OOIR: Observatory of International Research

Papers

(The median citation count of Drug Resistance Updates is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangemen	302
The uptake of extracellular vesicles: Research progress in cancer drug resistance and beyond	238
N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma	209
Low miR-224–5p in exosomes confers colorectal cancer 5-FU resistance by upregulating S100A4	157
Editorial Board	146
Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain	130
Paclitaxel resistance related to nuclear envelope structural sturdiness	123
The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells	122
Analysis of SARS-CoV-2 mutations associated with resistance to therapeutic monoclonal antibodies that emerge after treatment	110
ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance	93
Editorial Board	89
Editorial Board	89
Editorial Board	88
Editorial Board	86
Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma	85
Modulating undruggable targets to overcome cancer therapy resistance	84
Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins	83
Association of idealized amphiphiles and protease inhibitors: Conferring antimicrobial peptides with stable antibacterial activity under physiological conditions to combat multidrug-resistant bacteria	81
Molecular subtype changes after acquiring resistance to tarlatamab in small cell lung cancer	80
Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection	80
Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer	79
GATA3 mediates doxorubicin resistance by inhibiting CYB5R2-catalyzed iron reduction in breast cancer cells	76
LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein	72
Overexpression of ABCC1 and ABCG2 confers resistance to talazoparib, a poly (ADP-Ribose) polymerase inhibitor	70
Silver-dendrimer nanocomposite as emerging therapeutics in anti-bacteria and beyond	69

Intersecting pathways: The role of hybrid E/M cells and circulating tumor cells in cancer metastasis and drug resistance	68
Plasmid-borne tigecycline resistance gene tet(X4) in Salmonella enterica and Escherichia coli isolates from a pediatric patient with diarrhea	67
Widespread loss-of-function mutations implicating preexisting resistance to new or repurposed anti-tuberculosis drugs	64
Prophylactic use of antibiotics – A strategy with unforeseen risks?	64
The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity	56
Pyrazinamide-resistant Tuberculosis Obscured From Common Targeted Molecular Diagnostics	53
Acquired non-thermal plasma resistance mediates a shift towards aerobic glycolysis and ferroptotic cell death in melanoma	51
CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification	48
A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis	48
CCT251545 enhances drug delivery and potentiates chemotherapy in multidrug-resistant cancers by Rac1-mediated macropinocytosis	47
MAFF confers vulnerability to cisplatin-based and ionizing radiation treatments by modulating ferroptosis and cell cycle progression in lung adenocarcinoma	47
Circulating tumor cells with increasing aneuploidy predict inferior prognosis and therapeutic resistance in small cell lung cancer	47
Targeting undruggable phosphatase overcomes trastuzumab resistance by inhibiting multi-oncogenic kinases	47
CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance	46
lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2	45
CEA-induced PI3K/AKT pathway activation through the binding of CEA to KRT1 contributes to oxaliplatin resistance in gastric cancer	44
Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment	43
A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in lung adenocarcinoma	42
CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal cancer	42
Novel nanomedicines to overcome cancer multidrug resistance	41
Hypoxia as a driver of resistance to immunotherapy	39
Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance	39
Blockade of purine metabolism reverses macrophage immunosuppression and enhances anti-tumor immunity in non-small cell lung cancer	37
Molecular Modeling Strategies of Cancer Multidrug Resistance	37
Antibiotic failure: Beyond antimicrobial resistance	37
Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance	37
Hallmarks of anticancer and antimicrobial activities of corroles	36
Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy	35
Editorial Board	35
B7-H3-liquid biopsy for the characterization and monitoring of the dynamic biology of prostate cancer	34
Harnessing phytochemicals: Innovative strategies to enhance cancer immunotherapy	32
Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer	31
Osmotic stress influences microtubule drug response via WNK1 kinase signaling	31
Corrigendum to “Molecular basis of bacterial disinfectant resistance” [Drug Resist. Updates 48 (2020) 100672]	31
Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer	31
Editorial Board	30
Overexpression of blaGES-1 due to a strong promoter in the class 1 integron contributes to decreased ceftazidime-avibactam susceptibility in carbapenem-resistant Pseudomonas aeruginosa ST235	29
Editorial Board	29
Effective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells	28
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects	28
Targeting ACYP1-mediated glycolysis reverses lenvatinib resistance and restricts hepatocellular carcinoma progression	28
New emerging SARS-CoV-2 variants and antiviral agents	28
Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma	27
Cellular and molecular mechanisms of gastrointestinal cancer liver metastases and drug resistance	26
AI-driven visualization tool for analyzing data and predicting drug-resistant outbreaks	25
Understanding ER homeostasis and the UPR to enhance treatment efficacy of acute myeloid leukemia	24
crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer	24
Characterization difference of typical KL1, KL2 and ST11-KL64 hypervirulent and carbapenem-resistant Klebsiella pneumoniae	24
Cisplatin-activated ERβ/DCAF8 positive feedback loop induces chemoresistance in non-small cell lung cancer via PTEN/Akt axis	23
Anticancer drug resistance: An update and perspective	22

