OOIR: Observatory of International Research

Papers

(The median citation count of Biotechnology & Biotechnological Equipment is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
STING-associated vasculopathy with onset in infancy: the first case in Bulgaria and review of the literature	53
Decolourization of synthetic dyes by laccase produced from Bacillus sp. NU2	32
Implementation of DPYD testing in Bulgarian patients with cancer	26
GPC3 as a potential diagnostic and prognostic marker for lung adenocarcinoma	25
Structure and features of the complete chloroplast genome of Salix triandroides (Salicaceae)	24
Endodontic and surgical treatment of chronic apical periodontitis: a randomized clinical study	24
An algorithm and application to efficiently analyse DNA fibre data	22
Analysis of contrast sensitivity in patients implanted with Acunex Vario and LuxSmart extended depth of focus (E-DOF) intraocular lenses (IOLs)	21
Costs of treating type 2 diabetes mellitus and its complications	20
High cross-pollination rate of Greek oregano ( O. vulgare ssp. hirtum ) with Common oregano ( O. vulgare ss	19
Experimental temperature evaluation during a robotized bone drilling process	19
Fermentation medium optimization, molecular modelling and docking analysis of the alginate lyase of a novel Pseudomonas sp. LB56 isolated from seaweed waste	19
The rhizosphere of the pioneer plant Dicranopteris dichotoma (Thunb.) Bernh. contains powerful and robust rhizosphere growth-promoting bacteria	18
A comparison of dropout rate of three commonly used single cell RNA-sequencing protocols	15
Assaying for antiviral activity of the folkloric medicinal desert plant Rhazya stricta on coronavirus SARS-CoV-2	13
Identification and estimation of sequence variation dynamics of Tomato Leaf curl Palampur virus and betasatellite complex infecting a new weed host	13
Effect of mobile phone usage duration during pregnancy on the general motor movements of infants	12
Detection of chicken adulteration in beef via ladder-shape melting temperature isothermal amplification (LMTIA) assay	12
Development and application of HPV31-specific monoclonal antibodies	11
Review and a case of rare Rosai-Dorfman disease	11
Overexpression of MYB transcription factor LrAN2 from Lycium ruthenicum activated the anthocyanin biosynthesis in the leaf and fruit of	11
Leber’s hereditary optic neuropathy: clinical and genetic analysis of Bulgarian patients	11
Diagnostic value of hybrid perfusion SPECT/CT and CTPA for detection of pulmonary embolism	10
AcdS gene of Bacillus cereus enhances salt tolerance of seedlings in tobacco (Nicotiana tabacum L.)	10
Time-course RNA-seq analysis provides an improved understanding of genetic regulation in response to cold stress from white clover (Trifolium repens L.)	10

SARS-CoV-2 variants and genomic surveillance in the low-resource north-west region of Pakistan	10
Genome-wide analysis of the GRAS gene family in white clover ( Trifolium repens L.) provides insight into its critical role in response to cold stress	9
Toxicity and degradation of 2,4,6-trinitrotoluene in transgenic Arabidopsis expressing Citrobacter freundii nitroreductase	9
Refractive results after cataract surgery in patients: calculation with Holladay II and Barrett Universal II formulas	9
Mining public genomic databases for novel lanthipeptides: a case study on Bacillus amyloliquefaciens	9
Study on patients with Clostridioides difficile infection during the COVID-19 pandemic in Bulgaria	9
YKL-40 and LAMPs as possible markers in neuroinflammation and autophagy during central nervous system infections	9
West Nile virus meningoencephalitis and cytokines analysis: review and case report	8
Inhibitory effect of pentoxifylline on the synthesis and deposition of glycosaminoglycans in hypothyroid skin	8
3.5 GHz radiofrequency radiation may affect biomechanics of bone and muscle of diabetics	8
Antiviral activity of Humulus lupulus (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study	8
A novel prediction method for protein DNA-binding residues based on neighboring residue correlations	8
Metabolic profiling of probiotic strain Lactobacillus delbrueckii subsp. bulgaricus L14 cultivated in presence of prebiotic oligosaccharid	7
