OOIR: Observatory of International Research

Papers

(The median citation count of Progress in Retinal and Eye Research is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective	265
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration	250
The cell biology of the retinal pigment epithelium	193
Inflammation in Glaucoma: From the back to the front of the eye, and beyond	184
Clinical spectrum, genetic complexity and therapeutic approaches for retinal disease caused by ABCA4 mutations	175
Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index	144
Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities	139
Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)	139
Venous overload choroidopathy: A hypothetical framework for central serous chorioretinopathy and allied disorders	135
VEGFR1 signaling in retinal angiogenesis and microinflammation	130
Efficacy in myopia control	130
Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities	128
Progress in treating inherited retinal diseases: Early subretinal gene therapy clinical trials and candidates for future initiatives	125
Age-related macular degeneration: A two-level model hypothesis	107
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis	105
Immune responses to retinal gene therapy using adeno-associated viral vectors – Implications for treatment success and safety	104
Cell types and cell circuits in human and non-human primate retina	101
Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis	88
Corneal endothelial dysfunction: Evolving understanding and treatment options	87
Photoreceptor cells and RPE contribute to the development of diabetic retinopathy	86
Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier	86
Paracentral acute middle maculopathy and the organization of the retinal capillary plexuses	85
Advances in the diagnosis and treatment of dry eye	84
Early and late stage gene therapy interventions for inherited retinal degenerations	84
Optic nerve head anatomy in myopia and glaucoma, including parapapillary zones alpha, beta, gamma and delta: Histology and clinical features	81

Posterior capsule opacification: What's in the bag?	80
Normal and glaucomatous outflow regulation	77
Contact lens-related corneal infection: Intrinsic resistance and its compromise	73
Interpretation of OCT and OCTA images from a histological approach: Clinical and experimental implications	71
Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina	70
Extracellular vesicle therapy for retinal diseases	69
The X-linked retinopathies: Physiological insights, pathogenic mechanisms, phenotypic features and novel therapies	68
Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography	67
Retinal changes in Alzheimer's disease— integrated prospects of imaging, functional and molecular advances	66
Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities	63
Choriocapillaris: Fundamentals and advancements	60
Past, present and future role of retinal imaging in neurodegenerative disease	60
Adaptive responses to neurodegenerative stress in glaucoma	57
Fundus autofluorescence imaging	57
Sustained suppression of VEGF for treatment of retinal/choroidal vascular diseases	57
Artificial intelligence in OCT angiography	56
Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets	54
Corneal stromal repair and regeneration	54
Retinal energy metabolism in health and glaucoma	53
Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials	53
Critical analysis of techniques and materials used in devices, syringes, and needles used for intravitreal injections	52
Uncoupling proteins in the mitochondrial defense against oxidative stress	52
Dominant optic atrophy: Culprit mitochondria in the optic nerve	51
Regenerative therapy for the Cornea	51
Reticular pseudodrusen: A critical phenotype in age-related macular degeneration	51
Discovery and clinical translation of novel glaucoma biomarkers	50
The vital role for nitric oxide in intraocular pressure homeostasis	50
The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas	50
Human limbal epithelial stem cell regulation, bioengineering and function	49
Vitreous and Vision Degrading Myodesopsia	49
Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma	49
The innate immune system in diabetic retinopathy	48
Metastatic uveal melanoma: The final frontier	47
Pathogenesis of ocular toxoplasmosis	44
Ocular blood flow as a clinical observation: Value, limitations and data analysis	43
Aqueous outflow regulation – 21st century concepts	42
Retinal capillary basement membrane thickening: Role in the pathogenesis of diabetic retinopathy	42
TCF4-mediated Fuchs endothelial corneal dystrophy: Insights into a common trinucleotide repeat-associated disease	41
Cell fate decisions, transcription factors and signaling during early retinal development	40
Implications of genetic variation in the complement system in age-related macular degeneration	40
Serous business: Delineating the broad spectrum of diseases with subretinal fluid in the macula	39
Immunological aspects of RPE cell transplantation	39
Prospects for the application of Müller glia and their derivatives in retinal regenerative therapies	37
Assessment and management of retinopathy of prematurity in the era of anti-vascular endothelial growth factor (VEGF)	37
Zinn's zonule	37
Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions	36
The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems	36
Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis	36
Retinal pigment epithelium 65 kDa protein (RPE65): An update	36
No flow through the vitreous humor: How strong is the evidence?	35

Approaches for corneal endothelium regenerative medicine	35
Trustworthy AI: Closing the gap between development and integration of AI systems in ophthalmic practice	35
Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options	35
Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies	34
Detecting glaucoma with only OCT: Implications for the clinic, research, screening, and AI development	34
AI-based monitoring of retinal fluid in disease activity and under therapy	33
Müller cells and astrocytes in tractional macular disorders	32
Endoplasmic reticulum stress: New insights into the pathogenesis and treatment of retinal degenerative diseases	32
Plasmacytoid dendritic cells in the eye	32
Diabetic macular ischaemia- a new therapeutic target?	32
Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life	32
Photocoagulation for retinal vein occlusion	31
Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration	30
Molecular components affecting ocular carotenoid and retinoid homeostasis	30
Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease	29
Corneal xenotransplantation: Where are we standing?	29
Retinal vessel diameters and function in cardiovascular risk and disease	29
Spatiotemporal changes in the human lens proteome: Critical insights into long-lived proteins	28
A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head	28
Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration	28
The two-faced effects of nerves and neuropeptides in corneal diseases	27
Full-field stimulus testing: Role in the clinic and as an outcome measure in clinical trials of severe childhood retinal disease	27
Promises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO)	26
Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells	26
Beyond intraocular pressure: Optimizing patient-reported outcomes in glaucoma	26
Evolution of the genes mediating phototransduction in rod and cone photoreceptors	26
Challenges in the diagnosis and management of vitreoretinal lymphoma – Clinical and basic approaches	24
Role of glia in optic nerve	24
Single-cell RNA sequencing in vision research: Insights into human retinal health and disease	24
Bacterial keratitis: identifying the areas of clinical uncertainty	24
The retinal pigmentation pathway in human albinism: Not so black and white	23
Personalising surgical treatments for glaucoma patients	22
Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic	22
Non-specific orbital inflammation: Current understanding and unmet needs	22
A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork	21
Myopia: Histology, clinical features, and potential implications for the etiology of axial elongation	21
Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma	21
Iatrogenic ophthalmic artery occlusion and retinal artery occlusion	21
Towards a better understanding of non-exudative choroidal and macular neovascularization	21
Recapitulating developmental mechanisms for retinal regeneration	21
Splicing mutations in inherited retinal diseases	20
Rhodopsin, light-sensor of vision	20
The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens	20
Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation	19
Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma	19
The role of the gut microbiome in eye diseases	19
Therapy with voretigene neparvovec. How to measure success?	18
Quantitative approaches in multimodal fundus imaging: State of the art and future perspectives	18