Journal of Pharmacological Sciences

Papers
(The median citation count of Journal of Pharmacological Sciences is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Emodin-induced autophagic cell death hinders epithelial–mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis99
Effects of galantamine on social interaction impairments in cholecystokinin receptor-2 overexpression mice64
Potential effective treatment of shortening continuous erythropoietin receptor activator treatment interval combined with iron supplementation in hemodialysis patients54
Noradrenaline increases intracellular Ca2+ concentration in epithelial cells via α2-adrenoceptors in isolated mouse ileal crypts39
Analysis of effects of acute hypovolemia on arterial stiffness in rabbits monitored with cardio-ankle vascular index37
Quantitative prediction of pharmacokinetic properties of drugs in humans: Recent advance in in vitro models to predict the impact of efflux transporters in the small intestine and blood–brain barrier37
Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury34
Role of cardiac α1-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in the anesthetized atrioventricular block rabbit29
Schwann cell derived-peroxiredoxin protects motor neurons against hydrogen peroxide-induced cell death in mouse motor neuron cell line NSC-3429
The influence of OATP2B1 and atorvastatin on coproporphyrin isomers in rats28
Ameliorating effects of cystine and theanine in a cancer cachexia mouse model26
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice25
Inhibitory mechanism of tangeretin, a citrus flavone on the sphingosylphosphorylcholine (SPC)-induced vascular smooth muscle contraction24
Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice24
Impact of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of lenvatinib in patients with hepatocellular carcinoma23
Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice22
Resveratrol promotes autophagosome elimination via SIRT1 in cardiomyocytes22
Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice21
Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats21
Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis20
Granisetron attenuates liver injury and inflammation in a rat model of cecal ligation and puncture-induced sepsis20
Effects of molidustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, on sodium dynamics in hypertensive subtotally nephrectomized rats19
Safety and efficacy of using cereal food (Frugra®) to improve blood pressure and bowel health in patients undergoing chronic hemodialysis: A pilot study19
CYP11A1 silencing suppresses HMGCR expression via cholesterol accumulation and sensitizes CRPC cell line DU-145 to atorvastatin19
Potential treatments of COVID-19: Drug repurposing and therapeutic interventions19
Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness18
T-type Ca2+ channel enhancer SAK3 administration improves the BPSD-like behaviors in AppNL−G-F/NL−G-F knock-in mice17
Impairment of endothelium-dependent vasodilator function of retinal blood vessels in adult rats with a history of retinopathy of prematurity17
Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate17
Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation17
Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study16
Mucin 1 regulates the hypoxia response in head and neck cancer cells16
Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach15
Detrusor underactivity causes neurogenic voiding dysfunction in a rat bilateral accessory nerve-injury model15
Platelet-activating factor (PAF) enhances guinea pig detrusor smooth muscle contractile activities by stimulating voltage-dependent Ca2+ channels and store-operated Ca2+ channels15
Actions of remimazolam on inhibitory transmission of rat spinal dorsal horn neurons15
Peficitinib inhibits fibroblast-like synoviocyte activation and angiogenic vascular endothelial tube formation via inhibitory effects on PDGF and VEGF signaling in addition to JAK15
Sulfur metabolism as a new therapeutic target of heart failure14
Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells14
Characterization of remodeling processes in the atria of atrioventricular block dogs: Utility as an early-stage atrial fibrillation model14
Emodin alleviates lung injury via the miR-217-5p/Sirt1 axis in rats with severe acute pancreatitis14
Neohesperidin exerts antidepressant-like effect via the mechanistic target of rapamycin complex 1 in the medial prefrontal cortex in male mice14
Analgesic effect of Keishinieppiittokajutsubu on low barometric pressure-induced pain response in arthritic model rats14
Cystine transporter SLC7A11 regulates sensitivity to unsaturated carbonyl compounds in mouse macrophage cell lines14
Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin14
Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan13
Calycosin pretreatment enhanced the therapeutic efficacy of mesenchymal stem cells to alleviate unilateral ureteral obstruction-induced renal fibrosis by inhibiting necroptosis13
Corrigendum to ‘Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice’ [Journal of Pharmacological Sciences 148 (2022) 65–72]13
Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells12
Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects12
Atypical antidepressant mirtazapine inhibits 5-hydroxytryptamine3 receptor currents in NCB-20 cells12
Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS cell-derived cardiomyocytes12
Stathmin expression alters the antiproliferative effect of eribulin in leiomyosarcoma cells12
Development of gene silencer pyrrole-imidazole polyamides targeting GSK3β for treatment of polycystic kidney diseases12
Effects of TND1128 (a 5-deazaflavin derivative), with self-redox ability, as a mitochondria activator on the mouse brain slice and its comparison with β-NMN12
Aldo-keto reductase inhibitors increase the anticancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia11
Blueberry anthocyanins extract attenuated diabetic retinopathy by inhibiting endoplasmic reticulum stress via the miR-182/OGG1 axis11
Research on the protective effect of Rhizoma of Anemarrhena asphodeloides on TMT induced AD mice model based on network pharmacology combined with in vitro and in vivo experimental validation11
Ramelteon administration enhances novel object recognition and spatial working memory in mice10
Zinc transporters as potential therapeutic targets: An updated review10
Aronia melanocarpa polysaccharide ameliorates liver fibrosis through TGF-β1-mediated the activation of PI3K/AKT pathway and modulating gut microbiota10
Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination10
Dencichine prevents ovariectomy-induced bone loss and inhibits osteoclastogenesis by inhibiting RANKL-associated NF-κB and MAPK signaling pathways10
Lactate dehydrogenase A inhibition prevents RANKL-induced osteoclastogenesis by reducing enhanced glycolysis10
Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats10
l-DOPA receptor GPR143 inhibits neurite outgrowth via L-type calcium channels in PC12 cells9
The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment9
Proteasome inhibitors induce apoptosis by superoxide anion generation via NADPH oxidase 5 in human neuroblastoma SH-SY5Y cells9
Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/β-catenin signaling in methotrexate-induced rat ileal mucositis9
YAP activation in Müller cells alleviates oxidative stress in the rat retina after intravitreal injection with methylglyoxal9
Effects of fecal microbiota transplantation on behavioral abnormality in attention deficit hyperactivity disorder-like model rats9
N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy9
Evaluation of inhibitory actions of antidepressants on muscarinic receptors assessed by a binding assay in the mouse cerebral neocortex9
Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway9
Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation9
Targeting enteric glial CRF-R1/Cx43 attenuates stress-induced accelerated colonic motility9
Paeoniflorin, ferulic acid, and atractylenolide III improved LPS-induced neuroinflammation of BV2 microglia cells by enhancing autophagy9
Effect of antidepressants and social defeat stress on the activity of dorsal raphe serotonin neurons in free-moving animals9
Drug combination of topical ripasudil and brimonidine enhances neuroprotection in a mouse model of optic nerve injury8
Gadoxetic acid-enhanced magnetic resonance imaging predicts early nab-paclitaxel-induced peripheral neuropathy during pancreatic cancer treatment: A pilot study8
Gallic acid ameliorates endometrial hyperplasia through the inhibition of the PI3K/AKT pathway and the down-regulation of cyclin D1 expression8
Evaluation of intracellular signal molecules that regulate TLR4-stimulated inflammatory mediator expression in cultured rat chondrocytes8
Oroxylin-A and its phosphonate derivative potentiate eNOS/NO-mediated relaxation and attenuate vasoconstrictor-induced contraction in the mouse aorta8
CU06-1004 alleviates oxidative stress and inflammation on folic acid-induced acute kidney injury in mice8
Tolvaptan induces body fluid loss and subsequent water conservation in normal rats8
Retraction notice to “Polyphyllin I inhibits growth and invasion of cisplatin-resistant gastric cancer cells by partially inhibiting CIP2A/PP2A/Akt signaling axis” [J Pharmacol Sci 137 (2018) 305–312]8
Electrophysiological responses to seizurogenic compounds dependent on E/I balance in human iPSC-derived cortical neural networks8
Corrigendum to “Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinicepolycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells” [Journa8
Penehyclidine hydrochloride activates PARK2 and modulates ubiquitination of AIFM1 to rescue renal tubular injury in diabetic kidney disease8
The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory diseases8
Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways8
Paclitaxel-induced peripheral neuropathy in male rats attenuated by calmangafodipir, a superoxide dismutase mimetic8
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway8
An assessment of the spontaneous locomotor activity of BALB/c mice8
Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells7
Therapeutic effects of the alkaline extract of leaves of Sasa sp. and elucidation of its mechanism in acute kidney injury7
Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents7
Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice7
