Current Opinion in Chemical Biology

Article	Citations
Fluorogenic polymethine dyes by intramolecular cyclization	203
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	132
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	130
Glycoengineering in antigen-specific immunotherapies	91
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	87
Imaging of proteases using activity-based probes	71
Small-molecule modulators of protein–RNA interactions	70
Engineered metallobiocatalysts for energy–relevant reactions	67
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	62
Synthetic transporters for oxoanions	58
Extendable and explainable deep learning for pan-cancer radiogenomics research	57
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	56
Recent advances in methods for quantifying the cell penetration of macromolecules	52
Caged lipid probes for controlling lipid levels on subcellular scales	52
The Ramifications of synthetic biology	51
Characteristics of genetic tags for correlative light and electron microscopy	50
Activity-based protein profiling in microbes and the gut microbiome	49
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	47
Site-specific bioconjugation and nuclear imaging	46
New strategies for fluorescently labeling proteins in the study of amyloids	45
Chemical inhibitors of transcription-associated kinases	44
Chemical engineering of bacterial effectors for regulating cell signaling and responses	43
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	43
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	41
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	41

Genetically encoded fluorescent sensors for metals in biology	40
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	40
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	39
Chemical probes for tagging mycobacterial lipids	39
Advances in the understanding and exploitation of carbohydrate-active enzymes	38
Critical considerations in N-glycoproteomics	37
Highlighting the roles of transition metals and speciation in chemical biology	37
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	37
Editorial Board	36
Chemistry and biology of enzymes in protein glutathionylation	36
Editorial Board	36
Chemical approaches for investigating site-specific protein S-fatty acylation	34
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	34
Natural and engineered precision antibiotics in the context of resistance	33
Understanding and controlling amyloid aggregation with chirality	33
Super-multiplexed vibrational probes: Being colorful makes a difference	33
Mechanism and inhibition of BRAF kinase	33
How nature incorporates sulfur and selenium into bioactive natural products	32
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	32
Protein sequence design with deep generative models	32
Recent advances in computational algorithms and software for large-scale glycoproteomics	31
Virus-assisted directed evolution of biomolecules	31
Catalytic amyloids: Is misfolding folding?	31
Editorial: Unusual enzyme reactions in natural products biosynthesis	31
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	30
Sulfoxides in medicine	29
Recent progress of TP/NIR fluorescent probes for metal ions	29
Emerging mammalian gene switches for controlling implantable cell therapies	29
Induced proximity tools for precise manipulation of lipid signaling	29
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	29
Cysteine and methionine oxidation in thrombotic disorders	28
Recent advances in N- and C-terminus cysteine protein bioconjugation	28
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	28
Transferring enzyme features to molecular CO2 reduction catalysts	28
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	28
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	28
Bacterial peptidoglycan as a living polymer	27
Exploring amyloid oligomers with peptide model systems	27
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	26
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	26
Synthetic peptide scaffolds as ion channels and molecular carriers	26
Synthesis and application of bacterial exopolysaccharides	26
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	26
SOD mimics: From the tool box of the chemists to cellular studies	26
Peptides for disrupting and degrading amyloids	25
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	25
Promoting remyelination: A case study in regenerative medicine	25
Molecular glues to stabilise protein–protein interactions	25
New frontiers in sulfur and selenium chemical biology	25
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	25

Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	24
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	24
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	24
Editorial overview: Amyloid-inspired synthetic biomolecules	24
Fluorescent indicators for imaging membrane potential of organelles	24
Inhibitors of DHHC family proteins	24
Editorial Board	23
Editorial overview: Synthetic biomolecules for probing lipid membranes	23
Editorial Board	22
Editorial Board	22
Analytical techniques in chemical biology	22
Editorial overview: Recent advances in metabolomics	21
Editorial overview: Glycobiology (2024)	21
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	21
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	21
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	21
Image-based cell phenotyping with deep learning	20
Metalloprotein enabled redox signal transduction in microbes	20
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	20
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology	20
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	20
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	20
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	20
Glutathione dynamics in subcellular compartments and implications for drug development	20
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	20
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	19
Sensing and regulation of reactive sulfur species (RSS) in bacteria	19
Editorial: Mechanistic biology	19
Lipidomics analysis in drug discovery and development	19
Editorial Board	19
Catalyzing the future: recent advances in chemical synthesis using enzymes	19
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	18
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	18
Strategies in engineering sustainable biochemical synthesis through microbial systems	18
Discovery and evolution of [4 + 2] cyclases	18
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	18
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	18
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	18
Recent progress on small molecules targeting epigenetic complexes	18
Recent strides in macromolecular targeted photodynamic therapy for cancer	17
Chemical biology tools to probe bacterial glycans	17
Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity	17
Chemical synthesis and biological functions of carbohydrates	17
Discovering functional small molecules in the gut microbiome	17
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds	17
Inhibition of p53 protein aggregation as a cancer treatment strategy	17
Recent advances in the mass spectrometric profiling of bacterial lipids	17
Recent advances in high-throughput screening methods for small molecule modulators in bacteria	17
Supramolecular platinum complexes for cancer therapy	17
Small-molecule tools for YEATS domain proteins	17
Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes	17
Functions and mechanisms of enzymes assembling lignans and norlignans	16
Adapting protein sequences for optimized therapeutic efficacy	16
Systems for in vivo hypermutation: a quest for scale and depth in directed evolution	16
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	16
Show your true color: Mammalian cell surface staining for tracking cellular identity in multiplexing and beyond	16
Metabolite assemblies: A surprising extension to the amyloid hypothesis	16
Molecular probes for fluorescence image-guided cancer surgery	16
Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆	16
Realgar and arsenene nanomaterials as arsenic-based anticancer agents	16
Recent advances in the design and optimization of artificial metalloenzymes	15
Recent advances in developing degraders & inhibitors of lysine methyltransferases	15
New chemical processes to streamline carbohydrate synthesis	15
MicroRNA:Siglec crosstalk in cancer progression	15
Editorial Board	15
Probing immune infiltration dynamics in cancer by in vivo imaging	15
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	15
Editorial Board	15
Microbial metabolite-receptor interactions in the gut microbiome	14
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	14
Sulfur-containing marine natural products as leads for drug discovery and development	14
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	14
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	14
Recent advances in de novo designed metallopeptides as tailored enzyme mimics	14
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	14
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	14
Synthetic ion channels made of DNA	13
Foldamer-mediated transport across phospholipid bilayers	13
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	13
Emerging mechanisms of regulation for endoplasmic/sarcoplasmic reticulum Ca2+ stores by secretory pathway kinase FAM20C	13

Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	13
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	13
Stimuli-responsive synthetic ionophores for therapeutic applications	13
Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity	13
Natural and artificial siderophores: Iron-based applications and beyond	13
Recent advances on human milk oligosaccharide antimicrobial activity	13
Emerging fluorescence tools for the study of proteostasis in cells	13
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	13
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	13
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	13
Development of novel indicators and molecular systems for calcium sensing through protein engineering	12
Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling	12
Molecular-level interplay between intrinsically disordered clients and Hsp90	12
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism	12
Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must	12
Recent advances in the expanding genetic code	12
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer	12
Recent advances in kinase signaling network profiling by mass spectrometry	12
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation	11
Engineering novel adeno-associated viruses (AAVs) for improved delivery in the nervous system	11
Editorial Board	11
Creating and understanding new-to-nature chemistry	11
Biosynthesis and recruitment of reactive amino acids in nonribosomal peptide assembly lines	11
Microbial metabolism of host-derived antioxidants	11
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies	11
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	11
Quantitative interactome analysis with chemical cross-linking and mass spectrometry	11
Advances and challenges in programming pattern formation using living cells	11
Small molecules as modulators of phage–bacteria interactions	11
Recent advances in engineering microorganisms for the production of natural food colorants	11
F420-dependent transformations in biosynthesis of secondary metabolites	11
Editorial overview - Exploring the diversity of polysaccharides	11
The multifaceted repertoire of cellular reactive metabolites	10
Therapeutic synthetic anion transporters	10
Discovering microbiota functions via chemical probe incorporation for targeted sequencing	10
Editorial Board	10
The emerging role of mass spectrometry-based proteomics in molecular pharming practices	10
Synthetic fragments of plant polysaccharides as tools for cell wall biology	10
KATs off: Biomedical insights from lysine acetyltransferase inhibitors	10
Chemical biology approaches to uncovering nuclear ROS control	10
Recent advances in Zn2+ imaging: From organelles to in vivo applications	10
Machine learning for profile prediction in genomics	10
How do metabolic processes age: Evidence from human metabolomic studies	10
Illuminating antifungal mode of action and resistance with fluorescent probes	10
Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research	10
Expanding the viewpoint: Leveraging sequence information in enzymology	10
A phenazine-inspired framework for identifying biological functions of microbial redox-active metabolites	9
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities	9
Editorial Board	9
Decoding the cellular effects of genetic variation through interaction proteomics	9
Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs	9
Inverse Drug Discovery identifies weak electrophiles affording protein conjugates	9
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	9
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	9
Current strategies for characterization of mucin-domain glycoproteins	9
Development of effective therapeutics for polysubstance use disorders	9
Direct visualization and profiling of protein misfolding and aggregation in live cells	9
Editorial Board	8
Tuning specificity and topology of lectins through synthetic biology	8
Current mechanistic understanding of intermembrane lipid trafficking important for maintenance of bacterial outer membrane lipid asymmetry	8
Editorial Board	8
Towards sequence-based principles for protein phase separation predictions	8
Editorial overview: Glycobiology (2023)	8
Harnessing the power of directed evolution to improve genome editing systems	8
Editorial overview: Editorial of molecular imaging	8
How are hydrogen peroxide messages relayed to affect cell signalling?	8
Small-angle X-ray scattering studies of enzymes	8
Recent advances in drug repurposing using machine learning	8
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level	8
Compounds for selective translational inhibition	8