Drug Resistance Updates

Article	Citations
Editorial Board	501
Molecular subtype changes after acquiring resistance to tarlatamab in small cell lung cancer	261
Editorial Board	206
PARP inhibition elicits NK cell-associated immune evasion via potentiating HLA-G expression in tumor	197
Plasmid-borne tigecycline resistance gene tet(X4) in Salmonella enterica and Escherichia coli isolates from a pediatric patient with diarrhea	179
Overexpression of ABCC1 and ABCG2 confers resistance to talazoparib, a poly (ADP-Ribose) polymerase inhibitor	175
N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma	169
Modulating undruggable targets to overcome cancer therapy resistance	152
Erratum to “A highly potent small-molecule antagonist of exportin-1 selectively eliminates CD44+ CD24- enriched breast cancer stem-like cells” [Drug Resist. Updates 66 (2023) 100903]	148
Profiling the landscape of carbapenem resistance and hypervirulence in Klebsiella pneumoniae: A global epidemiological analysis of the plasmidome	131
Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer	127
Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma	127
Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance	122
Unraveling the secrets: Evolution of resistance mediated by membrane proteins	120
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects	119
Editorial Board	118
Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directions	117
Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine	99
A novel platinum(IV) prodrug, gramine-Pt(IV) enhances chemoimmunotherapy by activating cGAS-STING and modulating TGF-β-MHC-I axis	99
Evolution of RND efflux pumps in the development of a successful pathogen	98
Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer	90
Novel insights into taxane pharmacology: An update on drug resistance mechanisms, immunomodulation and drug delivery strategies	85
Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance	80
Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China	80
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges	78

Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae	76
Drug resistance mechanisms in dopamine agonist-resistant prolactin pituitary neuroendocrine tumors and exploration for new drugs	74
TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770–5p axis in PDAC	72
The novel strategy to overcome the drug-resistant lung cancer: Dual targeting delivery of PROTAC to inhibit cancer-associated fibroblasts and lung cancer cells	72
Peptide nanonet trapping suppresses bacterial motility and delays antibiotic resistance emergence	69
The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond	67
Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma	61
Enzymatic bionanocatalysts for combating peri-implant biofilm infections by specific heat-amplified chemodynamic therapy and innate immunomodulation	59
Network biology and artificial intelligence drive the understanding of the multidrug resistance phenotype in cancer	59
Treatment strategies and drug resistance mechanisms in adenocarcinoma of different organs	59
Editorial Board	58
Targeting anoikis resistance as a strategy for cancer therapy	58
Clinical implications of germline variations for treatment outcome and drug resistance for small molecule kinase inhibitors in patients with non-small cell lung cancer	57
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress	57
Emergence of silent NDM-1 carbapenemase gene in carbapenem-susceptible Klebsiella pneumoniae: Clinical implications and epidemiological insights	56
The role of tumor microenvironment and signaling pathways in regulating breast cancer stem cells: Implications for therapy resistance and tumor recurrence	56
Research progress on gene mutations and drug resistance in leukemia	54
Novel mobile colistin resistance gene mcr-4.9 in Vibrio cholerae from migratory birds	53
PDPN positive CAFs contribute to HER2 positive breast cancer resistance to trastuzumab by inhibiting antibody-dependent NK cell-mediated cytotoxicity	52
Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica	52
Myeloid Immune Checkpoint Blockade Overcomes Antibiotic Resistance in Bone Infection by Enhancing Efferocytosis and Suppressing MSC PANoptosis	50
Current therapy and drug resistance in metastatic castration-resistant prostate cancer	49
Framework nucleic acid-based nanoparticles enhance temozolomide sensitivity in glioblastoma	49
Inhibition of NF-κB signaling unveils novel strategies to overcome drug resistance in cancers	49
Overcoming cancer chemotherapy resistance by the induction of ferroptosis	48
Emergence of novel Klebsiella pneumoniae ST types with multidrug resistance in clinic	47
Organoid models of drug resistant gastric adenosquamous carcinoma: Recapitulating tumor features and refining precision treatment	46
Editorial Board	46
Editorial Board	46
Ferroptosis and the cGAS–STING pathway into precision nano-immuno-theranostics: A mechanistic paradigm for reversing drug resistance in hepatocellular carcinoma	45
Mechanisms of sensitivity and resistance to CDK4/CDK6 inhibitors in hormone receptor-positive breast cancer treatment	44
Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance	44
ABCB1-dependent collateral sensitivity of multidrug-resistant colorectal cancer cells to the survivin inhibitor MX106-4C	43
Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005–2023	43
Exosomal LOC85009 inhibits docetaxel resistance in lung adenocarcinoma through regulating ATG5-induced autophagy	42
Research progress of therapeutic effects and drug resistance of immunotherapy based on PD-1/PD-L1 blockade	42
The role of synthetic lethality in overcoming cancer therapy resistance: Emerging paradigm and recent advances	40
Global, regional, and national disease burden of multidrug-resistant tuberculosis without extensive drug resistance, 1990–2021: Findings from the Global Burden of Disease Study 2021	40
Autophagy in cancer development, immune evasion, and drug resistance	39
LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein	38
EMT and cancer stem cells: Drivers of therapy resistance and promising therapeutic targets	38
MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma	37
CEA-induced PI3K/AKT pathway activation through the binding of CEA to KRT1 contributes to oxaliplatin resistance in gastric cancer	37
Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer	37
Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins	37
Targeting SLC7A11 with sorafenib sensitizes stereotactic body radiotherapy in colorectal cancer liver metastasis	36
CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance	36
Cellular and molecular mechanisms of gastrointestinal cancer liver metastases and drug resistance	35
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation	35
Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma	35

Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer	34
Metabolic basis of fatty acid oxidation and immunotherapy resistance with clinical perspectives	34
Characterization difference of typical KL1, KL2 and ST11-KL64 hypervirulent and carbapenem-resistant Klebsiella pneumoniae	33
Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer	33
Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy	32
Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance	32
Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively	31
Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA	31
Emerging role of sialylation in cancer therapy resistance: Mechanisms and therapeutic implications	31
Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability	30
Nanoparticles-mediated mitochondrial relocation of lipid-lowering drugs shape energy metabolism to conquer acquired immune resistance	30
NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1	30
Endothelial cells sense temozolomide resistance to facilitate monocyte-derived macrophage infiltration in glioblastoma	30
Breaking the barrier: Epigenetic strategies to combat platinum resistance in colorectal cancer	29
Solving the antibacterial resistance in Europe: The multipronged approach of the COST Action CA21145 EURESTOP	29
Editorial Board	28
Wip1 phosphatase activator QGC-8–52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells	27
Editorial Board	27
The role of histone H1.2 in pancreatic cancer metastasis and chemoresistance	26
Single-cell transcriptional profiling uncovers the association between EOMES+CD8+ T cells and acquired EGFR-TKI resistance	26
Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome	26
Radioiodine therapy in advanced differentiated thyroid cancer: Resistance and overcoming strategy	26
Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics	26
Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis	26
Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae	25
Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays	25
The definition and global epidemiology of nonmobile colistin resistance (NMCR-3) determinants in Aeromonas from 1968 to 2022	23
O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma	23
The multifaceted contributions of cancer-associated fibroblasts to drug resistance in primary and metastatic tumors	23
Different mechanisms of drug resistance to hypomethylating agents in the treatment of myelodysplastic syndromes and acute myeloid leukemia	23
Revolutionising infection control: building the next generation of phage banks	23
CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis	22
AMPKα2 attenuates doxorubicin induced ferroptosis by promoting NCOA4 degradation in triple negative breast cancer	22
Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs	22
Gamma-synuclein drives bevacizumab resistance in colorectal cancer via VEGFR2 activation and angiogenesis	21
Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae	21
An increased prevalence of carbapenem-resistant hypervirulent Klebsiella pneumoniae associated with the COVID-19 pandemic	21
Editorial Board	21
HSA-templated synergistic platform boosts radiotherapy via enhanced radiosensitization and ferroptosis induction	20
The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: Therapeutic implications	20
Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis	20
