OOIR: Observatory of International Research

Papers

(The median citation count of Human Reproduction Update is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Maternal and perinatal outcomes in twin pregnancies following assisted reproduction: a systematic review and meta-analysis involving 802 462 pregnancies	394
Building a human pluripotent stem cell-based gonadal niche: improving in vitro systems with in vivo insights	193
BMI in children aged 1–18 years conceived after ART with fresh and frozen embryo transfer: a systematic review and meta-analyses	181
The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first t	126
Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women	118
Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association	100
Ultrasonographic criteria in the diagnosis of polycystic ovary syndrome: a systematic review and diagnostic meta-analysis	99
Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis	91
The complicated ART of finding consensus on family-building health policy: a comment on the IFFS consensus document	88
Correction to: Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis	86
Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation	84
What is the optimal GnRH antagonist protocol for ovarian stimulation during ART treatment? A systematic review and network meta-analysis	83
Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis	81
Driving factors in treatment decision-making of patients seeking medical assistance for infertility: a systematic review	78
Preconception lifestyle interventions for women—a systematic review and meta-analysis of intervention characteristics and behaviour change techniques	77
Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries	74
Autophagy: a multifaceted player in the fate of sperm	74
A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene–disease relationships	71
Obstetric and perinatal outcomes of singleton pregnancies after blastocyst-stage embryo transfer compared with those after cleavage-stage embryo transfer: a systematic review and cumulative meta-analy	65
RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications	65
Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: a systematic review and meta-analysis	60
Obstetric, neonatal, and child health outcomes following embryo biopsy for preimplantation genetic testing	58
HLA Class Ib-receptor interactions during embryo implantation and early pregnancy	58
Reproductive ability in survivors of childhood, adolescent, and young adult Hodgkin lymphoma: a review	56
Reply: Artificial cycle frozen embryo transfer and obstetric adverse outcomes: association or causation?	55

IVF and human evolution	54
The neglected members of the family: non-BRCAmutations in the Fanconi anemia/BRCA pathway and reproduction	52
Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies	52
The missing role of diagnosis of confined placental mosaicism in the management of fetal growth restriction	52
What is the expected live birth rate per thawed oocyte?	51
Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia	49
Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine	46
The LH surge and ovulation re-visited: a systematic review and meta-analysis and implications for true natural cycle frozen thawed embryo transfer	45
Correction to: Evaluating interventions and adjuncts to optimize pregnancy outcomes in subfertile women: an overview review	44
Infertility treatment and offspring blood pressure—a systematic review and meta-analysis	43
Administration of growth hormone improves endometrial function in women undergoing in vitro fertilization: a systematic review and meta-analysis	42
COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss	39
Reply: The missing role of diagnosis of confined placental mosaicism in the management of fetal growth restriction	38
The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain	38
Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies	38
Reply. How much evidence is needed to stop calling endometrial scratching ‘controversial’?	37
Reply: What is the expected live birth rate per thawed oocyte?	35
Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis	35
Development and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis	35
Molecular insights into sperm head shaping and its role in human male fertility	34
Advances in non-hormonal male contraception targeting sperm motility	34
Does the holy grail of the evidence pyramid vindicate the controversial practice of endometrial scratching or is there room for healthy skepticism?	33
Fertility in transgender and gender diverse people: systematic review of the effects of gender-affirming hormones on reproductive organs and fertility	33
Moving toward totipotency: the molecular and cellular features of totipotent and naive pluripotent stem cells	32
Spermatogonia: a unique stem cell orchestrating species-specific transition from pluripotency to sperm production	32
DNA methylation profiles after ART during human lifespan: a systematic review and meta-analysis	32
The epigenetic approach of varicocele: a focus on sperm DNA and m6A-RNA methylation	32
Bioengineering trends in female reproduction: a systematic review	31
Harnessing omics data for drug discovery and development in ovarian aging	31
DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies	30
Awareness and attitudes toward fertility preservation among healthcare providers: a scoping review of quantitative evidence	30
Anti-Müllerian hormone as a marker of ovarian reserve and premature ovarian insufficiency in children and women with cancer: a systematic review	28
Correction to: Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women	27
The impact of primary ciliary dyskinesia on female and male fertility: a narrative review	27
Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy	25
Remembering Professor John Collins	25
TGFβ signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy	24
Embryo metabolism as a novel non-invasive preimplantation test: nutrients turn over and metabolomic analysis of human spent embryo culture media (SECM)	24
Reply. The role of endometrial scratching in IVF/ICSI: a critical appraisal of individual participant data meta-analysis	24
Clinical application of aromatase inhibitors to treat male infertility	24
Indoor and outdoor air pollution and couple fecundability: a systematic review	24
Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities	23
Prevalence of PCOS and related hyperandrogenic traits in premenopausal women with type 1 diabetes: a systematic review and meta-analysis	23
A systematic review to determine use of the Endometriosis Health Profiles to measure quality of life outcomes in women with endometriosis	22
Declining global fertility rates and the implications for family planning and family building: an IFFS consensus document based on a narrative review of the literature	22
Impact of Bisphenol A and its alternatives on oocyte health: a scoping review	22
Bias busters: using the right risk-of-bias tools	21
Contribution of epididymal epithelial cell functions to sperm epigenetic changes and the health of progeny	21
Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis	21
Navigating fertility dilemmas across the lifespan in girls with Turner syndrome—a scoping review	20

Immunotherapies to optimize pregnancy outcomes in subfertile women	19
Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review	19
Reply: Endometrial scratching: the light at the end of the tunnel	19
Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and netwo	19
Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies	18
Evaluating the diagnostic accuracy of androgen measurement in polycystic ovary syndrome: a systematic review and diagnostic meta-analysis to inform evidence-based guidelines	18
BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis	18