OOIR: Observatory of International Research

Papers

(The TQCC of Cytokine & Growth Factor Reviews is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system	999
SARS-CoV-2 infection: The role of cytokines in COVID-19 disease	813
Cytokine storm intervention in the early stages of COVID-19 pneumonia	358
COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons	299
IL-6: Relevance for immunopathology of SARS-CoV-2	223
The global impact of the coronavirus pandemic	210
Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes	131
SARS-CoV-2 Mutations and their Viral Variants	107
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies	90
The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved	85
SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders	80
The potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19	78
Hallmarks of aging and immunosenescence: Connecting the dots	72
Understanding novel COVID-19: Its impact on organ failure and risk assessment for diabetic and cancer patients	70
Mechanisms of NLRP3 priming in inflammaging and age related diseases	68
A critical evaluation of glucocorticoids in the management of severe COVID-19	64
The Covid-19 pandemic in Denmark: Big lessons from a small country	64
Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?	60
Crosstalk between glucose metabolism, lactate production and immune response modulation	58
Applications of the regenerative capacity of platelets in modern medicine	54
Semaphorins in health and disease	48
Receptor binding competition: A paradigm for regulating TGF-β family action	47
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	46
ALCAM/CD166: A pleiotropic mediator of cell adhesion, stemness and cancer progression	45
SARS-CoV-2: Targeted managements and vaccine development	44

Chemokine networks modulating natural killer cell trafficking to solid tumors	44
Growth differentiation factor-15 and its role in diabetes and cardiovascular disease	43
Acute inflammation and pathogenesis of SARS-CoV-2 infection: Cannabidiol as a potential anti-inflammatory treatment?	40
SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities	40
Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia	40
Correlation between PD-1/PD-L1 expression and polarization in tumor-associated macrophages: A key player in tumor immunotherapy	39
S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes	39
Antiphospholipid antibodies and risk of post-COVID-19 vaccination thrombophilia: The straw that breaks the camel's back?	38
FGF/FGFR signaling: From lung development to respiratory diseases	37
Engineering and combining oncolytic measles virus for cancer therapy	37
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	36
Biological functions and therapeutic opportunities of soluble cytokine receptors	36
A cytokine super cyclone in COVID-19 patients with risk factors: the therapeutic potential of BCG immunization	36
Biological functions of NLRP3 inflammasome: A therapeutic target in inflammatory bowel disease	36
The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system	35
The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine	35
IL-15 immunotherapy is a viable strategy for COVID-19	34
The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment	33
Cytokines in oncolytic virotherapy	33
The involvement of TH17 cells in the pathogenesis of IBD	33
IL-36 in chronic inflammation and cancer	33
Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy	33
Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment	32
Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic	32
An evaluation of the effects of probiotics on tumoral necrosis factor (TNF-α) signaling and gene expression	32
Selective inhibition of Tumor necrosis factor receptor-1 (TNFR1) for the treatment of autoimmune diseases	32
The determinant role of IL-6 in the establishment of inflammation leading to spontaneous preterm birth	31
Secretory Leukocyte Protease Inhibitor (SLPI) in mucosal tissues: Protects against inflammation, but promotes cancer	31
The Coronavirus pandemic – 2022: Viruses, variants & vaccines	30
Mechanisms of measles virus oncolytic immunotherapy	29
Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions	29
The evolving epidemiology of monkeypox virus	29
Revisiting IRF1-mediated antiviral innate immunity	27
The cytokine interleukin-11 crucially links bone formation, remodeling and resorption	27
Principles of the activin receptor signaling pathway and its inhibition	27
Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer	26
Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence	26
Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolism	25
Galectins as modulators of receptor tyrosine kinases signaling in health and disease	24
Development of mRNA vaccines against respiratory syncytial virus (RSV)	23
The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy	23