Unraveling the secrets: Evolution of resistance mediated by membrane proteins	22
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation	22
Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance	22
Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance	21
Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance	21
KIAA1429 promotes tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/ MAPK pathway in an m6A-dependent manner	21
Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer	21
Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy	21
Multi-omics dissection of stage-specific artemisinin tolerance mechanisms in Kelch13-mutant Plasmodium falciparum	20
Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer	20
Regulation of cisplatin resistance in bladder cancer by epigenetic mechanisms	19
GSK3β as a novel promising target to overcome chemoresistance in pancreatic cancer	18
The role of endolysosomal trafficking in anticancer drug resistance	18
Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine	18
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2	18
Global phylogeography and antibiotic resistance characteristics of Morganella: An epidemiological, spatial, comparative genomic study	17
Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability	17
Vaccine effects on COVID-19 infection with bivalent boosting by age group	17
Editorial Board	17
TRAIL-driven targeting and reversing cervical cancer radioresistance by seleno-nanotherapeutics through regulating cell metabolism	16
Editorial Board	16
Lansoprazole (LPZ) reverses multidrug resistance (MDR) in cancer through impeding ATP-binding cassette (ABC) transporter-mediated chemotherapeutic drug efflux and lysosomal sequestration	15
Editorial Board	15
BCL7A inhibits the progression and drug-resistance in acute myeloid leukemia	15
Solving the antibacterial resistance in Europe: The multipronged approach of the COST Action CA21145 EURESTOP	15
Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae	14
Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA	14
Breaking the barrier: Epigenetic strategies to combat platinum resistance in colorectal cancer	14
Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability	14
Editorial: ABC transporters and drug resistance	14
Structural and functional analyses of STM14_5441-STM14_5442: A potential mechanism for persister formation against aminoglycosides	13
Rational design of peptides to overcome drug resistance by metabolic regulation	13
Genetic alterations shaping tumor response to anti-EGFR therapies	13
Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance	13
MYC expression and fatty acid oxidation in EGFR-TKI acquired resistance	13
Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China	12
Spotlight on ideal target antigens and resistance in antibody-drug conjugates: Strategies for competitive advancement	12
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency	12
Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling	12
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges	12
Mechanism of staphylococcal resistance to clinically relevant antibiotics	11
Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition	11
Dynamic evolution of KPC-230-mediated resistance to ceftazidime-avibactam during the treatment of carbapenem-resistant Klebsiella pnenmoniae	11
The Omicron variant of concern: Diversification and convergent evolution in spike protein, and escape from anti-Spike monoclonal antibodies	11
Cross-resistance and drug sequence in prostate cancer	11
Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?	11
CPSF6-mediated XBP1 3’UTR shortening attenuates cisplatin-induced ER stress and elevates chemo-resistance in lung adenocarcinoma	11
CRISPR screening reveals gleason score and castration resistance related oncodriver ring finger protein 19 A (RNF19A) in prostate cancer	11
Evolution of RND efflux pumps in the development of a successful pathogen	11
Fibroblast growth factor receptor 1 inhibition suppresses pancreatic cancer chemoresistance and chemotherapy-driven aggressiveness	10
A novel SIK2 inhibitor SIC-19 exhibits synthetic lethality with PARP inhibitors in ovarian cancer	10
Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers	10
NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1	10
Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively	10
A quiescence-like/TGF-β1-specific CRISPRi screen reveals drug uptake transporters as secondary targets of kinase inhibitors in AML	10
Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer	9
Antimicrobial peptides for combating drug-resistant bacterial infections	9
Identification of TMexCD-TOprJ-producing carbapenem-resistant Gram-negative bacteria from hospital sewage	9
The role of histone H1.2 in pancreatic cancer metastasis and chemoresistance	8
Editorial Board	8
Targeting anoikis resistance as a strategy for cancer therapy	8
Potential targets and therapeutics for cancer stem cell-based therapy against drug resistance in hepatocellular carcinoma	8
Editorial Board	8
Editorial Board	8
Editorial Board	8
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance	7
Wip1 phosphatase activator QGC-8–52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells	7
Advances in molecular targeted drugs in combination with CAR-T cell therapy for hematologic malignancies	7
Editorial Board	7
Why and how citrate may sensitize malignant tumors to immunotherapy	7
Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane	7