Current Opinion in Chemical Biology

Article	Citations
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]	198
Fluorogenic polymethine dyes by intramolecular cyclization	129
Glycoengineering in antigen-specific immunotherapies	123
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	91
Imaging of proteases using activity-based probes	86
Small-molecule modulators of protein–RNA interactions	70
Engineered metallobiocatalysts for energy–relevant reactions	69
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	64
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	60
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	60
Recent advances in methods for quantifying the cell penetration of macromolecules	57
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	56
Extendable and explainable deep learning for pan-cancer radiogenomics research	56
Synthetic transporters for oxoanions	51
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	48
The Ramifications of synthetic biology	48
Activity-based protein profiling in microbes and the gut microbiome	46
New strategies for fluorescently labeling proteins in the study of amyloids	45
Characteristics of genetic tags for correlative light and electron microscopy	45
Caged lipid probes for controlling lipid levels on subcellular scales	44
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	43
Site-specific bioconjugation and nuclear imaging	42
Chemical inhibitors of transcription-associated kinases	42
Chemical engineering of bacterial effectors for regulating cell signaling and responses	42
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	41

Genetically encoded fluorescent sensors for metals in biology	40
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	40
Chemistry and biology of enzymes in protein glutathionylation	39
Chemical probes for tagging mycobacterial lipids	39
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	39
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	38
Advances in the understanding and exploitation of carbohydrate-active enzymes	38
Critical considerations in N-glycoproteomics	38
Past, present, and perspectives of protein N-terminal methylation	36
Highlighting the roles of transition metals and speciation in chemical biology	36
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	36
Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF	36
Editorial Board	35
Editorial Board	35
Natural and engineered precision antibiotics in the context of resistance	34
Chemical approaches for investigating site-specific protein S-fatty acylation	33
Emerging tools for bioluminescence imaging	33
Mechanism and inhibition of BRAF kinase	33
Super-multiplexed vibrational probes: Being colorful makes a difference	32
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	32
Protein sequence design with deep generative models	31
Catalytic amyloids: Is misfolding folding?	31
Understanding and controlling amyloid aggregation with chirality	31
A chemical field guide to histone nonenzymatic modifications	31
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	31
How nature incorporates sulfur and selenium into bioactive natural products	31
Sulfoxides in medicine	30
Recent advances in computational algorithms and software for large-scale glycoproteomics	30
Editorial: Unusual enzyme reactions in natural products biosynthesis	29
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	29
Virus-assisted directed evolution of biomolecules	29
Recent progress of TP/NIR fluorescent probes for metal ions	29
Induced proximity tools for precise manipulation of lipid signaling	28
Emerging mammalian gene switches for controlling implantable cell therapies	28
Chemoenzymatic strategies for RNA modification and labeling	28
Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals	28
Recent advances in N- and C-terminus cysteine protein bioconjugation	28
Cysteine and methionine oxidation in thrombotic disorders	27
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	27
Transferring enzyme features to molecular CO2 reduction catalysts	27
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	26
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	26
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	26
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	26
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	26
Synthetic peptide scaffolds as ion channels and molecular carriers	25
Synthesis and application of bacterial exopolysaccharides	25
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	25
Peptides for disrupting and degrading amyloids	25
Exploring amyloid oligomers with peptide model systems	25

Bacterial peptidoglycan as a living polymer	25
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	24
New frontiers in sulfur and selenium chemical biology	24
Molecular glues to stabilise protein–protein interactions	24
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	24
SOD mimics: From the tool box of the chemists to cellular studies	24
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	23
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	23
Fluorescent indicators for imaging membrane potential of organelles	23
Inhibitors of DHHC family proteins	23
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	23
Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription	23
Promoting remyelination: A case study in regenerative medicine	23
Editorial overview: Amyloid-inspired synthetic biomolecules	22
Editorial Board	22
Editorial Board	22
Editorial overview: Synthetic biomolecules for probing lipid membranes	22
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	21
Editorial Board	21
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	21
Editorial overview: Recent advances in metabolomics	21
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	21
Analytical techniques in chemical biology	21
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	20
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	20
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	20
Metalloprotein enabled redox signal transduction in microbes	20
Glutathione dynamics in subcellular compartments and implications for drug development	20
Editorial overview: Glycobiology (2024)	20
Lipidomics analysis in drug discovery and development	20
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	19
Sensing and regulation of reactive sulfur species (RSS) in bacteria	19
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology	19
Image-based cell phenotyping with deep learning	19
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	19
Catalyzing the future: recent advances in chemical synthesis using enzymes	19
Recent advances in the mass spectrometric profiling of bacterial lipids	18
Editorial Board	18
Chemical synthesis and biological functions of carbohydrates	18
Recent progress on small molecules targeting epigenetic complexes	18
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	18
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	18
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	18
Strategies in engineering sustainable biochemical synthesis through microbial systems	18
Discovery and evolution of [4 + 2] cyclases	18
Structures of chromatin modulators in complex with nucleosome	18
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	18
Editorial: Mechanistic biology	18
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	18
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	18
Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity	17
Discovering functional small molecules in the gut microbiome	17
Supramolecular platinum complexes for cancer therapy	17
Recent advances in high-throughput screening methods for small molecule modulators in bacteria	17
Molecular probes for fluorescence image-guided cancer surgery	17
Chemical biology tools to probe bacterial glycans	17
Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes	17
Small-molecule tools for YEATS domain proteins	16
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	16
Imaging-guided nanomedicine development	16
Corrigendum to “Interaction profiling methods to map protein and pathway targets of bioactive ligands”, [Curr Opin Chem Biol 54 (February 2020) 76–84]	16
Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo	16
Inhibition of p53 protein aggregation as a cancer treatment strategy	16
Adapting protein sequences for optimized therapeutic efficacy	16
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds	16
Recent strides in macromolecular targeted photodynamic therapy for cancer	16
Systems for in vivo hypermutation: a quest for scale and depth in directed evolution	16
Show your true color: Mammalian cell surface staining for tracking cellular identity in multiplexing and beyond	15
Emerging chelators for nuclear imaging	15
Editorial Board	15
Probing immune infiltration dynamics in cancer by in vivo imaging	15
Metabolite assemblies: A surprising extension to the amyloid hypothesis	15
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	15
Recent advances in developing degraders & inhibitors of lysine methyltransferases	15
New chemical processes to streamline carbohydrate synthesis	15
Functions and mechanisms of enzymes assembling lignans and norlignans	15
Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆	15
Realgar and arsenene nanomaterials as arsenic-based anticancer agents	15
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	15
Editorial Board	15

Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	14
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	14
Recent advances in the design and optimization of artificial metalloenzymes	14
MicroRNA:Siglec crosstalk in cancer progression	14
Recent advances in de novo designed metallopeptides as tailored enzyme mimics	14
Sulfur-containing marine natural products as leads for drug discovery and development	14
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	14
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	14
Microbial metabolite-receptor interactions in the gut microbiome	13
Maximizing content across scales: Moving multimodal microscopy and mesoscopy toward molecular imaging	13
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	13
Emerging fluorescence tools for the study of proteostasis in cells	13
Foldamer-mediated transport across phospholipid bilayers	13
Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity	13
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	13
Natural and artificial siderophores: Iron-based applications and beyond	13
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	13
Stimuli-responsive synthetic ionophores for therapeutic applications	13
Recent advances on human milk oligosaccharide antimicrobial activity	13
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	13
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	12
Small molecules as modulators of phage–bacteria interactions	12
Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must	12
Emerging mechanisms of regulation for endoplasmic/sarcoplasmic reticulum Ca2+ stores by secretory pathway kinase FAM20C	12
Synthetic ion channels made of DNA	12
Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling	12
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism	12
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	12
Development of novel indicators and molecular systems for calcium sensing through protein engineering	12
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer	12
Molecular-level interplay between intrinsically disordered clients and Hsp90	12
Advances and challenges in programming pattern formation using living cells	11
Editorial overview - Exploring the diversity of polysaccharides	11
Recent advances in kinase signaling network profiling by mass spectrometry	11
Recent advances in engineering microorganisms for the production of natural food colorants	11
F420-dependent transformations in biosynthesis of secondary metabolites	11
Quantitative interactome analysis with chemical cross-linking and mass spectrometry	11
Illuminating antifungal mode of action and resistance with fluorescent probes	11
Engineering novel adeno-associated viruses (AAVs) for improved delivery in the nervous system	11
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies	11
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	11
Microbial metabolism of host-derived antioxidants	11
Recent advances in the expanding genetic code	11
Editorial Board	11
Biosynthesis and recruitment of reactive amino acids in nonribosomal peptide assembly lines	10
Chemical biology approaches to uncovering nuclear ROS control	10
A phenazine-inspired framework for identifying biological functions of microbial redox-active metabolites	10
Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research	10
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation	10
The multifaceted repertoire of cellular reactive metabolites	10
How do metabolic processes age: Evidence from human metabolomic studies	10
Discovering microbiota functions via chemical probe incorporation for targeted sequencing	10
Editorial Board	10
Therapeutic synthetic anion transporters	10
Synthetic fragments of plant polysaccharides as tools for cell wall biology	10
KATs off: Biomedical insights from lysine acetyltransferase inhibitors	10
Machine learning for profile prediction in genomics	10
The emerging role of mass spectrometry-based proteomics in molecular pharming practices	10
Expanding the viewpoint: Leveraging sequence information in enzymology	9
Development of effective therapeutics for polysubstance use disorders	9
Tuning specificity and topology of lectins through synthetic biology	9
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities	9
Inverse Drug Discovery identifies weak electrophiles affording protein conjugates	9
Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs	9
Recent advances in Zn2+ imaging: From organelles to in vivo applications	9
Current strategies for characterization of mucin-domain glycoproteins	9
Editorial Board	9
Small-angle X-ray scattering studies of enzymes	8
How are hydrogen peroxide messages relayed to affect cell signalling?	8
Decoding the cellular effects of genetic variation through interaction proteomics	8
Towards sequence-based principles for protein phase separation predictions	8
Editorial Board	8
Bacterial glycoengineering: Cell-based and cell-free routes for producing biopharmaceuticals with customized glycosylation	8
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	8
Programmable tools for targeted analysis of epigenetic DNA modifications	8
Recent advances in drug repurposing using machine learning	8
Current mechanistic understanding of intermembrane lipid trafficking important for maintenance of bacterial outer membrane lipid asymmetry	8
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level	8
Direct visualization and profiling of protein misfolding and aggregation in live cells	8
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	8
Editorial overview: Glycobiology (2023)	8
Harnessing the power of directed evolution to improve genome editing systems	8