OOIR: Observatory of International Research

Papers

(The TQCC of Allergology International is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Efficacy and safety of systemic targeted therapies for atopic dermatitis in children: A systematic review and meta-analysis	149
Three-year prognoses after low-dose oral food challenge for cow's milk	123
Exacerbated signs of atopic dermatitis with gut dysbiosis predominate in male than in female adult patients	105
Effects of raw seafood on the risk of hypersensitivity reaction recurrence in patients with an Anisakis allergy: A retrospective observational study in Japan	84
Investigator-initiated, multi-center, single-arm, open-label study of the effectiveness of canakinumab in Japanese patients with Schnitzler syndrome	81
Topical application of activator protein-1 inhibitor T-5224 suppresses inflammation and improves skin barrier function in a murine atopic dermatitis-like dermatitis	72
Analysis of drug-induced anaphylaxis cases using the Japanese Adverse Drug Event Report (JADER) database – secondary publication	60
IL-33-induced keratoconjunctivitis is mediated by group 2 innate lymphoid cells in mice	53
Advantage of spirometry over oscillometry to detect dupilumab's effect on small airway dysfunction	51
A diagnostic score for eosinophilic granulomatosis with polyangiitis among eosinophilic disorders	49
Peripheral itch sensitization in atopic dermatitis	47
Real-world safety and effectiveness of omalizumab in Japanese patients with chronic spontaneous urticaria: A post-marketing surveillance study	42
Novel inhibitors of histamine-releasing factor suppress food allergy in a murine model	39
The immune network across organs	37
Epidemiology and risk factors of non-esophageal eosinophilic gastrointestinal diseases in Japan: A population-based study	35
Japanese cedar pollen sublingual immunotherapy is effective in treating seasonal allergic rhinitis during the pollen dispersal period for Japanese cedar and Japanese cypress	34
Emerging cell and molecular targets for treating mucus hypersecretion in asthma	33
Fibrin and fibrinogen degradation products/D-dimer ratio can be a useful marker for differentiating an acute attack of hereditary angioedema from thrombotic conditions	28
Exacerbation rates in Japanese patients with obstructive lung disease: A subanalysis of the prospective, observational NOVELTY study	25
Filaggrin-deficient rats generated using zinc-finger nucleases spontaneously exhibit dry scaly skin	25
Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung	24
Mucus plugging on computed tomography and the sputum microbiome in patients with asthma, chronic obstructive pulmonary disease, and asthma-COPD overlap	22
A message from the new Editor-in-Chief	22
Factors contributing to the diagnosis and onset prediction of perennial allergic rhinitis in high-risk children: A sub-analysis of the CHIBA study	22
Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma	21

Skin barrier defects in atopic dermatitis: From old idea to new opportunity	21
Urticaria and basophils	20
Activated steady status and distinctive FcεRI-mediated responsiveness in basophils of atopic dermatitis	19
Real-life long-term safety and effectiveness of omalizumab in Japanese pediatric patients with severe allergic asthma: A post-marketing surveillance	19
Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation	19
Addictive behavior is not a comorbidity of chronic spontaneous urticaria	19
A micropeptide TREMP encoded by lincR-PPP2R5C promotes Th2 cell differentiation by interacting with PYCR1 in allergic airway inflammation	19
Improvement of atopic dermatitis-like symptoms in a murine model via the chromogranin A-derived peptide catestatin	19
Refractory dermatomyositis which developed in a patient with silicone breast implants	18
Mouse hygiene status–A tale of two environments for mast cells and allergy	18
Functional gastrointestinal disorders are associated with capsaicin cough sensitivity in severe asthma	18
Classifications of moderate to severe asthma phenotypes in Japan and analysis of serum biomarkers: A Nationwide Cohort Study in Japan (NHOM Asthma Study)	18
Critical pathomechanisms of NSAID-exacerbated respiratory disease (N-ERD) clarified by treatment with omalizumab, an anti-IgE antibody	18
Executive summary: Japanese pediatric guideline for the treatment and management of asthma (JPGL) 2020	17
Thymus and activation-regulated chemokine elevation in a child with acute generalized exanthematous pustulosis	17
Green tea-induced anaphylaxis: The first pediatric case report	17
Efficacy, pharmacokinetics, and safety of subcutaneous C1-esterase inhibitor as prophylaxis in Japanese patients with hereditary angioedema: Results of a Phase 3 study	17
Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic	17
Real-world effectiveness of mepolizumab in Japanese asthma patients with diverse backgrounds: Improvements in rhinosinusitis imaging (J-Real-Mepo)	16
Effectiveness of mucus plug removal by bronchoscopy for typical high-attenuation mucus with allergic bronchopulmonary mycosis	16
Wheezing trajectories from childhood to adulthood in a population-based cohort	16
Dupilumab improves eosinophilic otitis media associated with eosinophilic chronic rhinosinusitis	16
Current situation of anaphylaxis in Japan: Data from the anaphylaxis registry of training and teaching facilities certified by the Japanese Society of Allergology – secondary publication	16
Summary of the current status of clinically diagnosed cases of Schnitzler syndrome in Japan	15
Claudin-3 deficiency inhibits allergic responses in an ovalbumin-induced asthma mouse model	14
Role of nasal polyp-derived innate lymphoid cells in staphylococcal enterotoxin-induced cellular responses	14
Long-term impact of a birch/alder/hazel or birch-only liquid sublingual immunotherapy on birch-family pollen respiratory allergy: A real-world study	14
Current topics on urticaria, and urticaria-related diseases introduced in the Japanese urticaria clinical practice guidelines	14
Serum level of hemokinin-1 is significantly lower in patients with chronic spontaneous urticaria than in healthy subjects	14
Respiratory sensitization to insect allergens: Species, components and clinical symptoms	13
Fall birth is associated with prolonged elimination in Japanese children with hen's egg allergy: A population-based study	13
Gut microbiota of one-and-a-half-year-old food-allergic and healthy children	13
Recent progress in allergen immunotherapy	13
A case of organizing pneumonia in an asthmatic patient treated with benralizumab	13
Impact of the COVID-19 pandemic on asthma exacerbations in children: A multi-center survey using an administrative database in Japan	12
Dysbiosis of the human skin mycobiome in patients receiving systemic IL-23 inhibitors	12
Successful concomitant therapy with mepolizumab and dupilumab for atypical eosinophilic granulomatosis with polyangiitis	12
The dual aspects of IgD in the development of tolerance and the pathogenesis of allergic diseases	11
Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1	11
Two cases of edible cricket allergy: Antigen analysis and cross-reactivity with shrimp and mite allergens	11
Elevated MS4A2 and IgE interaction in nasal polyps contributing to poor postoperative prognosis in patients with eosinophilic chronic rhinosinusitis	11
Lipocalin-2 promotes neutrophilic inflammation in nasal polyps and its value as biomarker	11
T follicular helper cells and IgE	11
Cluster analysis of phenotypes, job exposure, and inflammatory patterns in elderly and nonelderly asthma patients	11
In vitro cross-reactivity between hen's egg and quail's egg in children with hen's egg allergy	11
Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma	11
Small airway dysfunction in asthma based on oscillometry	11
Control of immunity and allergy by steroid hormones	11
A 60-minute dosing interval is safer than a 30- or 40-minute interval in oral food challenge	10
Group 2 innate lymphoid cells in human asthma	10

