OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Natural Medicines is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content	33
Ecological and pharmacognostical characteristics in Ephedra saxatilis in the Yarlung Zangbo River Valley of southeastern Tibetan Plateau, China	29
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder	25
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway	21
Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation	19
Apoptosis-inducing activity of a steroidal glycoside from Allium chinense G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress	19
Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber	17
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in Aconitum japonicum	17
Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius	16
Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity	16
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells	15
Chlorinated illudalane sequiterpenoids from Saxiglossum angustissimum	14
Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.)	14
Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood	14
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability	14
A feruloylated acylglycerol isolated from Wikstroemia pilosa and its distribution in ten plants of Wikstroemia species	13
Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content	13
Lateral flow immunoassay for small-molecules detection in phytoproducts: a review	13
Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes	13
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis	13
Calycosin ameliorates inflammation and M1 macrophage polarization via Spon2 in LPS-triggered MH-S alveolar macrophages	12
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds	12
HPLC analysis of ammonium glycyrrhizate listed in the European, United States, and Japanese Pharmacopoeias under reported and modified conditions: revision of the peak assignment for 18α-glycyrrhizin	12
Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina	11
Mechanism study of the effects of astragaloside IV and quercetin on idiopathic pulmonary fibrosis	11

Ginsenoside Rh3-induced neurotoxicity involving the IP3R-Ca2+/NOX2/NF-κB signaling pathways	11
Panaxindole, a novel indole alkaloid N-glucoside from the leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng)	11
Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines	10
Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata	10
Correction: Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship	10
Development of a determination method for quality control markers utilizing metabolic profiling and its application on processed Zingiber officinale Roscoe rhizome	10
Pharmacokinetics of seven major components in Aβ1-42-treated rats after oral administration of an aqueous extract of Curculiginis Rhizoma and Epimedii Folium	10
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation	10
Correction to: Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients	10
Polysaccharides from Lentinus edodes prevent acquired drug resistance to docetaxel in prostate cancer cells by decreasing the TGF-β1 secretion of cancer-associated fibroblasts	10
Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia	10
Meroterpenoids with BACE1-inhibitory activity from the fruiting bodies of Suillus bovinus and Boletinus cavipes	10
17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1	10
Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy	10
Rapid determination of heavy metals and arsenic in herbal medicines using energy-dispersive X-ray fluorescence spectrometry	10
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway	9
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway	9
Promotion of neurite outgrowth by 3,5,7,3ʹ,4ʹ-pentamethoxyflavone is mediated through ERK signaling pathway in Neuro2a cells	9
Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation	9
Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway	9
Exploring the biological tissue toxicity and related toxic components of Euodiae Fructus through the multi-tissue spectrum–toxicity relationship	9
Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction	9
Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds	9
Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF-κB	8
Ergostane-type steroids from mushrooms of Pleurotus genus	8
Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications	8
Two new β-carboline alkaloids from the roots of Anemone altaica	8
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities	8
Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino	8
Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents	8
Rhein alleviates advanced glycation end products (AGEs)-induced inflammatory injury of diabetic cardiomyopathy in vitro and in vivo models	8
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway	8
Inhibitory functions of cornuside on TGFBIp-mediated septic responses	8
Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy	8
Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7	8
Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation	8
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways	7
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro	7
Shorter and more efficient pretreatment for germination of perilla mericarps	7
Optimizing blood–brain barrier permeability: the effect of wine processing on alkaloids in Phellodendri Chinensis Cortex	7
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose	7
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pat	7
Cathagines A–D, new bisindole alkaloids from Catharanthus roseus	7
Anti-allergic actions and pharmacokinetics of orally administered 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in mice	7
Correction: Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
Identification and characterization of organic and glycosidic acids in the crude resin glycoside fraction from the leaves and stems of Calystegia japonica	7
Cytotoxic activities of alkaloid constituents from the climbing stems and rhizomes of Sinomenium acutum against cancer stem cells	7
2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs	7
Chemical and pharmaceutical evaluation of roasted Ephedra herba and elucidation of the health hazards caused by white smoke generated during processing	7
Comprehensive profiling of phytochemicals in the fruits of Gardenia jasminoides Ellis and its variety using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass sp	7

Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light	7
Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239	7
Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor	7
Correction: Ellagic acid prevents ovariectomy-induced bone loss and attenuates oxidative damage of osteoblasts by activating SIRT1	6
Natural products that target p53 for cancer therapy	6
Interactions between turnover rate and bioactivity of atractylenolide III in Atractylodes macrocephala rhizome in the theory of crude drugs’ pairs and prescriptions in traditional Chinese and Japanese	6
New biofunctional effects of oleanane-type triterpene saponins	6
Unprecedented triterpenes with anti-inflammatory activity from Limax maximus	6
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity	6
The pleiotropic anti-cancer, antiviral, and anti-neuro-immunomodulatory role of methanolic neem bark extract	6
Inhibitory effects of reumycin produced by Streptomyces sp. TPMA0082 on virulence factors of Pseudomonas aeruginosa	6
Antimalarial ceramicines Q-T from Chisocheton ceramicus	6
Isovincathicine from Catharanthus roseus induces apoptosis in A549 cells	6
Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases	6
Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients	6
Mechanisms underlying the dynamic changes in tannins associated with food processing and plant growth	6
Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation	6
Recent trends in ginseng research	6
Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway	6
Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption	6
Oleanane-type triterpene saponins promote extracellular vesicle secretion of human adipose-derived mesenchymal stem cells	6
Nacre extract from pearl oyster attenuates amyloid beta-induced memory impairment	6