Drug Resistance Updates

Article	Citations
Molecular subtype changes after acquiring resistance to tarlatamab in small cell lung cancer	470
PARP inhibition elicits NK cell-associated immune evasion via potentiating HLA-G expression in tumor	299
Overexpression of ABCC1 and ABCG2 confers resistance to talazoparib, a poly (ADP-Ribose) polymerase inhibitor	231
Editorial Board	222
N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma	186
Plasmid-borne tigecycline resistance gene tet(X4) in Salmonella enterica and Escherichia coli isolates from a pediatric patient with diarrhea	184
Modulating undruggable targets to overcome cancer therapy resistance	176
Editorial Board	157
Erratum to “A highly potent small-molecule antagonist of exportin-1 selectively eliminates CD44+ CD24- enriched breast cancer stem-like cells” [Drug Resist. Updates 66 (2023) 100903]	156
Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma	154
Profiling the landscape of carbapenem resistance and hypervirulence in Klebsiella pneumoniae: A global epidemiological analysis of the plasmidome	138
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects	123
Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance	120
Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer	119
Unraveling the secrets: Evolution of resistance mediated by membrane proteins	117
A novel platinum(IV) prodrug, gramine-Pt(IV) enhances chemoimmunotherapy by activating cGAS-STING and modulating TGF-β-MHC-I axis	116
Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directions	115
Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine	114
Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China	114
Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance	113
Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer	110
Editorial Board	93
Novel insights into taxane pharmacology: An update on drug resistance mechanisms, immunomodulation and drug delivery strategies	88
Evolution of RND efflux pumps in the development of a successful pathogen	88
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges	84

Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae	78
Enzymatic bionanocatalysts for combating peri-implant biofilm infections by specific heat-amplified chemodynamic therapy and innate immunomodulation	77
The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond	76
Drug resistance mechanisms in dopamine agonist-resistant prolactin pituitary neuroendocrine tumors and exploration for new drugs	73
Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma	71
Treatment strategies and drug resistance mechanisms in adenocarcinoma of different organs	70
Network biology and artificial intelligence drive the understanding of the multidrug resistance phenotype in cancer	68
Targeting anoikis resistance as a strategy for cancer therapy	68
TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770–5p axis in PDAC	66
Editorial Board	64
Novel mobile colistin resistance gene mcr-4.9 in Vibrio cholerae from migratory birds	61
Inhibition of NF-κB signaling unveils novel strategies to overcome drug resistance in cancers	59
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress	59
Current therapy and drug resistance in metastatic castration-resistant prostate cancer	58
Clinical implications of germline variations for treatment outcome and drug resistance for small molecule kinase inhibitors in patients with non-small cell lung cancer	55
Research progress on gene mutations and drug resistance in leukemia	55
Emergence of silent NDM-1 carbapenemase gene in carbapenem-susceptible Klebsiella pneumoniae: Clinical implications and epidemiological insights	53
Framework nucleic acid-based nanoparticles enhance temozolomide sensitivity in glioblastoma	52
PDPN positive CAFs contribute to HER2 positive breast cancer resistance to trastuzumab by inhibiting antibody-dependent NK cell-mediated cytotoxicity	52
Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica	51
Emergence of novel Klebsiella pneumoniae ST types with multidrug resistance in clinic	49
Overcoming cancer chemotherapy resistance by the induction of ferroptosis	49
Exosomal LOC85009 inhibits docetaxel resistance in lung adenocarcinoma through regulating ATG5-induced autophagy	48
Research progress of therapeutic effects and drug resistance of immunotherapy based on PD-1/PD-L1 blockade	48
ABCB1-dependent collateral sensitivity of multidrug-resistant colorectal cancer cells to the survivin inhibitor MX106-4C	47
Mechanisms of sensitivity and resistance to CDK4/CDK6 inhibitors in hormone receptor-positive breast cancer treatment	47
Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance	47
Organoid models of drug resistant gastric adenosquamous carcinoma: Recapitulating tumor features and refining precision treatment	46
Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005–2023	46
The role of synthetic lethality in overcoming cancer therapy resistance: Emerging paradigm and recent advances	45
EMT and cancer stem cells: Drivers of therapy resistance and promising therapeutic targets	43
Autophagy in cancer development, immune evasion, and drug resistance	42
Editorial Board	42
Global, regional, and national disease burden of multidrug-resistant tuberculosis without extensive drug resistance, 1990–2021: Findings from the Global Burden of Disease Study 2021	42
Editorial Board	42
MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma	41
Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer	41
Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins	40
Hypoxia as a driver of resistance to immunotherapy	38
Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma	37
LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein	37
CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance	36
Cellular and molecular mechanisms of gastrointestinal cancer liver metastases and drug resistance	35
CEA-induced PI3K/AKT pathway activation through the binding of CEA to KRT1 contributes to oxaliplatin resistance in gastric cancer	35
Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer	35
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation	35
Targeting SLC7A11 with sorafenib sensitizes stereotactic body radiotherapy in colorectal cancer liver metastasis	35
Solving the antibacterial resistance in Europe: The multipronged approach of the COST Action CA21145 EURESTOP	34
Emerging role of sialylation in cancer therapy resistance: Mechanisms and therapeutic implications	34
Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer	34

