OOIR: Observatory of International Research

Papers

(The median citation count of Human Reproduction Update is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Contribution of epididymal epithelial cell functions to sperm epigenetic changes and the health of progeny	314
Genetic mechanisms of fertilization failure and early embryonic arrest: a comprehensive review	173
Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and netwo	144
Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis	110
Efficacy of psychological interventions for mental health and pregnancy rates among individuals with infertility: a systematic review and meta-analysis	107
Assessing the influence of preconception diet on male fertility: a systematic scoping review	98
The role of endometrial scratching in IVF/ICSI: a critical appraisal of individual participant data meta-analysis	87
Cellular mechanisms of monozygotic twinning: clues from assisted reproduction	81
Navigating fertility dilemmas across the lifespan in girls with Turner syndrome—a scoping review	80
Maternal and perinatal outcomes in twin pregnancies following assisted reproduction: a systematic review and meta-analysis involving 802 462 pregnancies	76
Barriers and facilitators for the inclusion of fertility care in reproductive health policies in Africa: a qualitative evidence synthesis	74
Cell dynamics in human villous trophoblast	66
Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women	66
IVF versus IUI with ovarian stimulation for unexplained infertility: a collaborative individual participant data meta-analysis	65
Epigenomic and enhancer dysregulation in uterine leiomyomas	63
Reply: Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis. Critical assessment of a review and meta-analysis	61
False hope for patients with Klinefelter syndrome on cryopreservation of spermatogonia at younger ages	57
The missing role of diagnosis of confined placental mosaicism in the management of fetal growth restriction	55
What is the expected live birth rate per thawed oocyte?	53
DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies	52
Number and function of uterine natural killer cells in recurrent miscarriage and implantation failure: a systematic review and meta-analysis	50
Contribution of semen to early embryo development: fertilization and beyond	49
Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis	48
Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia	47
The hypergonadotropic hypogonadism conundrum of classic galactosemia	47

Uterus transplantation: from research, through human trials and into the future	44
The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first t	44
The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions	44
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis	44
A fresh start for IVM: capacitating the oocyte for development using pre-IVM	42
Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review	42
Planned oocyte cryopreservation: a systematic review and meta-regression analysis	41
Thank you to our reviewers – 2020	41
Parental conditions, modifiable lifestyle factors, and first trimester growth and development: a systematic review	39
Plasticity of the human preimplantation embryo: developmental dogmas, variations on themes and self-correction	39
Artificial cycle frozen embryo transfer and obstetric adverse outcomes: association or causation?	38
Contraceptives and cancer risks in BRCA1/2 pathogenic variant carriers: a systematic review and meta-analysis	38
Defects in mRNA splicing and implications for infertility: a comprehensive review and in silico analysis	38
Immunotherapies to optimize pregnancy outcomes in subfertile women	37
Reply: Immunotherapies to optimize pregnancy outcomes in subfertile women	36
Transcriptional control of human gametogenesis	36
Evaluating interventions and adjuncts to optimize pregnancy outcomes in subfertile women: an overview review	35
Navigating parent–child disagreement about fertility preservation in minors: scoping review and ethical considerations	35
Reply: Endometrial scratching: the light at the end of the tunnel	33
Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine	32
Evaluating the diagnostic accuracy of androgen measurement in polycystic ovary syndrome: a systematic review and diagnostic meta-analysis to inform evidence-based guidelines	32
Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association	32
Epigenetic clocks provide clues to the mystery of uterine ageing	31
All you need to know about sperm RNAs	31
Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis	31
Ultrasonographic criteria in the diagnosis of polycystic ovary syndrome: a systematic review and diagnostic meta-analysis	30
Confined placental mosaicism and the association with pregnancy outcome and fetal growth: a review of the literature	30
BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis	29
The LH surge and ovulation re-visited: a systematic review and meta-analysis and implications for true natural cycle frozen thawed embryo transfer	29
Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies	28
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life	28
Correction to: Evaluating interventions and adjuncts to optimize pregnancy outcomes in subfertile women: an overview review	27
Maternal germline factors associated with aneuploid pregnancy loss: a systematic review	27
Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis	27
Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis. Critical assessment of a review and meta-analysis	27
Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects	27
The impact of vincristine on testicular development and function in childhood cancer	26
Finding a way through the review maze: systematic, scoping, or an overview	25
Offspring physiology following the use of IVM, IVF and ICSI: a systematic review and meta-analysis of animal studies	25
The complicated ART of finding consensus on family-building health policy: a comment on the IFFS consensus document	23
Infertility treatment and offspring blood pressure—a systematic review and meta-analysis	23
Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation	19
Correction to: Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis	19
Genetic and reproductive strategies to prevent mitochondrial diseases	18
Celebrating 30 years at Human Reproduction Update	18
The impact of primary ciliary dyskinesia on female and male fertility: a narrative review	18
Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies	17
What is the optimal GnRH antagonist protocol for ovarian stimulation during ART treatment? A systematic review and network meta-analysis	17
Anti-Müllerian hormone as a marker of ovarian reserve and premature ovarian insufficiency in children and women with cancer: a systematic review	17
Adenomyosis pathogenesis: insights from next-generation sequencing	17

Sexual function in women with polycystic ovary syndrome: a systematic review and meta-analysis	16
Administration of growth hormone improves endometrial function in women undergoing in vitro fertilization: a systematic review and meta-analysis	16
Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations	15
Correction to: Planned oocyte cryopreservation: a systematic review and meta-regression analysis	14
Endometrial receptivity in women of advanced age: an underrated factor in infertility	14
The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain	14
COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss	14
A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene–disease relationships	13
Correction to: Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women	13
Effects of different frozen embryo transfer regimens on abnormalities of fetal weight: a systematic review and meta-analysis	13
Morphological and morphokinetic associations with aneuploidy: a systematic review and meta-analysis	13
Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy	13