OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Natural Medicines is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Two new β-carboline alkaloids from the roots of Anemone altaica	41
Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC50: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation	24
Potential α-glucosidase inhibitors from cultures of Biscogniauxia capnodes SWUF15-40 fungus	24
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus	22
Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan	21
Biotransformation of ginsenoside Rb1 and Rd to four rare ginsenosides and evaluation of their anti-melanogenic effects	19
Cryptadine C, a new C27N3-type Lycopodium alkaloid from Lycopodium cryptomerinum	18
Growth characteristics, optimal harvest timing, and quality assessment of three Evodia species cultivated in Japan	17
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder	17
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells	17
Antibiofilm activity of marine microbial natural products: potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens	16
Ligustilide enhances pregnancy outcomes via improvement of endometrial receptivity and promotion of endometrial angiogenesis in rats	16
Podocarpusflavone alleviated renal fibrosis in obstructive nephropathy by inhibiting Fyn/Stat3 signaling pathway	16
Investigation of microsatellite loci for the identification of registered varieties of Perilla frutescens and a discussion on the ancestor species of P. frutescens	15
Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity	15
Correction to: The ability of callus tissues induced from three Allium plants to accumulate health-beneficial natural products, S-alk(en)ylcysteine sulfoxides	14
Anti-Helicobacter pylori activity of swertianolin, isolated from swertia herb	13
Hepatoprotective functions of jujuboside B	13
The extract based on the Kampo formula daikenchuto (Da Jian Zhong Tang) induces Bdnf expression and has neurotrophic effects in cultured cortical neurons	13
Effects of Ephedra Herb extract on the expression of EGFR-activating mutations and c-Met in non-small-cell lung cancer cell line, H1975, and its combined effects with osimertinib	13
Publisher Correction: New biofunctional effects of oleanane-type triterpene saponins	13
Genetic identification of the original plant species for Mentha Herb listed in the Japanese Pharmacopoeia and analyses of their essential oil composition	12
Eumitrins I–K: three new xanthone dimers from the lichen Usnea baileyi	12
Cinnamon bark extract suppresses metastatic dissemination of cancer cells through inhibition of glycolytic metabolism	11
Integerrima A–E, phenylethanoid glycosides from the stem of Callicarpa integerrima	11

Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation	11
Comprehensive profiling of phytochemicals in the fruits of Gardenia jasminoides Ellis and its variety using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass sp	11
Non-carcinogenic/non-nephrotoxic aristolochic acid IVa exhibited anti-inflammatory activities in mice	11
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in Aconitum japonicum	11
Effect of glucoglycyrrhizin on IgE-mediated immediate hypersensitivity in mice	11
Shin’iseihaito (Xinyiqingfeitang) extract ameliorates ovalbumin-induced murine allergic rhinitis by regulating cytokines	10
Two new ɑ-pyrone derivatives from the endophytic Diaporthe sp. ECN371	10
Efficient fertilization in the cultivation of Angelica acutiloba (Siebold & Zucc.) Kitag. in Hokkaido: Effect of amount of supplied nitrogen on growth, yield, and quality of A. acutiloba	10
Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG	10
Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron	10
Antiatherosclerotic effects of corilagin via suppression of the LOX-1/MyD88/NF-κB signaling pathway in vivo and in vitro	10
Eleven new C19-diterpenoid alkaloids from Delphinium elatum cv. Pacific Giant	10
22-O-(N-Boc-l-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial–mesenchymal transition in human lung cancer cells	10
Correction to: Solubility enhancement of berberine–baicalin complex by the constituents of Gardenia Fruit	10
Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation	9
Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber	9
Polymorphism analysis of TCP gene region to intraspecific analysis of Paeonia lactiflora, and application for authentication of Paeoniae Radix	9
Humulus lupulus L. extract and its active constituent xanthohumol attenuate oxidative stress and nerve injury induced by iron overload via activating AKT/GSK3β and Nrf2/NQO1 pathways	9
Methoxyflavones isolated from the whole plant of Scutellaria rubropunctata Hayata var. rubropunctata promote osteoblast differentiation in MC3T3-E1 cells	9
Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius	9
Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship	9
Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine	9
Cliniatines A–C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase	9
Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability	8
Resultant compound from sublimation test for Gentianae Radix in Japanese Pharmacopoeia was 5-(hydroxymethyl)furfural	8
Search for natural products from actinomycetes of the genus Nocardia	8
Ecological and pharmacognostical characteristics in Ephedra saxatilis in the Yarlung Zangbo River Valley of southeastern Tibetan Plateau, China	8
Photoreaction products of extract from the fruiting bodies of Polyozellus multiplex	8
Revision of NMR assignment for Morin-3-O-glucoside and microbial production of Morin-2’-O-glucoside	8
Cryptobuchanosides A–G: seven previously undescribed triterpene glycosides from Cryptolepis buchananii R.Br. ex Roem. and Schult. with nitric oxide production inhibition activity	8
Dihydroartemisinin abolishes cisplatin-induced nephrotoxicity in vivo	8
A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities	8
Byakangelicin alleviates sepsis-associated acute kidney injury by inhibiting inflammation and apoptosis	8
Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content	8
Thiolane-type sulfides from garlic, onion, and Welsh onion	7
Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1	7
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline N-oxides from the aerial parts of Leptopyrum fumarioides as potential COX-2 inhibitors: in vitro and in silico studies	7
Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases	7
Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.)	7
New abietane-type diterpenoids from roots of Euonymus hamiltonianus and their cytotoxicity in human cancer cell	7
Limonoids isolated from the Fortunella crassifolia and the Citrus junos with their cell death-inducing activity on Adriamycin-treated cancer cell	7
Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes	7
Phytomedicinal therapeutics for male infertility: critical insights and scientific updates	7
Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack	7
Anti-coronavirus and anti-pulmonary inflammation effects of iridoids, the common component from Chinese herbal medicines for the treatment of COVID-19	7
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation	7
Extraction, characterization, and biological activities of a novel polysaccharide extract from Fructus caryophylli	7
Asiaticoside conveys an antifibrotic effect by inhibiting activation of hepatic stellate cells via the Jagged-1/Notch-1 pathway	7
New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities	7
Correlation between the metabolic profile of Nelumbo Seed, a component of Seishinrenshiin, and its inhibitory activity on bladder smooth muscle contraction	7

Optimizing post-harvest processing conditions for Angelica acutiloba roots in Hokkaido: storage temperature and duration	7
Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content	6
Drug-interaction between paclitaxel and goshajinkigan extract and its constituents	6
Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium	6
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability	6
Cordythiazole A, the first member of thiazole alkaloids from Chinese cordyceps, with α-glucosidase inhibitory activity	6
Correction: Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	6
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway	6
Total syntheses of surugamides and thioamycolamides toward understanding their biosynthesis	6
Preparation and pharmaceutical properties of Hangeshashinto oral ointment and its safety and efficacy in Syrian hamsters with 5-fluorouracil-induced oral mucositis	6
Lateral flow immunoassay for small-molecules detection in phytoproducts: a review	6
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation	6
Correction to: Metabolic fingerprinting for discrimination of DNA-authenticated Atractylodes plants using 1H NMR spectroscopy	6
Population genetic structure of wild Angelica acutiloba, A. acutiloba var. iwatensis, and their hybrids by atpF–atpA intergenic spacer in chloroplast DNA and genome-wide SNP analysis using MIG-seq	6
Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood	6
Identification and characterization of organic and glycosidic acids in the crude resin glycoside fraction from the leaves and stems of Calystegia japonica	6
Pentacyclic triterpenes from the leaves extract of Sandoricum koetjape	6
Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	6
New monoterpenoids from the stigmas of Crocus sativus	6
Screening of growth inhibitors for epithelial–mesenchymal transition-induced cells by TGF-β from plant-based sources identified the active compound hydroxychavicol from Piper bitle	6
Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters	6
Picrotoxane sesquiterpene and α-pyrone derivative from Dendrobium signatum and their free radical scavenging potency	6
Hydrophobic constituents of Polygonum multiflorum roots promote renal erythropoietin expression in healthy mice	6
Saikokeishikankyoto extract alleviates muscle atrophy in KKAy mice	6
Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice	6