OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]	198
Fluorogenic polymethine dyes by intramolecular cyclization	129
Glycoengineering in antigen-specific immunotherapies	123
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	91
Imaging of proteases using activity-based probes	86
Small-molecule modulators of protein–RNA interactions	70
Engineered metallobiocatalysts for energy–relevant reactions	69
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	64
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	60
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	60
Recent advances in methods for quantifying the cell penetration of macromolecules	57
Extendable and explainable deep learning for pan-cancer radiogenomics research	56
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	56
Synthetic transporters for oxoanions	51
The Ramifications of synthetic biology	48
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	48
Activity-based protein profiling in microbes and the gut microbiome	46
Characteristics of genetic tags for correlative light and electron microscopy	45
New strategies for fluorescently labeling proteins in the study of amyloids	45
Caged lipid probes for controlling lipid levels on subcellular scales	44
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	43
Site-specific bioconjugation and nuclear imaging	42
Chemical inhibitors of transcription-associated kinases	42
Chemical engineering of bacterial effectors for regulating cell signaling and responses	42
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	41

Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	40
Genetically encoded fluorescent sensors for metals in biology	40
Chemical probes for tagging mycobacterial lipids	39
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	39
Chemistry and biology of enzymes in protein glutathionylation	39
Advances in the understanding and exploitation of carbohydrate-active enzymes	38
Critical considerations in N-glycoproteomics	38
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	38
Highlighting the roles of transition metals and speciation in chemical biology	36
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	36
Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF	36
Past, present, and perspectives of protein N-terminal methylation	36
Editorial Board	35
Editorial Board	35
Natural and engineered precision antibiotics in the context of resistance	34
Emerging tools for bioluminescence imaging	33
Mechanism and inhibition of BRAF kinase	33
Chemical approaches for investigating site-specific protein S-fatty acylation	33
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	32
Super-multiplexed vibrational probes: Being colorful makes a difference	32
Understanding and controlling amyloid aggregation with chirality	31
A chemical field guide to histone nonenzymatic modifications	31
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	31
How nature incorporates sulfur and selenium into bioactive natural products	31
Protein sequence design with deep generative models	31
Catalytic amyloids: Is misfolding folding?	31
Recent advances in computational algorithms and software for large-scale glycoproteomics	30
Sulfoxides in medicine	30
Editorial: Unusual enzyme reactions in natural products biosynthesis	29
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	29
Virus-assisted directed evolution of biomolecules	29
Recent progress of TP/NIR fluorescent probes for metal ions	29
Chemoenzymatic strategies for RNA modification and labeling	28
Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals	28
Recent advances in N- and C-terminus cysteine protein bioconjugation	28
Induced proximity tools for precise manipulation of lipid signaling	28
Emerging mammalian gene switches for controlling implantable cell therapies	28
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	27
Transferring enzyme features to molecular CO2 reduction catalysts	27
Cysteine and methionine oxidation in thrombotic disorders	27
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	26
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	26
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	26
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	26
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	26
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	25
Peptides for disrupting and degrading amyloids	25
Exploring amyloid oligomers with peptide model systems	25
Bacterial peptidoglycan as a living polymer	25
Synthetic peptide scaffolds as ion channels and molecular carriers	25

Synthesis and application of bacterial exopolysaccharides	25
New frontiers in sulfur and selenium chemical biology	24
Molecular glues to stabilise protein–protein interactions	24
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	24
SOD mimics: From the tool box of the chemists to cellular studies	24
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	24
Fluorescent indicators for imaging membrane potential of organelles	23
Inhibitors of DHHC family proteins	23
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	23
Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription	23
Promoting remyelination: A case study in regenerative medicine	23
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	23
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	23
Editorial overview: Amyloid-inspired synthetic biomolecules	22
Editorial Board	22
Editorial Board	22
Editorial overview: Synthetic biomolecules for probing lipid membranes	22
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	21
Editorial Board	21
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	21
Editorial overview: Recent advances in metabolomics	21
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	21
Analytical techniques in chemical biology	21
Editorial overview: Glycobiology (2024)	20
Lipidomics analysis in drug discovery and development	20
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	20
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	20
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	20
Metalloprotein enabled redox signal transduction in microbes	20
Glutathione dynamics in subcellular compartments and implications for drug development	20
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	19
Catalyzing the future: recent advances in chemical synthesis using enzymes	19
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	19
Sensing and regulation of reactive sulfur species (RSS) in bacteria	19
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology	19
Image-based cell phenotyping with deep learning	19
Recent advances in the mass spectrometric profiling of bacterial lipids	18
Editorial Board	18
Chemical synthesis and biological functions of carbohydrates	18
Recent progress on small molecules targeting epigenetic complexes	18
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	18
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	18
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	18
Strategies in engineering sustainable biochemical synthesis through microbial systems	18
Discovery and evolution of [4 + 2] cyclases	18
Structures of chromatin modulators in complex with nucleosome	18
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	18
Editorial: Mechanistic biology	18
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	18
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	18