1 subtypes on gross deletion in the nef gene after Korean Red Ginseng treatment	13
Korean Red ginseng supplements improve quality of life in patients with mild chronic pancreatitis symptoms: A prospective clinical trial	13