OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Natural Medicines is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Ecological and pharmacognostical characteristics in Ephedra saxatilis in the Yarlung Zangbo River Valley of southeastern Tibetan Plateau, China	36
Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity	27
Chlorinated illudalane sequiterpenoids from Saxiglossum angustissimum	25
Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content	24
Apoptosis-inducing activity of a steroidal glycoside from Allium chinense G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress	21
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells	21
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder	21
Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber	20
Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius	19
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in Aconitum japonicum	18
Mosloflavone induces pancreatic α cells transdifferentiation into β cells through PDX1	16
Betulinic acid increases brain-derived neurotrophic factor expression via the PKA, NMDA receptor, and calcineurin pathways in cultured cortical neurons	16
Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation	16
Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.)	15
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway	15
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis	14
A novel mechanism for treating acute lung injury with ligustilide: elucidation via network pharmacology and in vitro validation	14
Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood	14
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability	14
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds	13
Mechanism study of the effects of astragaloside IV and quercetin on idiopathic pulmonary fibrosis	13
Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes	13
Calycosin ameliorates inflammation and M1 macrophage polarization via Spon2 in LPS-triggered MH-S alveolar macrophages	13
Alcoholic extract of Salvia castanea Diels f. tomentosa Stib. ameliorates hypobaric hypoxia-induced right ventricular hypertrophy by inhibiting the P53-SAT1-ALOX15 pathway and up-regulating the SLC7A1	13
Panaxindole, a novel indole alkaloid N-glucoside from the leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng)	13

Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina	13
Rapid determination of heavy metals and arsenic in herbal medicines using energy-dispersive X-ray fluorescence spectrometry	12
HPLC analysis of ammonium glycyrrhizate listed in the European, United States, and Japanese Pharmacopoeias under reported and modified conditions: revision of the peak assignment for 18α-glycyrrhizin	12
Ginsenoside Rh3-induced neurotoxicity involving the IP3R-Ca2+/NOX2/NF-κB signaling pathways	12
Saponins from cactus and their inhibitory effects on amyloid β aggregation	12
17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1	12
A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis	12
Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content	12
Nemophilosides A–I, nine meroterpenoid glucosides isolated from Nemophila menziesii	11
Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy	11
Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia	11
Polysaccharides from Lentinus edodes prevent acquired drug resistance to docetaxel in prostate cancer cells by decreasing the TGF-β1 secretion of cancer-associated fibroblasts	11
Development of a determination method for quality control markers utilizing metabolic profiling and its application on processed Zingiber officinale Roscoe rhizome	11
Correction: Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship	11
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation	11
Promotion of neurite outgrowth by 3,5,7,3ʹ,4ʹ-pentamethoxyflavone is mediated through ERK signaling pathway in Neuro2a cells	10
Antioxidative effects of diarylheptanoids	10
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway	10
Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata	10
Herbal medicine for melanin regulation: biological synthesis, effective formulas/compounds, and biopharmaceutical methods	10
Pharmacokinetics of seven major components in Aβ1-42-treated rats after oral administration of an aqueous extract of Curculiginis Rhizoma and Epimedii Folium	10
Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation	9
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway	9
Correction to: Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients	9
Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds	9
Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway	9
Meroterpenoids with BACE1-inhibitory activity from the fruiting bodies of Suillus bovinus and Boletinus cavipes	9
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities	9
Exploring the biological tissue toxicity and related toxic components of Euodiae Fructus through the multi-tissue spectrum–toxicity relationship	9
Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction	9
Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino	8
Rhein alleviates advanced glycation end products (AGEs)-induced inflammatory injury of diabetic cardiomyopathy in vitro and in vivo models	8
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway	8
Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents	8
Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7	8
Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy	8
Ergostane-type steroids from mushrooms of Pleurotus genus	7
Comprehensive profiling of phytochemicals in the fruits of Gardenia jasminoides Ellis and its variety using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass sp	7
Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light	7
Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation	7
Two new β-carboline alkaloids from the roots of Anemone altaica	7
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro	7
Inhibitory effects of three genuine resin glycosides from Calystegia hederacea on in vitro porcine lipase assay and in silico docking simulation analysis	7
Anti-allergic actions and pharmacokinetics of orally administered 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in mice	7
Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
Correction: Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pat	6
Correction: Ellagic acid prevents ovariectomy-induced bone loss and attenuates oxidative damage of osteoblasts by activating SIRT1	6
Cathagines A–D, new bisindole alkaloids from Catharanthus roseus	6
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose	6

Ninjin’yoeito Kampo medicine enhances zebrafish endurance under forced-swimming conditions via muscle hypertrophy	6
Oleanane-type triterpene saponins promote extracellular vesicle secretion of human adipose-derived mesenchymal stem cells	6
Mechanisms underlying the dynamic changes in tannins associated with food processing and plant growth	6
Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation	6
Inhibitory effects of reumycin produced by Streptomyces sp. TPMA0082 on virulence factors of Pseudomonas aeruginosa	6
Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor	6
2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs	6
Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells	6
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways	6
Chemical and pharmaceutical evaluation of roasted Ephedra herba and elucidation of the health hazards caused by white smoke generated during processing	6
Optimizing blood–brain barrier permeability: the effect of wine processing on alkaloids in Phellodendri Chinensis Cortex	6
Identification and characterization of organic and glycosidic acids in the crude resin glycoside fraction from the leaves and stems of Calystegia japonica	6
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity	6
The pleiotropic anti-cancer, antiviral, and anti-neuro-immunomodulatory role of methanolic neem bark extract	6
Recent trends in ginseng research	5
Exploring new natural products by utilizing untapped secondary metabolic pathways in actinomycetes	5
Processed phellodendri Chinensis cortex attenuates diabetic nephropathy via ferroptosis inhibition through GPX4/SLC7A11/Nrf2/HO-1 signaling pathway	5
Unprecedented triterpenes with anti-inflammatory activity from Limax maximus	5
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro	5
Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase	5
The root bark of Paeonia suffruticosa alleviates Staphylococcus aureus-induced pneumonia in mice by modulating toxin secretion and function	5
Selective α-glucosidase inhibitory activity of (+)-eupenoxide and 3-ketone derivatives produced by the endophytic fungus of Aspergillus sp.	5
Four new lignans obtained from the leaves of Schisandra cauliflora and their effect on skeletal muscle cell proliferation	5
Correction: Ceramicines U–Z from Chisocheton ceramicus and structure–antimalarial activity relationship study	5
Isovincathicine from Catharanthus roseus induces apoptosis in A549 cells	5
Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases	5
Natural products that target p53 for cancer therapy	5
Screening and identification of reactive metabolic compounds of Cortex Periplocae based on glutathione capture-mass spectrometry	5
Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption	5
Dihydroartemisinin inhibited the Warburg effect through YAP1/SLC2A1 pathway in hepatocellular carcinoma	5
Correction: Visualizing the spatial distribution of ustalic acid in the fruiting body of Tricholoma kakishimeji	5
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression	5
Chemical quality evaluation and characteristics of interspecific hybrid (G. uralensis × G. glabra) C-18 strain as a new Licorice cultivar	5
Total flavonoids from Carthamus tinctorius L. inhibit the liver fibrosis progression via Hippo/YAP pathway	5
Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway	5
Interactions between turnover rate and bioactivity of atractylenolide III in Atractylodes macrocephala rhizome in the theory of crude drugs’ pairs and prescriptions in traditional Chinese and Japanese	5
Olive (Olea europaea) phenolics for the control of psoriasis via targeting SMYD2 and IL-17A protein–protein interaction networks	5
New biofunctional effects of oleanane-type triterpene saponins	5
Resveratrol as a BCL6 natural inhibitor suppresses germinal center derived Non-Hodgkin lymphoma cells growth	5
Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments	5
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells	5
The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse	5
Antimalarial ceramicines Q-T from Chisocheton ceramicus	5