OOIR: Observatory of International Research

Papers

(The median citation count of Biotechnology & Biotechnological Equipment is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
STING-associated vasculopathy with onset in infancy: the first case in Bulgaria and review of the literature	50
Implementation of DPYD testing in Bulgarian patients with cancer	31
GPC3 as a potential diagnostic and prognostic marker for lung adenocarcinoma	30
The rhizosphere of the pioneer plant Dicranopteris dichotoma (Thunb.) Bernh. contains powerful and robust rhizosphere growth-promoting bacteria	26
Experimental temperature evaluation during a robotized bone drilling process	24
Identification and estimation of sequence variation dynamics of Tomato Leaf curl Palampur virus and betasatellite complex infecting a new weed host	24
A comparison of dropout rate of three commonly used single cell RNA-sequencing protocols	22
Analysis of contrast sensitivity in patients implanted with Acunex Vario and LuxSmart extended depth of focus (E-DOF) intraocular lenses (IOLs)	21
High cross-pollination rate of Greek oregano ( O. vulgare ssp. hirtum ) with Common oregano ( O. vulgare ss	16
Leber’s hereditary optic neuropathy: clinical and genetic analysis of Bulgarian patients	14
Costs of treating type 2 diabetes mellitus and its complications	14
An algorithm and application to efficiently analyse DNA fibre data	14
Endodontic and surgical treatment of chronic apical periodontitis: a randomized clinical study	14
Review and a case of rare Rosai-Dorfman disease	14
Development and application of HPV31-specific monoclonal antibodies	13
Overexpression of MYB transcription factor LrAN2 from Lycium ruthenicum activated the anthocyanin biosynthesis in the leaf and fruit of	13
YKL-40 and LAMPs as possible markers in neuroinflammation and autophagy during central nervous system infections	12
Time-course RNA-seq analysis provides an improved understanding of genetic regulation in response to cold stress from white clover (Trifolium repens L.)	12
Mining public genomic databases for novel lanthipeptides: a case study on Bacillus amyloliquefaciens	12
AcdS gene of Bacillus cereus enhances salt tolerance of seedlings in tobacco (Nicotiana tabacum L.)	12
Diagnostic value of hybrid perfusion SPECT/CT and CTPA for detection of pulmonary embolism	12
SARS-CoV-2 variants and genomic surveillance in the low-resource north-west region of Pakistan	12
Genome-wide analysis of the GRAS gene family in white clover ( Trifolium repens L.) provides insight into its critical role in response to cold stress	11
Refractive results after cataract surgery in patients: calculation with Holladay II and Barrett Universal II formulas	11
3.5 GHz radiofrequency radiation may affect biomechanics of bone and muscle of diabetics	10

A novel prediction method for protein DNA-binding residues based on neighboring residue correlations	10
Study on patients with Clostridioides difficile infection during the COVID-19 pandemic in Bulgaria	10
West Nile virus meningoencephalitis and cytokines analysis: review and case report	10
Inhibitory effect of pentoxifylline on the synthesis and deposition of glycosaminoglycans in hypothyroid skin	10
Cost/effectiveness of elivaldogene autotemcel vs. hematopoietic stem cells transplantation in patients with cerebral adrenoleukodystrophy (CALD)	9
Improvement of the antibacterial and skin-protective performance of alcohol-based sanitizers using hydroglycolic phytocompounds	9
Combinations of mild chemical and bacterial pretreatment for improving enzymatic saccharification of corn stover	9
COVID-19 vaccination and potential predictors for vaccination among students in Bulgarian medical universities	8
Antiviral activity of Humulus lupulus (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study	8
Research and pilot analysis of bevacizumab repurposing potential and its impact in clinical practice	8
The common bean (Phaseolus vulgaris) SULTR gene family: genome-wide identification, phylogeny, evolutionary expansion and expression patterns	7
Whole genome sequencing and functional analysis of porcine-borne Bacillus coagulans LYBC06	7
