OOIR: Observatory of International Research

Papers

(The median citation count of Cytokine & Growth Factor Reviews is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy	132
Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases	131
LC3B: A microtubule-associated protein influences disease progression and prognosis	116
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	109
Neurotrophic factors and their receptors in lung development and implications in lung diseases	108
Development of mRNA vaccines against respiratory syncytial virus (RSV)	100
COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon	95
The anti-inflammatory effects of itaconate and its derivatives in neurological disorders	88
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	83
Editorial Board	73
Editorial Board	70
Editorial Board	67
Editorial Board	66
ORF8a as a viroporin in SARS-CoV-2 infection?	64
The conundrum of current anti-SARS-CoV-2 vaccines	61
Targeting PD-1/PD-L1 in tumor immunotherapy: Mechanisms and interactions with host growth regulatory pathways	61
Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases	60
COVID-19 and dys-regulation of pulmonary endothelium: implications for vascular remodeling	59
Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics	59
Antiphospholipid antibodies and risk of post-COVID-19 vaccination thrombophilia: The straw that breaks the camel's back?	56
Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic	53
Response to: Letter to the Editor on “Bonafè M, Prattichizzo F, Giuliani A, Storci G, Sabbatinelli J, Olivieri F. Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcom	49
Galectins as modulators of receptor tyrosine kinases signaling in health and disease	48
MDSCs might be “Achilles heel” for eradicating CSCs	47
Retard or exacerbate: Role of long non-coding RNA growth arrest-specific 5 in the fibrosis	47

The cytokine interleukin-11 crucially links bone formation, remodeling and resorption	46
Influence of adipose tissue immune dysfunction on childhood obesity	45
The functional roles of m6A modification in T lymphocyte responses and autoimmune diseases	45
GLP-1R agonist therapy and vaccine response: Neglected implications	43
Impact of chronic stress on intestinal mucosal immunity in colorectal cancer progression	42
Serum amyloid A and inflammasome activation: A link to breast cancer progression?	41
The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis	40
COVID-19: From emerging variants to vaccination	40
T cell receptor signaling in the differentiation and plasticity of CD4+ T cells	39
Roles of the gut microbiota in severe SARS-CoV-2 infection	38
Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment	37
Role of circular RNA in myocardial ischemia and ageing-related diseases	37
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	33
Old drugs, new tricks: Emerging role of drug repurposing in the management of atopic dermatitis	33
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders	33
MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets	33
FGF/FGFR signaling: From lung development to respiratory diseases	33
Exosomes as a modulator of immune resistance in human cancers	32
The immunopathogenesis of a cytokine storm: The key mechanisms underlying severe COVID-19	31
Harnessing the potential of CD40 agonism in cancer therapy	31
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	31
Endothelial and macrophage interactions in the angiogenic niche	30
Crosstalk between glucose metabolism, lactate production and immune response modulation	30
Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolism	29
The role of transforming growth factor β in cervical carcinogenesis	28
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	28
Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia	28
Multifaceted role of CD14 in innate immunity and tissue homeostasis	27
Apoptotic cell-derived metabolites in efferocytosis-mediated resolution of inflammation	27
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	26
Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury	26
Editorial Board	25
Editorial Board	25
Pharmacological therapies and drug development targeting SARS-CoV-2 infection	25
Editorial Board	24
Editorial Board	23
Decoding the roles of heat shock proteins in liver cancer	23
Editorial Board	23
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	22
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	21
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases	21
Editorial Board	21
Snake venom vascular endothelial growth factors (svVEGFs): Unravelling their molecular structure, functions, and research potential	21
Role of the APRIL molecule in solid tumors	20
Cytokines on the way to secretion	20
From orphan to oncogene: The role of GPR35 in cancer and immune modulation	20
Role of gremlin-1 in the pathophysiology of the adipose tissues	20
A quartet of cancer stem cell niches in hepatocellular carcinoma	20
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	19
Radiation-targeted immunotherapy: A new perspective in cancer radiotherapy	19

Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders	19
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy	19
Exosome-mediated metabolic reprogramming: Implications in esophageal carcinoma progression and tumor microenvironment remodeling	18
Hallmarks of aging and immunosenescence: Connecting the dots	17
Interferon-I modulation and natural products: Unraveling mechanisms and therapeutic potential in severe COVID-19	17
Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication	17
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	17
NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies	16
Secretory Leukocyte Protease Inhibitor (SLPI) in mucosal tissues: Protects against inflammation, but promotes cancer	16
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	16
B cell-activating factor and its targeted therapy in autoimmune diseases	16
Revisiting IRF1-mediated antiviral innate immunity	16
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies	16
Inflamm-ageing: How cytokines and nutrition shape the trajectory of ageing	15
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	15
The impact of cytokines in neuroinflammation-mediated stroke	15
Extracellular vesicles in cancer: Shaping the intricate network of metabolic reprogramming and immune interactions in the tumor microenvironment	15
Small extracellular vesicle-mediated bidirectional crosstalk between neutrophils and tumor cells	15
SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities	15
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	14
Netrin-1: An emerging player in inflammatory diseases	14
Targeting NKG2D/NKG2DL axis in multiple myeloma therapy	14
Type I IFN-dependent antibody response at the basis of sex dimorphism in the outcome of COVID-19	14
Editorial Board	13
Editorial Board	13
Molecular regulation of autophagy in a pro-inflammatory tumour microenvironment: New insight into the role of serum amyloid A	13
Assessment of clinical studies evaluating combinations of immune checkpoint inhibitors with locoregional treatments in solid tumors	13
Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications	13
Editorial Board	13
Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron	13
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus	12
Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunity	12
Cytokine storm with rapidly elevated interleukin-6 indicates sudden death in patients with critical COVID-19	12
The determinant role of IL-6 in the establishment of inflammation leading to spontaneous preterm birth	12
Anticancer innovative therapy congress: Highlights from the 10th anniversary edition	12
The intersection of microbiome and autoimmunity in long COVID-19: Current insights and future directions	12
Genetically modified immunomodulatory cell-based biomaterials in tissue regeneration and engineering	11
The impact of adipokines on vascular networks in adipose tissue	11
Participation of interferons in psoriatic inflammation	11
Biomarker discovery in hepatocellular carcinoma (HCC) for personalized treatment and enhanced prognosis	11
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	11
The Coronavirus pandemic – 2022: Viruses, variants & vaccines	11
Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy	11
Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions	10
IL-33 in cancer immunotherapy: Pleiotropic functions and biological strategies	10
Unravelling the immunobiology of innate lymphoid cells (ILCs): Implications in health and disease	10
Mechanisms coupling the mTOR pathway to chronic obstructive pulmonary disease (COPD) pathogenesis	10
Corrigendum to “Dually modified transmembrane proteoglycans in development and disease” [Cytokine Growth Factor Rev. 39 (2018) 124–136]	10
The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy	10
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	10
Distinct roles of MIF in the pathogenesis of ischemic heart disease	10
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs	9
Clinical progress in MSC-based therapies for the management of severe COVID-19	9
Forgetting COVID-19 – Introduction to the special issue	9
Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression	9
S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes	9