The roles of lipid mediators in type I hypersensitivity7
PP2A regulates metastasis and vasculogenic mimicry formation via PI3K/AKT/ZEB1 axis in non-small cell lung cancers7
Neurotropin® alleviates nerve damage in a mouse chronic nerve compression model7
Phloroglucinol attenuates oligomeric amyloid beta peptide1-42-induced astrocytic activation by reducing oxidative stress7
2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induce7
Amitriptyline and duloxetine attenuate activities of superficial dorsal horn neurons in a rat reserpine-induced fibromyalgia model7
Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice7
Andrographolide improves PCP-induced schizophrenia-like behaviors through blocking interaction between NRF2 and KEAP17
Comparison of cytotoxicity of cigarette smoke extract derived from heat-not-burn and combustion cigarettes in human vascular endothelial cells7
Development of hepatic impairment aggravates chemotherapy-induced peripheral neuropathy following oxaliplatin treatment: Evidence from clinical and preclinical studies7
Different voltage dependence of ICaL blockade in nonselective IKr blockers causes their opposite effects on early afterdepolarization in drug-induced arrhythmia7
Effects of dapagliflozin on peripheral sympathetic nerve activity in standard chow- and high-fat-fed rats after a glucose load7
Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT106
Preservation of vascular endothelial glycocalyx and barrier by activation of adenosine A2A receptor (A2AR) improved renal dysfunction in cirrhotic rats6
Establishing a high throughput drug screening system for cerebral ischemia using zebrafish larvae6
Generation of DNA-aptamers targeting galectin-7 for the identification of cholesteatoma residue6
Platinum-based anticancer drugs-induced downregulation of myosin heavy chain isoforms in skeletal muscle of mouse6
Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases6
A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats6
Platelet-activating factor contracts guinea pig esophageal muscularis mucosae by stimulating extracellular Ca2+ influx through diltiazem-insensitive Ca2+ channels6
Simultaneous XIAP and cIAP1/2 inhibition by a dimeric SMAC mimetic AZD5582 induces apoptosis in multiple myeloma6
Therapeutic effect of allicin in a mouse model of intracerebral hemorrhage6
Mechanism of canagliflozin-induced vasodilation in resistance mesenteric arteries and the regulation of systemic blood pressure6
Peptides obtained by enzymatic decomposition of mackerel induce recovery from physical fatigue by enhancing the SIRT1-mediated antioxidant effect in the soleus muscle of mice6
The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters6
In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan6
Role of transient receptor potential vanilloid subtype 2 in lower oesophageal sphincter in rat acid reflux oesophagitis6
Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells6
Pharmacological study on the enhancing effects of U46619 on guinea pig urinary bladder smooth muscle contraction induced by acetylcholine and α,β-methylene ATP and the possible involvement of protein 6
Presynaptic inhibition of excitatory synaptic transmission from the calcitonin gene-related peptide-containing parabrachial neurons to the central amygdala in mice – unexpected influence of systemic i6
Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor5
Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats5
P2Y2 receptor mediates dying cell removal via inflammatory activated microglia5
Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC45
Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission5
Darbepoetin alfa enhances exercise performance in trained mice in a sex-specific manner5
Combined antiallodynic effects of Neurotropin®–tramadol and Neurotropin®–mirogabalin in rats with L5-spinal nerve ligation5
Pterostilbene alleviates liver ischemia/reperfusion injury via PINK1-mediated mitophagy5
Glucocorticoid-induced acute diuresis in rats in relation to the reduced renal expression of sodium-dependent cotransporter genes5
Effect of ASP8062 on morphine self-administration and morphine-induced respiratory suppression in monkeys5
circ_0101802 functions as a sponge of miR-1236-3p to facilitate the proliferation, migration and invasion of colorectal cancer via regulating MACC15
TND1128, a 5-deazaflavin derivative with auto-redox ability, facilitates polarization of mitochondrial membrane potential (ΔΨm) and on-demand ATP synthesis in mice brain slices5
Comparative characterization of β-adrenoceptors in the bladder, heart, and lungs of rats: Alterations in spontaneously hypertensive rats5
Retraction notice to " LncRNA NEAT1 acts as a key regulator of cell apoptosis and inflammatory response by the miR-944/TRIM37 axis in acute lung injury'" [J. Pharmacol. Sci. 145 (2021) 202–212]5
ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis5
Imeglimin profoundly affects the circadian clock in mouse embryonic fibroblasts5
Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors5
TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway5
Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization5
Protective effects of tadalafil on damaged podocytes in an adriamycin-induced nephrotic syndrome model5