Metabolic profiling of probiotic strain Lactobacillus delbrueckii subsp. bulgaricus L14 cultivated in presence of prebiotic oligosaccharid	7
Cytokines levels in saliva in periodontitis, oral potentially malignant disorders and squamous cell carcinoma	7
Development and validation of a functional molecular marker for a CaAPRR2-like gene that controls green fruit colour in pepper	7
Promoting effect of biogenic AgNPs on Echinops macrochaetus for improving growth parameters and mitigating the toxic effect caused by salinity stress	7
Polymorphism in SNP G1 of the GDF9 gene associated with reproductive traits in Bulgarian dairy sheep	7
Production and biochemical characterization of keratinase enzyme from Bacillus subtilis ES5 and its potential application in leather dehairing process: a clean leather t	6
Cost-effectiveness of therapeutic drug monitoring (TDM) of biologic treatment in rheumatic diseases: a narrative review	6
Nanodiamonds improve amaranth biodegradation in a lab-scale biofilter	6
Synthesis, antiproliferative and antimicrobial activities of (KLAKLAK) ₂ -NH ₂ analogue containing nor-Leu and its conjugates with	6
The concept for the antivirulence therapeutics approach as alternative to antibiotics: hope or still a fiction?	6
Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study	6
Research advance and clinical implication of circZNF609 in human diseases	6
Optimization of intracellular L-Asparaginase production by Streptomyces paulus CA01 isolated from wheat bran using the response surface methodology	6
SRAP markers for characterization of the genetic diversity and differentiation of Pinus nigra populations in protected forested areas in Bulgaria, Greece, and Cyprus	5
Surveillance over cytomegalovirus (CMV) reactivation following hematopoietic stem cell transplantation: a single-center experience	5
Investigation of IDO1 and TDO2 expression in breast tumors by immunohistochemistry and real-time polymerase chain reaction methods	5
Extensive characterization of COVID-19 convalescent plasma from Bulgarian donors	5
Micropropagation of guava ( Psidium guajava ) seedlings, a plant with interest in cool subtropics, using an innovative BB culture medium	5
Analyzing real-world data to understand COVID-19 vaccination effects on hospitalization rates in patients with solid malignancies	5
35 blood and urine biomarkers in Polycystic Kidney Disease: a bidirectional Mendelian randomization study	5
Chemical composition, antimicrobial and anticancer activities of Paederia lanuginosa WALL	5
Analysis of cytokinin content and associated genes at different developmental stages in pak choi (Brassica rapa ssp. chinensis Makino)	5
Genome sequence of Bacillus velezensis LZN01 inhibiting Fusarium oxysporum f. sp. niveum and producing myri	5
Role of pharmacists in adherence in oncology patients	5
Deep learning in oral surgery for third molar extraction: empirical evidence and original model	5
Inhibiting immune escape in lung adenocarcinoma: the role of SPARC in suppressing CD276 function	5
Sex-specific functional effect of IL-12 gene polymorphisms in brain tumours	5
Antibacterial potential of Piper nigrum L. essential oil targeting FtsZ, GyrB, murA, and PTP proteins: in silico	5
Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants	4
Bacterial functional responses to environmental variability: a case study in three distinct mountain lakes within a single watershed	4
A galantamine–curcumin hybrid lacks the depressant side effect of acetylcholinesterase inhibitors	4
Plant extracts and Trichoderma spp: possibilities for implementation in agriculture as biopesticides	4
In silico analysis of Hsp70 genes in Ctenopharyngodon idella and their expression profiles in response to environmental stresses	4
Astragalus glycyphyllos L.: antiviral activity and tablet dosage formulation of a standardized dry extract	4
A novel characterization of alginate-attapulgite-calcium carbonate (AAC) gel adsorption in bacterial biodegradation of used engine oil (UEO)	4
An overview of the role of MMP-8 and ADAM-33 in bronchial asthma	4
