OOIR: Observatory of International Research

Papers

(The TQCC of Cytokine & Growth Factor Reviews is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Editorial Board	271
Corrigendum to “Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy” [Cytokine Growth Factor Rev. 84 (2025) 59–73]	148
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	143
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	130
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	130
COVID-19: From emerging variants to vaccination	119
Editorial Board	117
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	89
Editorial Board	87
Editorial Board	84
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	81
Erratum to “TLR-Based therapeutic strategies for Hepatocellular carcinoma” [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179–189]	80
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications	75
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	74
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	71
Targeting cytokines: Reshaping the pancreatic tumor microenvironment	68
Natural killers or natural regulators? Dual roles of NK cells in checkpoint immunotherapy	62
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	58
Molecular mechanisms of regulation of IL-1 and its receptors	55
Editorial Board	49
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	48
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	48
Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer	48
TGF-β mediated drug resistance in solid cancer	47
Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	47

Exogenous drug-induced mouse models of atopic dermatitis	47
The immunodynamics of pulmonary fibrosis	46
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	46
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	43
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	43
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	43
Exosomes as a modulator of immune resistance in human cancers	42
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	42
MDSCs might be “Achilles heel” for eradicating CSCs	42
Post COVID-19 pandemic Inflammatory Insights into Cancer: Consequences for immunotherapy	40
Multifaceted role of CD14 in innate immunity and tissue homeostasis	40
The role of neurotransmitter signaling in colorectal cancer progression: Opportunities for drug repurposing	40
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	40
Editorial Board	40
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies	39
Decoding the roles of heat shock proteins in liver cancer	39
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	38
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	38
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression	37
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	37
Forgetting COVID-19 – Introduction to the special issue	36
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	35
From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis	35
The impact of adipokines on vascular networks in adipose tissue	35
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	33
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	31
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	31
mTOR in programmed cell death and its therapeutic implications	31
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	31
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	30
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	30
Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy	30
Editorial Board	29
Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance	29
Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk	28
Spatiotemporal dynamic regulation of the CX3CL1-CX3CR1 axis: A double-edged sword in the tumor immune microenvironment and new strategies for precision therapy	28
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression	28
Cholecystokinin and gastrin as immune modulating hormones: Implications and applications	28
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders	27
Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment	27
Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer	26
The IL-2A receptor pathway and its role in lymphocyte differentiation and function	26