Human Reproduction Update

Papers
(The median citation count of Human Reproduction Update is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first t368
Maternal and perinatal outcomes in twin pregnancies following assisted reproduction: a systematic review and meta-analysis involving 802 462 pregnancies185
Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women175
Building a human pluripotent stem cell-based gonadal niche: improving in vitro systems with in vivo insights121
Ultrasonographic criteria in the diagnosis of polycystic ovary syndrome: a systematic review and diagnostic meta-analysis115
Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis95
Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association89
Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis86
The complicated ART of finding consensus on family-building health policy: a comment on the IFFS consensus document86
What is the optimal GnRH antagonist protocol for ovarian stimulation during ART treatment? A systematic review and network meta-analysis83
Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation82
Correction to: Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis82
A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene–disease relationships77
Driving factors in treatment decision-making of patients seeking medical assistance for infertility: a systematic review77
Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries75
Autophagy: a multifaceted player in the fate of sperm73
Obstetric and perinatal outcomes of singleton pregnancies after blastocyst-stage embryo transfer compared with those after cleavage-stage embryo transfer: a systematic review and cumulative meta-analy72
Obstetric, neonatal, and child health outcomes following embryo biopsy for preimplantation genetic testing65
RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications64
Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: a systematic review and meta-analysis63
HLA Class Ib-receptor interactions during embryo implantation and early pregnancy59
Reproductive ability in survivors of childhood, adolescent, and young adult Hodgkin lymphoma: a review57
Reply: Artificial cycle frozen embryo transfer and obstetric adverse outcomes: association or causation?57
The neglected members of the family: non-BRCAmutations in the Fanconi anemia/BRCA pathway and reproduction56
Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies52
The missing role of diagnosis of confined placental mosaicism in the management of fetal growth restriction51
IVF and human evolution51
Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia51
What is the expected live birth rate per thawed oocyte?50
Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine49
The LH surge and ovulation re-visited: a systematic review and meta-analysis and implications for true natural cycle frozen thawed embryo transfer49
Correction to: Evaluating interventions and adjuncts to optimize pregnancy outcomes in subfertile women: an overview review49
Infertility treatment and offspring blood pressure—a systematic review and meta-analysis44
Administration of growth hormone improves endometrial function in women undergoing in vitro fertilization: a systematic review and meta-analysis43
Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies43
The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain42
COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss40
Reply: The missing role of diagnosis of confined placental mosaicism in the management of fetal growth restriction39
Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis38
Reply. How much evidence is needed to stop calling endometrial scratching ‘controversial’?38
Reply: What is the expected live birth rate per thawed oocyte?37
Development and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis35
The effects of bariatric surgery on periconception maternal health: a systematic review and meta-analysis34
Fertility in transgender and gender diverse people: systematic review of the effects of gender-affirming hormones on reproductive organs and fertility34
Advances in non-hormonal male contraception targeting sperm motility34
Molecular insights into sperm head shaping and its role in human male fertility34
Does the holy grail of the evidence pyramid vindicate the controversial practice of endometrial scratching or is there room for healthy skepticism?33
The epigenetic approach of varicocele: a focus on sperm DNA and m6A-RNA methylation33
DNA methylation profiles after ART during human lifespan: a systematic review and meta-analysis33
Moving toward totipotency: the molecular and cellular features of totipotent and naive pluripotent stem cells33
Harnessing omics data for drug discovery and development in ovarian aging32
Bioengineering trends in female reproduction: a systematic review31
Awareness and attitudes toward fertility preservation among healthcare providers: a scoping review of quantitative evidence31
Spermatogonia: a unique stem cell orchestrating species-specific transition from pluripotency to sperm production31
DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies31
The impact of primary ciliary dyskinesia on female and male fertility: a narrative review30
Anti-Müllerian hormone as a marker of ovarian reserve and premature ovarian insufficiency in children and women with cancer: a systematic review29
Correction to: Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women29
Remembering Professor John Collins25
Indoor and outdoor air pollution and couple fecundability: a systematic review24
Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy24
Embryo metabolism as a novel non-invasive preimplantation test: nutrients turn over and metabolomic analysis of human spent embryo culture media (SECM)24
Reply. The role of endometrial scratching in IVF/ICSI: a critical appraisal of individual participant data meta-analysis23
Clinical application of aromatase inhibitors to treat male infertility23
Declining global fertility rates and the implications for family planning and family building: an IFFS consensus document based on a narrative review of the literature22
Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities22
Impact of Bisphenol A and its alternatives on oocyte health: a scoping review22
A systematic review to determine use of the Endometriosis Health Profiles to measure quality of life outcomes in women with endometriosis21
TGFβ signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy21
Bias busters: using the right risk-of-bias tools21
Prevalence of PCOS and related hyperandrogenic traits in premenopausal women with type 1 diabetes: a systematic review and meta-analysis21
Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis20
Navigating fertility dilemmas across the lifespan in girls with Turner syndrome—a scoping review20
Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review20
Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and netwo19
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life19
Immunotherapies to optimize pregnancy outcomes in subfertile women19
Reply: Endometrial scratching: the light at the end of the tunnel19
Contribution of epididymal epithelial cell functions to sperm epigenetic changes and the health of progeny19
BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis19
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