Characterization difference of typical KL1, KL2 and ST11-KL64 hypervirulent and carbapenem-resistant Klebsiella pneumoniae	34
Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance	34
Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy	34
Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability	33
Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively	33
Breaking the barrier: Epigenetic strategies to combat platinum resistance in colorectal cancer	32
Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA	31
Editorial Board	30
NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1	30
Radioiodine therapy in advanced differentiated thyroid cancer: Resistance and overcoming strategy	29
Single-cell transcriptional profiling uncovers the association between EOMES+CD8+ T cells and acquired EGFR-TKI resistance	29
Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome	29
Wip1 phosphatase activator QGC-8–52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells	29
The role of histone H1.2 in pancreatic cancer metastasis and chemoresistance	29
Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics	28
Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis	28
Editorial Board	28
Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs	27
Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays	27
An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment	25
Revolutionising infection control: building the next generation of phage banks	25
CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis	25
The multifaceted contributions of cancer-associated fibroblasts to drug resistance in primary and metastatic tumors	25
Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae	25
The definition and global epidemiology of nonmobile colistin resistance (NMCR-3) determinants in Aeromonas from 1968 to 2022	24
Different mechanisms of drug resistance to hypomethylating agents in the treatment of myelodysplastic syndromes and acute myeloid leukemia	24
Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae	23
Impact of cancer metabolism on therapy resistance – Clinical implications	23
O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma	23
Exosome-derived lnc-FAM72D-3 promotes lenvatinib resistance by remodeling hepatocellular carcinoma cytoskeleton via MBNL1/FAK axis	22
HSA-templated synergistic platform boosts radiotherapy via enhanced radiosensitization and ferroptosis induction	22
Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis	21
An increased prevalence of carbapenem-resistant hypervirulent Klebsiella pneumoniae associated with the COVID-19 pandemic	21
Editorial Board	21
Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells	21
N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells	20
Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis	20
Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangemen	20
The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: Therapeutic implications	20
Targeting undruggable phosphatase overcomes trastuzumab resistance by inhibiting multi-oncogenic kinases	19
Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection	19
Defining homologous recombination deficiency status in pancreatic ductal adenocarcinoma: Clinical implications for evaluating response to platinum chemotherapy	19
The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity	18
Association of idealized amphiphiles and protease inhibitors: Conferring antimicrobial peptides with stable antibacterial activity under physiological conditions to combat multidrug-resistant bacteria	18
New emerging SARS-CoV-2 variants and antiviral agents	17
Molecular Modeling Strategies of Cancer Multidrug Resistance	17
Anticancer drug resistance: An update and perspective	17
Editorial Board	17
Intersecting pathways: The role of hybrid E/M cells and circulating tumor cells in cancer metastasis and drug resistance	17
DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma	17
A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis	17
Dynamic evolution of KPC-230-mediated resistance to ceftazidime-avibactam during the treatment of carbapenem-resistant Klebsiella pnenmoniae	16
CD105 blockade restores osimertinib sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer	16
Identification of TMexCD-TOprJ-producing carbapenem-resistant Gram-negative bacteria from hospital sewage	16
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency	16
Vaccine effects on COVID-19 infection with bivalent boosting by age group	16
Editorial Board	16
BCL7A inhibits the progression and drug-resistance in acute myeloid leukemia	16
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2	16
Engineering nanoplatforms of bacterial outer membrane vesicles to overcome cancer therapy resistance	15
TRAIL-driven targeting and reversing cervical cancer radioresistance by seleno-nanotherapeutics through regulating cell metabolism	15
The important role of lactylation in regulating DNA damage repair and tumor chemotherapy resistance	15
Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability	15
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance	15
Precision medicine: Ray of hope in overcoming cancer multidrug resistance	15
Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?	15
Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers	15
Editorial Board	15
Targeting TRAP1-dependent metabolic reprogramming to overcome doxorubicin resistance in quiescent breast cancer	14
CBX4 counteracts cellular senescence to desensitize gastric cancer cells to chemotherapy by inducing YAP1 SUMOylation	14
Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer	14
Pdr5: A master of asymmetry	14
Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis	14
TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4	13
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer	13
Carbapenemase-loaded outer membrane vesicles protect Pseudomonas aeruginosa by degrading imipenem and promoting mutation of antimicrobial resistance gene	13
Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis	13
Editorial Board	12
Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents	12
Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies	12

CYP1B1 promotes PARPi-resistance via histone H1.4 interaction and increased chromatin accessibility in ovarian cancer	12
Zebrafish patient-derived xenograft system for predicting carboplatin resistance and metastasis of ovarian cancer	12
Targeting NQO1 induces ferroptosis and triggers anti-tumor immunity in immunotherapy-resistant KEAP1-deficient cancers	12
RGS5+ lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism	11
Structure, function, and inhibition of catalytically asymmetric ABC transporters: Lessons from the PDR subfamily	11
Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity	11
Phage-mediated colistin resistance in Acinetobacter baumannii	11
Corrigendum to “Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae” [Drug Resist. Updat. 66 (2023) 100891]	11
CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification	10
MAFF confers vulnerability to cisplatin-based and ionizing radiation treatments by modulating ferroptosis and cell cycle progression in lung adenocarcinoma	10
Overcoming cancer therapy resistance: From drug innovation to therapeutics	10
Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis	10
Silver-dendrimer nanocomposite as emerging therapeutics in anti-bacteria and beyond	10
Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain	10
Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance	10
Resistance to immunotherapy in non-small cell lung cancer: Unraveling causes, developing effective strategies, and exploring potential breakthroughs	10
Acquired non-thermal plasma resistance mediates a shift towards aerobic glycolysis and ferroptotic cell death in melanoma	10
The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells	10
Circulating tumor cells with increasing aneuploidy predict inferior prognosis and therapeutic resistance in small cell lung cancer	10
Paclitaxel resistance related to nuclear envelope structural sturdiness	10