Drug Metabolism and Pharmacokinetics

Article	Citations
Corrigendum to “Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration” [Drug Metabol Pharmacokinet 41 (2021) 100408]	218
Effects of genetic polymorphisms of canine CYP2D15 on in vitro hepatic metabolism and in vivo pharmacokinetics of celecoxib, and the strategy for the accurate prediction of human pharmacokinetics	116
The spectrum of hepatic clearance models, from old to new	67
Monocarboxylate transporter 10: substrate-dependent mode of transport	27
Development of an in vitro metabolism approach of acrylamide covalent drugs for predicting metabolism and disposition in human	25
The mass balance recovery, absorption, metabolism, and excretion of [14C]-orvepitant in healthy male subjects after oral dosing: radiosynthesis of [14c]-orvepitant	20
Beyond non-human primates: Transgenics and PBPK models for predicting the human PK of protein therapeutics	18
Clinical studies on pharmacogenomics and DDIS involving drug transporters	16
Role of intestinal transporters in regional absorption kinetics and intricate pharmacokinetic profiles of talinolol	15
Effect of lipopolysaccharide on P-Glycoprotein at the inner blood-retinal barrier in vivo	15
Establishment of DoE-IVIVC model for the pharmacokinetic prediction of ruxolitinib sustained-release dosage forms	14
Thinking beyond cytochrome P450 inactivation kinetics: Enhanced understanding of the mechanism of tucatinib interaction with CYP3A4	12
Effect of substrates and inhibitors of breast cancer resistance protein on apixaban and rivaroxaban pharmacokinetics in Japanese patients	11
Authenticity and adulteration of botanical natural products: Lessons from a decade of sourcing materials for scientific investigation	10
Trends in in vitro potency and PK parameters; can therapeutic doses be estimated from in vitro KI?	10
Pegylated testosterone with enhanced pharmacokinetic properties in mice	10
Drug read-out in untargeted metabolomics using a MS/MS library of drugs and metabolites propagated from metabolomics data repository	9
Primary human intestinal cell model for estimating drug absorption, efflux and metabolism	9
Roles of NOLC1 in nuclear translocation of PXR	9
In vitro plasma or whole blood stability method for ADCS	9
Formation of reactive metabolites of benzbromarone in humanized-liver mice	8
Development of a new assay system for bladder cancer using interactions between cytochromes P450 and serum	8
Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors	8
The in vivo pharmacokinetics of cross-linking antisense-modified nucleic acids radiolabeled by FT-labelling method	8
Prediction and validation of fetal exposure to dual BCRP/P-GP drug substrates using the proteomics informed efflux ratio-relative expression factor (ER-REF) approach and PBPK modeling and simulation	8

Effects of MIR-222-3P-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation	8
Screening methods comparison of the effect of pharmaceutical excipients on drug permeability	7
Food-derived neurotrophic amino acid ergothioneine and its transporter SLC22A4: From bench to healthy food	7
Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems	7
Potential transporter-mediated HERB-drug interactions of Zingiber officinale and uncaria tomentosa	7
Applications of model simulation in pharmacological fields and the problems of theoretical reliability	7
Assessment of in vitro methods for UGT1A1 inhibition in recombinant isozyme	7
Solanidine metabolites as dietary CYP2D6 biomarkers of tamoxifen metabolism	7
Carboxylesterase-2 plays a critical role in dabigatran etexilate active metabolite formation	6
Human liver chimeric mouse and trasngenic animals are useful tools for quantitatively predicting clearance and drug-drug interactions in human	6
Gene and Oligonucleotide Delivery	6
Illustrating the mechanistic absorption and disposition of OATP1B and BCRP probe substrates and the transporter-mediated drug-drug interactions using physiologically based pharmacokinetic (PBPK) model	6
Mass balance recovery, absorption, metabolism, and excretion of [14C]-Acoziborole in healthy male subjects after single microtracer oral dosing – III – Investigation of metabolite profile in plasma, u	6
The impact of glucose levels on efficacy of the FDA-approved antisense oligonucleotide drugs	6
Strategies for enhancing oral exposure of water-insoluble compounds	6
Lysosomal trapping measurement in multiple cell types using a high content imaging (HCI) system	6
