OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Biochemistry & Cell Biology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The ever-changing roles of serotonin	112
Viroporins and inflammasomes: A key to understand virus-induced inflammation	91
The therapeutic potential of galectin-3 inhibition in fibrotic disease	71
Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells	67
Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics	66
The extracellular matrix and mechanotransduction in pulmonary fibrosis	59
Circular RNA expression profile of Alzheimer’s disease and its clinical significance as biomarkers for the disease risk and progression	51
Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1	45
Statins reduce vascular inflammation in atherogenesis: A review of underlying molecular mechanisms	43
ROS enhances the cytotoxicity of cisplatin by inducing apoptosis and autophagy in tongue squamous cell carcinoma cells	39
Keratin intermediate filaments in the colon: guardians of epithelial homeostasis	38
Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis	38
Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression	34
Cardiac optical mapping – State-of-the-art and future challenges	32
Imaging in focus: An introduction to denoising bioimages in the era of deep learning	31
Perlecan, a modular instructive proteoglycan with diverse functional properties	30
Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2	29
lncRNA ADAMTS9-AS1 promotes bladder cancer cell invasion, migration, and inhibits apoptosis and autophagy through PI3K/AKT/mTOR signaling pathway	28
Cholesterol metabolism: At the cross road between cancer cells and immune environment	28
pH gradient reversal fuels cancer progression	28
NAMPT: A critical driver and therapeutic target for cancer	27
The mitochondrial unfolded protein response and its diverse roles in cellular stress	27
Long-read sequencing to understand genome biology and cell function	26
Circular RNA circ-ZEB1 acts as an oncogene in triple negative breast cancer via sponging miR-448	26
Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies	24

Signaling pathways targeting mitochondrial potassium channels	24
PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation	24
Metabolic perturbations in fibrosis disease	24
Defective insulin receptor signaling in patients with gestational diabetes is related to dysregulated miR-140 which can be improved by naringenin	23
The relevance of mitochondrial morphology for human disease	23
State-of-the-art genome inference in the human MHC	21
The ketogenic diet as a therapeutic intervention strategy in mitochondrial disease	20
Calcium-activated potassium channels: implications for aging and age-related neurodegeneration	20
Bcl-xL inhibits PINK1/Parkin-dependent mitophagy by preventing mitochondrial Parkin accumulation	20
TMPO-AS1/miR-98-5p/EBF1 feedback loop contributes to the progression of bladder cancer	20
Increasing CRISPR/Cas9-mediated homology-directed DNA repair by histone deacetylase inhibitors	19
The role of basement membrane laminins in vascular function	19
Endothelial signaling at the core of neurovascular coupling: The emerging role of endothelial inward-rectifier K+ (Kir2.1) channels and N-methyl-d-aspartate receptors in the regulation of cerebral blo	18
linc01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize HTR3A mRNA	18
Exosomes produced by adipose-derived stem cells inhibit schwann cells autophagy and promote the regeneration of the myelin sheath	18
Attenuating PI3K/Akt- mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells	18
Self-polymerized polydopamine-based nanoparticles for acute kidney injury treatment through inhibiting oxidative damages and inflammatory	18
Cancer: The role of iron and ferroptosis	18
Splenectomy provides protective effects against CLP-induced sepsis by reducing TRegs and PD-1/PD-L1 expression	18
MurC ligase of multi-drug resistant Salmonella Typhi can be inhibited by novel Curcumin derivative: Evidence from molecular docking and dynamics simulations	18
Redox signalling and regulation of the blood-brain barrier	17
Epithelial-mesenchymal crosstalk in COPD: An update from in vitro model studies	17
Toll-like Receptor (TLR)-induced Rasgef1b expression in macrophages is regulated by NF-κB through its proximal promoter	17
microRNA-34 family: From mechanism to potential applications	17
SCAMP4 is a novel prognostic marker and correlated with the tumor progression and immune infiltration in glioma	17
