OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology & Biotechnological Equipment is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
STING-associated vasculopathy with onset in infancy: the first case in Bulgaria and review of the literature	47
Structure and features of the complete chloroplast genome of Salix triandroides (Salicaceae)	23
Implementation of DPYD testing in Bulgarian patients with cancer	22
Decolourization of synthetic dyes by laccase produced from Bacillus sp. NU2	22
GPC3 as a potential diagnostic and prognostic marker for lung adenocarcinoma	21
Endodontic and surgical treatment of chronic apical periodontitis: a randomized clinical study	20
Detection of chicken adulteration in beef via ladder-shape melting temperature isothermal amplification (LMTIA) assay	19
Fermentation medium optimization, molecular modelling and docking analysis of the alginate lyase of a novel Pseudomonas sp. LB56 isolated from seaweed waste	19
Experimental temperature evaluation during a robotized bone drilling process	18
Assaying for antiviral activity of the folkloric medicinal desert plant Rhazya stricta on coronavirus SARS-CoV-2	18
Identification and estimation of sequence variation dynamics of Tomato Leaf curl Palampur virus and betasatellite complex infecting a new weed host	17
Effect of mobile phone usage duration during pregnancy on the general motor movements of infants	17
Analysis of contrast sensitivity in patients implanted with Acunex Vario and LuxSmart extended depth of focus (E-DOF) intraocular lenses (IOLs)	13
A comparison of dropout rate of three commonly used single cell RNA-sequencing protocols	11
The rhizosphere of the pioneer plant Dicranopteris dichotoma (Thunb.) Bernh. contains powerful and robust rhizosphere growth-promoting bacteria	11
High cross-pollination rate of Greek oregano ( O. vulgare ssp. hirtum ) with Common oregano ( O. vulgare ss	11
An algorithm and application to efficiently analyse DNA fibre data	11
Costs of treating type 2 diabetes mellitus and its complications	11
Time-course RNA-seq analysis provides an improved understanding of genetic regulation in response to cold stress from white clover (Trifolium repens L.)	10
Development and application of HPV31-specific monoclonal antibodies	10
SARS-CoV-2 variants and genomic surveillance in the low-resource north-west region of Pakistan	9
AcdS gene of Bacillus cereus enhances salt tolerance of seedlings in tobacco (Nicotiana tabacum L.)	9
Leber’s hereditary optic neuropathy: clinical and genetic analysis of Bulgarian patients	9
Diagnostic value of hybrid perfusion SPECT/CT and CTPA for detection of pulmonary embolism	9
Review and a case of rare Rosai-Dorfman disease	9

Toxicity and degradation of 2,4,6-trinitrotoluene in transgenic Arabidopsis expressing Citrobacter freundii nitroreductase	8
YKL-40 and LAMPs as possible markers in neuroinflammation and autophagy during central nervous system infections	8
Mining public genomic databases for novel lanthipeptides: a case study on Bacillus amyloliquefaciens	8
3.5 GHz radiofrequency radiation may affect biomechanics of bone and muscle of diabetics	8
Overexpression of MYB transcription factor LrAN2 from Lycium ruthenicum activated the anthocyanin biosynthesis in the leaf and fruit of	8
West Nile virus meningoencephalitis and cytokines analysis: review and case report	8
Antiviral activity of Humulus lupulus (HOP) aqueous extract against MERS-CoV and SARS-CoV-2: in-vitro and in-silico study	7
Genome-wide analysis of the GRAS gene family in white clover ( Trifolium repens L.) provides insight into its critical role in response to cold stress	7
A novel prediction method for protein DNA-binding residues based on neighboring residue correlations	7
Refractive results after cataract surgery in patients: calculation with Holladay II and Barrett Universal II formulas	7
Study on patients with Clostridioides difficile infection during the COVID-19 pandemic in Bulgaria	7
Combinations of mild chemical and bacterial pretreatment for improving enzymatic saccharification of corn stover	6
Functional characterization of Medicago truncatula GRAS7, a member of the GRAS family transcription factors, in response to abiotic stress	6
Diversity of nirS and nirK denitrifying bacteria in rhizosphere and non-rhizosphere soils of halophytes in Ebinur Lake Wetland	6
Metabolic profiling of probiotic strain Lactobacillus delbrueckii subsp. bulgaricus L14 cultivated in presence of prebiotic oligosaccharid	6
Inhibitory effect of pentoxifylline on the synthesis and deposition of glycosaminoglycans in hypothyroid skin	6
Improvement of the antibacterial and skin-protective performance of alcohol-based sanitizers using hydroglycolic phytocompounds	6
Cost/effectiveness of elivaldogene autotemcel vs. hematopoietic stem cells transplantation in patients with cerebral adrenoleukodystrophy (CALD)	6
Development and validation of a functional molecular marker for a CaAPRR2-like gene that controls green fruit colour in pepper	5
Genetic analysis of yield and yield contributing traits in rice (Oryza sativa L.) BC₂F₃ population derived from MR264 × PS2	5
Synthesis, antiproliferative and antimicrobial activities of (KLAKLAK) ₂ -NH ₂ analogue containing nor-Leu and its conjugates with	5
Evaluation of advanced protein oxidation and RAGE gene variants in the risk of laryngeal cancer	5