Application of a permeability-limited multi-compartment liver (PerMCL) model to predict zonal hepatocellular statin concentrations in metabolic dysfunction-associated steatohepatitis (MASH)	6
In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition	6
Pharmacokinetics of ginsenosides and effect of the lactic acid bacteria on pharmacokinetics of ginsenosides in mice and human	6
Physiologically based pharmacokinetic modeling to predict the clinical effect of azole antifungal agents as CYP3A inhibitors on azelnidipine pharmacokinetics	6
Mucoadhesive hemi-porous Janus microparticles: Potential formulation to improve intestinal absorption for BCS Class 3 drugs	6
Comparative metabolite profiling and identification of GalNAc-conjugated siRNA, siRNA01, in plasma prepared with various anticoagulants, serum, and in vivo plasma using LC-UV-HRMS	6
Appreciation to Reviewers	5
Enzyme induction fundamentals, assays, data interpretation and in vivo translation	5
Pharmacokinetic interaction of caffeine and theophylline in mice	5
Clinical studies on pharmacogenomics and DDIS involving drug transporters	5
IN VITRO AND IN VIVO SYSTEMS FOR PREDICTING THE ADME OF PROTEIN THERAPEUTICS: ARE WE THERE YET?”	5
Mathematical modeling of affinity design goals for CIS-binding BI-specific antibody-based molecules	5
In vitro and in vivo interactions between nicotine and the cannabis terpene limonene	5
Effect of antibiotic-administration period on hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries	5
Lecture title not available	5
Use of mathematical modeling to guide out-of-the-box thinking for ADC development	5
Effect of linker-payload design on the PK of ADCS	5
This is no longer just about liver: LC-MS proteomics for organ exposure brain/kidney/gut/skin/placenta	5
Suppression and induction of UGT by rhein and alvocidib in intestinal epithelial cells	5
Strategies for de-risking n-nitrosamine impurities in APIS	5
Assess CYP450 induction by qRT-PCR quantificaiton of CYP450 mRNAs from Small Extracellular Vesicles (SEVS) derived from plasma	4
Closing the translational gap: Human multi-tissue chip platform for predictive and mechanistic preclinical studies	4
Simple confirmation methods for rare but impaired variants of human flavin-containing monooxygenase 3 (FMO3) found in an updated genome resource databank	4
Development of physiologically-based pharmacokinetic models to predict food effects and co-administration of proton pump inhibitors on the pharmacokinetics of sonidegib and vismodegib	4
Identification of pazopanib as an OATP1B1 substrate by competitive counterflow screeen	4
Plasma concentration of LAT1 substrate amino acids affects the spinal cord transfer and the analgesic effect of pregabalin	4
Implementation of blood collection using the Tasso microsampling device to measure thyroid hormone biomarkers	4
Effect of pregnancy-related hormones on mRNA expression of hepatic drug transporters and enzymes	4
Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice	4
Update from the IQ TALG quantitative fraction metabolized working group	4
Investigating the role and function of OATP drug transporters in relation to tamoxifen therapy	4
Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network	4
A workflow for oligonucleotide metabolite identification studies	4
Clarifying metabolism of the natural product drug troxerutin in vitro and in vivo	4

Regulation of rat hepatic monocarboxylate transporter expression by sex and cross-sex hormone treatment	4
Prediction of pharmacokinetics and pharmacodynamics in human for IRAK4 targeted protein degrader	3
Spatial mapping of gemcitabine and its pharmacologically active metabolites in tissues using MALDI mass spectrometry imaging	3
The effect of clofazimine in modulating intracellular concentrations of remdesivir and GS-441524: A potential mechanism of enhancing antiviral effects against SARS-COV-2	3
Discovery of PF-07817883, a second-generation oral SARS-CoV2 main protease inhibitor	3
Optimization of linker sequence of aminopeptidase A-Fc fusion proteins in pharmacokinetics and antihypertensive effect	3
Corrigendum to “Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study” [Drug Metabol Pharmacokine	3
OCT1 transporter kinetics and long-term modulation studies in 3D cultured primary human hepatocytes	3
Drug-drug interaction studies of cortisol in cynomolgus monkeys by measuring cortisol, cortisol-D4, and their 6β-hydroxymetabolites in plasma	3
Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture	3
Mass balance recovery, absorption, metabolism, and excretion of [14C]-Acoziborole in healthy male subjects after single microtracer oral dosing – I – Preparation of GMP [14C]- acoziborole drug substan	3
