Drug Metabolism and Pharmacokinetics

Article	Citations
Corrigendum to “Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration” [Drug Metabol Pharmacokinet 41 (2021) 100408]	204
Effects of genetic polymorphisms of canine CYP2D15 on in vitro hepatic metabolism and in vivo pharmacokinetics of celecoxib, and the strategy for the accurate prediction of human pharmacokinetics	111
The spectrum of hepatic clearance models, from old to new	66
Monocarboxylate transporter 10: substrate-dependent mode of transport	27
Development of an in vitro metabolism approach of acrylamide covalent drugs for predicting metabolism and disposition in human	25
The mass balance recovery, absorption, metabolism, and excretion of [14C]-orvepitant in healthy male subjects after oral dosing: radiosynthesis of [14c]-orvepitant	23
Beyond non-human primates: Transgenics and PBPK models for predicting the human PK of protein therapeutics	19
Clinical studies on pharmacogenomics and DDIS involving drug transporters	18
Applications of model simulation in pharmacological fields and the problems of theoretical reliability	16
Effects of MIR-222-3P-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation	15
In vitro plasma or whole blood stability method for ADCS	15
Primary human intestinal cell model for estimating drug absorption, efflux and metabolism	15
The in vivo pharmacokinetics of cross-linking antisense-modified nucleic acids radiolabeled by FT-labelling method	13
Thinking beyond cytochrome P450 inactivation kinetics: Enhanced understanding of the mechanism of tucatinib interaction with CYP3A4	11
Authenticity and adulteration of botanical natural products: Lessons from a decade of sourcing materials for scientific investigation	10
Trends in in vitro potency and PK parameters; can therapeutic doses be estimated from in vitro KI?	10
Pegylated testosterone with enhanced pharmacokinetic properties in mice	10
Effect of substrates and inhibitors of breast cancer resistance protein on apixaban and rivaroxaban pharmacokinetics in Japanese patients	10
Roles of NOLC1 in nuclear translocation of PXR	10
Effect of lipopolysaccharide on P-Glycoprotein at the inner blood-retinal barrier in vivo	9
Establishment of DoE-IVIVC model for the pharmacokinetic prediction of ruxolitinib sustained-release dosage forms	9
Drug read-out in untargeted metabolomics using a MS/MS library of drugs and metabolites propagated from metabolomics data repository	9
Prediction and validation of fetal exposure to dual BCRP/P-GP drug substrates using the proteomics informed efflux ratio-relative expression factor (ER-REF) approach and PBPK modeling and simulation	9
Role of intestinal transporters in regional absorption kinetics and intricate pharmacokinetic profiles of talinolol	9
Development of a new assay system for bladder cancer using interactions between cytochromes P450 and serum	9

Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors	8
In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition	7
The impact of glucose levels on efficacy of the FDA-approved antisense oligonucleotide drugs	7
Screening methods comparison of the effect of pharmaceutical excipients on drug permeability	7
Solanidine metabolites as dietary CYP2D6 biomarkers of tamoxifen metabolism	7
Comparative metabolite profiling and identification of GalNAc-conjugated siRNA, siRNA01, in plasma prepared with various anticoagulants, serum, and in vivo plasma using LC-UV-HRMS	7
Illustrating the mechanistic absorption and disposition of OATP1B and BCRP probe substrates and the transporter-mediated drug-drug interactions using physiologically based pharmacokinetic (PBPK) model	7
Assessment of in vitro methods for UGT1A1 inhibition in recombinant isozyme	7
Food-derived neurotrophic amino acid ergothioneine and its transporter SLC22A4: From bench to healthy food	7
Double Trap Interface: A novel gas interface for high throughput analysis of biomedical samples by AMS	7
Formation of reactive metabolites of benzbromarone in humanized-liver mice	7
Mass balance recovery, absorption, metabolism, and excretion of [14C]-Acoziborole in healthy male subjects after single microtracer oral dosing – III – Investigation of metabolite profile in plasma, u	7
Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems	7
Application of a permeability-limited multi-compartment liver (PerMCL) model to predict zonal hepatocellular statin concentrations in metabolic dysfunction-associated steatohepatitis (MASH)	7
Mucoadhesive hemi-porous Janus microparticles: Potential formulation to improve intestinal absorption for BCS Class 3 drugs	6
