OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Fluorogenic polymethine dyes by intramolecular cyclization	215
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	142
Imaging of proteases using activity-based probes	136
Engineered metallobiocatalysts for energy–relevant reactions	98
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	90
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	76
Small-molecule modulators of protein–RNA interactions	75
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	72
Glycoengineering in antigen-specific immunotherapies	62
Recent advances in methods for quantifying the cell penetration of macromolecules	58
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	58
Synthetic transporters for oxoanions	57
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	57
The Ramifications of synthetic biology	56
Characteristics of genetic tags for correlative light and electron microscopy	51
Caged lipid probes for controlling lipid levels on subcellular scales	50
Activity-based protein profiling in microbes and the gut microbiome	49
Chemical inhibitors of transcription-associated kinases	48
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	47
Extendable and explainable deep learning for pan-cancer radiogenomics research	47
Site-specific bioconjugation and nuclear imaging	46
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	45
Highlighting the roles of transition metals and speciation in chemical biology	44
Genetically encoded fluorescent sensors for metals in biology	44
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	43

Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	43
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	41
Chemistry and biology of enzymes in protein glutathionylation	41
Advances in the understanding and exploitation of carbohydrate-active enzymes	39
Chemical probes for tagging mycobacterial lipids	39
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	38
Critical considerations in N-glycoproteomics	38
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	37
Editorial Board	37
Chemical approaches for investigating site-specific protein S-fatty acylation	36
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	36
How nature incorporates sulfur and selenium into bioactive natural products	35
Natural and engineered precision antibiotics in the context of resistance	35
Editorial Board	35
Protein sequence design with deep generative models	34
Super-multiplexed vibrational probes: Being colorful makes a difference	34
Recent progress of TP/NIR fluorescent probes for metal ions	33
Mechanism and inhibition of BRAF kinase	33
Editorial: Unusual enzyme reactions in natural products biosynthesis	33
Virus-assisted directed evolution of biomolecules	32
Recent advances in computational algorithms and software for large-scale glycoproteomics	32
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	32
Sulfoxides in medicine	32
Induced proximity tools for precise manipulation of lipid signaling	32
Recent advances in N- and C-terminus cysteine protein bioconjugation	32
Transferring enzyme features to molecular CO2 reduction catalysts	31
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	30
Cysteine and methionine oxidation in thrombotic disorders	30
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	30
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	30
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	29
Synthetic peptide scaffolds as ion channels and molecular carriers	29
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	29
Molecular glues to stabilise protein–protein interactions	29
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	28
Bacterial peptidoglycan as a living polymer	28
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	28
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	28
Fluorescent indicators for imaging membrane potential of organelles	27
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	27
Synthesis and application of bacterial exopolysaccharides	27
SOD mimics: From the tool box of the chemists to cellular studies	27
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	26
Inhibitors of DHHC family proteins	25
Promoting remyelination: A case study in regenerative medicine	25
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	25
New frontiers in sulfur and selenium chemical biology	25
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	24
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	23
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	23

Lipidomics analysis in drug discovery and development	23
Glutathione dynamics in subcellular compartments and implications for drug development	23
Editorial overview: Recent advances in metabolomics	23
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	23
Editorial overview: Glycobiology (2024)	23
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	22
Editorial Board	22
Editorial overview: Synthetic biomolecules for probing lipid membranes	22
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	22
Metalloprotein enabled redox signal transduction in microbes	22
Editorial Board	21
Catalyzing the future: recent advances in chemical synthesis using enzymes	21
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology	21
Analytical techniques in chemical biology	21
Image-based cell phenotyping with deep learning	21
Editorial Board	21
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	21
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	20
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	20
Strategies in engineering sustainable biochemical synthesis through microbial systems	20
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	20
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	20
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	20
Sensing and regulation of reactive sulfur species (RSS) in bacteria	20
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	20
Discovery and evolution of [4 + 2] cyclases	20
Chemical synthesis and biological functions of carbohydrates	20
Recent progress on small molecules targeting epigenetic complexes	19
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	19
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds	19
Recent advances in the mass spectrometric profiling of bacterial lipids	19
Recent advances in high-throughput screening methods for small molecule modulators in bacteria	19
Chemical biology tools to probe bacterial glycans	19
Editorial: Mechanistic biology	19
Editorial Board	19
Inhibition of p53 protein aggregation as a cancer treatment strategy	19