OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological Sciences is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Cystine transporter SLC7A11 regulates sensitivity to unsaturated carbonyl compounds in mouse macrophage cell lines	110
Potential effective treatment of shortening continuous erythropoietin receptor activator treatment interval combined with iron supplementation in hemodialysis patients	66
Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice	57
Inhibitory mechanism of tangeretin, a citrus flavone on the sphingosylphosphorylcholine (SPC)-induced vascular smooth muscle contraction	41
CYP11A1 silencing suppresses HMGCR expression via cholesterol accumulation and sensitizes CRPC cell line DU-145 to atorvastatin	41
The influence of OATP2B1 and atorvastatin on coproporphyrin isomers in rats	40
Noradrenaline increases intracellular Ca2+ concentration in epithelial cells via α2-adrenoceptors in isolated mouse ileal crypts	36
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice	31
Peficitinib inhibits fibroblast-like synoviocyte activation and angiogenic vascular endothelial tube formation via inhibitory effects on PDGF and VEGF signaling in addition to JAK	31
Zinc transporters as potential therapeutic targets: An updated review	30
Receptor-mediated Gi-3 activation in mammalian and human brain membranes: Reestablishment method and its application to nociceptin/orphanin FQ opioid peptide (NOP) receptor/Gi-3 interaction	27
N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy	27
Platelet-activating factor contracts guinea pig esophageal muscularis mucosae by stimulating extracellular Ca2+ influx through diltiazem-insensitive Ca2+ channels	25
The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters	25
Corrigendum to “Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinicepolycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells” [Journa	25
Generation of DNA-aptamers targeting galectin-7 for the identification of cholesteatoma residue	23
Role of transient receptor potential vanilloid subtype 2 in lower oesophageal sphincter in rat acid reflux oesophagitis	23
Pharmacological study on the enhancing effects of U46619 on guinea pig urinary bladder smooth muscle contraction induced by acetylcholine and α,β-methylene ATP and the possible involvement of protein	22
Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/β-catenin signaling in methotrexate-induced rat ileal mucositis	22
In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan	21
Tolvaptan induces body fluid loss and subsequent water conservation in normal rats	21
Mirogabalin and pregabalin alleviate nociplastic sensitization induced by chemogenetic activation of the central amygdala neurons in rodents	20
TND1128, a 5-deazaflavin derivative with auto-redox ability, facilitates polarization of mitochondrial membrane potential (ΔΨm) and on-demand ATP synthesis in mice brain slices	19
CCN1 derived from vascular endothelial cells impairs cognitive function in Alzheimer’s disease model mice	19
The citrus flavonoid nobiletin prevents the development of doxorubicin-induced heart failure by inhibiting apoptosis	19

Combined antiallodynic effects of Neurotropin®–tramadol and Neurotropin®–mirogabalin in rats with L5-spinal nerve ligation	19
Piezo 1 is involved in intraocular pressure regulation	19
Glucocorticoid-induced acute diuresis in rats in relation to the reduced renal expression of sodium-dependent cotransporter genes	19
Intraoral treatment of persimmon tannin, a polyphenol extracted from persimmon, significantly ameliorates gingivitis, plaque and halitosis via directly influence the periodontal bacteria Porphyromonas	19
Dasatinib suppresses atherosclerotic lesions by suppressing cholesterol uptake in a mouse model of hypercholesterolemia	18
Targeting TMEM16A ion channels suppresses airway hyperreactivity, inflammation, and remodeling in an experimental Guinea pig asthma model	18
KCa3.1 regulates cell cycle progression by modulating Ca2+ signaling in murine preosteoblasts	18
Darbepoetin alfa enhances exercise performance in trained mice in a sex-specific manner	17
Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization	17
Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects	16
Analyses of the onset mechanisms of cardio-stimulatory action by aciclovir	16
Diverse intracellular signaling pathways mediate the effects of neurotensin on the excitability of type II neurons in the rat dorsolateral bed nucleus of the stria terminalis	15
Linalyl acetate as a potential preventive agent against muscle wasting in rheumatoid arthritis rats chronically exposed to nicotine	15
Acetaminophen improves tardive akathisia induced by dopamine D2 receptor antagonists	15
Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification	15
Mechanisms underlying the methylglyoxal-induced enhancement of uridine diphosphate-mediated contraction in rat femoral artery	15
Transient receptor potential melastatin 2 is involved in trinitrobenzene sulfonic acid-induced acute and chronic colitis-associated fibrosis progression in mice	14
Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats	14
Inhibition of thymic stromal lymphopoietin production by FK3453	14
ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum	14
Deletion of intestinal SIRT1 exacerbated muscle wasting in cirrhotic mice by decreasing the intestinal concentration of short-chain fatty acids and inflammation	14
In vivo cardiovascular profile of ryanodine receptor 2 inhibitor M201-A: Utility as an anti-atrial fibrillatory drug for patients suffering from heart failure with preserved ejection fraction	14
Different sensitivities of porcine coronary arteries and veins to BAY 60–2770, a soluble guanylate cyclase activator	13
Antidepressant effect of globin digest through enhanced hippocampal neurogenesis in a mouse model of lipopolysaccharide-induced depression	13
Suppressing SPARC gene with siRNA exerts therapeutic effects and inhibits MMP-2/9 and ADAMTS1 overexpression in a murine model of ischemia/reperfusion-induced acute kidney injury	13
Novel aspects of sepsis pathophysiology: NETs, plasma glycoproteins, endotheliopathy and COVID-19	13
Oral allergy induction through skin exposure to previously tolerated food antigens in murine models	13
The adenosine A2A receptor antagonist/inverse agonist, KW-6356 enhances the anti-parkinsonian activity of L-DOPA with a low risk of dyskinesia in MPTP-treated common marmosets	13
Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats	13
Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice	13
Pituitary adenylate cyclase-activating polypeptide deficient mice show length abnormalities of the axon initial segment	12
Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses	12
Involvement of Cav3.2 T-type Ca2+ channels and cystathionine-β-synthase in colitis-related visceral hypersensitivity in mice	12
Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice	12
Targeting 14-3-3ζ by a small-molecule compound AI-34 maintains epithelial barrier integrity and alleviates colitis in mice via stabilizing β-catenin	12
A novel lysophosphatidic acid receptor 1 antagonist with high brain penetrability has a curative effect in the empathic pain-related fibromyalgia model	12
Development of multifunctional pyrrole-imidazole polyamides that increase hepatocyte growth factor and suppress transforming growth factor-β1	11
Imeglimin attenuates NLRP3 inflammasome activation by restoring mitochondrial functions in macrophages	11
Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles	11
Contribution of MLKL to the development of doxorubicin-induced cardiomyopathy and its amelioration by rapamycin	11
Potential role of inducible GPR3 expression under stimulated T cell conditions	11
Histamine promotes angiogenesis through a histamine H1 receptor-PKC-VEGF-mediated pathway in human endothelial cells	10
Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation	10
Corrigendum to ‘Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells’ [J Pharmacol Sci 139 (	10
Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid	10
Paclitaxel-induced peripheral neuropathy in male rats attenuated by calmangafodipir, a superoxide dismutase mimetic	10
Platelet-activating factor (PAF) enhances guinea pig detrusor smooth muscle contractile activities by stimulating voltage-dependent Ca2+ channels and store-operated Ca2+ channels	10
Emodin-induced autophagic cell death hinders epithelial–mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis	10
l-DOPA receptor GPR143 inhibits neurite outgrowth via L-type calcium channels in PC12 cells	10
Neurotropin® alleviates nerve damage in a mouse chronic nerve compression model	10

Ca2+ microdomains in vascular smooth muscle cells: Roles in vascular tone regulation and hypertension	10
Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway	10
YAP activation in Müller cells alleviates oxidative stress in the rat retina after intravitreal injection with methylglyoxal	10
Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors	10
Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10	9
Establishing a high throughput drug screening system for cerebral ischemia using zebrafish larvae	9
ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis	9
Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice	9
Penehyclidine hydrochloride activates PARK2 and modulates ubiquitination of AIFM1 to rescue renal tubular injury in diabetic kidney disease	9
circ_0101802 functions as a sponge of miR-1236-3p to facilitate the proliferation, migration and invasion of colorectal cancer via regulating MACC1	9
Comparison of cytotoxicity of cigarette smoke extract derived from heat-not-burn and combustion cigarettes in human vascular endothelial cells	9
Effect of antidepressants and social defeat stress on the activity of dorsal raphe serotonin neurons in free-moving animals	9
The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment	9
Dihydroartemisinin regulates apoptosis, migration, and invasion of ovarian cancer cells via mediating RECK	8
EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome	8
Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways	8
SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium	8
Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling	8
Corrigendum to ‘Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489e3p/Sirt1 axis’[Journal of Pharmacological Sciences 147 (2021) 271–283]	8
Guanabenz inhibits alveolar bone resorption in a rat model of periodontitis	8
Sperm-associated antigen 6 (Spag6) mutation leads to vestibular dysfunction in mice	8
Behavioral changes of food allergic model mice during light and dark period	8
Oxymatrine alleviates NSAID-associated small bowel mucosal injury by regulating MIP-1/CCR1 signalling and gut microbiota	7
Efficacy and safety of propranolol cream in infantile hemangioma: A prospective pilot study	7
Catalpol ameliorates dexamethasone-induced osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via the activation of PKD1 promoter	7
The inhibitory effect of DIF-3 on polyinosinic–polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells	7
The change of the electrophysiological parameters using human intestinal tissues from ulcerative colitis and Crohn's disease	7
Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anestheti	7
Sodium/glucose cotransporter 2 and renoprotection: From the perspective of energy regulation and water conservation	7
Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes	7
NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis	7
Impact of fatty acid-binding proteins and dopamine receptors on α-synucleinopathy	7
A novel AKR1C3 specific prodrug AST-3424 and its combination therapy in hepatocellular carcinoma	7
Publisher's note	7
Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis	7
Protective effect and regulatory mechanism of salidroside on skin inflammation induced by imiquimod in psoriasis mice	7
Supersulfide catabolism participates in maladaptive remodeling of cardiac cells	7
Targeting protein–protein interaction for immunomodulation: A sunflower trypsin inhibitor analog peptidomimetic suppresses RA progression in CIA model	7
Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinic–polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells	7
Rhizoma Paridis saponins suppresses vasculogenic mimicry formation and metastasis in osteosarcoma through regulating miR-520d-3p/MIG-7 axis	7
An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK	7
Protective effect of SGL5213, a potent intestinal sodium–glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice	7
Galantamine suppresses α-synuclein aggregation by inducing autophagy via the activation of α7 nicotinic acetylcholine receptors	7