Human liver chimeric mouse and trasngenic animals are useful tools for quantitatively predicting clearance and drug-drug interactions in human	6
Gene and Oligonucleotide Delivery	6
Effect of linker-payload design on the PK of ADCS	6
This is no longer just about liver: LC-MS proteomics for organ exposure brain/kidney/gut/skin/placenta	6
Lysosomal trapping measurement in multiple cell types using a high content imaging (HCI) system	6
Strategies for enhancing oral exposure of water-insoluble compounds	6
Appreciation to Reviewers	6
Enzyme induction fundamentals, assays, data interpretation and in vivo translation	6
Pharmacokinetic interaction of caffeine and theophylline in mice	6
Potential transporter-mediated HERB-drug interactions of Zingiber officinale and uncaria tomentosa	6
Pharmacokinetics of ginsenosides and effect of the lactic acid bacteria on pharmacokinetics of ginsenosides in mice and human	6
Physiologically based pharmacokinetic modeling to predict the clinical effect of azole antifungal agents as CYP3A inhibitors on azelnidipine pharmacokinetics	6
Mathematical modeling of affinity design goals for CIS-binding BI-specific antibody-based molecules	6
In vitro and in vivo interactions between nicotine and the cannabis terpene limonene	6
Suppression and induction of UGT by rhein and alvocidib in intestinal epithelial cells	5
Lecture title not available	5
Plasma concentration of LAT1 substrate amino acids affects the spinal cord transfer and the analgesic effect of pregabalin	5
Assess CYP450 induction by qRT-PCR quantificaiton of CYP450 mRNAs from Small Extracellular Vesicles (SEVS) derived from plasma	5
Implementation of blood collection using the Tasso microsampling device to measure thyroid hormone biomarkers	5
IN VITRO AND IN VIVO SYSTEMS FOR PREDICTING THE ADME OF PROTEIN THERAPEUTICS: ARE WE THERE YET?”	5
Effect of antibiotic-administration period on hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries	5
Strategies for de-risking n-nitrosamine impurities in APIS	5
Identification of pazopanib as an OATP1B1 substrate by competitive counterflow screeen	5
Investigating the role and function of OATP drug transporters in relation to tamoxifen therapy	5
Carboxylesterase-2 plays a critical role in dabigatran etexilate active metabolite formation	5
Clinical studies on pharmacogenomics and DDIS involving drug transporters	5
Use of mathematical modeling to guide out-of-the-box thinking for ADC development	5
Update from the IQ TALG quantitative fraction metabolized working group	5
Regulation of rat hepatic monocarboxylate transporter expression by sex and cross-sex hormone treatment	5
Closing the translational gap: Human multi-tissue chip platform for predictive and mechanistic preclinical studies	4
Simple confirmation methods for rare but impaired variants of human flavin-containing monooxygenase 3 (FMO3) found in an updated genome resource databank	4
Development of physiologically-based pharmacokinetic models to predict food effects and co-administration of proton pump inhibitors on the pharmacokinetics of sonidegib and vismodegib	4
Micro-physiological system of human lung: The current status and application to drug discovery	4
OCT1 transporter kinetics and long-term modulation studies in 3D cultured primary human hepatocytes	4
Corrigendum to “Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study” [Drug Metabol Pharmacokine	4

Clarifying metabolism of the natural product drug troxerutin in vitro and in vivo	4
Effect of pregnancy-related hormones on mRNA expression of hepatic drug transporters and enzymes	4
Prediction of pharmacokinetics and pharmacodynamics in human for IRAK4 targeted protein degrader	4
Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 1	4
Mechanisms of afatinib-induced intestinal epithelial barrier dysfunction using human mini-gut model	4
Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network	4
A workflow for oligonucleotide metabolite identification studies	4
Exposure to mixed microplastic particles altered the fecal microbiome and its associated predictive functional pathways in mice	4
Spatial mapping of gemcitabine and its pharmacologically active metabolites in tissues using MALDI mass spectrometry imaging	4
The effect of clofazimine in modulating intracellular concentrations of remdesivir and GS-441524: A potential mechanism of enhancing antiviral effects against SARS-COV-2	4
Membrane transporters in drug development and as determinants of precision medicine; an update from the international transporter consortium	3