Combinations of mild chemical and bacterial pretreatment for improving enzymatic saccharification of corn stover	7
Diversity of nirS and nirK denitrifying bacteria in rhizosphere and non-rhizosphere soils of halophytes in Ebinur Lake Wetland	7
Cost/effectiveness of elivaldogene autotemcel vs. hematopoietic stem cells transplantation in patients with cerebral adrenoleukodystrophy (CALD)	7
Functional characterization of Medicago truncatula GRAS7, a member of the GRAS family transcription factors, in response to abiotic stress	7
Improvement of the antibacterial and skin-protective performance of alcohol-based sanitizers using hydroglycolic phytocompounds	7
Promoting effect of biogenic AgNPs on Echinops macrochaetus for improving growth parameters and mitigating the toxic effect caused by salinity stress	6
Development and validation of a functional molecular marker for a CaAPRR2-like gene that controls green fruit colour in pepper	6
COVID-19 vaccination and potential predictors for vaccination among students in Bulgarian medical universities	6
Cytokines levels in saliva in periodontitis, oral potentially malignant disorders and squamous cell carcinoma	6
Whole genome sequencing and functional analysis of porcine-borne Bacillus coagulans LYBC06	6
Evaluation of advanced protein oxidation and RAGE gene variants in the risk of laryngeal cancer	5
Synthesis, antiproliferative and antimicrobial activities of (KLAKLAK) ₂ -NH ₂ analogue containing nor-Leu and its conjugates with	5
Cost-effectiveness of therapeutic drug monitoring (TDM) of biologic treatment in rheumatic diseases: a narrative review	5
Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study	5
Research and pilot analysis of bevacizumab repurposing potential and its impact in clinical practice	5
Genetic analysis of yield and yield contributing traits in rice (Oryza sativa L.) BC₂F₃ population derived from MR264 × PS2	5
Optimization of intracellular L-Asparaginase production by Streptomyces paulus CA01 isolated from wheat bran using the response surface methodology	5
Production and biochemical characterization of keratinase enzyme from Bacillus subtilis ES5 and its potential application in leather dehairing process: a clean leather t	5
Analyzing real-world data to understand COVID-19 vaccination effects on hospitalization rates in patients with solid malignancies	5
The common bean (Phaseolus vulgaris) SULTR gene family: genome-wide identification, phylogeny, evolutionary expansion and expression patterns	5
Research advance and clinical implication of circZNF609 in human diseases	5
Polymorphism in SNP G1 of the GDF9 gene associated with reproductive traits in Bulgarian dairy sheep	5
Nanodiamonds improve amaranth biodegradation in a lab-scale biofilter	5
The concept for the antivirulence therapeutics approach as alternative to antibiotics: hope or still a fiction?	5
Sex-specific functional effect of IL-12 gene polymorphisms in brain tumours	4
Astragalus glycyphyllos L.: antiviral activity and tablet dosage formulation of a standardized dry extract	4
Antibacterial potential of Piper nigrum L. essential oil targeting FtsZ, GyrB, murA, and PTP proteins: in silico study	4
SRAP markers for characterization of the genetic diversity and differentiation of Pinus nigra populations in protected forested areas in Bulgaria, Greece, and Cyprus	4
Analysis of cytokinin content and associated genes at different developmental stages in pak choi (Brassica rapa ssp. chinensis Makino)	4
Impact of CYP3A7, CYP2D6 and ABCC2/ABCC3 polymorphisms on tacrolimus steady state concentrations in Bulgarian kidney transplant recipients	4
Genome sequence of Bacillus velezensis LZN01 inhibiting Fusarium oxysporum f. sp. niveum and producing myri	4
Extensive characterization of COVID-19 convalescent plasma from Bulgarian donors	4
C-peptide levels and glycemic indices in COVID-19 patients	4
Chemical composition, antimicrobial and anticancer activities of Paederia lanuginosa WALL	4
Role of pharmacists in adherence in oncology patients	4
Micropropagation of guava ( Psidium guajava ) seedlings, a plant with interest in cool subtropics, using an innovative BB culture medium	4
Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants	4

