OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological Sciences is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia	134
Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice	77
Oren-gedoku-to inhibits calcification of human aortic valve interstitial cells in vitro and aortic valve in spontaneously hypertensive rats in vivo	69
Cystine transporter SLC7A11 regulates sensitivity to unsaturated carbonyl compounds in mouse macrophage cell lines	49
CYP11A1 silencing suppresses HMGCR expression via cholesterol accumulation and sensitizes CRPC cell line DU-145 to atorvastatin	46
The influence of OATP2B1 and atorvastatin on coproporphyrin isomers in rats	40
Noradrenaline increases intracellular Ca2+ concentration in epithelial cells via α2-adrenoceptors in isolated mouse ileal crypts	39
Inhibitory mechanism of tangeretin, a citrus flavone on the sphingosylphosphorylcholine (SPC)-induced vascular smooth muscle contraction	30
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice	27
Peficitinib inhibits fibroblast-like synoviocyte activation and angiogenic vascular endothelial tube formation via inhibitory effects on PDGF and VEGF signaling in addition to JAK	27
Zinc transporters as potential therapeutic targets: An updated review	27
Early temporal suppression of SPARC inhibits oxidative stress, inflammation, and fibrosis in the chronic phase after renal ischemia/reperfusion	26
Receptor-mediated Gi-3 activation in mammalian and human brain membranes: Reestablishment method and its application to nociceptin/orphanin FQ opioid peptide (NOP) receptor/Gi-3 interaction	26
Generation of DNA-aptamers targeting galectin-7 for the identification of cholesteatoma residue	25
The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters	25
Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/β-catenin signaling in methotrexate-induced rat ileal mucositis	24
Tolvaptan induces body fluid loss and subsequent water conservation in normal rats	24
Pharmacological study on the enhancing effects of U46619 on guinea pig urinary bladder smooth muscle contraction induced by acetylcholine and α,β-methylene ATP and the possible involvement of protein	23
Corrigendum to “Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinicepolycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells” [Journa	23
In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan	22
Platelet-activating factor contracts guinea pig esophageal muscularis mucosae by stimulating extracellular Ca2+ influx through diltiazem-insensitive Ca2+ channels	22
N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy	21
TND1128, a 5-deazaflavin derivative with auto-redox ability, facilitates polarization of mitochondrial membrane potential (ΔΨm) and on-demand ATP synthesis in mice brain slices	21
Intraoral treatment of persimmon tannin, a polyphenol extracted from persimmon, significantly ameliorates gingivitis, plaque and halitosis via directly influence the periodontal bacteria Porphyromonas	20
Combined antiallodynic effects of Neurotropin®–tramadol and Neurotropin®–mirogabalin in rats with L5-spinal nerve ligation	20

Targeting TMEM16A ion channels suppresses airway hyperreactivity, inflammation, and remodeling in an experimental Guinea pig asthma model	19
Glucocorticoid-induced acute diuresis in rats in relation to the reduced renal expression of sodium-dependent cotransporter genes	19
Lactucin alleviates lipid accumulation via AMPK-mediated autophagy and fatty acid β-oxidation in FFA-induced HepG2 cells	19
Direct effects of cigarette smoke extract from heated tobacco products on cardiomyocyte: Comparison with combustible cigarettes	18
CCN1 derived from vascular endothelial cells impairs cognitive function in Alzheimer’s disease model mice	18
Darbepoetin alfa enhances exercise performance in trained mice in a sex-specific manner	17
Nerol enhances lipid synthesis in human sebocytes via cannabinoid receptor-2-mediated MAPK signaling	17
Mirogabalin and pregabalin alleviate nociplastic sensitization induced by chemogenetic activation of the central amygdala neurons in rodents	16
KCa3.1 regulates cell cycle progression by modulating Ca2+ signaling in murine preosteoblasts	16
Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization	15
Dasatinib suppresses atherosclerotic lesions by suppressing cholesterol uptake in a mouse model of hypercholesterolemia	15
In vivo cardiovascular profile of ryanodine receptor 2 inhibitor M201-A: Utility as an anti-atrial fibrillatory drug for patients suffering from heart failure with preserved ejection fraction	15
The citrus flavonoid nobiletin prevents the development of doxorubicin-induced heart failure by inhibiting apoptosis	15
Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification	14
Acetaminophen improves tardive akathisia induced by dopamine D2 receptor antagonists	14
LncRNA Mir155hg contributes to hippocampal injury in status epilepticus rats through miR-155/Socs1/NF-κΒ signaling axis	14
Mechanisms underlying the methylglyoxal-induced enhancement of uridine diphosphate-mediated contraction in rat femoral artery	14
Analyses of the onset mechanisms of cardio-stimulatory action by aciclovir	14
Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects	14
ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum	14
Suppressing SPARC gene with siRNA exerts therapeutic effects and inhibits MMP-2/9 and ADAMTS1 overexpression in a murine model of ischemia/reperfusion-induced acute kidney injury	13
Different sensitivities of porcine coronary arteries and veins to BAY 60–2770, a soluble guanylate cyclase activator	13
The adenosine A2A receptor antagonist/inverse agonist, KW-6356 enhances the anti-parkinsonian activity of L-DOPA with a low risk of dyskinesia in MPTP-treated common marmosets	13
Antidepressant effect of globin digest through enhanced hippocampal neurogenesis in a mouse model of lipopolysaccharide-induced depression	13
Deletion of intestinal SIRT1 exacerbated muscle wasting in cirrhotic mice by decreasing the intestinal concentration of short-chain fatty acids and inflammation	13
