Current Opinion in Chemical Biology

Article	Citations
Fluorogenic polymethine dyes by intramolecular cyclization	173
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	81
Engineered metallobiocatalysts for energy–relevant reactions	74
Imaging of proteases using activity-based probes	69
Small-molecule modulators of protein–RNA interactions	68
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	64
Glycoengineering in antigen-specific immunotherapies	61
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	61
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	58
Activity-based protein profiling in microbes and the gut microbiome	56
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	54
Editorial Board	54
Synthetic transporters for oxoanions	53
The Ramifications of synthetic biology	52
Recent advances in methods for quantifying the cell penetration of macromolecules	51
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	50
Caged lipid probes for controlling lipid levels on subcellular scales	49
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	47
Characteristics of genetic tags for correlative light and electron microscopy	43
Site-specific bioconjugation and nuclear imaging	43
Chemical inhibitors of transcription-associated kinases	42
Chemistry and biology of enzymes in protein glutathionylation	42
Editorial Board	42
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	42
Genetically encoded fluorescent sensors for metals in biology	41

From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	40
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	40
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	40
Highlighting the roles of transition metals and speciation in chemical biology	39
Advances in the understanding and exploitation of carbohydrate-active enzymes	39
Critical considerations in N-glycoproteomics	39
Editorial Board	38
Editorial Board	38
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	37
How nature incorporates sulfur and selenium into bioactive natural products	37
Mechanism and inhibition of BRAF kinase	37
Natural and engineered precision antibiotics in the context of resistance	35
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	34
Virus-assisted directed evolution of biomolecules	34
Editorial: Unusual enzyme reactions in natural products biosynthesis	34
Sulfoxides in medicine	33
Recent progress of TP/NIR fluorescent probes for metal ions	33
Recent advances in computational algorithms and software for large-scale glycoproteomics	33
Recent advances in N- and C-terminus cysteine protein bioconjugation	32
Transferring enzyme features to molecular CO2 reduction catalysts	32
Cysteine and methionine oxidation in thrombotic disorders	32
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	32
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	32
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	31
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	31
Synthesis and application of bacterial exopolysaccharides	31
Synthetic peptide scaffolds as ion channels and molecular carriers	30
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	30
Bacterial peptidoglycan as a living polymer	30
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	29
Promoting remyelination: A case study in regenerative medicine	29
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	29
Molecular glues to stabilise protein–protein interactions	29
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	28
Editorial Board	28
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	28
New frontiers in sulfur and selenium chemical biology	28
Editorial overview: Synthetic biomolecules for probing lipid membranes	27
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	27
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	27
Fluorescent indicators for imaging membrane potential of organelles	27
Editorial overview: Glycobiology (2024)	27
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	27
Editorial Board	26
Editorial Board	26
Editorial Board	26
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	26
Editorial overview: Recent advances in metabolomics	26
Sensing and regulation of reactive sulfur species (RSS) in bacteria	26
Metalloprotein enabled redox signal transduction in microbes	25

Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	25
Catalyzing the future: recent advances in chemical synthesis using enzymes	25
Lipidomics analysis in drug discovery and development	25
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	25
Analytical techniques in chemical biology	25
Chemical synthesis and biological functions of carbohydrates	24
Glutathione dynamics in subcellular compartments and implications for drug development	24
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	24
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	24
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	24
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	24
Editorial Board	24
Editorial: Mechanistic biology	24
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	24
Strategies in engineering sustainable biochemical synthesis through microbial systems	23
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	23
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	23
Discovery and evolution of [4 + 2] cyclases	23
Inhibition of p53 protein aggregation as a cancer treatment strategy	22
Discovering functional small molecules in the gut microbiome	22
Chemical biology tools to probe bacterial glycans	22
Supramolecular platinum complexes for cancer therapy	22
Recent strides in macromolecular targeted photodynamic therapy for cancer	22
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds	22
Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes	22
Recent advances in high-throughput screening methods for small molecule modulators in bacteria	21
Realgar and arsenene nanomaterials as arsenic-based anticancer agents	21
Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity	21
Functions and mechanisms of enzymes assembling lignans and norlignans	21
Small-molecule tools for YEATS domain proteins	21
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	21
Editorial Board	20
Recent advances in developing degraders & inhibitors of lysine methyltransferases	20
Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆	20
Editorial Board	20
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	20
MicroRNA:Siglec crosstalk in cancer progression	20
Microbial metabolite-receptor interactions in the gut microbiome	19
Recent advances in de novo designed metallopeptides as tailored enzyme mimics	19
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	19
Sulfur-containing marine natural products as leads for drug discovery and development	19
New chemical processes to streamline carbohydrate synthesis	19
Recent advances in the design and optimization of artificial metalloenzymes	18
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	18
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	18
Foldamer-mediated transport across phospholipid bilayers	18
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	18
Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity	18
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	18
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	18
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	18
Natural and artificial siderophores: Iron-based applications and beyond	18
Recent advances on human milk oligosaccharide antimicrobial activity	18
Emerging mechanisms of regulation for endoplasmic/sarcoplasmic reticulum Ca2+ stores by secretory pathway kinase FAM20C	17
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer	17
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	17
Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling	17
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism	17
Stimuli-responsive synthetic ionophores for therapeutic applications	17
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	17
Creating and understanding new-to-nature chemistry	17
Synthetic ion channels made of DNA	17
Recent advances in engineering microorganisms for the production of natural food colorants	16
Recent advances in kinase signaling network profiling by mass spectrometry	16
Small molecules as modulators of phage–bacteria interactions	16
Molecular-level interplay between intrinsically disordered clients and Hsp90	16
Engineering novel adeno-associated viruses (AAVs) for improved delivery in the nervous system	16
Development of novel indicators and molecular systems for calcium sensing through protein engineering	16
Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must	16
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies	16
Recent advances in the expanding genetic code	16
Microbial metabolism of host-derived antioxidants	15
Chemical biology approaches to uncovering nuclear ROS control	15
Advances and challenges in programming pattern formation using living cells	15
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation	15
Editorial overview - Exploring the diversity of polysaccharides	15
The multifaceted repertoire of cellular reactive metabolites	15
F420-dependent transformations in biosynthesis of secondary metabolites	15
Biosynthesis and recruitment of reactive amino acids in nonribosomal peptide assembly lines	14
Illuminating antifungal mode of action and resistance with fluorescent probes	14

Expanding the viewpoint: Leveraging sequence information in enzymology	14
Synthetic fragments of plant polysaccharides as tools for cell wall biology	14
How do metabolic processes age: Evidence from human metabolomic studies	14
The emerging role of mass spectrometry-based proteomics in molecular pharming practices	14
Evolving advances of proximity labeling in capturing biomolecular interactions	14
KATs off: Biomedical insights from lysine acetyltransferase inhibitors	14
Therapeutic synthetic anion transporters	14
Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research	14
Towards sequence-based principles for protein phase separation predictions	13
Editorial Board	13
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities	13
Editorial Board	13
A phenazine-inspired framework for identifying biological functions of microbial redox-active metabolites	13
Discovering microbiota functions via chemical probe incorporation for targeted sequencing	13
Current strategies for characterization of mucin-domain glycoproteins	13
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	13
Recent advances in Zn2+ imaging: From organelles to in vivo applications	13
Editorial Board	13
Small-angle X-ray scattering studies of enzymes	12
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	12
Bacterial glycoengineering: Cell-based and cell-free routes for producing biopharmaceuticals with customized glycosylation	12
How are hydrogen peroxide messages relayed to affect cell signalling?	12
Editorial overview: Editorial of molecular imaging	12
Tuning specificity and topology of lectins through synthetic biology	12
Small RNAs, big potential: Engineering microRNA-based synthetic gene circuits	11
Corrigendum to “Drug discovery targeting Nav1.8: Structural insights and therapeutic potential” [Curr Opin Chem Biol 83 (2024) 102538]	11
Editorial Board	11
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level	11
Compounds for selective translational inhibition	11
Advancements in boron difluoride formazanate dyes for biological imaging	11
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products	11
Editorial overview: Glycobiology (2023)	11