Bacterial diversity and functional characteristics of natural rainwater lakes in Saihanba artificial forest farm as revealed by 16S rRNA sequencing	4
Genome-wide identification, phylogeny and expression analyses of group III WRKY genes in cotton (Gossypium hirsutum)	4

Microbial functional diversity in rhizosphere and non-rhizosphere soil of different dominant species in a vegetation concrete slope	4
Combined diabetes and chronic stress exacerbates cytokine production and oxidative stress in rat liver and kidney	4
On disagreements of theories of evolution	4
Comparative transcriptome analysis of two varieties of common bean ( Phaseolus vulgaris L. ) to identify candidate drought resistance genes	4
Kawasaki disease with giant coronary aneurysms formation in a 3-month old infant: a case report and review of the literature	4
C-peptide levels and glycemic indices in COVID-19 patients	4
High quality RNA extraction from Pseudomonas aeruginosa and other bacteria with a novel rapid and cost-effective method	3
Oligo-dT anchored cDNA-SRAP and cDNA-SCoT aided identification of transcripts differentially expressed during the early stages of recovery of resurrection plant Haberlea rhodopensis	3
In silico discovering relationship between bacteriophages and antimicrobial resistance	3
Impact of continuous cropping on tobacco growth, stress resistance, and soil microecological structure	3
Enhancement of taxane production in cell suspension culture of Corylus avellana L. Kalınkara by elicitation and precursor feeding	3
Thermal deactivation studies of alpha-amylase immobilized onto core-shell structured aniline formaldehyde crosslinked polyaniline magnetic nanocomposite	3
Effect of exogenous melatonin on salt stress in cucumber: alleviating effect and molecular basis	3
Effect of 4 Hz and multifrequency pulsed electromagnetic field (PEMF) on bone fracture healing	3
Letter to the Editor concerning ‘cost-effectiveness of velmanase alfa vs. bone marrow transplantation or no causal therapy in patients with mild to moderate alpha-mannosidosis’	3
Genetic modifications to push L -tyrosine synthesis in Escherichia coli	3
Overexpression of GhSWEET42 , a SWEET -like gene from cotton, enhances the oil content and seed size	3
Genetic diversity and phylogeography of Japanese brome ( Bromus japonicus Thunb. ex Murr.) populations in China	3
The prospect of antimicrobial peptides from Bacillus species with biological control potential against insect pests and diseases of economic importance in agriculture, f	3
Tumor treating fields: a new treatment for glioblastoma	3
Enhancing the nutritional values of tiger nut meal through solid-state fermentation	3
Preoperative ultrasound assessment of myometrial invasion in endometrial cancer and prediction of surgical stage	3
Adequate effectiveness of ribociclib plus letrozole or fulvestrant in patients with advanced or metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer tr	3
A novel TaqMan qPCR system for the detection of Diaporthe citri , the causative agent of citrus melanose	3
Placenta accreta spectrum: ultrasound diagnosis and clinical correlation	3
Relationship between Vitamin D status and microbiome changes in Bulgarian patients with type 2 diabetes mellitus	3
Pigment production of Nannochloropsis oculata (eustigmatophyceae) under different colchicine concentration	2
Comparative analysis of retrosynthesis applications for predicting of pathways for plant Secondary metabolite production	2
Microsatellite unstable colorectal cancers are associated with increased CD1a- and CD83-positive dendritic cell infiltration	2
Understanding the concept of Nattokinase use: a few years after beginning	2
Comparative analysis of prices, public expenditures, and utilization of biological disease modifying drugs for treatment of inflammatory joint diseases in Bulgaria and Serbia	2
New perspectives into the application of Effective Microorganism (EM) on phytopathogenic fungi: in-vitro antioxidant capacity, bioactive substances and fungicidal efficacy	2
Transcriptome analysis unravels differential genes involved in essential oil content in callus and tissue culture seedlings of Lavandula angustifolia	2