Exosome-derived lnc-FAM72D-3 promotes lenvatinib resistance by remodeling hepatocellular carcinoma cytoskeleton via MBNL1/FAK axis	20
Beyond the boundary: The emerging roles of ATP-binding cassette transporters in multidrug resistance (MDR) and therapeutic targeting in cancer	19
Defining homologous recombination deficiency status in pancreatic ductal adenocarcinoma: Clinical implications for evaluating response to platinum chemotherapy	19
Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis	19
The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity	19
A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis	19
N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells	19
Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangemen	19
Intersecting pathways: The role of hybrid E/M cells and circulating tumor cells in cancer metastasis and drug resistance	19
Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells	19
Targeting undruggable phosphatase overcomes trastuzumab resistance by inhibiting multi-oncogenic kinases	18
DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma	18
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency	18
Association of idealized amphiphiles and protease inhibitors: Conferring antimicrobial peptides with stable antibacterial activity under physiological conditions to combat multidrug-resistant bacteria	18
Editorial Board	18
Vaccine effects on COVID-19 infection with bivalent boosting by age group	18
Overcoming Resistance in Oncolytic Virotherapy: Nano-Engineered Solutions for Systemic Delivery and Efficacy Boost	18
Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection	18
Editorial Board	18
New emerging SARS-CoV-2 variants and antiviral agents	18
Identification of TMexCD-TOprJ-producing carbapenem-resistant Gram-negative bacteria from hospital sewage	17
BCL7A inhibits the progression and drug-resistance in acute myeloid leukemia	17
TRAIL-driven targeting and reversing cervical cancer radioresistance by seleno-nanotherapeutics through regulating cell metabolism	17
Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?	17
Dynamic evolution of KPC-230-mediated resistance to ceftazidime-avibactam during the treatment of carbapenem-resistant Klebsiella pnenmoniae	16
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2	16
Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability	16
Engineering nanoplatforms of bacterial outer membrane vesicles to overcome cancer therapy resistance	16
Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers	16
CD105 blockade restores osimertinib sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer	16
Targeting TRAP1-dependent metabolic reprogramming to overcome doxorubicin resistance in quiescent breast cancer	15
The important role of lactylation in regulating DNA damage repair and tumor chemotherapy resistance	15
Disruption of NANOG-driven epithelial-mesenchymal transition (EMT) and self-renewal restores drug sensitivity in colorectal cancer	15
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance	15
Editorial Board	15
Precision medicine: Ray of hope in overcoming cancer multidrug resistance	15
Difluoroboron Curcumin/Glycyrrhizic Acid Liposome-Incorporated Mg²⁺-Chelated Microgel for MRSA-Infected Wound Photothermal Therapy	14
Pdr5: A master of asymmetry	14
Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents	14

Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer	14
TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4	14
CBX4 counteracts cellular senescence to desensitize gastric cancer cells to chemotherapy by inducing YAP1 SUMOylation	13
Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis	13
Carbapenemase-loaded outer membrane vesicles protect Pseudomonas aeruginosa by degrading imipenem and promoting mutation of antimicrobial resistance gene	13
Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis	13
RGS5+ lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism	12
Editorial Board	12
Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity	12
Targeting NQO1 induces ferroptosis and triggers anti-tumor immunity in immunotherapy-resistant KEAP1-deficient cancers	12
Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies	12
Structure, function, and inhibition of catalytically asymmetric ABC transporters: Lessons from the PDR subfamily	12
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer	12
CYP1B1 promotes PARPi-resistance via histone H1.4 interaction and increased chromatin accessibility in ovarian cancer	11
Phage-mediated colistin resistance in Acinetobacter baumannii	11
Zebrafish patient-derived xenograft system for predicting carboplatin resistance and metastasis of ovarian cancer	11
Circulating tumor cells with increasing aneuploidy predict inferior prognosis and therapeutic resistance in small cell lung cancer	10
Acquired non-thermal plasma resistance mediates a shift towards aerobic glycolysis and ferroptotic cell death in melanoma	10
Corrigendum to “Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae” [Drug Resist. Updat. 66 (2023) 100891]	10
Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis	10
Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain	10