OOIR: Observatory of International Research

Papers

(The H4-Index of Current Opinion in Chemical Biology is 36. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Fluorogenic polymethine dyes by intramolecular cyclization	215
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	142
Imaging of proteases using activity-based probes	136
Engineered metallobiocatalysts for energy–relevant reactions	98
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	90
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	76
Small-molecule modulators of protein–RNA interactions	75
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	72
Glycoengineering in antigen-specific immunotherapies	62
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	58
Recent advances in methods for quantifying the cell penetration of macromolecules	58
Synthetic transporters for oxoanions	57
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	57
The Ramifications of synthetic biology	56
Characteristics of genetic tags for correlative light and electron microscopy	51
Caged lipid probes for controlling lipid levels on subcellular scales	50
Activity-based protein profiling in microbes and the gut microbiome	49
Chemical inhibitors of transcription-associated kinases	48
Extendable and explainable deep learning for pan-cancer radiogenomics research	47
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	47
Site-specific bioconjugation and nuclear imaging	46
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	45
Genetically encoded fluorescent sensors for metals in biology	44
Highlighting the roles of transition metals and speciation in chemical biology	44
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	43

Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	43
Chemistry and biology of enzymes in protein glutathionylation	41
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	41
Chemical probes for tagging mycobacterial lipids	39
Advances in the understanding and exploitation of carbohydrate-active enzymes	39
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	38
Critical considerations in N-glycoproteomics	38
Editorial Board	37
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	37
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	36
Chemical approaches for investigating site-specific protein S-fatty acylation	36