Micro-physiological system of human lung: The current status and application to drug discovery	3
L-Type amino acid transporter 1-mediated developmental change of cerebral gabapentin distribution across the rat blood-brain barrier	3
Mechanisms of afatinib-induced intestinal epithelial barrier dysfunction using human mini-gut model	3
Investigation of pharmacokinetic properties and brain penetration of genipin: A potential pharmacophore for Parkinson's disease treatment	3
Membrane transporters in drug development and as determinants of precision medicine; an update from the international transporter consortium	3
Insights into drug development with quantitative systems pharmacology: A prospective case study of uncovering hyperkalemia risk in diabetic nephropathy with virtual clinical trials	2
Pharmacokinetic and pharmacodynamic interactions between astragalus membranaceus polysaccharides and metformin in diabetic mice	2
Microfluidic chip for construction of 3D microvascular network of blood-brain barrier	2
Impact of donor diversity on phase I and phase II activities in cryopreserved human hepatocytes and human liver microsomes	2
Opportunities for microphysiological systems from the view of Japanese industries	2
Use of human liver microsomes to assess flavin-containing monooxygenase (FMO) metabolism in vitro	2
In vitro metabolic stability and in vivo phaarmacokinetic behavior of panobinostat in mouse models for the treatment of CNS tumors	2
An improved sample preparation and analysis procedure for estradiol LC-MS/MS quantification	2
Enhancing drug-drug interaction prediction by integrating physiologically-based pharmacokinetic model with fraction metabolized by CYP3A4	2
Exploring the impact of PCB-18 (2,2',5-Trichlorobiphenyl) exposure on hepatic drug metabolizing enzymes and xenobiotic responses in humanzied mice	2
Building robust human liver microsomal stability predictions: Leveraging inter- species correlation with rat data	2
Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants	2
Therapeutic application of sequence-specific binding molecules for novel genome editing tools	2
Comparative analysis of microcystin toxicity in 2D and 3D cultured primary human hepatocytes	2
Determination of drug-to-antibody ratio of T-DXD in plsama sample by LBA-LC-MS	2
Generation of in vitro blood-placental barrier (BPB) models using human placental stem cells	2
Discovery of genetic biomarkers associated with antituberculosis drug-induced liver injury in the Korean population: Insights from nuclear and mitochondrial DNA variations	2
Interactions of sutezolid and its active metabolite with human transporters	2
Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration	2
Experimental validation of the reliability of dilution method for plasma protein binding assay in human plasma using 12 commercial compounds	2
Evaluation of OSTΑ/Β transporter activity on the basal membrane of CACO-2 cell monolayers	1
Change in transport function of drugs into the multicellular inner blood-retinal barrier spheroids under hypoxic culture with advanced glycation end-products	1
Protein abundance of hydrolytic drug metabolizing enzymes in different tissues and across species	1
ADME: 14C-RLY-4008 following oral administration to rats	1
Prediction of drug-drug interaction risk of P-glycoprotein substrate in drug discovery	1
Comparative pharmacokinetic profiles of favipiravir alone and in combination with Thai herbal extract in rats	1
Evaluation for biotransformation of antibody-peptide conjugates using native mass spectrometry	1
Oligonucleotide delivery to antigen presenting cells by using schizophyllan	1
Increasing the therapeutic index of ADCs with payload binding selectivity enhancers	1
Acetaminophen-induced liver injury and the microbiome	1
In vitro metabolism of kobusin in human liver preparations	1
Promiscuity and quantitative contribution of UGT2B17 in drug and steroid metabolism determined by experimental and computational approaches	1
Comparison on metabolic fate of dendrobium polysaccharides in gut microbiota fermentation process between healty and diabetic status	1
Effects of valproate, an HDAC inhibitor, on the expression of folate carriers and folate metabolism-related genes in the placenta of rats	1
Effects of mefenamic acid on the conjugative metabolism of indole and p-cresol in relation to cellular necrosis in a metabolically competent human hepatoma cell line	1
