OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	190
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]	125
Fluorogenic polymethine dyes by intramolecular cyclization	111
Glycoengineering in antigen-specific immunotherapies	99
Engineered metallobiocatalysts for energy–relevant reactions	89
Imaging of proteases using activity-based probes	87
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	84
Small-molecule modulators of protein–RNA interactions	76
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	70
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	69
Caged lipid probes for controlling lipid levels on subcellular scales	67
Extendable and explainable deep learning for pan-cancer radiogenomics research	60
Activity-based protein profiling in microbes and the gut microbiome	58
Synthetic transporters for oxoanions	56
New strategies for fluorescently labeling proteins in the study of amyloids	56
Recent advances in methods for quantifying the cell penetration of macromolecules	55
The Ramifications of synthetic biology	55
Characteristics of genetic tags for correlative light and electron microscopy	54
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	53
Site-specific bioconjugation and nuclear imaging	51
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	50
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	48
Chemical inhibitors of transcription-associated kinases	48
Chemical engineering of bacterial effectors for regulating cell signaling and responses	44
Genetically encoded fluorescent sensors for metals in biology	44

From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	44
Chemical probes for tagging mycobacterial lipids	43
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	42
Advances in the understanding and exploitation of carbohydrate-active enzymes	40
Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF	40
Past, present, and perspectives of protein N-terminal methylation	39
Chemistry and biology of enzymes in protein glutathionylation	39
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	37
Critical considerations in N-glycoproteomics	37
Highlighting the roles of transition metals and speciation in chemical biology	36
Editorial Board	36
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	36
Understanding and controlling amyloid aggregation with chirality	35
Natural and engineered precision antibiotics in the context of resistance	35
Editorial Board	35
Mechanism and inhibition of BRAF kinase	35
How nature incorporates sulfur and selenium into bioactive natural products	34
Chemical approaches for investigating site-specific protein S-fatty acylation	34
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	34
Super-multiplexed vibrational probes: Being colorful makes a difference	34
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	33
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	31
Induced proximity tools for precise manipulation of lipid signaling	31
Emerging tools for bioluminescence imaging	31
Virus-assisted directed evolution of biomolecules	31
A chemical field guide to histone nonenzymatic modifications	31
Catalytic amyloids: Is misfolding folding?	31
Protein sequence design with deep generative models	31
Recent progress of TP/NIR fluorescent probes for metal ions	30
Targeting Son of Sevenless 1: The pacemaker of KRAS	30
Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals	30
Chemoenzymatic strategies for RNA modification and labeling	29
Sulfoxides in medicine	29
Transferring enzyme features to molecular CO2 reduction catalysts	29
Recent advances in computational algorithms and software for large-scale glycoproteomics	29
Cysteine and methionine oxidation in thrombotic disorders	28
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	28
New approaches to target RNA binding proteins	28
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	28
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment	27
Recent advances in N- and C-terminus cysteine protein bioconjugation	27
Emerging mammalian gene switches for controlling implantable cell therapies	27
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	26
Synthesis and application of bacterial exopolysaccharides	25
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	25
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	25
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	25
Bacterial peptidoglycan as a living polymer	25
Exploring amyloid oligomers with peptide model systems	24
SOD mimics: From the tool box of the chemists to cellular studies	24

Molecular glues to stabilise protein–protein interactions	24
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	24
Peptides for disrupting and degrading amyloids	23
New frontiers in sulfur and selenium chemical biology	23
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	23
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	23
Synthetic peptide scaffolds as ion channels and molecular carriers	23
Fluorescent indicators for imaging membrane potential of organelles	23
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	22
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	22
Promoting remyelination: A case study in regenerative medicine	22
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	22
Editorial overview: Amyloid-inspired synthetic biomolecules	21
Inhibitors of DHHC family proteins	21
Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription	21
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology	21
Editorial Board	21
Metalloprotein enabled redox signal transduction in microbes	21
Editorial overview: Synthetic biomolecules for probing lipid membranes	20
Editorial overview: Recent advances in metabolomics	20
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	20
Editorial Board	20
Editorial Board	20
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	20
Analytical techniques in chemical biology	20
Sensing and regulation of reactive sulfur species (RSS) in bacteria	20
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	20
Glutathione dynamics in subcellular compartments and implications for drug development	19
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	19
Lipidomics analysis in drug discovery and development	19
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	19
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	19
Image-based cell phenotyping with deep learning	18
Editorial: Mechanistic biology	18
Recent advances in the mass spectrometric profiling of bacterial lipids	18
Editorial Board	18
Catalyzing the future: recent advances in chemical synthesis using enzymes	18
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	18
Recent progress on small molecules targeting epigenetic complexes	18
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	18
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	18
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	18
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	18