HDL-S1P protects endothelial function and reduces lung injury during sepsis in vivo and in vitro	17
Hepatocellular carcinoma cell-derived extracellular vesicles encapsulated microRNA-584-5p facilitates angiogenesis through PCK1-mediated nuclear factor E2-related factor 2 signaling pathway	16
Emerging mechanisms to modulate VWF release from endothelial cells	16
MMP-1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via the JNK and ERK pathway	16
The pivotal role of ubiquitin-activating enzyme E1 (UBA1) in neuronal health and neurodegeneration	16
The entangled relationship between cilia and actin	16
Free radicals: Relationship to Human Diseases and Potential Therapeutic applications	16
SNF5 promotes IL-1β expression via H3K4me1 in atherosclerosis induced by homocysteine	15
Competing endogenous RNAs and cancer: How coding and non-coding molecules cross-talk can impinge on disease	15
Hsa_circ_0008934 promotes the proliferation and migration of osteosarcoma cells by targeting miR-145-5p to enhance E2F3 expression	15
Lutein attenuates excessive lipid accumulation in differentiated 3T3-L1 cells and abdominal adipose tissue of rats by the SIRT1-mediated pathway	15
The two faces of the Integrated Stress Response in cancer progression and therapeutic strategies	15
THE NUCLEUS: Mechanosensing in cardiac disease	15
Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway	14
Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space	14
Beta1-integrin/Hedgehog-Gli1 signaling pathway fuels the diameter-dependent osteoblast differentiation on different TiO2 nanotubes	14
Src kinase: Key effector in mechanosignalling	14
MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation	14
MicroRNA-431-5p encapsulated in serum extracellular vesicles as a biomarker for proliferative diabetic retinopathy	14
An introduction to the methodology of expansion microscopy	13
Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) inhibits cutaneous squamous cell carcinoma cell proliferation via targeting PP2A/PP5-mediated MAPK signaling pathway	13
Metformin enhances the osteogenesis and angiogenesis of human umbilical cord mesenchymal stem cells for tissue regeneration engineering	13
Pulmonary macrophages and their different roles in health and disease	13
Asthma: Pharmacological degradation of the airway smooth muscle layer	13
Chitosan/PCL nanoparticles can improve anti-neoplastic activity of 5-fluorouracil in head and neck cancer through autophagy activation	13

KANK family proteins in cancer	13
“STRESSED OUT”: The role of FUS and TDP-43 in amyotrophic lateral sclerosis	13
Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson’s disease: Pot	13
Impact of type 2 diabetes mellitus on the immunoregulatory characteristics of adipose tissue-derived mesenchymal stem cells	13
Long non-coding RNA CCAT1 is overexpressed in endometrial cancer and regulates growth and transcriptome of endometrial adenocarcinoma cells	13
Coordinating Synaptic Signaling with CRMP2	13
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway	12
Metabolome analysis of the response and tolerance mechanisms of Saccharomyces cerevisiae to formic acid stress	12
Influence of tumor cell-derived TGF-β on macrophage phenotype and macrophage-mediated tumor cell invasion	12
Mitochondrial α7 nicotinic acetylcholine receptors are displaced from complexes with VDAC1 to form complexes with Bax upon apoptosis induction	12
Cancer stem cell antigens as targets for new combined anti-cancer therapies	12
Methionine deficiency promoted mitophagy via lncRNA PVT1-mediated promoter demethylation of BNIP3 in gastric cancer	12
CREB activation affects mesenchymal stem cell migration and differentiation in periodontal tissues due to orthodontic force	12
Tackling mitochondrial diversity in brain function: from animal models to human brain organoids	12
A comprehensive insight into autophagy and its potential signaling pathways as a therapeutic target in podocyte injury	12
The diagnostic, prognostic and therapeutic potential of circulating microRNAs in ovarian cancer	12
Microvascular cells: A special focus on heterogeneity of pericytes in diabetes associated complications	12
TRIM58 inactivates p53/p21 to promote chemoresistance via ubiquitination of DDX3 in breast cancer	12
HDAC3 increases HMGB3 expression to facilitate the immune escape of breast cancer cells via down-regulating microRNA-130a-3p	12
Apolipoprotein H drives hepatitis B surface antigen retention and endoplasmic reticulum stress during hepatitis B virus infection	12
The role of neuropeptides in learning: Insights from C. elegans	12