Investigation of IDO1 and TDO2 expression in breast tumors by immunohistochemistry and real-time polymerase chain reaction methods	4
Combined diabetes and chronic stress exacerbates cytokine production and oxidative stress in rat liver and kidney	4
Genome-wide identification and expression analysis of tomato glycoside hydrolase family 1 β-glucosidase genes in response to abiotic stresses	4
Deep learning in oral surgery for third molar extraction: empirical evidence and original model	4
35 blood and urine biomarkers in Polycystic Kidney Disease: a bidirectional Mendelian randomization study	4
Inhibiting immune escape in lung adenocarcinoma: the role of SPARC in suppressing CD276 function	4
Surveillance over cytomegalovirus (CMV) reactivation following hematopoietic stem cell transplantation: a single-center experience	4
Plant extracts and Trichoderma spp: possibilities for implementation in agriculture as biopesticides	3
Bacterial functional responses to environmental variability: a case study in three distinct mountain lakes within a single watershed	3
In silico analysis of Hsp70 genes in Ctenopharyngodon idella and their expression profiles in response to environmental stresses	3
Kawasaki disease with giant coronary aneurysms formation in a 3-month old infant: a case report and review of the literature	3
Placenta accreta spectrum: ultrasound diagnosis and clinical correlation	3
Overexpression of GhSWEET42 , a SWEET -like gene from cotton, enhances the oil content and seed size	3
A galantamine–curcumin hybrid lacks the depressant side effect of acetylcholinesterase inhibitors	3
Relationship between Vitamin D status and microbiome changes in Bulgarian patients with type 2 diabetes mellitus	3
Innovative technological advancements in laboratory medicine: Predicting the lab of the future	3
An overview of the role of MMP-8 and ADAM-33 in bronchial asthma	3
Investigation of soil microbiota reveals variable dominant species at different land areas in China	3
Enhancement of taxane production in cell suspension culture of Corylus avellana L. Kalınkara by elicitation and precursor feeding	3
What food will we be eating on our journey to Mars?	3
Bacterial diversity and functional characteristics of natural rainwater lakes in Saihanba artificial forest farm as revealed by 16S rRNA sequencing	3
On disagreements of theories of evolution	3
A novel characterization of alginate-attapulgite-calcium carbonate (AAC) gel adsorption in bacterial biodegradation of used engine oil (UEO)	3
Genome-wide identification, phylogeny and expression analyses of group III WRKY genes in cotton (Gossypium hirsutum)	3
Microbial functional diversity in rhizosphere and non-rhizosphere soil of different dominant species in a vegetation concrete slope	3
In silico discovering relationship between bacteriophages and antimicrobial resistance	3
Comparative transcriptome analysis of two varieties of common bean ( Phaseolus vulgaris L. ) to identify candidate drought resistance genes	3
Adequate effectiveness of ribociclib plus letrozole or fulvestrant in patients with advanced or metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer tr	3
High quality RNA extraction from Pseudomonas aeruginosa and other bacteria with a novel rapid and cost-effective method	3
Expression of membrane-bound β-Klotho on peripheral blood CD4+ and CD8+ T lymphocytes of healthy subjects	2
Tumor treating fields: a new treatment for glioblastoma	2
High sensitive cardiac troponin: biological variation, circadian rhythm and diagnostic algorithms	2
Association between endometrial microbiome and implantation success in women with frozen embryo transfer: results of a prospective cohort study	2
Letter to the Editor concerning ‘cost-effectiveness of velmanase alfa vs. bone marrow transplantation or no causal therapy in patients with mild to moderate alpha-mannosidosis’	2
Genetic architecture of microhabitat adaptation traits in a pair of sympatric Primulina species	2
Determination of expression level of AP1S1, CDK9, FIGF and HDAC11 genes in bladder tumors for aggressive phenotype characterization	2
The impact of size for liposomes modified with pH-responsive β-glucan derivatives on the initiation of cellular and humoral immune responses in murine models	2