A novel lysophosphatidic acid receptor 1 antagonist with high brain penetrability has a curative effect in the empathic pain-related fibromyalgia model	12
Novel aspects of sepsis pathophysiology: NETs, plasma glycoproteins, endotheliopathy and COVID-19	12
Transient receptor potential melastatin 2 is involved in trinitrobenzene sulfonic acid-induced acute and chronic colitis-associated fibrosis progression in mice	12
Involvement of Cav3.2 T-type Ca2+ channels and cystathionine-β-synthase in colitis-related visceral hypersensitivity in mice	12
Inhibition of thymic stromal lymphopoietin production by FK3453	12
Potential role of inducible GPR3 expression under stimulated T cell conditions	11
Protocatechuic aldehyde restrains NLRP3 inflammasome activation to alleviate inflammatory response in sepsis	11
Oral allergy induction through skin exposure to previously tolerated food antigens in murine models	11
Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles	11
Targeting 14-3-3ζ by a small-molecule compound AI-34 maintains epithelial barrier integrity and alleviates colitis in mice via stabilizing β-catenin	11
Development of multifunctional pyrrole-imidazole polyamides that increase hepatocyte growth factor and suppress transforming growth factor-β1	11
Contribution of MLKL to the development of doxorubicin-induced cardiomyopathy and its amelioration by rapamycin	11
Pituitary adenylate cyclase-activating polypeptide deficient mice show length abnormalities of the axon initial segment	11
Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice	10
YAP activation in Müller cells alleviates oxidative stress in the rat retina after intravitreal injection with methylglyoxal	10
Penehyclidine hydrochloride activates PARK2 and modulates ubiquitination of AIFM1 to rescue renal tubular injury in diabetic kidney disease	10
Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses	10
Histamine promotes angiogenesis through a histamine H1 receptor-PKC-VEGF-mediated pathway in human endothelial cells	10
Platelet-activating factor (PAF) enhances guinea pig detrusor smooth muscle contractile activities by stimulating voltage-dependent Ca2+ channels and store-operated Ca2+ channels	10
Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation	10
Imeglimin attenuates NLRP3 inflammasome activation by restoring mitochondrial functions in macrophages	10
Ca2+ microdomains in vascular smooth muscle cells: Roles in vascular tone regulation and hypertension	10
Paclitaxel-induced peripheral neuropathy in male rats attenuated by calmangafodipir, a superoxide dismutase mimetic	10
Effect of antidepressants and social defeat stress on the activity of dorsal raphe serotonin neurons in free-moving animals	9
Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10	9

Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid	9
Sperm-associated antigen 6 (Spag6) mutation leads to vestibular dysfunction in mice	9
Oral administration of undenatured type II collagen significantly inhibits arthritis-associated pain signal in a mouse model of collagen antibody-induced arthritis and meniscus removal	9
Neurotropin® alleviates nerve damage in a mouse chronic nerve compression model	9
Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice	9
Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors	9
ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis	9
Guanabenz inhibits alveolar bone resorption in a rat model of periodontitis	9
l-DOPA receptor GPR143 inhibits neurite outgrowth via L-type calcium channels in PC12 cells	9
Comparison of cytotoxicity of cigarette smoke extract derived from heat-not-burn and combustion cigarettes in human vascular endothelial cells	9
The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment	9
Aprepitant attenuates cutaneous mast cell migration in oxaliplatin-treated mice	9
SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium	9
Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways	8
Corrigendum to ‘Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489e3p/Sirt1 axis’[Journal of Pharmacological Sciences 147 (2021) 271–283]	8
The inhibitory effect of DIF-3 on polyinosinic–polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells	8
Publisher's note	8
Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling	8
Behavioral changes of food allergic model mice during light and dark period	8
Galantamine suppresses α-synuclein aggregation by inducing autophagy via the activation of α7 nicotinic acetylcholine receptors	8
The change of the electrophysiological parameters using human intestinal tissues from ulcerative colitis and Crohn's disease	8
Rhizoma Paridis saponins suppresses vasculogenic mimicry formation and metastasis in osteosarcoma through regulating miR-520d-3p/MIG-7 axis	8
Impact of fatty acid-binding proteins and dopamine receptors on α-synucleinopathy	8
Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anestheti	7
Diurnal variations of neurokinin-1 receptor defines dosing time-dependent differences in antitumor effects of aprepitant in mice	7
Effect of anti-claudin 18.2 monoclonal antibody zolbetuximab alone or combined with chemotherapy or programmed cell death-1 blockade in syngeneic and xenograft gastric cancer models	7
Theanine boosts frontal theta and hippocampal beta and gamma oscillations for familiarity in object recognition	7
An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK	7
Neuroprotective effects of compounds interacting with carrier-mediated amantadine transport across the blood–retinal barrier in rats	7
Sulfide and polysulfide as pronociceptive mediators: Focus on Cav3.2 function enhancement and TRPA1 activation	7
Sodium/glucose cotransporter 2 and renoprotection: From the perspective of energy regulation and water conservation	7
A novel AKR1C3 specific prodrug AST-3424 and its combination therapy in hepatocellular carcinoma	7
The role of ZEB1 in mediating the protective effects of metformin on skeletal muscle atrophy	7
Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis	7
Protective effect and regulatory mechanism of salidroside on skin inflammation induced by imiquimod in psoriasis mice	7