Current Opinion in Chemical Biology

Article	Citations
Engineered metallobiocatalysts for energy–relevant reactions	191
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	93
Glycoengineering in antigen-specific immunotherapies	78
Fluorogenic polymethine dyes by intramolecular cyclization	77
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	77
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	76
Proximity chemistries to study RNA biology at the subcellular scale	72
Imaging of proteases using activity-based probes	65
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	63
Editorial Board	60
Characteristics of genetic tags for correlative light and electron microscopy	55
Recent advances in methods for quantifying the cell penetration of macromolecules	55
The Ramifications of synthetic biology	55
Covalent lysine targeting is coming of age	54
Chemical inhibitors of transcription-associated kinases	54
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	53
Toward universal binder discovery: Advances in display, computational design and in vivo platforms	49
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	47
Always on the move: Mapping spatiotemporal interactome with proximity labeling in mammalian cells	46
Activity-based protein profiling in microbes and the gut microbiome	46
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	45
Self-resistance as a guide to discovering bioactive natural products	45
Caged lipid probes for controlling lipid levels on subcellular scales	45
Site-specific bioconjugation and nuclear imaging	45
Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry	45

Controlling distance, time and reactivity: Chemical principles of proximity labeling	44
Synthetic transporters for oxoanions	43
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	43
Editorial Board	42
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	42
DVD-IgG1 antibody–drug conjugates: Expanding the landscape of targeted cancer therapy	41
Chemistry and biology of enzymes in protein glutathionylation	41
Advances in the understanding and exploitation of carbohydrate-active enzymes	40
Genetically encoded fluorescent sensors for metals in biology	40
Highlighting the roles of transition metals and speciation in chemical biology	39
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	39
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	39
Critical considerations in N-glycoproteomics	39
Genetic code expansion: Bridging synthetic biology precision and cellular complexity to decipher molecular mechanisms of diseases	39
From generation to validation: Deep generative models for antimicrobial peptide discovery	38
Synthetic DNA circuits for programming cell functions	38
Editorial Board	38
Natural and engineered precision antibiotics in the context of resistance	37
Editorial Board	37
Mechanism and inhibition of BRAF kinase	36
How nature incorporates sulfur and selenium into bioactive natural products	36
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	35
Virus-assisted directed evolution of biomolecules	35
Editorial: Unusual enzyme reactions in natural products biosynthesis	34
Recent advances in computational algorithms and software for large-scale glycoproteomics	34
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	33
Recent progress of TP/NIR fluorescent probes for metal ions	33
Sulfoxides in medicine	33
Cysteine and methionine oxidation in thrombotic disorders	32
Transferring enzyme features to molecular CO2 reduction catalysts	32
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	31
Recent advances in N- and C-terminus cysteine protein bioconjugation	31
Recent advances in protein modification–enabled potential therapeutics	31
In vivo-compatible proximity labeling technologies	31
Recent advances in enzyme cascade reactions for the efficient synthesis of functionalized chemicals and complex pharmaceuticals	31
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	30
Molecular glues to stabilise protein–protein interactions	30
Defining the rules of biocompatible chemistry	30
Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation	30
Editorial Board	30
Synthetic peptide scaffolds as ion channels and molecular carriers	30
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	29
Bacterial peptidoglycan as a living polymer	29
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	29
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	29
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	28
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	28
Synthesis and application of bacterial exopolysaccharides	28
The evolving logic of biocatalyzed nucleic acid synthesis	28
New frontiers in sulfur and selenium chemical biology	27

Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	27
Promoting remyelination: A case study in regenerative medicine	27
Editorial Board	27
Fluorescent indicators for imaging membrane potential of organelles	27
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	26
Editorial overview: Synthetic biomolecules for probing lipid membranes	26
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	26
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	26
Next-generation interleukin-enhanced immunotherapies: From molecular engineering to armored T-cell architectures	26
Editorial overview: Recent advances in metabolomics	25
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	25
Editorial Board	25
Editorial overview: Glycobiology (2024)	25
Editorial Board	25
Metalloprotein enabled redox signal transduction in microbes	25
Editorial Board	25
Sensing and regulation of reactive sulfur species (RSS) in bacteria	24
Analytical techniques in chemical biology	24
Catalyzing the future: recent advances in chemical synthesis using enzymes	24
Recent advances in mapping protein networks regulated by post-translational modifications via proximity tagging	24
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	24
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	24
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	23
Advances in proximity labeling strategies for interactome mapping and functional interrogation	23
Glutathione dynamics in subcellular compartments and implications for drug development	23
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	23
Lipidomics analysis in drug discovery and development	23
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	23
Discovery and evolution of [4 + 2] cyclases	22
Editorial Board	22
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	22
Editorial: Mechanistic biology	22
Strategies in engineering sustainable biochemical synthesis through microbial systems	22
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	22
Chemical synthesis and biological functions of carbohydrates	21
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	21
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	21
Small-molecule tools for YEATS domain proteins	21
Inhibition of p53 protein aggregation as a cancer treatment strategy	21
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	21
Discovering functional small molecules in the gut microbiome	20
Supramolecular platinum complexes for cancer therapy	20
Chemical biology tools to probe bacterial glycans	20
Recent advances in high-throughput screening methods for small molecule modulators in bacteria	20
Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆	20
Realgar and arsenene nanomaterials as arsenic-based anticancer agents	20
Recent strides in macromolecular targeted photodynamic therapy for cancer	20
Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes	20
Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity	20
Functions and mechanisms of enzymes assembling lignans and norlignans	20
Recent advances in de novo designed metallopeptides as tailored enzyme mimics	19
Editorial Board	19
Recent advances in developing degraders & inhibitors of lysine methyltransferases	19
Prediction of protein–protein interactions and co-complex models with deep learning	19
Editorial Board	19
MicroRNA:Siglec crosstalk in cancer progression	18
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	18
Sulfur-containing marine natural products as leads for drug discovery and development	18
Microbial metabolite-receptor interactions in the gut microbiome	18
Recent advances on human milk oligosaccharide antimicrobial activity	18
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	18
Recent development of fluorescent probes for hydrogen per/polysulfides	18
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	18
Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity	18
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	18
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	18
New chemical processes to streamline carbohydrate synthesis	18
Recent advances in the design and optimization of artificial metalloenzymes	18
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	18
Natural and artificial siderophores: Iron-based applications and beyond	18
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	17
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	17
Nucleic acid catalysts: From the origin of life to modern applications	17
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	16
Foldamer-mediated transport across phospholipid bilayers	16
Stimuli-responsive synthetic ionophores for therapeutic applications	16
Creating and understanding new-to-nature chemistry	16
Recent advances in spatial proteomics by super-resolution proximity labeling	16
Synthetic ion channels made of DNA	16
Recent advances in engineering microorganisms for the production of natural food colorants	15

Recent advances in the expanding genetic code	15
Emerging mechanisms of regulation for endoplasmic/sarcoplasmic reticulum Ca2+ stores by secretory pathway kinase FAM20C	15
Editorial Board	15
Molecular-level interplay between intrinsically disordered clients and Hsp90	15
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies	15
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer	15
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism	14
Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must	14
Recent advances in kinase signaling network profiling by mass spectrometry	14
Small molecules as modulators of phage–bacteria interactions	14
Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling	14
Development of novel indicators and molecular systems for calcium sensing through protein engineering	14
Proximity labeling tools for studying chromatin interactomes	13
The multifaceted repertoire of cellular reactive metabolites	13
Engineering novel adeno-associated viruses (AAVs) for improved delivery in the nervous system	13
Editorial overview - Exploring the diversity of polysaccharides	13
F420-dependent transformations in biosynthesis of secondary metabolites	13
Engineering alternative bacterial platforms for sustainable bioproduction	13
Imaging genome dynamics in real time with CRISPR-based technologies	13
Illuminating antifungal mode of action and resistance with fluorescent probes	12
KATs off: Biomedical insights from lysine acetyltransferase inhibitors	12
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation	12
Evolving advances of proximity labeling in capturing biomolecular interactions	12
Microbial metabolism of host-derived antioxidants	12
Chemical biology approaches to uncovering nuclear ROS control	12
Therapeutic synthetic anion transporters	12
Biosynthesis and recruitment of reactive amino acids in nonribosomal peptide assembly lines	12
Synthetic fragments of plant polysaccharides as tools for cell wall biology	12
How do metabolic processes age: Evidence from human metabolomic studies	12
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities	11
Chemical and synthetic biology tools to interrogate and control cell–cell interactions in vivo	11
Discovering microbiota functions via chemical probe incorporation for targeted sequencing	11
A phenazine-inspired framework for identifying biological functions of microbial redox-active metabolites	11
Recent advances beyond classical bioorthogonal chemistry	11
Editorial Board	11
Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research	11
Recent advances in Zn2+ imaging: From organelles to in vivo applications	11
Expanding the viewpoint: Leveraging sequence information in enzymology	11
Small RNAs, big potential: Engineering microRNA-based synthetic gene circuits	10
How are hydrogen peroxide messages relayed to affect cell signalling?	10
Current strategies for characterization of mucin-domain glycoproteins	10
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	10
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	10
Bacterial glycoengineering: Cell-based and cell-free routes for producing biopharmaceuticals with customized glycosylation	10
Compounds for selective translational inhibition	10
Editorial Board	10
Small-angle X-ray scattering studies of enzymes	10
Editorial overview: Editorial of molecular imaging	10
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level	10
Editorial overview: Glycobiology (2023)	10
Towards sequence-based principles for protein phase separation predictions	10
Editorial Board	10
Tuning specificity and topology of lectins through synthetic biology	10