Mass balance recovery, absorption, metabolism, and excretion of [14C]-Acoziborole in healthy male subjects after single microtracer oral dosing – I – Preparation of GMP [14C]- acoziborole drug substan	3
Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture	3
Determination of drug-to-antibody ratio of T-DXD in plsama sample by LBA-LC-MS	3
Microfluidic chip for construction of 3D microvascular network of blood-brain barrier	3
Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites	3
Investigation of pharmacokinetic properties and brain penetration of genipin: A potential pharmacophore for Parkinson's disease treatment	3
Optimization of linker sequence of aminopeptidase A-Fc fusion proteins in pharmacokinetics and antihypertensive effect	3
Pharmacokinetic and pharmacodynamic interactions between astragalus membranaceus polysaccharides and metformin in diabetic mice	3
An improved sample preparation and analysis procedure for estradiol LC-MS/MS quantification	3
Drug-drug interaction studies of cortisol in cynomolgus monkeys by measuring cortisol, cortisol-D4, and their 6β-hydroxymetabolites in plasma	3
Discovery of PF-07817883, a second-generation oral SARS-CoV2 main protease inhibitor	3
Enhancing drug-drug interaction prediction by integrating physiologically-based pharmacokinetic model with fraction metabolized by CYP3A4	3
Generation of in vitro blood-placental barrier (BPB) models using human placental stem cells	3
Building robust human liver microsomal stability predictions: Leveraging inter- species correlation with rat data	3
Global proteomic profiling of a patient-derived 3D CYST model and reference tissue of polycystic kidney disease	2
Interactions of sutezolid and its active metabolite with human transporters	2
Insights into drug development with quantitative systems pharmacology: A prospective case study of uncovering hyperkalemia risk in diabetic nephropathy with virtual clinical trials	2
Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase	2
Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration	2
Prediction of drug-drug interaction risk of P-glycoprotein substrate in drug discovery	2
Evaluation for biotransformation of antibody-peptide conjugates using native mass spectrometry	2
Exploring the impact of PCB-18 (2,2',5-Trichlorobiphenyl) exposure on hepatic drug metabolizing enzymes and xenobiotic responses in humanzied mice	2
Impact of donor diversity on phase I and phase II activities in cryopreserved human hepatocytes and human liver microsomes	2
Oligonucleotide delivery to antigen presenting cells by using schizophyllan	2
Comparative analysis of microcystin toxicity in 2D and 3D cultured primary human hepatocytes	2
Therapeutic application of sequence-specific binding molecules for novel genome editing tools	2
Experimental validation of the reliability of dilution method for plasma protein binding assay in human plasma using 12 commercial compounds	2
Discovery of genetic biomarkers associated with antituberculosis drug-induced liver injury in the Korean population: Insights from nuclear and mitochondrial DNA variations	2
Opportunities for microphysiological systems from the view of Japanese industries	2
In vitro metabolic stability and in vivo phaarmacokinetic behavior of panobinostat in mouse models for the treatment of CNS tumors	2
Use of human liver microsomes to assess flavin-containing monooxygenase (FMO) metabolism in vitro	2
Keyword Index	1
Substrate-dependent characteristics in the transport function of SLC19A3: examination of the aspect of its sensitivity to flavonoids	1
Triggering of paclitaxel release from PEG monoglyceride niosomes by empty Span85 niosomes	1
Circulating tumor cells kinetics after short- and long-term folfirinox and GEM/NAB-PTX chemotherapy in xenograft mouse models of human pancreatic cancer	1
Protein expression as endpoint for assessment of CYP2B6 induction: Application of immuno-affinity capture method reveals improved dynamic response range	1
Evaluating the impact of glycocalyx on partitioning and distribution of basic drugs	1
Beyond the basics: A deep dive into parameter estimation for advanced PBPK and QSP models	1
Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants	1
A new indicator for detecting weak inducers by 4Β-Hydroxycholesterol as a biomarker of CYP3A4 induction, and protocol for handling clinical samples	1
Assessment of unintentional effects on endangered species endemic to the Bonin Islands caused by deployment of anticoagulant rodenticide	1