Genetic diversity and population structure analysis of wild kiwifruit ( Actinidia spp.) using SRAP markers	2
Prospective study of uveitis in children with juvenile idiopathic arthritis over a 3-year period	2
Impact of continuous cropping on tobacco growth, stress resistance, and soil microecological structure	2
Transferability of new methods for health technology assessment in the field of diabetes between early and late adopters’ countries	2
Improved drought tolerance in soybean by protein elicitor AMEP412 induced ROS accumulation and scavenging	2
Systematic identification and characterization of the soybean ( Glycine max ) B-box transcription factor family	2
Effect of 4 Hz and multifrequency pulsed electromagnetic field (PEMF) on bone fracture healing	2
Expression analysis of CsNAC30 gene in cucumber under drought stress	2
A novel TaqMan qPCR system for the detection of Diaporthe citri , the causative agent of citrus melanose	2
Genetic modifications to push L -tyrosine synthesis in Escherichia coli	2
The prospect of antimicrobial peptides from Bacillus species with biological control potential against insect pests and diseases of economic importance in agriculture, f	2
Detection of pathogenic variants in Alzheimer’s disease related genes in Bulgarian patients by pooled whole-exome sequencing	2
An appropriate unstructured kinetic model describing the batch fermentation growth ofDebaryomyces hanseniifor xylitol production using hydrolysis of oil palm empty fruit bunch	2
The wheat (Triticum aestiveum L.) MADS-box transcription factor TaMADS32 plays a role in response to abiotic stresses	2
Analysis on bacterial community structure of new and old fermented pit mud of Shedian Liquor	2
Ellagic acid for oral mucositis: investigation of the therapeutic effect in rats	2
State of the art and applications in nanostructured biocatalysis	2
Oligo-dT anchored cDNA-SRAP and cDNA-SCoT aided identification of transcripts differentially expressed during the early stages of recovery of resurrection plant Haberlea rhodopensis	2
Taxonomic and molecular characterization of 15 wild-growing tulip species of Greece using the internal transcribed spacer (ITS) nuclear marker in combination with the psb	2
Protein engineering of CMP kinases to improve thermal stability and resultant production of 3′-sialyllactose	2
Flaxseed protein isolate-alginate microbeads as encapsulating agents for enhanced survival of Enterococcus faecalis HZNU S1 during storage and in vitro	2
Thermal deactivation studies of alpha-amylase immobilized onto core-shell structured aniline formaldehyde crosslinked polyaniline magnetic nanocomposite	2
High rate of fluoroquinolone resistant Neisseria gonorrhoeae detected by molecular surveillance of antimicrobial resistance determinants in Bulgaria	2
Preoperative ultrasound assessment of myometrial invasion in endometrial cancer and prediction of surgical stage	2
Genetic diversity and phylogeography of Japanese brome ( Bromus japonicus Thunb. ex Murr.) populations in China	2
Effect of exogenous melatonin on salt stress in cucumber: alleviating effect and molecular basis	2
Design, synthesis and evaluation of semi- and thiosemicarbazides containing a methylxanthine moiety within vitroneuroprotective and MAO-B inhibitory activities	2
Transcriptome analysis unravels differential genes involved in essential oil content in callus and tissue culture seedlings of Lavandula angustifolia	2
Aquaponic systems: biological and technological parameters	2
Microsatellite unstable colorectal cancers are associated with increased CD1a- and CD83-positive dendritic cell infiltration	2
Correction	2
Hyperglycemia attenuates fibroblast contractility via suppression of TβRII receptor modulated α-smooth muscle actin expression	2
Review on the NGS-based studies of microbiotas of artisanal and regional kinds of cheese with potential as functional foods: composition and functional analysis	2
Pituitary apoplexy associated with COVID-19 infection: review and a case report	2
Bacillus velezensis R22 inhibits the growth of multiple fungal phytopathogens by producing surfactin and four fengycin homologues	2
35-bp deletion in ABCG2 gene: mini-review and report on two herds of Bulgarian dairy synthetic population sheep breed	2