OOIR: Observatory of International Research

Papers

(The median citation count of Drug Metabolism and Pharmacokinetics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs	116
Adenovirus vector-based vaccine for infectious diseases	61
Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics	36
Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics	34
Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells	33
Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers	20
An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals	19
Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development	19
Pharmacogenomics research and its clinical implementation in Thailand: Lessons learned from the resource-limited settings	18
Ideal pharmacokinetic profile of dotinurad as a selective urate reabsorption inhibitor	15
Suppressive effect of quercetin against bleomycin-induced epithelial-mesenchymal transition in alveolar epithelial cells	15
Cellular uptake properties of lamotrigine in human placental cell lines: Investigation of involvement of organic cation transporters (SLC22A1–5)	13
Functional characterization of monocarboxylate transporter 12 (SLC16A12/MCT12) as a facilitative creatine transporter	13
Exosomes: Breast cancer-derived extracellular vesicles; recent key findings and technologies in disease progression, diagnostics, and cancer targeting	12
Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins	12
Classification of drugs for evaluating drug interaction in drug development and clinical management	12
Transport via Niemann-Pick C1 Like 1 contributes to the intestinal absorption of ubiquinone	12
Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir	11
Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers	11
Delivery of small interfering RNAs by nanovesicles for cancer therapy	11
Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse	10
Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources	10
Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study	10
Feature importance of machine learning prediction models shows structurally active part and important physicochemical features in drug design	10
Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24	10

Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants	9
Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template	9
The utility of CYP3A activity endogenous markers for evaluating drug-drug interaction between sildenafil and CYP3A inhibitors in healthy subjects	8
Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes	8
Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers	8
WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes	8
Synthetic molecule libraries for nucleic acid delivery: Design parameters in cationic/ionizable lipids and polymers	8
Application of comprehensive lipidomics to biomarker research on adverse drug reactions	8
Recent progress in the use of microRNAs as biomarkers for drug-induced toxicities in contrast to traditional biomarkers: A comparative review	8
Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide	7
Food effects on gastrointestinal physiology and drug absorption	7
Establishment of MDR1-knockout human induced pluripotent stem cell line	7
A physiologically based pharmacokinetic/pharmacodynamic modeling approach for drug-drug interaction evaluation of warfarin enantiomers with sorafenib	7
A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects	7
Mathematical modeling analysis of hepatic uric acid disposition using human sandwich-cultured hepatocytes	7
Applications of a grid-based CYP3A4 Template system to understand the interacting mechanisms of large-size ligands; part 4 of CYP3A4 Template study	7
Associations of HLA and drug-metabolizing enzyme genes in co-trimoxazole-induced severe cutaneous adverse reactions	7
PreMetabo: An in silico phase I and II drug metabolism prediction platform	7
Refined CYP2E1∗ Template∗∗ system to decipher the ligand-interactions	7
Extrapolation for a pharmacokinetic model for acetaminophen from adults to neonates: A Latin Hypercube Sampling analysis	6
Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors	6
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6	6
Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1)	6
High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in t	6
Gene and oligonucleotide delivery via micro- and nanobubbles by ultrasound exposure	6
Urinary metabolic markers reflect on hepatic, not intestinal, CYP3A activity in healthy subjects	5
A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria	5
Inhibitory effects of non-steroidal anti-inflammatory drugs on human liver microsomal morphine glucuronidation: Implications for drug-drug interaction liability	5
Feasibility of physiologically based pharmacokinetic simulations for assessing pediatric patients after accidental drug ingestion: A case study of a 1.4-year-old girl who ingested alprazolam	5
Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration	5
Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration	5
Multivalent cation and polycation polymer preparations influence pharmacokinetics of dolutegravir via chelation-type drug interactions	5
Diclofenac potentiates the antitumor effect of cisplatin in a xenograft mouse model transplanted with cisplatin-resistant cells without enhancing cisplatin-induced nephrotoxicity	5
Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase	5
Predicting drug metabolism and pharmacokinetics features of in-house compounds by a hybrid machine-learning model	5
BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS	5
Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption	5
Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury	4
Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria	4
Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites	4
Visualisation of real-time oral biodistribution of fluorescent labeled self-microemulsifying drug delivery system of olmesartan medoxomil using optical imaging method	4
Interleukin-1β and tumor necrosis factor-α affect cytochrome P450 expression in cynomolgus macaque hepatocytes	4
6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients	4
Oligonucleotide delivery to antigen presenting cells by using schizophyllan	4
Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants	4
Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase	4
Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents	4
Establishment of MDR1-knockout human enteroids for pharmaceutical application	4
Prediction methods of drug-drug interactions of non-oral CYP3A4 substrates based on clinical interaction data after oral administrations – Validation with midazolam, alfentanil, and verapamil after in	4
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data	4