Assessment of unintentional effects on endangered species endemic to the Bonin Islands caused by deployment of anticoagulant rodenticide	1
Global proteomic profiling of a patient-derived 3D CYST model and reference tissue of polycystic kidney disease	1
Analysis of influx/efflux kinetics of metformin in Caco-2 cells	1
Circulating tumor cells kinetics after short- and long-term folfirinox and GEM/NAB-PTX chemotherapy in xenograft mouse models of human pancreatic cancer	1
Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range	1
Substrate-dependent characteristics in the transport function of SLC19A3: examination of the aspect of its sensitivity to flavonoids	1
Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs	1
A new indicator for detecting weak inducers by 4Β-Hydroxycholesterol as a biomarker of CYP3A4 induction, and protocol for handling clinical samples	1
Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling	1
Keyword Index	1
Hepatic expression of drug metabolizing enzymes is altered by concomitant obesogenic lipids and alcohol in mice and human hepatic organoids	1
In vitro inhibitory effects of components from Salvia miltiorrhiza on catalytic activity of three human Arachidonic acid ω-hydroxylases	0
Intra-patient variation in CYP2D6 activity over time assessed using the dietary biomarker solanidine in breast cancer patients on tamoxifen	0
Improving in vitro clearance assay performance and prediction accuracy with advanced human hepatocyte models for highly stable RO5 and BRO5 compounds	0
Development of plasma stability assay for oligonucleotides	0
A synthetic G protein-coupled receptor 40 agonist GW9508 mitigates airway inflammation and mucus secretion in allergic asthma	0
Expanding pharmacogenomics panel assay to include transporter genes and more phase I metabolism variants	0
Encequidar is a gut-restricted P-GP specific inhibitor that boosts oral bioavailability and inhibits intestinal secretion in rats and dogs.	0
Targeted Protein Degraders (TPD): PK/PD translation from preclinical to clinical	0
Preclinical DDI risk assessment in drug discovery and development	0
Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis	0
Development of a fluorescent-labeled trapping reagent to evaluate the risk posed by acyl-CoA conjugates	0
How do i use PBPK modeling to discern complex drug-drug interactions?	0
Future direction of animal alternative/microphysiological systems in drug discovery and development	0
Unveiling the mechanistic involvement of the human microbiome and human drug- processing genes in modulating the hepatic transcriptome in mice in vivo	0
Impact of DNA G-Quadruplex formation on CYP3A4 gene transcription	0
Experiences in industry predicting hepatic clearance: Successes, disconnects, failures, and room for improvement	0
A retrospective comparison of the PK profiles of lipid 5, the ionizable lipid in LNP2, across rat, NHP, and human	0
In vitro assessment of potential for onvansertib to cause cytochrome P450 and transporter-mediated pharmacokinetic drug-drug interactions	0

Pharmacokinetic interactions of niclosamide in rats: Involvement of organic anion transporters 1 and 3 and organic cation transporter 2	0
Smart compound library based on machine learning, sensing technology, and programmable logic control	0
Biotransformation of protein degraders bavdegalutamide and XL01126 in permeabilized cryopreserved human hepatocytes	0
Functional characterization of ATP13A3 as a plasma membrane polyamine transporter	0
Systematic investigation of the metabolism of cannabinoids by human cytochrome p450s	0
Availability of polydimethylsiloxane chip in evaluation of small intestinal absorption	0
OMICS data-based analysis of mitochondrial characteristics and toxicity mechanisms	0
Opportunities and challenges in drug development for retinal diseases	0
Air–liquid interface culture and modified culture medium promote the differentiation of human induced pluripotent stem cells into intestinal epithelial cells	0
Uncovering Target-Mediated Drug Disposition (TMDD) of small molecule brain penetrant EBP inhibitors	0
Characteristics of membrane transport, metabolism, and target protein binding of cyclic depsipeptide destruxin E in HeLa cells	0
Using quantitative systems pharmacology (QSP) models to characterize the PK of novel drug modalities	0
Involvement of efflux transporters ABCG2 and ABCB1 in overall disposition of multikinase inhibitor pazopanib	0
Functional characteristics of a newly identified vesicular membrane-localized monoamine transporter for serotonin transport	0
