OOIR: Observatory of International Research

Papers

(The TQCC of Apoptosis is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity	343
Molecular probes for monitoring pyroptosis: design, imaging and theranostic application	302
An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness	216
Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis	137
ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP	101
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner	65
Exosomes derived from FN14-overexpressing BMSCs activate the NF-κB signaling pathway to induce PANoptosis in osteosarcoma	58
Nobiletin as an inducer of programmed cell death in cancer: a review	55
Programmed cell death lives	53
The STING signaling pathways and bacterial infection	51
Global trends in PANoptosis research: bibliometrics and knowledge graph analysis	51
Higher replication potential of West Nile virus governs apoptosis induction in human neuroblastoma cells	50
Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration	48
Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury	48
Tumor cell-derived exosome RNF126 affects the immune microenvironment and promotes nasopharyngeal carcinoma progression by regulating PTEN ubiquitination	48
LncRNA PVT1 delays skin photoaging by sequestering miR-551b-3p to release AQP3 expression via ceRNA mechanism	48
The CXCL8-CXCR2 axis promotes M2 macrophage polarization in ovarian cancer via RASGRP4-mediated mTOR-STAT3 signaling	46
Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak	46
Mitophagy: a novel avenue for herbal medicines alleviating myocardial ischemia/reperfusion injury	43
Multiple myeloma with high expression of SLC7A11 is sensitive to erastin-induced ferroptosis	43
An immunogenic cell death-related signature predicts prognosis and immunotherapy response in stomach adenocarcinoma	41
GSDME-dependent astrocyte pyroptosis promotes the progression of neuroinflammation in experimental cerebral malaria	41
Elevated serum mtDNA in COVID-19 patients is linked to SARS-CoV-2 envelope protein targeting mitochondrial VDAC1, inducing apoptosis and mtDNA release	41
Transcriptomic responses of cumulus granulosa cells to SARS-CoV-2 infection during controlled ovarian stimulation	40
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury	39

Genipin protects against acute liver injury by abrogating ferroptosis via modification of GPX4 and ALOX15-launched lipid peroxidation in mice	37
Necroptosis in myocardial ischaemia-reperfusion injury: current update on mechanisms, therapeutic targets, and translational potential	37
m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling	36
Manipulating the PANoptosome: baseless hype or a newfound hope for human immunity?	35
Targeting cuproptosis in liver cancer: Molecular mechanisms and therapeutic implications	35
Regulation of autophagy of the heart in ischemia and reperfusion	35
PTGR1-mediated immune evasion mechanisms in late-stage triple-negative breast cancer: mechanisms of M2 macrophage infiltration and CD8+ T cell suppression	35
PLAGL2-STAU1-NCOA4 axis enhances gastric cancer peritoneal metastasis by resisting ferroptosis via ferritinophagy	34
The role of lncRNA OIP5-AS1 in cancer development and progression	33
Correction: Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer	33
Dual role of endoplasmic reticulum stress-ATF-6 activation in autophagy and apoptosis induced by cyclic stretch in myoblast	33
Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway	32
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis	32
Endothelial HMGB1-AIM2 axis worsens myocardial ischemia—reperfusion injury by regulating endothelial pyroptosis	32
Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons	30
JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis	30
Exploring the role of ITGB6: fibrosis, cancer, and other diseases	29
Endothelial SPRY1 deficiency associates with angiogenic-metabolic reprogramming in pulmonary arterial hypertension: a multi-omics analysis of bulk and single-cell transcriptomic profiles	29
Analysis of cuproptosis-related lncRNA signature for predicting prognosis and tumor immune microenvironment in pancreatic cancer	28
LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis	27
Novel dual inhibitor targeting CDC25 and HDAC for treating triple-negative breast cancer	27
Rising impact of cell death research	27
CHI3L1 promotes myocardial fibrosis via regulating lncRNA TUG1/miR-495-3p/ETS1 axis	26
5-Aminolevulinic acid-mediated photodynamic therapy in combination with kinase inhibitor lapatinib enhances glioblastoma cell death	25
Casein kinase 1α mediates eryptosis: a review	25
Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis	24
Exosome-mediated triple drug delivery enhances apoptosis in pancreatic cancer cells	24
The role of the NcRNA/ferroptosis axis in lung cancer: molecular mechanisms and potential therapeutic targets	24
Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer	23
The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development	23
Harnessing cuproptosis: a new avenue for targeted cancer therapies	23
A ZFP42/MARK2 regulatory network reduces the damage of retinal ganglion cells in glaucoma: a study based on GEO dataset and in vitro experiments	23
HMGB1: a multifaceted mediator of cell death pathways in cardiovascular diseases	23
Ferroptosis: a novel therapeutic warrior in the battle against leukemia	23
Zincoptosis: does it exist?	23
CACNA1C-AS2 inhibits cell proliferation and suppresses cell migration and invasion via targeting FBXO45 and PI3K/AKT/mTOR pathways in glioma	23
XIAP as a multifaceted molecule in Cellular Signaling	23
Exploring a specialized programmed-cell death patterns to predict the prognosis and sensitivity of immunotherapy in cutaneous melanoma via machine learning	23
Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury	22
The role of TIGIT-CD226-PVR axis in mediating T cell exhaustion and apoptosis in NSCLC	22
USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/β-catenin signaling pathway	22
The N6-methyladenosine writer METTL3 promotes breast cancer progression through YTHDF2-dependent posttranscriptional silencing of GSDMD	22
Live-cell imaging and mathematical analysis of the “community effect” in apoptosis	22
Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis	21
Oxidative stress and ferroptosis in diabetic cardiomyopathy: mechanistic interplay and therapeutic implications	21
PANoptosis: a potential new target for programmed cell death in breast cancer treatment and prognosis	21
His-tagged pro-apoptotic peptides: enhancing cell internalization and anticancer effect in vitro	21
Brazilin alleviates acute lung injury via inhibition of ferroptosis through the SIRT3/GPX4 pathway	21
Correction to: NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis	20
Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction	20

EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma	20
Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission	19
Targeting mitochondria as a therapeutic anti-gastric cancer approach	19
Anticancer effect and apoptosis induction by azaflavanone derivative in human prostate cancer cells	19
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	19
Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma	19
The regulation of necroptosis by ubiquitylation	19
Correction to: Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis	18
Unveiling the hidden role of disulfidptosis in kidney renal clear cell carcinoma: a prognostic signature for personalized treatment	18
The mechanistic study of quercetin in the treatment of alcoholic brain injury via the JNK/P38 MAPK signaling pathway	18
Is long-term administration of PLD-pegylated liposomal doxorubicin able to induce oral cancer?	18
Deciphering macrophage heterogeneity and factors driving M2 polarization in lung adenocarcinoma through single-cell RNA sequencing	18
TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway	18
DJ-1-mediated p62 degradation delays intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus cells	18
Role of the USP family in autophagy regulation and cancer progression	18
MARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1	18
SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	18
Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects	18
Bushen Jianpi Tiaoxue Decoction (BJTD) inhibits the LIF-mTOR signaling axis to regulate mitochondrial function and alleviate cyclophosphamide-induced diminished ovarian reserve	17
Unlocking Parkinson’s disease: the role of microRNAs in regulation, diagnosis, and therapy	17
GJB2 as a novel prognostic biomarker associated with immune infiltration and cuproptosis in ovarian cancer	17
Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carcinoma progression	17
IGF2BP3 boosts lactate generation to accelerate gastric cancer immune evasion	17
DLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	17
Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling	17
Role of ferroptosis in food-borne mycotoxin-induced toxicities	17
Integrating single-cell sequencing and machine learning to uncover the role of mitophagy in subtyping and prognosis of esophageal cancer	17
A new perspective on iron-dependent cell death: PRDX-1-mediated ferroptosis in tumor cells	17
Emerging role of PANoptosis in kidney diseases: molecular mechanisms and therapeutic opportunities	17
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries	16
Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells	16
DDI2 promotes tumor metastasis and resists antineoplastic drugs-induced apoptosis in colorectal cancer	16
Prognostic implications and therapeutic opportunities related to CAF subtypes in CMS4 colorectal cancer: insights from single-cell and bulk transcriptomics	16
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis	16
Development and experimental validation of a machine learning-based disulfidptosis-related ferroptosis score for hepatocellular carcinoma	16
EVA1A reverses lenvatinib resistance in hepatocellular carcinoma through regulating PI3K/AKT/p53 signaling axis	15
A novel programmed cell death signature predicts clinical outcomes in clear cell renal cell carcinoma and identifies PLK1 as a therapeutic target	15
A deadly taste: linking bitter taste receptors and apoptosis	15
microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane	15
Correction: Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomalmitochondrial axis	15
Emerging role of RNA m6A modifications in laryngeal squamous cell carcinoma: insights into tumorigenesis and therapeutic potential	15
Context-dependent activation of p53 target genes and induction of apoptosis by actinomycin D in aerodigestive tract cancers	15
Bufalin inhibits immune escape in metastatic colorectal cancer by regulating M2 macrophage polarization	15
Research progress on the mechanism of curcumin in cerebral ischemia/reperfusion injury: a narrative review	14
MLKL and other necroptosis-related genes promote the tumor immune cell infiltration, guiding for the administration of immunotherapy in bladder urothelial carcinoma	14
Intravenous immunoglobulin ameliorates doxorubicin-induced intestinal mucositis by inhibiting the Syk/PI3K/Akt axis and ferroptosis	14
Bibliometric analysis and mini-review of global research on pyroptosis in the field of cancer	14
Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases	14
Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy	14
Microplastics promote chemoresistance by mediating lipid metabolism and suppressing pyroptosis in colorectal cancer	14
Multi-omics nominates VDAC2 as a candidate protective locus in sepsis-associated cholesterol dysregulation	14
Diallyl disulfide in oncotherapy: molecular mechanisms and therapeutic potentials	14