Comparison on metabolic fate of dendrobium polysaccharides in gut microbiota fermentation process between healty and diabetic status	1
ADME: 14C-RLY-4008 following oral administration to rats	1
TLC-2716, a novel Liver X Receptor (LXR) inverse agonist with high enterohepatic but low systemic exposure	1
Change in transport function of drugs into the multicellular inner blood-retinal barrier spheroids under hypoxic culture with advanced glycation end-products	1
Assessing complex drug-drug interactions using the truvivotm hepatocyte model	1
Promiscuity and quantitative contribution of UGT2B17 in drug and steroid metabolism determined by experimental and computational approaches	1
Acetaminophen-induced liver injury and the microbiome	1
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6	1
Analysis of influx/efflux kinetics of metformin in Caco-2 cells	1
Effects of mefenamic acid on the conjugative metabolism of indole and p-cresol in relation to cellular necrosis in a metabolically competent human hepatoma cell line	1
Evaluation of OSTΑ/Β transporter activity on the basal membrane of CACO-2 cell monolayers	1
Hepatic expression of drug metabolizing enzymes is altered by concomitant obesogenic lipids and alcohol in mice and human hepatic organoids	1
Alteration in intercellular lipid composition of stratum corneum in Goto-Kakizaki rats: A model of type 2 diabetes with an increased fentanyl release ratio from the transdermal formulation	1
Protein abundance of hydrolytic drug metabolizing enzymes in different tissues and across species	1
Radiokinetics, pharmacokinetics, mass balance and excretion, and metabolism of radiolabeled PROTAC® androgen receptor degrader bavdegalutamide (ARV-110) following intravenous and oral administration i	1
Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration	1
In vitro metabolism of kobusin in human liver preparations	1
Increasing the therapeutic index of ADCs with payload binding selectivity enhancers	1
Effects of valproate, an HDAC inhibitor, on the expression of folate carriers and folate metabolism-related genes in the placenta of rats	1
Comparative pharmacokinetic profiles of favipiravir alone and in combination with Thai herbal extract in rats	1
Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling	1
NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine	0
Quantitative prediction of P-GP/CYP3A substrate drug absorption in humans using a monolayer model derived from intestinal organoids	0
Advanced in vitro evaluation of drug-induced kidney injury using microphysiological systems in drug discovery and development	0
Development of quantitative translational model of neutropenia using nonclinical animal data and physiological parameters	0
Approach to de-risk structural alerts in compound progression	0
Xenobiotic transporter SLC22A4 expressed in microglia and neuron as a potential target for neurogenesis in Alzheimer's disease model mice	0
Does cannabidiol (CBD) or delta-9-tetrahydrocannabinol (THC) induce drug metabolizing enzymes in human hepatocytes?	0

Intra-patient variation in CYP2D6 activity over time assessed using the dietary biomarker solanidine in breast cancer patients on tamoxifen	0
Absorption, metabolism, and excretion of inavolisib (GDC-0077), a PI3KA inhibitor in humans	0
Exposure-response analysis of the efficacy and safety of esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker, in hypertensive patients with or without diabetic kidney disease	0
Functional characterization of ATP13A3 as a plasma membrane polyamine transporter	0
Development of a novel in silico classification model to assess reactive metabolite formation in cysteine trapping assay and investigation of important substructures	0
Prevention of irinotecan-induced intestinal toxicity by locally bioavailable herbal components via maintaining gut oxidative stress homeostasis	0
Expanding pharmacogenomics panel assay to include transporter genes and more phase I metabolism variants	0
Assessing the first-pass effects of of felodipine with the small intestine-liver coupled microphysiological system	0
Method development to correct tissue concentrations for residual blood: Application to drug distribution in brain tumors	0
Bioavailability of tetracyclines is substantially increased by administration of cyclosporine A, a non-specific efflux-pump blocker	0
Preclinical DDI risk assessment in drug discovery and development	0
Hepatocyte formation, reactivity, and stability differences of acyl glucuronide and acyl coenzyme a conjugates	0
