OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Synthetic peptide scaffolds as ion channels and molecular carriers	187
Lipid probes to study ion channels	119
Chemical tools targeting readers of lysine methylation	98
New analytical methods focusing on polar metabolite analysis in mass spectrometry and NMR-based metabolomics	95
Role of conformational dynamics in pathogenic protein aggregation	94
Decoding the cellular effects of genetic variation through interaction proteomics	83
Direct visualization and profiling of protein misfolding and aggregation in live cells	80
New chemical processes to streamline carbohydrate synthesis	77
Editorial Board	73
Covalent labeling of immune cells	69
Editorial Board	66
Editorial overview: Imaging metal ions in biological systems	65
Synthesis and application of bacterial exopolysaccharides	59
Small molecule fluorescent probes for the study of protein phase separation	55
Editorial Board	54
How are hydrogen peroxide messages relayed to affect cell signalling?	54
MicroRNA:Siglec crosstalk in cancer progression	53
Drugging the undruggable proteins in cancer: A systems biology approach	52
The chemical biology of NAD+ regulation in axon degeneration	52
Recent advances in developing degraders & inhibitors of lysine methyltransferases	48
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	48
Recent advances in induced proximity modalities	48
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	46
Sulfur-containing marine natural products as leads for drug discovery and development	45
Microbial metabolite-receptor interactions in the gut microbiome	45

Programmable tools for targeted analysis of epigenetic DNA modifications	44
Engineered metallobiocatalysts for energy–relevant reactions	44
From structure to application: Progress and opportunities in peptide materials development	44
NMR spectroscopy to study the fate of metallodrugs in cells	43
Supramolecular coordination complexes as diagnostic and therapeutic agents	42
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]	42
Recent advances in drug repurposing using machine learning	41
Peptides for disrupting and degrading amyloids	41
Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes	40
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	36
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	36
Chemical biology tools for imaging-based analysis of organelle membranes and lipids	35
Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches	35
Tuning specificity and topology of lectins through synthetic biology	35
Chemical regulation of the cGAS-STING pathway	35
Fluorogenic polymethine dyes by intramolecular cyclization	34
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	34
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	34
Small-molecule modulators of protein–RNA interactions	34
Activity-based probes in pathogenic bacteria: Investigating drug targets and molecule specificity	34
Towards sequence-based principles for protein phase separation predictions	34
Glycoengineering in antigen-specific immunotherapies	33
Bacterial peptidoglycan as a living polymer	33
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	33
Enzymatic strategies for selenium incorporation into biological molecules	32
Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system	30
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	30
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	30
Biochemistry of the hypoxia-inducible factor hydroxylases	30
Recent advances in the design and optimization of artificial metalloenzymes	30
Recent progresses in the cyclization and oxidation of polyketide biosynthesis	30
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	30
Luminescent lanthanide probes for cations and anions: Promises, compromises, and caveats	29
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	29
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	29
Recent advances in intravital microscopy for preclinical research	28
Molecular glues to stabilise protein–protein interactions	28
Exploring amyloid oligomers with peptide model systems	28
Toward synthetic life: Biomimetic synthetic cell communication	28
Development of effective therapeutics for polysubstance use disorders	28
Small-angle X-ray scattering studies of enzymes	27
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	26
Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts	26
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	26
SOD mimics: From the tool box of the chemists to cellular studies	26
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	25
Characterising biomolecular interactions and dynamics with mass photometry	25
Mass spectrometry techniques for imaging and detection of metallodrugs	25
Promising heterometallic compounds as anticancer agents: Recent studies in vivo	25
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	25

Recent progress in metal-based molecular probes for optical bioimaging and biosensing	25
Advanced functional fluorescent probes for cell plasma membranes	24
Probing immune infiltration dynamics in cancer by in vivo imaging	24
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	24
Imaging of proteases using activity-based probes	24
Stimuli-responsive synthetic ionophores for therapeutic applications	24
Deuterium Raman imaging for lipid analysis	23
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	23
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	23
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	22
Editorial overview: Glycobiology (2023)	22
Editorial Board	22
New frontiers in sulfur and selenium chemical biology	22
Publisher’s Note	21
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	21
Synthetic transporters for oxoanions	21
Cytokine engineering for targeted cancer immunotherapy	21
The Ramifications of synthetic biology	21
Emerging roles of low-molecular-weight thiols at the host–microbe interface	20
Fluorescent indicators for imaging membrane potential of organelles	20
Emerging fluorescence tools for the study of proteostasis in cells	20
Synthetic ion channels made of DNA	20
Shedding light on current trends in molecular optogenetics	20
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	19
Foldamer-mediated transport across phospholipid bilayers	19
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	19
Molecular simulations of complex carbohydrates and glycoconjugates	19
A new era of cysteine proteomics – Technological advances in thiol biology	19
Characteristics of genetic tags for correlative light and electron microscopy	19
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	18
Chemiluminescent spiroadamantane-1,2-dioxetanes: Recent advances in molecular imaging and biomarker detection	18
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo	18
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	18
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products	18
Synthetic probes and chemical tools in sphingolipid research	17
Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis	17
Maximizing content across scales: Moving multimodal microscopy and mesoscopy toward molecular imaging	17
Developing photoactivated artificial enzymes for sustainable fuel production	17
Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine	17
Harnessing the power of directed evolution to improve genome editing systems	17
Extendable and explainable deep learning for pan-cancer radiogenomics research	17
Caged lipid probes for controlling lipid levels on subcellular scales	16
Recent advances in methods for quantifying the cell penetration of macromolecules	16
Recent progress in mass spectrometry for single-cell metabolomics	16
Current insights into the role of citrullination in thrombosis	16
Site-specific bioconjugation and nuclear imaging	16
Promoting remyelination: A case study in regenerative medicine	16
Engaging with benzoyllysine through a π-π-π mechanism	16
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	16