OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Natural Medicines is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content	28
Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity	25
Ecological and pharmacognostical characteristics in Ephedra saxatilis in the Yarlung Zangbo River Valley of southeastern Tibetan Plateau, China	21
Eleven new C19-diterpenoid alkaloids from Delphinium elatum cv. Pacific Giant	20
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in Aconitum japonicum	18
Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation	17
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder	17
Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius	17
Chlorinated illudalane sequiterpenoids from Saxiglossum angustissimum	17
Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber	16
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells	16
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability	15
Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG	15
Anti-trypanosomal screening of Salvadoran flora	14
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis	14
Lateral flow immunoassay for small-molecules detection in phytoproducts: a review	14
Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.)	14
Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina	13
Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood	13
Panaxindole, a novel indole alkaloid N-glucoside from the leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng)	12
Factors affecting 2-(2-phenylethyl)chromones in artificial agarwood	12
HPLC analysis of ammonium glycyrrhizate listed in the European, United States, and Japanese Pharmacopoeias under reported and modified conditions: revision of the peak assignment for 18α-glycyrrhizin	12
A feruloylated acylglycerol isolated from Wikstroemia pilosa and its distribution in ten plants of Wikstroemia species	12
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds	12
Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes	12

Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia	11
Polysaccharides from Lentinus edodes prevent acquired drug resistance to docetaxel in prostate cancer cells by decreasing the TGF-β1 secretion of cancer-associated fibroblasts	11
Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content	11
Mechanism study of the effects of astragaloside IV and quercetin on idiopathic pulmonary fibrosis	11
Ginsenoside Rh3-induced neurotoxicity involving the IP3R-Ca2+/NOX2/NF-κB signaling pathways	11
Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish	11
Correction: Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship	10
Bie Jia Jian pill enhances the amelioration of bone mesenchymal stem cells on hepatocellular carcinoma progression	10
Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy	10
Walsogynes H–O from Walsura chrysogyne	10
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation	10
Development of a determination method for quality control markers utilizing metabolic profiling and its application on processed Zingiber officinale Roscoe rhizome	10
17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1	10
Pharmacokinetics of seven major components in Aβ1-42-treated rats after oral administration of an aqueous extract of Curculiginis Rhizoma and Epimedii Folium	9
Correction to: Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients	9
Meroterpenoids with BACE1-inhibitory activity from the fruiting bodies of Suillus bovinus and Boletinus cavipes	9
Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata	9
Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines	9
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway	8
Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation	8
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities	8
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway	8
Promotion of neurite outgrowth by 3,5,7,3ʹ,4ʹ-pentamethoxyflavone is mediated through ERK signaling pathway in Neuro2a cells	8
Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds	8
Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7	8
Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents	8
Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction	8
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway	8
Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway	8
Ergostane-type steroids from mushrooms of Pleurotus genus	8
Rhein alleviates advanced glycation end products (AGEs)-induced inflammatory injury of diabetic cardiomyopathy in vitro and in vivo models	8
Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro	7
Identification and characterization of organic and glycosidic acids in the crude resin glycoside fraction from the leaves and stems of Calystegia japonica	7
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity	7
22-O-(N-Boc-l-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial–mesenchymal transition in human lung cancer cells	7
Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation	7
Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF-κB	7
Inhibitory functions of cornuside on TGFBIp-mediated septic responses	7
Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites	7
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose	7
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pat	7
Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells	7
Two new β-carboline alkaloids from the roots of Anemone altaica	7
Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy	7
Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino	7
Picrotoxane sesquiterpene and α-pyrone derivative from Dendrobium signatum and their free radical scavenging potency	7
Shorter and more efficient pretreatment for germination of perilla mericarps	7
Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light	7
Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients	7

Correction: Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron	7
Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications	7
Comprehensive profiling of phytochemicals in the fruits of Gardenia jasminoides Ellis and its variety using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass sp	7
Four new lignans obtained from the leaves of Schisandra cauliflora and their effect on skeletal muscle cell proliferation	6
The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse	6
Natural products that target p53 for cancer therapy	6
Exploring new natural products by utilizing untapped secondary metabolic pathways in actinomycetes	6
Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides	6
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways	6
Inhibitory effects of reumycin produced by Streptomyces sp. TPMA0082 on virulence factors of Pseudomonas aeruginosa	6
Diversity in principal constituents of plants with a lemony scent and the predominance of citral	6
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells	6
Correction to: Leveraging knowledge of Asian herbal medicine and its active compounds as COVID-19 treatment and prevention	6
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro	6
Nacre extract from pearl oyster attenuates amyloid beta-induced memory impairment	6
New biofunctional effects of oleanane-type triterpene saponins	6
Cathagines A–D, new bisindole alkaloids from Catharanthus roseus	6
2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs	6
Antimalarial ceramicines Q-T from Chisocheton ceramicus	6
Recent trends in ginseng research	6
Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption	6
Screening and identification of reactive metabolic compounds of Cortex Periplocae based on glutathione capture-mass spectrometry	6
Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU	6
Chemical quality evaluation and characteristics of interspecific hybrid (G. uralensis × G. glabra) C-18 strain as a new Licorice cultivar	6
Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation	6
Oleanane-type triterpene saponins promote extracellular vesicle secretion of human adipose-derived mesenchymal stem cells	6
Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway	6
Isovincathicine from Catharanthus roseus induces apoptosis in A549 cells	6