Research and pilot analysis of bevacizumab repurposing potential and its impact in clinical practice	5
The common bean (Phaseolus vulgaris) SULTR gene family: genome-wide identification, phylogeny, evolutionary expansion and expression patterns	5
COVID-19 vaccination and potential predictors for vaccination among students in Bulgarian medical universities	5
Promoting effect of biogenic AgNPs on Echinops macrochaetus for improving growth parameters and mitigating the toxic effect caused by salinity stress	5
Cytokines levels in saliva in periodontitis, oral potentially malignant disorders and squamous cell carcinoma	5
Whole genome sequencing and functional analysis of porcine-borne Bacillus coagulans LYBC06	5
Role of pharmacists in adherence in oncology patients	4
Surveillance over cytomegalovirus (CMV) reactivation following hematopoietic stem cell transplantation: a single-center experience	4
Research advance and clinical implication of circZNF609 in human diseases	4
Optimization of intracellular L-Asparaginase production by Streptomyces paulus CA01 isolated from wheat bran using the response surface methodology	4
Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study	4
SRAP markers for characterization of the genetic diversity and differentiation of Pinus nigra populations in protected forested areas in Bulgaria, Greece, and Cyprus	4
35 blood and urine biomarkers in Polycystic Kidney Disease: a bidirectional Mendelian randomization study	4
Nanodiamonds improve amaranth biodegradation in a lab-scale biofilter	4
Production and biochemical characterization of keratinase enzyme from Bacillus subtilis ES5 and its potential application in leather dehairing process: a clean leather t	4
Cost-effectiveness of therapeutic drug monitoring (TDM) of biologic treatment in rheumatic diseases: a narrative review	4
Chemical composition, antimicrobial and anticancer activities of Paederia lanuginosa WALL	4
Inhibiting immune escape in lung adenocarcinoma: the role of SPARC in suppressing CD276 function	4
Analysis of cytokinin content and associated genes at different developmental stages in pak choi (Brassica rapa ssp. chinensis Makino)	4
The concept for the antivirulence therapeutics approach as alternative to antibiotics: hope or still a fiction?	4
Polymorphism in SNP G1 of the GDF9 gene associated with reproductive traits in Bulgarian dairy sheep	4
Analyzing real-world data to understand COVID-19 vaccination effects on hospitalization rates in patients with solid malignancies	4
Deep learning in oral surgery for third molar extraction: empirical evidence and original model	4
Microbial functional diversity in rhizosphere and non-rhizosphere soil of different dominant species in a vegetation concrete slope	3
Extensive characterization of COVID-19 convalescent plasma from Bulgarian donors	3
Adequate effectiveness of ribociclib plus letrozole or fulvestrant in patients with advanced or metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer tr	3
Bacterial functional responses to environmental variability: a case study in three distinct mountain lakes within a single watershed	3
C-peptide levels and glycemic indices in COVID-19 patients	3

Micropropagation of guava ( Psidium guajava ) seedlings, a plant with interest in cool subtropics, using an innovative BB culture medium	3
Kawasaki disease with giant coronary aneurysms formation in a 3-month old infant: a case report and review of the literature	3
Genome sequence of Bacillus velezensis LZN01 inhibiting Fusarium oxysporum f. sp. niveum and producing myri	3
An overview of the role of MMP-8 and ADAM-33 in bronchial asthma	3
Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants	3
Antibacterial potential of Piper nigrum L. essential oil targeting FtsZ, GyrB, murA, and PTP proteins: in silico study	3
Innovative technological advancements in laboratory medicine: Predicting the lab of the future	3
On disagreements of theories of evolution	3
Investigation of soil microbiota reveals variable dominant species at different land areas in China	3
A galantamine–curcumin hybrid lacks the depressant side effect of acetylcholinesterase inhibitors	3
Sex-specific functional effect of IL-12 gene polymorphisms in brain tumours	3
In silico analysis of Hsp70 genes in Ctenopharyngodon idella and their expression profiles in response to environmental stresses	3
Impact of CYP3A7, CYP2D6 and ABCC2/ABCC3 polymorphisms on tacrolimus steady state concentrations in Bulgarian kidney transplant recipients	3
Plant extracts and Trichoderma spp: possibilities for implementation in agriculture as biopesticides	3
Combined diabetes and chronic stress exacerbates cytokine production and oxidative stress in rat liver and kidney	3
What food will we be eating on our journey to Mars?	3
Genome-wide identification and expression analysis of tomato glycoside hydrolase family 1 β-glucosidase genes in response to abiotic stresses	3
Genome-wide identification, phylogeny and expression analyses of group III WRKY genes in cotton (Gossypium hirsutum)	3
Astragalus glycyphyllos L.: antiviral activity and tablet dosage formulation of a standardized dry extract	3
Investigation of IDO1 and TDO2 expression in breast tumors by immunohistochemistry and real-time polymerase chain reaction methods	3
A novel characterization of alginate-attapulgite-calcium carbonate (AAC) gel adsorption in bacterial biodegradation of used engine oil (UEO)	3