OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Natural Medicines is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis	57
Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway	35
Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus	30
Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota	24
Cytotoxic activities of sesquiterpenoids from the aerial parts of Petasites japonicus against cancer stem cells	21
Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1	20
The search for, and chemistry and mechanism of, neurotrophic natural products	19
Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases	19
Lateral flow immunoassay for small-molecules detection in phytoproducts: a review	18
A novel challenge of nondestructive analysis on OGATA Koan’s sealed medicine by muonic X-ray analysis	18
Characteristic metabolites of Hypericum plants: their chemical structures and biological activities	17
Sedative effects of l-menthol, d-camphor, phenylethyl alcohol, and geraniol	17
A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia	17
Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway	16
Structure and anticancer activity of a new lectin from the cultivated red alga, Kappaphycus striatus	15
Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study	15
Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU	15
Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells	15
The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro	14
Characterization of metabolites in Saposhnikovia divaricata root from Mongolia	14
Cell death-inducing activities via Hsp inhibition of the sesquiterpenes isolated from Valeriana fauriei	13
Bufadienolides and ecdysteroids from the whole plants of Helleborus niger and their cytotoxicity	13
Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell	13
Camalexin, an indole phytoalexin, inhibits cell proliferation, migration, and mammosphere formation in breast cancer cells via the aryl hydrocarbon receptor	13
Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack	13

Phytochemical studies on traditional herbal medicines based on the ethnopharmacological information obtained by field studies	13
Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia	13
Bisindole alkaloids from Voacanga grandifolia leaves	13
Magnolol upregulates CHRM1 to attenuate Amyloid-β-triggered neuronal injury through regulating the cAMP/PKA/CREB pathway	12
Thiolane-type sulfides from garlic, onion, and Welsh onion	12
Inhibitory effect of ergosterol on bladder carcinogenesis is due to androgen signaling inhibition by brassicasterol, a metabolite of ergosterol	12
Triterpenoids from Walsura trichostemon	12
Caffeic acid and rosmarinic acid contents in genus Perilla	12
PTP1B and α-glucosidase inhibitors from Selaginella rolandi-principis and their glucose uptake stimulation	12
The acrid raphides in tuberous root of Pinellia ternata have lipophilic character and are specifically denatured by ginger extract	11
4β-Hydroxywithanolide E and withanolide E from Physalis peruviana L. inhibit adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion	11
Marine natural products that inhibit osteoclastogenesis and promote osteoblast differentiation	11
Epoxyquinophomopsins A and B from endophytic fungus Phomopsis sp. and their activity against tyrosine kinase	10
EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol	10
Antiangiogenic effects of AG36, a triterpenoid saponin from Ardisia gigantifolia stapf.	10
Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke (Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins	10
Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC–MS analysis and phytochemical investigation	10
Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway	10
Macrocarquinoids A–C, new meroterpenoids from Sargassum macrocarpum	9
Leveraging knowledge of Asian herbal medicine and its active compounds as COVID-19 treatment and prevention	9
Simultaneous UHPLC/MS quantitative analysis and comparison of Saposhnikoviae radix constituents in cultivated, wild and commercial products	9
Prenylflavonoids from fruit of Macaranga tanarius promote glucose uptake via AMPK activation in L6 myotubes	9
Amyloid β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus pruinosus	9
Effects of clovamide and its related compounds on the aggregations of amyloid polypeptides	9
Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications	9
Tigliane and daphnane diterpenoids from Thymelaeaceae family: chemistry, biological activity, and potential in drug discovery	9
Analysis of anti-obesity and anti-diabetic effects of acacia bark-derived proanthocyanidins in type 2 diabetes model KKAy mice	9
Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina	9
UHPLC-MS-based metabolomic approach for the quality evaluation of Pinellia ternata tubers grown in shaded environments	9
Five matrine-type alkaloids from Sophora tonkinensis	9
Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity	9