In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice	4
Identification of miRNAs that regulate human CYP2B6 expression	4
Inhibiting uptake activity of organic anion transporter 2 by bile acids	4
Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin	3
Comparison of human biopsy-derived and human iPS cell-derived intestinal organoids established from a single individual	3
The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes	3
Construction of a fused grid-based template system of CYP2C9 and its application	3
Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis	3
Bioavailability of tetracyclines is substantially increased by administration of cyclosporine A, a non-specific efflux-pump blocker	3
Inhibitory effects of sesamin on CYP2C9-dependent 7-hydroxylation of S-warfarin	3
Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3)	3
Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes	3
A UPLC-MS/MS method reveals the pharmacokinetics and metabolism characteristics of kaempferol in rats under hypoxia	3
Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic model	3
Therapeutic application of sequence-specific binding molecules for novel genome editing tools	3
Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation	3
Inhibitory effects of type 2 diabetes serum components in P450 inhibition assays can potential diagnose asymptomatic diabetic mice	3
Highly specific, quantitative polymerase chain reaction probe for the quantification of human cells in cynomolgus monkeys	3
Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers	3
Carboxylesterase-2 plays a critical role in dabigatran etexilate active metabolite formation	3
Double Trap Interface: A novel gas interface for high throughput analysis of biomedical samples by AMS	3
Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor	3
Synthetic mRNA for ex vivo therapeutic applications	3
Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3)	3
Construction of a fused grid-based CYP2C19-Template system and the application	3
Molecular cloning, sequence analysis, and tissue distribution of marmoset monoamine oxidases A and B	3
Pharmacokinetic/pharmacodynamic modeling of roxadustat's effect on LDL cholesterol in patients in Japan with dialysis-dependent chronic kidney disease and anemia	3
Investigation of the role and quantitative impact of breast cancer resistance protein on drug distribution into brain and CSF in rats	3
Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo	3
Imaging Mass Spectrometry (IMS) for drug discovery and development survey: Results on methods, applications and regulatory compliance	3
Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity	3
Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats	3
Pharmacokinetics of genistein distribution in blood and retinas of diabetic and non-diabetic rats	3
A model-based pharmacokinetic assessment of drug–drug interaction between tacrolimus and nirmatrelvir/ritonavir in a kidney transplant patient with COVID-19	2
Update on next generation sequencing of pharmacokinetics-related genes: Development of the PKseq panel, a platform for amplicon sequencing of drug-metabolizing enzyme and drug transporter genes	2
Black ginger extract and its active compound, 5,7-dimethoxyflavone, increase intestinal drug absorption via efflux drug transporter inhibitions	2
Administration of erlotinib in apple juice overcomes decreased absorption in a rat model of gastric acid suppression	2
Reduced theophylline clearance due to hepatic congestion secondary to right heart failure - A population pharmacokinetic study	2
Substrate recognition of renally eliminated angiotensin II receptor blockers by organic anion transporter 4	2
Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms	2
Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles	2
The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9	2
Extrapolation of physiologically based pharmacokinetic model for tacrolimus from renal to liver transplant patients	2
Effect of deuteration on the single dose pharmacokinetic properties and postoperative analgesic activity of methadone	2
Estimation of absolute oral bioavailability without performing an intravenous clinical study	2
Novel variants in outer protein surface of flavin-containing monooxygenase 3 found in an Argentinian case with impaired capacity for trimethylamine N-oxygenation	2
Molecular characterization of UDP-glucuronosyltransferases 3A and 8A in cynomolgus macaques	2
In vitro metabolism of the new antifungal dapaconazole using liver microsomes	2
Development of a new assay system for bladder cancer using interactions between cytochromes P450 and serum	2
Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα	2
Impacts of SNPs on adverse events and trough concentration of imatinib in patients with gastrointestinal stromal tumors	2
Model-based assessment of pharmacokinetic changes of sunitinib, tacrolimus, and everolimus in a patient with metastatic renal cell carcinoma after renal transplantation	2
A procedure for method development and protein binding ratio as the indicator of sensitivity with anticancer agents on MALDI mass spectrometry imaging	2
Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network	2
13C-caffeine breath test identifies single nucleotide polymorphisms associated with caffeine metabolism	2
Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol, on CYP2C9 activity	2
Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter	2