OOIR: Observatory of International Research

Papers

(The TQCC of Cytokine & Growth Factor Reviews is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Editorial Board	206
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	147
Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases	140
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	128
COVID-19: From emerging variants to vaccination	123
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	121
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	104
Erratum to “TLR-Based therapeutic strategies for Hepatocellular carcinoma” [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179–189]	98
Editorial Board	94
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	87
Editorial Board	81
Editorial Board	78
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications	77
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	69
Participation of interferons in psoriatic inflammation	67
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	65
Targeting cytokines: Reshaping the pancreatic tumor microenvironment	63
Molecular mechanisms of regulation of IL-1 and its receptors	61
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	60
Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer	58
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	58
Natural killers or natural regulators? Dual roles of NK cells in checkpoint immunotherapy	54
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	52
TGF-β mediated drug resistance in solid cancer	48
Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer	45

Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	45
Exogenous drug-induced mouse models of atopic dermatitis	44
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	43
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	43
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	43
Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review	41
Suppressor of cytokine signaling 6 in cancer development and therapy: Deciphering its emerging and suppressive roles	39
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	39
MDSCs might be “Achilles heel” for eradicating CSCs	38
Exosomes as a modulator of immune resistance in human cancers	37
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	37
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	37
COVID-19 and dys-regulation of pulmonary endothelium: implications for vascular remodeling	36
Multifaceted role of CD14 in innate immunity and tissue homeostasis	35
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	35
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies	35
Netrin-1: An emerging player in inflammatory diseases	33
Editorial Board	33
Decoding the roles of heat shock proteins in liver cancer	32
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	32
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	31
B cell-activating factor and its targeted therapy in autoimmune diseases	30
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression	30
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	30
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	30
Forgetting COVID-19 – Introduction to the special issue	29
From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis	29
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	29
mTOR in programmed cell death and its therapeutic implications	28
The impact of adipokines on vascular networks in adipose tissue	28
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	27
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	27
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	27
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	27
Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk	26
Editorial Board	26
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	26
Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance	26
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	26
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression	25
Cholecystokinin and gastrin as immune modulating hormones: Implications and applications	25
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders	25