A systematic study to evaluate the safety of ticagrelor combined with aspirin in the treatment of PCI patients in Chinese population: A single nucleotide polymorphisms study	0
Pharmacokinetics of monoclonal antibodies locally-applied into the middle ear of guinea pigs	0
Xenobiotic transporter SLC22A4 expressed in microglia and neuron as a potential target for neurogenesis in Alzheimer's disease model mice	0
Advanced in vitro evaluation of drug-induced kidney injury using microphysiological systems in drug discovery and development	0
Mechanisms underlying cognitive enhancement induced by oral ingestion of yeast- derived RNA using comprehensive targeted lipidomics	0
Construction and functional of human BBB model derived from MDR1 gene- transfected human iPS cells in two- and three-dimensional culture plate	0
Quantification of fluticasone propionate in human plasma by LC–MS/MS and its application in the pharmacokinetic study of nasal spray at clinical doses	0
Development of a novel in silico classification model to assess reactive metabolite formation in cysteine trapping assay and investigation of important substructures	0
Characterization of plasma vonoprazan and CYP3A activity using its endogenous marker and genetic variants in patients with digestive system disorders	0
Absorption, metabolism, and excretion of inavolisib (GDC-0077), a PI3KA inhibitor in humans	0
Method development to correct tissue concentrations for residual blood: Application to drug distribution in brain tumors	0
Characterization of an 3D-printed expandable drug delivery system for tofacitinib in beagle dogs	0
Prevention of irinotecan-induced intestinal toxicity by locally bioavailable herbal components via maintaining gut oxidative stress homeostasis	0
The site-selective tritium labeling of modified nucleic acids using functionality transfer reaction for pharmacokinetic studies	0
Gastrointestinal imaging with MRI: Insights into the behavior of dosage forms and the conditions at the site of drug release	0
Bioavailability of tetracyclines is substantially increased by administration of cyclosporine A, a non-specific efflux-pump blocker	0
Mechanistic pharmacokinetics & pharmacodynamics of GaINAc-siRNA	0
High-throughput assessment for drug protein binding using magnetized silica beads method in human liver microsomes	0
In vitro characterization of taurine transport using the human brain microvascular endothelial cell line as a human blood-brain barrier model	0
CYP7A1 gene induction via SHP-dependent or independent mechanisms can increase the risk of drug-induced liver injury independent or in synergy with BSEP inhibition	0
Oligonucleotide target engagement	0
The inhibitory effects of major cannabinoids and their metabolites on R- and S-oxazepam metabolism	0
Implication of H+/peptide transporters (PEPTS) on uptake of N-lactoylphenylalanine (LAC-PHE) in the intestinal and renal epithelial cells	0
In vitro - In vivo extrapolation approaches for glucuronidated drugs: Promises and pitfalls	0
ARE Δ9-tetrahydrocannabinol and its major metabolites substrates or inhibitors of the human hepatic and placental solute-carrier transporters?	0
A successful preclinical toxicology package	0
Investigating cross-species differences of MDR1-mediated drug transport	0
Assessing the first-pass effects of of felodipine with the small intestine-liver coupled microphysiological system	0
Development of quantitative translational model of neutropenia using nonclinical animal data and physiological parameters	0
Novel metabolomics approach to identify biomarkers of organic anion renal transporters	0
Characterization of long-lasting inhibition of amino acid transporter LAT1 by nanvuranlat (JPH203) in cholangiocellular carcinoma	0
Hepatocyte formation, reactivity, and stability differences of acyl glucuronide and acyl coenzyme a conjugates	0
Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics	0
Cytochrome P450 (CYP) phenotyping of aficamten, a next-in-class inhibitor of cardiac myosin, using human liver microsomes and human recombinant CYP enzymes	0
Functional characteristics of equilibrative nucleoside transporter 2 (ENT2/SLC29A2) for the transport of urate as a newly identified substrate	0
An overview of CDE technical guideline for nonclinical study of ADCS: importance and strategy of studying release of payload-containing components from ADC and their further metabolism	0
Assessment of integrated strategy for prodrug metabolic transformation in plasma: Statistical and analytical	0
Quantitative prediction of P-GP/CYP3A substrate drug absorption in humans using a monolayer model derived from intestinal organoids	0