Development of a high throughput screen for cytochrome P450-ligand binding assays	0
The inhibitory effects of major cannabinoids and their metabolites on R- and S-oxazepam metabolism	0
How do i use PBPK modeling to discern complex drug-drug interactions?	0
Pharmacokinetics of perfluoroocanoic acid and perfluorohexane sulfonic acid in various rat models	0
Development of human glucuronide atlas and its application for identifying endogenous UGT substrates by a novel metabolomic-based DMET biomarker discovery (MDBD) approach	0
Mechanistic pharmacokinetics & pharmacodynamics of GaINAc-siRNA	0
In vitro assessment of potential for onvansertib to cause cytochrome P450 and transporter-mediated pharmacokinetic drug-drug interactions	0
Future direction of animal alternative/microphysiological systems in drug discovery and development	0
Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine	0
Using quantitative systems pharmacology (QSP) models to characterize the PK of novel drug modalities	0
Implication of H+/peptide transporters (PEPTS) on uptake of N-lactoylphenylalanine (LAC-PHE) in the intestinal and renal epithelial cells	0
Unveiling the mechanistic involvement of the human microbiome and human drug- processing genes in modulating the hepatic transcriptome in mice in vivo	0
A systematic study to evaluate the safety of ticagrelor combined with aspirin in the treatment of PCI patients in Chinese population: A single nucleotide polymorphisms study	0
Availability of polydimethylsiloxane chip in evaluation of small intestinal absorption	0
Elucidation of the properties of fatty acid amide hydrolase 2 as a drug-metabolizing enzyme	0
Oligonucleotide target engagement	0
Cytochrome P450 (CYP) phenotyping of aficamten, a next-in-class inhibitor of cardiac myosin, using human liver microsomes and human recombinant CYP enzymes	0
In vitro inhibitory effects of components from Salvia miltiorrhiza on catalytic activity of three human Arachidonic acid ω-hydroxylases	0
Characterization of long-lasting inhibition of amino acid transporter LAT1 by nanvuranlat (JPH203) in cholangiocellular carcinoma	0
Impact of DNA G-Quadruplex formation on CYP3A4 gene transcription	0
Targeted Protein Degraders (TPD): PK/PD translation from preclinical to clinical	0
Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis	0
Characterization of human immortalized cell-based blood-brain barrier spheroid models as a tool for brain vascular inflammation studies	0
Pharmacokinetic interactions of niclosamide in rats: Involvement of organic anion transporters 1 and 3 and organic cation transporter 2	0
Air–liquid interface culture and modified culture medium promote the differentiation of human induced pluripotent stem cells into intestinal epithelial cells	0
Transporter activity characterization in a novel human hepatic cell-based tri-culture system	0
Improving in vitro clearance assay performance and prediction accuracy with advanced human hepatocyte models for highly stable RO5 and BRO5 compounds	0
Unexpected major circulating metabolite M219 detected in 14C-labeled human adme study of brilaroxazine	0
Hepatocyte CEBPA restricts the progression of liver fibrosis	0
Development of intestinal organoids and microphysiological systems and their application to drug discovery	0
Characterization of an 3D-printed expandable drug delivery system for tofacitinib in beagle dogs	0
Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice	0
Mechanisms underlying cognitive enhancement induced by oral ingestion of yeast- derived RNA using comprehensive targeted lipidomics	0
Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo	0
Gastrointestinal imaging with MRI: Insights into the behavior of dosage forms and the conditions at the site of drug release	0
Development of a fluorescent-labeled trapping reagent to evaluate the risk posed by acyl-CoA conjugates	0
14C-radiolabeled human ADME: a review of clinical microtracer mass balance data	0
Prediction of the in vivo pharmacokinetics of sustained-release injections for semaglutide by a novel ivivc model combined with DoE	0
CYP7A1 gene induction via SHP-dependent or independent mechanisms can increase the risk of drug-induced liver injury independent or in synergy with BSEP inhibition	0
Diclofenac potentiates the antitumor effect of cisplatin in a xenograft mouse model transplanted with cisplatin-resistant cells without enhancing cisplatin-induced nephrotoxicity	0
In vitro - In vivo extrapolation approaches for glucuronidated drugs: Promises and pitfalls	0
