OOIR: Observatory of International Research

Papers

(The median citation count of Cytokine & Growth Factor Reviews is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Editorial Board	147
Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases	139
COVID-19: From emerging variants to vaccination	119
COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon	114
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	112
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	96
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	94
Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics	79
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	76
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	75
Editorial Board	74
Editorial Board	67
Editorial Board	67
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	65
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	63
Participation of interferons in psoriatic inflammation	63
Molecular mechanisms of regulation of IL-1 and its receptors	60
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	59
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	58
Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms	54
The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment	52
Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	51
TGF-β mediated drug resistance in solid cancer	51
Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer	47
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	46

Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence	45
Exogenous drug-induced mouse models of atopic dermatitis	45
Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review	44
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	43
Principles of the activin receptor signaling pathway and its inhibition	43
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	41
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	40
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	38
Suppressor of cytokine signaling 6 in cancer development and therapy: Deciphering its emerging and suppressive roles	38
COVID-19 and dys-regulation of pulmonary endothelium: implications for vascular remodeling	37
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	37
MDSCs might be “Achilles heel” for eradicating CSCs	36
Exosomes as a modulator of immune resistance in human cancers	36
Multifaceted role of CD14 in innate immunity and tissue homeostasis	35
Neurotrophic factors and their receptors in lung development and implications in lung diseases	35
Decoding the roles of heat shock proteins in liver cancer	34
Editorial Board	34
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	34
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	33
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies	33
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	33
Exploring Inflammatory and Fibrotic Mechanisms Driving Diabetic Nephropathy Progression	32
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	30
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	30
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	28
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	28
B cell-activating factor and its targeted therapy in autoimmune diseases	28
Netrin-1: An emerging player in inflammatory diseases	28
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	27
Forgetting COVID-19 – Introduction to the special issue	27
Chemokine networks modulating natural killer cell trafficking to solid tumors	27
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	27
The impact of adipokines on vascular networks in adipose tissue	27
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	26
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	25
mTOR in programmed cell death and its therapeutic implications	24
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	23
Editorial Board	23
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	23
Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk	22
Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance	22
Cholecystokinin and gastrin as immune modulating hormones: Implications and applications	22
ALCAM/CD166: A pleiotropic mediator of cell adhesion, stemness and cancer progression	22
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders	21
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression	21
Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?	20
The role and transformative potential of IL-19 in atherosclerosis	20
Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer	19
Alternative pathways driven by STING: From innate immunity to lipid metabolism	19
JAK inhibitors in immune regulation and treatment of vitiligo	19

Multiple post-translational modifications ensure EGFR functionality: Potential therapeutic targets to overcome its drug-resistance mutations	18
Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies	18
Regulation of regulated cell death by extracellular vesicles in acute kidney injury and chronic kidney disease	18
The journey of STING: Guiding immune signaling through membrane trafficking	17
Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment	17
Uncovering key mechanisms and intervention therapies in aging skin	17
The IL-2A receptor pathway and its role in lymphocyte differentiation and function	17
The critical role of osteopontin (OPN) in fibrotic diseases	17
The conundrum of current anti-SARS-CoV-2 vaccines	16
Retard or exacerbate: Role of long non-coding RNA growth arrest-specific 5 in the fibrosis	16
Antiphospholipid antibodies and risk of post-COVID-19 vaccination thrombophilia: The straw that breaks the camel's back?	16
Editorial Board	16
T cell receptor signaling in the differentiation and plasticity of CD4+ T cells	15
The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis	15
Galectins as modulators of receptor tyrosine kinases signaling in health and disease	15
The functional roles of m6A modification in T lymphocyte responses and autoimmune diseases	15
Decoding the neuroimmune axis in colorectal cancer: From neural circuitry to therapeutic innovation	15
The anti-inflammatory effects of itaconate and its derivatives in neurological disorders	15
Serum amyloid A and inflammasome activation: A link to breast cancer progression?	15
LC3B: A microtubule-associated protein influences disease progression and prognosis	14
GLP-1R agonist therapy and vaccine response: Neglected implications	14
SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities	14
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders	14
Pharmacological therapies and drug development targeting SARS-CoV-2 infection	14
Endothelial and macrophage interactions in the angiogenic niche	14
FGF/FGFR signaling: From lung development to respiratory diseases	14
An emerging paradigm of CXCL16 involvement in cancer progression	14
Cytokines on the way to secretion	13
Exosome-mediated metabolic reprogramming: Implications in esophageal carcinoma progression and tumor microenvironment remodeling	13
Revisiting IRF1-mediated antiviral innate immunity	13
The impact of cytokines in neuroinflammation-mediated stroke	12
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases	12
Molecular regulation of autophagy in a pro-inflammatory tumour microenvironment: New insight into the role of serum amyloid A	12
Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication	12
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy	12
Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron	12
The involvement of TH17 cells in the pathogenesis of IBD	12
THE CENTRAL ROLE OF CXCL10-CXCR3 SIGNALING IN NEUROINFLAMMATION AND NEUROPATHOLOGY	12
Hallmarks of aging and immunosenescence: Connecting the dots	12
Assessment of clinical studies evaluating combinations of immune checkpoint inhibitors with locoregional treatments in solid tumors	12
Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury	12
The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy	11
The Coronavirus pandemic – 2022: Viruses, variants & vaccines	11
Targeting interleukin-17 in radiation-induced toxicity and cancer progression	11
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus	11
The odyssey of cGAS: From cytosol to nucleus	11
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs	11
Editorial Board	10
BCR-ABL: The molecular mastermind behind chronic myeloid leukemia	10
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors	10
Unveiling the role of IL-17: Therapeutic insights and cardiovascular implications	10
The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors	10
Preexisting immunity: Barrier or bridge to effective oncolytic virus therapy?	10