Cell Death and Differentiation

Article	Citations
COVID-19 vaccines: where we stand and challenges ahead	601
Cell cycle regulation: p53-p21-RB signaling	320
Cellular degradation systems in ferroptosis	290
Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease	284
Molecular mechanisms of cell death in neurological diseases	281
The multifaceted role of ferroptosis in liver disease	231
An aberrant STAT pathway is central to COVID-19	215
p53 in ferroptosis regulation: the new weapon for the old guardian	202
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities	202
Patients with COVID-19: in the dark-NETs of neutrophils	184
Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)	184
Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis	174
Ubiquitin signaling in cell cycle control and tumorigenesis	151
Ubiquitination in the regulation of inflammatory cell death and cancer	149
Organelle-specific regulation of ferroptosis	148
Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics	140
Specific expression and functions of circular RNAs	128
Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells	117
SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination	112
Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2	111
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer	110
Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis	102
PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway	100
Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease	100
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1	98

Ki-67 gene expression	95
CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin α5 expression	91
T cell apoptosis characterizes severe Covid-19 disease	89
YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect	88
TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα	86
Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis	86
Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA	85
lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus	84
The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities	82
Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis	82
Apoptotic cell death in disease—Current understanding of the NCCD 2023	82
Crosstalk between cGAS–STING signaling and cell death	81
LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway	81
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1	81
SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma	80
The role of Ubiquitination in Apoptosis and Necroptosis	77
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy	76
Targeting mitochondrial metabolism for precision medicine in cancer	75
Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis	71
The regulation of necroptosis by post-translational modifications	71
ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms	70
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment	69
Immune response in COVID-19: what is next?	69
WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis	69
Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma	69
BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer	68
Mutant p53: it’s not all one and the same	67
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression	67
The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses	66
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis	65
Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration	64
USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1	64
Organoid-based modeling of intestinal development, regeneration, and repair	62
MLKL in cancer: more than a necroptosis regulator	62
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway	62
Mitochondria and cell death-associated inflammation	61
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production	60
Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer’s mice	60
Organoid systems to study the human female reproductive tract and pregnancy	60
Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy	60
Cuproptosis: p53-regulated metabolic cell death?	59
Gastric organoids—an in vitro model system for the study of gastric development and road to personalized medicine	58
The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute	57
IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages	57
Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity to eliminate lymphocytes	56
Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease	56
Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease	55
Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment	55
Cell death and inflammation during obesity: “Know my methods, WAT(son)”	53
The miR-92a-2-5p in exosomes from macrophages increases liver cancer cells invasion via altering the AR/PHLPP/p-AKT/β-catenin signaling	52

Non-coding RNAs and ferroptosis: potential implications for cancer therapy	52
PLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma	51
Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury	50
p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways	50
EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma	50
E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer	50
RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages	50
Should mutant TP53 be targeted for cancer therapy?	49
The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis	49
Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation	48
Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury	48
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?	47
ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation	47
M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway	46
Primidone blocks RIPK1-driven cell death and inflammation	46
Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins	46
The role of E3 ubiquitin ligases in the development and progression of glioblastoma	45
Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance	44
Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer	44
Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma	44
Functional crosstalk between myeloid Foxo1–β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response	43
DAPK3 inhibits gastric cancer progression via activation of ULK1-dependent autophagy	43
Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death	43
The Met1-linked ubiquitin machinery in inflammation and infection	42
Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation	42
LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance	42
Circular RNA Cwc27 contributes to Alzheimer’s disease pathogenesis by repressing Pur-α activity	42
Building inner ears: recent advances and future challenges for in vitro organoid systems	41
Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions	40
Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL	40
Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice	40
Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition	40
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis	39
Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy	39
Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective	39
UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance	39
p53-dependent elimination of aneuploid mitotic offspring by entosis	38
Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19	38
Histone deacetylase 3 aberration inhibits Klotho transcription and promotes renal fibrosis	38
Build-UPS and break-downs: metabolism impacts on proteostasis and aging	37
USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription	37
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells	37
SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK	37
The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression	37
MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly	36
Repurposing the estrogen receptor modulator raloxifene to treat SARS-CoV-2 infection	36
Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus	36
Epithelium- and endothelium-derived exosomes regulate the alveolar macrophages by targeting RGS1 mediated calcium signaling-dependent immune response	36
O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression	36
SARS-CoV-2 N501Y variants of concern and their potential transmission by mouse	36
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling	36
YAP–TEAD1 control of cytoskeleton dynamics and intracellular tension guides human pluripotent stem cell mesoderm specification	35
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration	34
TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis	34
Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations	34
Met1-linked ubiquitin signalling in health and disease: inflammation, immunity, cancer, and beyond	34
The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target	33
Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt–β-catenin–STAT3 signaling	33
Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries	33
Targeting androgen receptor (AR) with antiandrogen Enzalutamide increases prostate cancer cell invasion yet decreases bladder cancer cell invasion via differentially altering the AR/circRNA-ARC1/miR-1	33
Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy	32
Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2	32
TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization	32
TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1	31
A novel HIF-2α targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPRER axis	31
Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin	31
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer	30
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2	30
LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2	30
Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer	30
Trends and challenges in modeling glioma using 3D human brain organoids	30
Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase	30
BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer	30
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1	29
Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage	29
Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice	29
Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3	29
Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function	28
Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in SEPN1-related myopathy	28
RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif	28

Deubiquitylases in developmental ubiquitin signaling and congenital diseases	28
Sequential ubiquitination of p53 by TRIM28, RLIM, and MDM2 in lung tumorigenesis	28
USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer	28
Inhibiting the Pkm2/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI	28
TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes	27
Beyond DNA repair and chromosome instability—Fanconi anaemia as a cellular senescence-associated syndrome	27
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation	27
RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis	27
Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation	26
Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation	26
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease	26
Long Covid: where we stand and challenges ahead	26
Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene	26
Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis	26
Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability	26
Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response	26
Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a	26
Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer	26
CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway	26
dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury	26
Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond	26
O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction	26
Deubiquitination of MYC by OTUB1 contributes to HK2 mediated glycolysis and breast tumorigenesis	26
SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer	26
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer	25
USP42 drives nuclear speckle mRNA splicing via directing dynamic phase separation to promote tumorigenesis	25
The noncoding RNAs SNORD50A and SNORD50B-mediated TRIM21-GMPS interaction promotes the growth of p53 wild-type breast cancers by degrading p53	25
SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis	25
Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesity	25
Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense	25
Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes	24
E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis	24
Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation	24
Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants	24
RGS5–TGFβ–Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth	24
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions	24
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1	24
Single-cell RNA-seq reveals novel mitochondria-related musculoskeletal cell populations during adult axolotl limb regeneration process	24
The integrated stress response in ischemic diseases	24
PKA compartmentalization links cAMP signaling and autophagy	24
Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer	24
YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer	24