OOIR: Observatory of International Research

Papers

(The TQCC of Apoptosis is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Investigation of GPR143 as a promising novel marker for the progression of skin cutaneous melanoma through bioinformatic analyses and cell experiments	227
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	175
Bufalin reverses cancer-associated fibroblast-mediated colorectal cancer metastasis by inhibiting the STAT3 signaling pathway	156
Cuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma	119
A quarter century of Apoptosis	106
Retraction Note to: Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular c	102
PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition	72
Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives	70
Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission	61
Nobiletin as an inducer of programmed cell death in cancer: a review	46
Gamma irradiation induces a pro-apoptotic state in longer stored platelets, without progressing to an overt apoptosis by day 7 of storage	44
Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity	43
Resveratrol suppresses liver cancer progression by downregulating AKR1C3: targeting HCC with HSA nanomaterial as a carrier to enhance therapeutic efficacy	37
The role of hydrogen sulfide regulation of ferroptosis in different diseases	36
Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation	35
Machine learning framework develops neutrophil extracellular traps model for clinical outcome and immunotherapy response in lung adenocarcinoma	35
Programmed cell death lives	33
IRF-1-inhibited lncRNA XIST regulated the osteogenic differentiation via miR-450b/FBXW7 axis	33
Melatonin attenuates inflammatory bone loss by alleviating mitophagy and lactate production	33
N6-methyladenosine writer METTL3 accelerates the sepsis-induced myocardial injury by regulating m6A-dependent ferroptosis	33
Notch1 signaling activation alleviates coronary microvascular dysfunction through histone modification of Nrg-1 via the interaction between NICD and GCN5	31
Study on the activation of cell death mechanisms: in search of new therapeutic targets in glioblastoma multiforme	30
AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via BadSer136 phosphorylation	30
ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP	30
Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer	30

Targeting mitochondria as a therapeutic anti-gastric cancer approach	29
Comprehensive analysis of mitochondrial dysfunction and necroptosis in intracranial aneurysms from the perspective of predictive, preventative, and personalized medicine	29
An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness	28
MARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1	27
BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibition	25
Advancing the frontiers of colorectal cancer treatment: harnessing ferroptosis regulation	25
Benefits of high-intensity interval training compared to continuous training to reduce apoptotic markers in female rats with cisplatin nephrotoxicity – possible modulatory role of IL-11	25
A novel safer CD19CAR with shRNA interference of IFN-γ can reduce multiple cytokine levels without significantly compromising its killing efficacy	24
Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells	24
Glutamine deprivation in glioblastoma stem cells triggers autophagic SIRT3 degradation to epigenetically restrict CD133 expression and stemness	23
Integrated analysis reveals a novel 5-fluorouracil resistance-based prognostic signature with promising implications for predicting the efficacy of chemotherapy and immunotherapy in patients with colo	23
Anticancer effect and apoptosis induction by azaflavanone derivative in human prostate cancer cells	22
EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma	22
Ambra1 in cancer: implications for clinical oncology	21
Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1	21
Up-regulation of pro-angiogenic molecules and events does not relate with an angiogenic switch in metastatic osteosarcoma cells but to cell survival features	20
The cross-talk between Bax, Bcl2, caspases, and DNA damage in bystander HepG2 cells is regulated by γ-radiation dose and time of conditioned media transfer	20
Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli	20
MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis	20
Mechanisms of nucleophosmin (NPM)-mediated regulated cell death elucidated by Hsp70 during renal ischemia	19
Exploration of microRNA-106b-5p as a therapeutic target in intervertebral disc degeneration: a preclinical study	19
Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax	19
Role of APR3 in cancer: apoptosis, autophagy, oxidative stress, and cancer therapy	19
mTOR deletion ameliorates CD4 + T cell apoptosis during sepsis by improving autophagosome-lysosome fusion	19
IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease	18
Programmed cell death, redox imbalance, and cancer therapeutics	18
C-terminal region of Rv1039c (PPE15) protein of Mycobacterium tuberculosis targets host mitochondria to induce macrophage apoptosis	18
Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis	18
Enhancing or inhibiting apoptosis? The effects of ucMSC-Ex in the treatment of different degrees of traumatic pancreatitis	18
ARPC5 is transcriptionally activated by KLF4, and promotes cell migration and invasion in prostate cancer via up-regulating ADAM17	18
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner	18
Pyroptosis in acute pancreatitis and its therapeutic regulation	18
A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells	17
Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer’s disease	16
Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma	16
Revealing the role of necroptosis microenvironment: FCGBP + tumor-associated macrophages drive primary liver cancer differentiation towards cHCC-CCA or iCCA	16
Ferroptosis: underlying mechanisms and involvement in neurodegenerative diseases	16
TRIM23 promotes 5-Fluorouracil resistance in colorectal cancer by upregulating GALNT4 expression	16
New prospects of cancer therapy based on pyroptosis and pyroptosis inducers	15
TM2, a novel semi-synthetic taxoid, exerts anti-MDR activity in NSCLC by inhibiting P-gp function and stabilizing microtubule polymerization	15
Targeting PAX8 sensitizes ovarian cancer cells to ferroptosis by inhibiting glutathione synthesis	15
Molecular probes for monitoring pyroptosis: design, imaging and theranostic application	15
Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD	15
Recent advances in the role of gasotransmitters in necroptosis	14
Correction to: NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis	14
Cancer-associated fibroblasts promote malignant phenotypes of prostate cancer cells via autophagy	14
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage	14
The regulation of necroptosis by ubiquitylation	14
Exosomes derived from FN14-overexpressing BMSCs activate the NF-κB signaling pathway to induce PANoptosis in osteosarcoma	13
Role of the USP family in autophagy regulation and cancer progression	13

Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury	13
Isolation, identification, and challenges of extracellular vesicles: emerging players in clinical applications	13
Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction	13
SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway	13
Global trends in PANoptosis research: bibliometrics and knowledge graph analysis	13
Nutrient deficiency-induced downregulation of SNX1 inhibits ferroptosis through PPARs-ACSL1/4 axis in colorectal cancer	13
SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	13
Letter to the editor: fasting decreases expression of microRNAs linked to endothelial pathophysiology in mononuclear cells of healthy subjects	12
IRG1/Itaconate inhibits proliferation and promotes apoptosis of CD69+CD103+CD8+ tissue-resident memory T cells in autoimmune hepatitis by regulating the JAK3/STAT3/P53 signalling pathway	12
Bushen Jianpi Tiaoxue Decoction (BJTD) inhibits the LIF-mTOR signaling axis to regulate mitochondrial function and alleviate cyclophosphamide-induced diminished ovarian reserve	12
Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects	12
Pyroptosis, a target for cancer treatment?	12
Correction to: Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis	12
TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway	12
Myeloma extracellular vesicle-derived RAGE increases inflammatory responses and myotube atrophy in multiple myeloma through activation of the TLR4/NF-κB p65 pathway	12
N6-methyladenosine reader protein IGF2BP1 suppresses CD8 + T cells-mediated tumor cytotoxicity and apoptosis in colon cancer	12
Exploring caspase functions in mouse models	12
Role of oxeiptosis in disease mechanisms and therapeutic opportunities	12
Mechanism of tumor-derived extracellular vesicles in prostatic cancer progression through the circFMN2/KLF2/RNF128 axis	12
Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: involvement of glucose import, ROS, NF-κB and lncRNAs	12
Downregulation of circ-STK39 suppresses pancreatic cancer progression by sponging mir-140-3p and regulating TRAM2-mediated epithelial-mesenchymal transition	12
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia	11
IGF2BP3 boosts lactate generation to accelerate gastric cancer immune evasion	11
New insights into pulmonary arterial hypertension: interaction between PANoptosis and perivascular inflammatory responses	11
Is long-term administration of PLD-pegylated liposomal doxorubicin able to induce oral cancer?	11
Correction: The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD + redox state	11
Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration	11
Apoptosis-related prognostic biomarkers and potential targets for acute kidney injury based on machine learning algorithm and in vivo experiments	11
Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia–reperfusion injury	11
LncRNA PVT1 delays skin photoaging by sequestering miR-551b-3p to release AQP3 expression via ceRNA mechanism	10
Zhongfeng Capsules protects against cerebral ischemia–reperfusion injury via mediating the phosphoinositide 3-kinase/Akt and toll-like receptor 4/nuclear factor kappa B signaling pathways by regulatin	10
Disulfidptosis-related long non-coding RNA signature predicts the prognosis, tumor microenvironment, immunotherapy, and antitumor drug options in colon adenocarcinoma	10
Long non-coding RNA SNHG4 enhances RNF14 mRNA stability to promote the progression of colorectal cancer by recruiting TAF15 protein	10
Multiple myeloma with high expression of SLC7A11 is sensitive to erastin-induced ferroptosis	10
Retraction Note: ICB3E induces iNOS expression by ROS-dependent JNK and ERK activation for apoptosis of leukemic cells	10
Unveiling the hidden role of disulfidptosis in kidney renal clear cell carcinoma: a prognostic signature for personalized treatment	10
Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak	10
Acetylcholine exerts cytoprotection against hypoxia/reoxygenation-induced apoptosis, autophagy and mitochondrial impairment through both muscarinic and nicotinic receptors	10
Cuproptosis in lung cancer: therapeutic options and prognostic models	10
Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism	10