Effects of syndecan-4 gene silencing by micro RNA interference in anoikis resistant endothelial cells	12
Clinical features and mechanistic insights into drug repurposing for combating COVID-19	11
Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression	11
Emerging strategies for sensitization of therapy resistant tumors toward cancer therapeutics by targeting the Bcl-2 family, TGF-β, Wnt/β-Catenin, RASSF and miRNA regulated signaling pathways	11
Molecular mechanisms in governing genomic stability and tumor suppression by the SETD2 H3K36 methyltransferase	11
Mitochondrial nicotinic acetylcholine receptors: Mechanisms of functioning and biological significance	11
LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGFβ/smad signaling pathway	11
Annexin A1 promotes the nuclear localization of the epidermal growth factor receptor in castration-resistant prostate cancer	10
Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells	10
HDAC6 suppresses microRNA-199a transcription and augments HPV-positive cervical cancer progression through Wnt5a upregulation	10
SPAG5 promotes osteosarcoma metastasis via activation of FOXM1/MMP2 axis	10
Deregulated levels of RUVBL1 induce transcription-dependent replication stress	10
Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension	10
Cell specific tumor suppressor effect of Hsa-miR-1226-3p through downregulation of HER2, PIK3R2, and AKT1 genes	10
The long noncoding RNA Ptprd-IR is a novel molecular target for TGF-β1-mediated nephritis	10
An update on molecular counting in fluorescence microscopy	10
DNA, protein and lipid oxidative damage in tissues of spontaneously hypertensive versus normotensive rats	10
Pan-HDAC inhibitor panobinostat, as a single agent or in combination with PI3K inhibitor, induces apoptosis in APL cells: An emerging approach to overcome MSC-induced resistance	10
Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation	10
Valproic acid overcomes sorafenib resistance by reducing the migration of Jagged2-mediated Notch1 signaling pathway in hepatocellular carcinoma cells	10
The non-canonical functions of HIF prolyl hydroxylases and their dual roles in cancer	10
Lysyl oxidase-like 2 promotes esophageal squamous cell carcinoma cell migration independent of catalytic activity	10
Development and in vitro characterisation of an induced pluripotent stem cell model of ovarian cancer	10
Electronic cigarettes: Modern instruments for toxic lung delivery and posing risk for the development of chronic disease	10
Mechanisms of NLRP3 activation and pathology during neurodegeneration	9
Primary hypercholesterolemia and development of cardiovascular disorders: Cellular and molecular mechanisms involved in low-grade systemic inflammation and endothelial dysfunction	9
Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission	9
PRMT1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the AKT/FOXO1 signaling pathway	9
Stem cell-derived exosomes: Role in the pathogenesis and treatment of atherosclerosis	9
VEGFa/VEGFR2 autocrine and paracrine signaling promotes cervical carcinogenesis via β-catenin and snail	9
ABAT targeted by miR-183-5p regulates cell functions in liver cancer	9
The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics	9
JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1	9
Chitosan-coated Selenium nanoparticles enhance the efficiency of stem cells in the neuroprotection of streptozotocin-induced neurotoxicity in male rats.	9
Unwrapping the mechanisms of ceramide and fatty acid-initiated signals leading to immune-inflammatory responses in obesity	9
Histone modifications influence the insulin-signaling genes and are related to insulin resistance in human adipocytes	9
Estrogen receptor β alleviates inflammatory lesions in a rat model of inflammatory bowel disease via down-regulating P2X7R expression in macrophages	9
AQP2 trafficking in health and diseases: an updated overview	9
Metabolomics study of the metabolic changes in hepatoblastoma cells in response to NTCP/SLC10A1 overexpression	9
Graphene oxide leads to mitochondrial-dependent apoptosis by activating ROS-p53-mPTP pathway in intestinal cells	9
Activation of PPARγ intensified the effects of arsenic trioxide in acute promyelocytic leukemia through the suppression of PI3K/Akt pathway: Proposing a novel anticancer effect for pioglitazone	9
Acute myeloid leukemia: Therapy resistance and a potential role for tetraspanin membrane scaffolds	9
Analysis methods for interrogating spatial organisation of single molecule localisation microscopy data	9