The hepatoprotective efficacy and biological mechanisms of three phenylethanoid glycosides from cistanches herba and their metabolites based on intestinal bacteria and network pharmacology	9
Appetite-enhancing effects of inhaling cinnamon, clove, and fennel essential oils containing phenylpropanoid analogues	9
Comparison of various commercially available cinnamon barks using NMR metabolomics and the quantification of coumarin by quantitative NMR methods	9
Metabolic fingerprinting for discrimination of DNA-authenticated Atractylodes plants using 1H NMR spectroscopy	9
Polypunctosides E-K: seven new steroidal saponins from Polygonatum punctatum Royle ex Kunth and their nitric oxide production inhibitory activities	8
Anti-inflammatory canthin-6-one alkaloids from the roots of Thailand Eurycoma longifolia Jack	8
Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts	8
Anti-insulin resistance effect of constituents from Senna siamea on zebrafish model, its molecular docking, and structure–activity relationships	8
Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan	8
Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice	8
Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway	8
Relationship between ephedrine alkaloid profile in Ephedra gerardiana and soil characteristics of glacial landforms in southeastern Tibetan Plateau, China	8
Identification of herbal components as TRPA1 agonists and TRPM8 antagonists	8
Complanadine F, a novel dimeric alkaloid from Lycopodium complanatum	8
Environmental and soil characteristics in Ephedra habitats of Uzbekistan	8
Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/β-catenin pathway	8
Walsogynes H–O from Walsura chrysogyne	8
One-pot enantioselective synthesis of (S)-spirobrassinin and non-natural (S)-methylspirobrassinin from amino acids using a turnip enzyme	8
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway	8

Cliniatines A–C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase	8
Essential oils from Melia azedarach L. (Meliaceae) leaves: chemical variability upon environmental factors	7
Magnolol inhibits myotube atrophy induced by cancer cachexia through myostatin signaling pathway in vitro	7
Quality evaluation of Angelicae acutilobae radix: individual differences and localization of (Z)-ligustilide in Angelica acutiloba root	7
Saponin constituents of Achyranthes root	7
Dihydroartemisinin inhibited the Warburg effect through YAP1/SLC2A1 pathway in hepatocellular carcinoma	7
Diversity in principal constituents of plants with a lemony scent and the predominance of citral	7
Design and synthesis of analogues of RA-VII—an antitumor bicyclic hexapeptide from Rubiae radix	7
Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2	7
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder	7
Solubility enhancement of berberine–baicalin complex by the constituents of Gardenia Fruit	7
Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3β/β-catenin transduction pathway	7
New biofunctional effects of oleanane-type triterpene saponins	7
Physical and chemical characteristics of soils in Ephedra gerardiana and E. pachyclada habitats of Kali Gandaki Valley in Central Nepal	7
Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium	7
Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship	7
Iridoids isolated from Viticis Fructus inhibit paclitaxel-induced mechanical allodynia in mice	7
Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans	7
Anthraquinone-containing compound in rhubarb prevents indole production via functional changes in gut microbiota	6
Alginic acid inhibits non-small cell lung cancer-induced angiogenesis via activating miR-506 expression	6
Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease	6
Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana	6
Genomics-directed activation of cryptic natural product pathways deciphers codes for biosynthesis and molecular function	6
Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1	6
Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital	6
Triterpenoids from Celastrus orbiculatus Thunb. inhibit RANKL-induced osteoclast formation and bone resorption via c-Fos signaling	6
Structural revision of sesbagrandiflorains A and B, and synthesis and biological evaluation of 6-methoxy-2-arylbenzofuran derivatives	6
Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats	6
β-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha	6
Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes	6
Seasonal variation of alkaloids and polyphenol in Ephedra sinica cultivated in Japan and controlling factors	6
Antimalarial ceramicines Q-T from Chisocheton ceramicus	6
Screening for inhibitory effects of crude drugs on furin-like enzymatic activities	6
Discovery and investigation of natural Diels–Alderases	6
Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice	6
Phytomedicinal therapeutics for male infertility: critical insights and scientific updates	6