Analysis on bacterial community structure of new and old fermented pit mud of Shedian Liquor	2
Determination of expression level of AP1S1, CDK9, FIGF and HDAC11 genes in bladder tumors for aggressive phenotype characterization	2
Biotransformation of ginsenosides by glycoside hydrolase from an endophytic fungus of Panax ginseng	2
Expression analysis of CsNAC30 gene in cucumber under drought stress	2
Protein engineering of CMP kinases to improve thermal stability and resultant production of 3′-sialyllactose	2
Transferability of new methods for health technology assessment in the field of diabetes between early and late adopters’ countries	2
Drill-bit upper limit temperature calculation when drilling bones in orthopedic surgery	2
Transcriptome analysis identifies key genes involved in anthocyanin biosynthesis in black and purple fruits (Lycium ruthenicum Murr. L)	2
Identification and quantification of anthocyanins of 62 blueberry cultivars via UPLC-MS	2
Insights into effects of sodium phytate on gut microbiome of mice by high-throughput sequencing	2
Systematic identification and characterization of the soybean ( Glycine max ) B-box transcription factor family	2
Economic consequences of the implementation of primary DNA-HPV genotype testing in Bulgaria	2
Ellagic acid for oral mucositis: investigation of the therapeutic effect in rats	2
Genetic mapping of QTL for three root-related traits in wheat (Triticum aestivum)	2
Improved drought tolerance in soybean by protein elicitor AMEP412 induced ROS accumulation and scavenging	2
Genetic diversity and population structure analysis of wild kiwifruit ( Actinidia spp.) using SRAP markers	2
Detection of pathogenic variants in Alzheimer’s disease related genes in Bulgarian patients by pooled whole-exome sequencing	2
Genetic architecture of microhabitat adaptation traits in a pair of sympatric Primulina species	2
Association between endometrial microbiome and implantation success in women with frozen embryo transfer: results of a prospective cohort study	2
Flaxseed protein isolate-alginate microbeads as encapsulating agents for enhanced survival of Enterococcus faecalis HZNU S1 during storage and in vitro	2
The impact of size for liposomes modified with pH-responsive β-glucan derivatives on the initiation of cellular and humoral immune responses in murine models	2
Detection of Helicobacter pylori in saliva based on surface plasmon resonance by binding of Lewis b (Le ^b ) blood group antigen to spe	2
An appropriate unstructured kinetic model describing the batch fermentation growth ofDebaryomyces hanseniifor xylitol production using hydrolysis of oil palm empty fruit bunch	2
Exogenous application of melatonin improves the growth and physiological properties of blueberry seedlings under salt stress	2
Review on the NGS-based studies of microbiotas of artisanal and regional kinds of cheese with potential as functional foods: composition and functional analysis	2
Correction	2
High rate of fluoroquinolone resistant Neisseria gonorrhoeae detected by molecular surveillance of antimicrobial resistance determinants in Bulgaria	2
Taxonomic and molecular characterization of 15 wild-growing tulip species of Greece using the internal transcribed spacer (ITS) nuclear marker in combination with the psb	2
Bacillus velezensis R22 inhibits the growth of multiple fungal phytopathogens by producing surfactin and four fengycin homologues	2
The wheat (Triticum aestiveum L.) MADS-box transcription factor TaMADS32 plays a role in response to abiotic stresses	2
Expression of membrane-bound β-Klotho on peripheral blood CD4+ and CD8+ T lymphocytes of healthy subjects	2
35-bp deletion in ABCG2 gene: mini-review and report on two herds of Bulgarian dairy synthetic population sheep breed	2
Design, synthesis and evaluation of semi- and thiosemicarbazides containing a methylxanthine moiety within vitroneuroprotective and MAO-B inhibitory activities	2
Prospective study of uveitis in children with juvenile idiopathic arthritis over a 3-year period	2
Restoring mitophagy in prostate cancer cells: the role of miR-141 rescue in counteracting MAPK1/ERK2-dependent autophagy suppression	2