Analysis of the relationship between comorbid obstructive sleep apnea and clinical outcomes in patients with asthma in Japan	10
Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives	10
Hyper-IgE syndrome, 2021 update	10
Potential determinants of T helper 2 markers and their distribution in school-aged children	10
Detrimental impact of the IL-33/ST2 axis in an animal infection model with Cryptococcus neoformans	10
Allergic bronchopulmonary mycosis associated with a novel pathogen: Bjerkandera adusta	10
Blood eosinophil count variability in chronic obstructive pulmonary disease and severe asthma	10
S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis	10
A clinical and canine experimental study in small-airway response to bronchial thermoplasty: Role of the neuronal effect	10
Multiple at-risk groups have lower lung function during the grass pollen season	9
Innovation in the treatment of atopic dermatitis: Emerging topical and oral Janus kinase inhibitors	9
Biologics for severe asthma: The real-world evidence, effectiveness of switching, and prediction factors for the efficacy	8
Welcome to “Circadian Immunology & Allergology”: Why timing matters in diagnosing and treating allergies	8
Dust mite-dominant sensitization pattern as a causal factor for adult-onset asthma	8
Characteristics of food protein-induced enterocolitis syndrome with metabolic acidosis: A case–control study	8
Gut microbiota and fecal metabolites in sustained unresponsiveness by oral immunotherapy in school-age children with cow's milk allergy	8
Delayed drug hypersensitivity reactions: How p-i transforms pharmacology into immunology	8
Multiple fixed drug eruption due to carbocysteine: Presence of circulating interferon-γ-producing CD8+ T cells reactive with its night metabolite thiodiglycolic acid	8
Inborn errors of immunity with eosinophilia	8
Executive summary: Japanese guidelines for allergic rhinitis 2020	8
Neuro-immune crosstalk and food allergy: Focus on enteric neurons and mucosal mast cells	8
15-Hydroxyeicosatrienoic acid induces nasal congestion by changing vascular functions in mice	8
Tolerability and safety of a new elimination diet for pediatric eosinophilic gastritis and duodenitis	8
Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms	8
Questionnaire for diagnosing asthma-COPD overlap in COPD: Development of ACO screening questionnaire (ACO-Q)	8
Real-world impact of dupilumab on asthma disease burden in Japan: The CROSSROAD study	8
Management of severe asthma during the COVID-19 pandemic: A retrospective study using a Japanese database	8
Contribution of monocyte and macrophage extracellular traps to neutrophilic airway inflammation in severe asthma	8
Distinct subsets of innate lymphoid cells in nasal polyp	8
Skin testing and challenge in patients with immediate hypersensitivity reactions to gadolinium-based contrast agents identify safe future options	8
Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients	8