OOIR: Observatory of International Research

Papers

(The TQCC of Apoptosis is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Release mechanisms of major DAMPs	232
The function and mechanism of ferroptosis in cancer	119
Mechanism of interaction between autophagy and apoptosis in cancer	104
BCL-2 protein family: attractive targets for cancer therapy	78
Terpenoids’ anti-cancer effects: focus on autophagy	61
BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis	55
Mechanisms of cancer cell death induction by paclitaxel: an updated review	55
Programmed cell death detection methods: a systematic review and a categorical comparison	52
Targeting of cancer cell death mechanisms by resveratrol: a review	52
The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases	41
Ca2+ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells	39
COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis	35
Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death	32
Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro	32
Programmed cell death, redox imbalance, and cancer therapeutics	32
Photodynamic therapy: apoptosis, paraptosis and beyond	31
Apoptosis in Alzheimer’s disease: insight into the signaling pathways and therapeutic avenues	31
FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes	30
New insights into targeting mitochondria in ischemic injury	26
Acetylcholinesterase promotes apoptosis in insect neurons	25
Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside	24
Nobiletin as an inducer of programmed cell death in cancer: a review	24
Pyroptosis in acute pancreatitis and its therapeutic regulation	24
Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax	23
XIAP as a multifaceted molecule in Cellular Signaling	23

Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation	23
Regulation of autophagy of the heart in ischemia and reperfusion	22
COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus	22
Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells	21
Apoptosis induced by SARS-CoV-2: can we target it?	21
Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis	21
The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury	20
A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis	20
Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation	19
Gedunin isolated from the mangrove plant Xylocarpus granatum exerts its anti-proliferative activity in ovarian cancer cells through G2/M-phase arrest and oxidative stress-mediated intrinsic apoptosis	19
DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients	19
Citarinostat and Momelotinib co-target HDAC6 and JAK2/STAT3 in lymphoid malignant cell lines: a potential new therapeutic combination	18
The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state	18
Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects	18
The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis	17
Heat shock proteins-driven stress granule dynamics: yet another avenue for cell survival	16
Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins	16
Maslinic acid differentially exploits the MAPK pathway in estrogen-positive and triple-negative breast cancer to induce mitochondrion-mediated, caspase-independent apoptosis	16
Interconnections among major forms of regulated cell death	16
m6A writer WTAP targets NRF2 to accelerate bladder cancer malignancy via m6A-dependent ferroptosis regulation	16
Regulatory T cells are less sensitive to glucocorticoid hormone induced apoptosis than CD4+ T cells	16
Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis	16
Casein kinase 1α mediates eryptosis: a review	16
miR-30b-5p inhibits cancer progression and enhances cisplatin sensitivity in lung cancer through targeting LRP8	16
Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease	15
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	15
p53 m6A modulation sensitizes hepatocellular carcinoma to apatinib through apoptosis	15
Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells	15
Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated interverte	14
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis	14
Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway	14
The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation	14
The role of lncRNA OIP5-AS1 in cancer development and progression	13
Triclosan induces apoptosis in Burkitt lymphoma-derived BJAB cells through caspase and JNK/MAPK pathways	13
Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis	13
The interplay between apoptosis and ferroptosis mediated by ER stress	13
Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis	13
Pyroptosis, a target for cancer treatment?	13
Tumor cell-derived exosome RNF126 affects the immune microenvironment and promotes nasopharyngeal carcinoma progression by regulating PTEN ubiquitination	12
LncRNA FGD5-AS1 promotes the malignant phenotypes of ovarian cancer cells via targeting miR-142-5p	12
Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis	12
Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart	12
Valproic acid upregulates the expression of the p75NTR/sortilin receptor complex to induce neuronal apoptosis	12
Epoxyazadiradione exhibit activities in head and neck squamous cell carcinoma by targeting multiple pathways	12
Regulation of autophagy as a therapeutic option in glioblastoma	12
Cardiac Mitochondrial PTEN-L determines cell fate between apoptosis and survival during chronic alcohol consumption	12
The role of the DFF40/CAD endonuclease in genomic stability	11
Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1	11
The delay in cell death caused by the induction of autophagy by P2Et extract is essential for the generation of immunogenic signals in melanoma cells	11
H2S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434	11

N6-methyladenosine writer METTL3 accelerates the sepsis-induced myocardial injury by regulating m6A-dependent ferroptosis	11
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1	11
Molecular mechanisms of cell death in bronchopulmonary dysplasia	11
Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway	10
Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism	10
Crosstalk of ferroptosis regulators and tumor immunity in pancreatic adenocarcinoma: novel perspective to mRNA vaccines and personalized immunotherapy	10
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries	10
Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases	10
Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: involvement of glucose import, ROS, NF-κB and lncRNAs	10
High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis	9
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells	9
LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis	9
Targeting lipid metabolism for ferroptotic cancer therapy	9
RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells	9
Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling	9
Apoptotic proteins with non-apoptotic activity: expression and function in cancer	9