OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Fluorogenic polymethine dyes by intramolecular cyclization	177
Small-molecule modulators of protein–RNA interactions	82
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	81
Imaging of proteases using activity-based probes	71
Engineered metallobiocatalysts for energy–relevant reactions	71
Glycoengineering in antigen-specific immunotherapies	68
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	68
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	61
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	60
Activity-based protein profiling in microbes and the gut microbiome	58
Editorial Board	57
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	54
Characteristics of genetic tags for correlative light and electron microscopy	53
The Ramifications of synthetic biology	53
Recent advances in methods for quantifying the cell penetration of macromolecules	52
Chemical inhibitors of transcription-associated kinases	51
Site-specific bioconjugation and nuclear imaging	50
Synthetic transporters for oxoanions	50
Caged lipid probes for controlling lipid levels on subcellular scales	45
Always on the move: Mapping spatiotemporal interactome with proximity labeling in mammalian cells	44
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	44
Covalent lysine targeting is coming of age	44
Toward universal binder discovery: Advances in display, computational design and in vivo platforms	43
Chemistry and biology of enzymes in protein glutathionylation	43
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	43

Highlighting the roles of transition metals and speciation in chemical biology	42
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	42
DVD-IgG1 antibody–drug conjugates: Expanding the landscape of targeted cancer therapy	42
Editorial Board	40
Advances in the understanding and exploitation of carbohydrate-active enzymes	40
Critical considerations in N-glycoproteomics	40
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	39
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	39
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	38
Editorial Board	37
Genetically encoded fluorescent sensors for metals in biology	37
Editorial Board	37
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	36
Natural and engineered precision antibiotics in the context of resistance	35
How nature incorporates sulfur and selenium into bioactive natural products	35
Sulfoxides in medicine	34
Mechanism and inhibition of BRAF kinase	34
Recent advances in computational algorithms and software for large-scale glycoproteomics	34
Virus-assisted directed evolution of biomolecules	34
Editorial: Unusual enzyme reactions in natural products biosynthesis	34
Recent progress of TP/NIR fluorescent probes for metal ions	33
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	32
Recent advances in protein modification–enabled potential therapeutics	32
Transferring enzyme features to molecular CO2 reduction catalysts	32
Cysteine and methionine oxidation in thrombotic disorders	32
In vivo-compatible proximity labeling technologies	32
Recent advances in N- and C-terminus cysteine protein bioconjugation	31
Recent advances in enzyme cascade reactions for the efficient synthesis of functionalized chemicals and complex pharmaceuticals	31
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	31
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	30
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	30
Synthetic peptide scaffolds as ion channels and molecular carriers	30
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	29
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	29
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	29
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	29
New frontiers in sulfur and selenium chemical biology	28
Bacterial peptidoglycan as a living polymer	28
Fluorescent indicators for imaging membrane potential of organelles	28
Molecular glues to stabilise protein–protein interactions	28
Promoting remyelination: A case study in regenerative medicine	28
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	28
Synthesis and application of bacterial exopolysaccharides	28
Editorial Board	27
Next-generation interleukin-enhanced immunotherapies: From molecular engineering to armored T-cell architectures	27
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	27
The evolving logic of biocatalyzed nucleic acid synthesis	27
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	27
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	27
Editorial Board	26

Editorial overview: Synthetic biomolecules for probing lipid membranes	26
Editorial Board	26
Metalloprotein enabled redox signal transduction in microbes	25
Editorial overview: Recent advances in metabolomics	25
Editorial overview: Glycobiology (2024)	25
Editorial Board	25
Sensing and regulation of reactive sulfur species (RSS) in bacteria	25
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	25
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	24
Catalyzing the future: recent advances in chemical synthesis using enzymes	24
Analytical techniques in chemical biology	24
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	24
Glutathione dynamics in subcellular compartments and implications for drug development	24
Lipidomics analysis in drug discovery and development	24
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	24
Recent advances in mapping protein networks regulated by post-translational modifications via proximity tagging	24
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	24
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	24
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	23
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	23
Editorial: Mechanistic biology	22
Chemical synthesis and biological functions of carbohydrates	22
Editorial Board	22
Discovery and evolution of [4 + 2] cyclases	22
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	22
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	22