Role of CD34 in calcification of human aortic valve interstitial cells from patients with aortic valve stenosis5
Guanabenz inhibits alveolar bone resorption in a rat model of periodontitis5
Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid5
Perineural treatment with anti-TNF-α antibody ameliorates persistent allodynia and edema in novel mouse models with complex regional pain syndrome5
Laminar-selective spinal astrocyte population capable of converting tactile information into nociceptive in rats4
Vascular sympathetic neurotransmission and its serotonergic regulation are modified by chronic fluoxetine treatment4
SMTP-44D alleviates diabetic retinopathy by suppressing inflammation and oxidative stress in in vivo and in vitro models4
Icariin alleviates diabetic renal interstitial fibrosis aggravation by inhibiting miR-320a-3p targeting BMP64
Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality4
Peficitinib improves bone fragility by recovering bone turnover imbalance in arthritic mice4
Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels4
KCa3.1 regulates cell cycle progression by modulating Ca2+ signaling in murine preosteoblasts4
Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study4
CCN1 derived from vascular endothelial cells impairs cognitive function in Alzheimer’s disease model mice4
Icariin inhibits epithelial mesenchymal transition of renal tubular epithelial cells via regulating the miR-122-5p/FOXP2 axis in diabetic nephropathy rats4
Post-stroke treatment with K-134, a phosphodiesterase 3 inhibitor, improves stroke outcomes in the stroke-prone spontaneously hypertensive rat model–A comparative evaluation of antiplatelet drugs4
Mitochondrial toxins potentiate hydroxyl radical production in rat striatum during carbon monoxide poisoning4
Extraction and measurement of urinary tetranor-PGDM in disposable diapers4
Long-term glucocorticoid treatment increases CD204 expression by activating the MAPK pathway and enhances modified LDL uptake in murine macrophages4
Farrerol suppresses osteoclast differentiation and postmenopausal osteoporosis by inhibiting the nuclear factor kappa B signaling pathway4
Dihydroartemisinin regulates apoptosis, migration, and invasion of ovarian cancer cells via mediating RECK4
Goreisan suppresses cardiac remodeling and dysfunction in a new mouse model with diabetic cardiomyopathy4
Minocycline prevents monocrotaline-induced pulmonary hypertension through the attenuation of endothelial dysfunction and vascular wall thickening4
Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia4
CSF1R inhibitor PLX3397 depletes microglia in Mongolian gerbil Meriones unguiculatus, but not in syrian hamster Mesocricetus auratus4
Inflammation in the brain and periphery found in animal models of depression and its behavioral relevance4
Sperm-associated antigen 6 (Spag6) mutation leads to vestibular dysfunction in mice4
Targeting TMEM16A ion channels suppresses airway hyperreactivity, inflammation, and remodeling in an experimental Guinea pig asthma model4
Repeated topical paeoniflorin attenuates postoperative pain and accelerates cutaneous fibroblast proliferation in mice3
Lactucin & Lactucopicrin ameliorates FFA-induced steatosis in HepG2 cells via modulating lipid metabolism3
LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC) progression by sponging miR-4651 and subsequently upregulating FOXO63
Histamine enhances ATP-induced itching and responsiveness to ATP in keratinocytes3
Involvement of N-methyl-D-aspartate receptor GluN2C/GluN2D subunits in social behavior impairments in mice exposed to social defeat stress as juveniles3
Liraglutide ameliorates diabetes-associated cognitive dysfunction via rescuing autophagic flux3
Midnolin gene expression is enhanced by Gq-coupled muscarinic acetylcholine receptor stimulation in SH-SY5Y human neuroblastoma cells3
Dasatinib suppresses atherosclerotic lesions by suppressing cholesterol uptake in a mouse model of hypercholesterolemia3
Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice3
SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium3
Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice3
Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency in mouse model3
Intraoral treatment of persimmon tannin, a polyphenol extracted from persimmon, significantly ameliorates gingivitis, plaque and halitosis via directly influence the periodontal bacteria Porphyromonas3
Protein kinase Cβ is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages3
Sulconazole induces pyroptosis promoted by interferon-γ in monocyte/macrophage lineage cells3
Computational study of the therapeutic potentials of a new series of imidazole derivatives against SARS-CoV-23
Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-1273
Piezo 1 is involved in intraocular pressure regulation3
Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction3
Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation3
Spinal dorsal horn neurons involved in the alleviating effects of cannabinoid receptor agonists on neuropathic allodynia-like behaviors in rats3
Caffeic acid protects against atherosclerotic lesions and cognitive decline in ApoE−/− mice3
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