In vitro characterization of taurine transport using the human brain microvascular endothelial cell line as a human blood-brain barrier model	0
Biotransformation of protein degraders bavdegalutamide and XL01126 in permeabilized cryopreserved human hepatocytes	0
An overview of CDE technical guideline for nonclinical study of ADCS: importance and strategy of studying release of payload-containing components from ADC and their further metabolism	0
Expression and functional analyses of the PK-related genes in differentiated intestinal epithelial cells derived from cryopreserved human intestinal mucosal epithelium (CHIM)	0
Construction and functional of human BBB model derived from MDR1 gene- transfected human iPS cells in two- and three-dimensional culture plate	0
Functional characteristics of equilibrative nucleoside transporter 2 (ENT2/SLC29A2) for the transport of urate as a newly identified substrate	0
Mass balance, pharmacokinetics, and tissue distribution of [14C] Zetomipzomib in rats by quantitative whole-body autoradiography	0
A successful preclinical toxicology package	0
Schisandra sphenanthera: Its hepatoprotection and beyond	0
DMPK perspective on quantitative model analysis for chimeric antigen receptor cell therapy: Advances and challenges	0
Quantification of fluticasone propionate in human plasma by LC–MS/MS and its application in the pharmacokinetic study of nasal spray at clinical doses	0
Moxidectin metabolism in reindeer	0
OMICS data-based analysis of mitochondrial characteristics and toxicity mechanisms	0
Multicellular spheroidal human blood-brain barrier models are a useful tool for characterization of brain-penetrating antibodies	0
Development of plasma stability assay for oligonucleotides	0
Next generation quantitative proteomics-based central nervous system barrier studies	0
ARE Δ9-tetrahydrocannabinol and its major metabolites substrates or inhibitors of the human hepatic and placental solute-carrier transporters?	0
Preface: In silico technologies to facilitate drug development	0
Encequidar is a gut-restricted P-GP specific inhibitor that boosts oral bioavailability and inhibits intestinal secretion in rats and dogs.	0
Characterization of plasma vonoprazan and CYP3A activity using its endogenous marker and genetic variants in patients with digestive system disorders	0
Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers	0
A synthetic G protein-coupled receptor 40 agonist GW9508 mitigates airway inflammation and mucus secretion in allergic asthma	0
Exploring the potential of machine learning approach in predicting clinical CYP3A induction-mediated drug-drug interaction	0
Comparative analysis of pharmacokinetic characteristics for the in-situ albumin drug conjugate	0
Opportunities and challenges in drug development for retinal diseases	0
Analysis of government regulation effectiveness based on phthalate risk assessment	0
Experiences in industry predicting hepatic clearance: Successes, disconnects, failures, and room for improvement	0
Why and when do i use PBPK modeling	0
Novel metabolomics approach to identify biomarkers of organic anion renal transporters	0
Smart compound library based on machine learning, sensing technology, and programmable logic control	0
High-throughput assessment for drug protein binding using magnetized silica beads method in human liver microsomes	0
Monkey blood-brain barrier co-culture model as an alternative method for predicting brain penetration	0
Converting suspension-type human primary hepatocytes to be plateable-type for use as an in vitro pharmacokinetics model	0
Elucidating mechanisms of promiscuous aggregation on CYP inhibition assays	0
Functional role of serine 318 of the proton-coupled folate transporter in methotrexate transport	0
A retrospective comparison of the PK profiles of lipid 5, the ionizable lipid in LNP2, across rat, NHP, and human	0
Investigating cross-species differences of MDR1-mediated drug transport	0
Optimization of methods for reducing turnaround time and compound consumptionwith echo liquid handling and automation enabling high capacity analysis for ADME screening	0
What is new in LC-MS proteomics: Techniques and applications in IVIVE and precision medicine	0
Functional characteristics of a newly identified vesicular membrane-localized monoamine transporter for serotonin transport	0
Characteristics of membrane transport, metabolism, and target protein binding of cyclic depsipeptide destruxin E in HeLa cells	0
Uncovering Target-Mediated Drug Disposition (TMDD) of small molecule brain penetrant EBP inhibitors	0