Unexpected major circulating metabolite M219 detected in 14C-labeled human adme study of brilaroxazine	0
Understanding mechanisms of negative food effect for voclosporin using physiologically based pharmacokinetic modeling	0
Next generation quantitative proteomics-based central nervous system barrier studies	0
Approach to de-risk structural alerts in compound progression	0
Multicellular spheroidal human blood-brain barrier models are a useful tool for characterization of brain-penetrating antibodies	0
What is new in LC-MS proteomics: Techniques and applications in IVIVE and precision medicine	0
Development of intestinal organoids and microphysiological systems and their application to drug discovery	0
Hepatocyte CEBPA restricts the progression of liver fibrosis	0
Metabolic stability assessment of the tau PET tracer [18F] GTP1	0
Transporter activity characterization in a novel human hepatic cell-based tri-culture system	0
An in vitro microphysiological model of subcutaneous delivery	0
Comparative analysis of pharmacokinetic characteristics for the in-situ albumin drug conjugate	0
Pharmacokinetics of perfluoroocanoic acid and perfluorohexane sulfonic acid in various rat models	0
Physiological effects of food ingredients on intestinal epithelial cell function	0
Why and when do i use PBPK modeling	0
Converting suspension-type human primary hepatocytes to be plateable-type for use as an in vitro pharmacokinetics model	0
Prediction of the in vivo pharmacokinetics of sustained-release injections for semaglutide by a novel ivivc model combined with DoE	0
Elucidation of the properties of fatty acid amide hydrolase 2 as a drug-metabolizing enzyme	0
Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo	0
Diclofenac potentiates the antitumor effect of cisplatin in a xenograft mouse model transplanted with cisplatin-resistant cells without enhancing cisplatin-induced nephrotoxicity	0
Monkey blood-brain barrier co-culture model as an alternative method for predicting brain penetration	0
Does cannabidiol (CBD) or delta-9-tetrahydrocannabinol (THC) induce drug metabolizing enzymes in human hepatocytes?	0
14C-radiolabeled human ADME: a review of clinical microtracer mass balance data	0
Expression and functional analyses of the PK-related genes in differentiated intestinal epithelial cells derived from cryopreserved human intestinal mucosal epithelium (CHIM)	0
Elucidating mechanisms of promiscuous aggregation on CYP inhibition assays	0
DMPK perspective on quantitative model analysis for chimeric antigen receptor cell therapy: Advances and challenges	0
Rifampin- and silymarin-mediated pharmcokinetic interactions of pitavastatin, pravastatin, coproporphyrin I, and coproporphyrin III in a transgenic OATP1B mouse model	0
Exploring the potential of machine learning approach in predicting clinical CYP3A induction-mediated drug-drug interaction	0
Development of human glucuronide atlas and its application for identifying endogenous UGT substrates by a novel metabolomic-based DMET biomarker discovery (MDBD) approach	0
Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice	0
Preface: In silico technologies to facilitate drug development	0
Characterization of human immortalized cell-based blood-brain barrier spheroid models as a tool for brain vascular inflammation studies	0
NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine	0
Functional role of serine 318 of the proton-coupled folate transporter in methotrexate transport	0
Current status of Imaging Mass Spectrometry in drug discovery and development: A survey highlighting technical challenges and future directions	0
Schisandra sphenanthera: Its hepatoprotection and beyond	0
Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers	0
Optimization of methods for reducing turnaround time and compound consumptionwith echo liquid handling and automation enabling high capacity analysis for ADME screening	0
Biopharmaceutical, pharmacokinetic, and activity profiling of a novel locally bioavailable selectivE COX-2 inhibitor for colorectal cancer prevention	0
Moxidectin metabolism in reindeer	0
Tyrosine kinase inhibitors, nilotinib and radotinib, suppress both catalytic function and mRNA expression of human cytochrome P450 2J2 and 2C8	0
Endogenous biomarker-informed approaches for evaluation of transporter-mediated drug-drug and drug-disease interactions	0
Mass balance, pharmacokinetics, and tissue distribution of [14C] Zetomipzomib in rats by quantitative whole-body autoradiography	0