OOIR: Observatory of International Research

Papers

(The TQCC of Drug Resistance Updates is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangemen	302
The uptake of extracellular vesicles: Research progress in cancer drug resistance and beyond	238
N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma	209
Low miR-224–5p in exosomes confers colorectal cancer 5-FU resistance by upregulating S100A4	157
Editorial Board	146
Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain	130
Paclitaxel resistance related to nuclear envelope structural sturdiness	123
The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells	122
Analysis of SARS-CoV-2 mutations associated with resistance to therapeutic monoclonal antibodies that emerge after treatment	110
ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance	93
Editorial Board	89
Editorial Board	89
Editorial Board	88
Editorial Board	86
Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma	85
Modulating undruggable targets to overcome cancer therapy resistance	84
Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins	83
Association of idealized amphiphiles and protease inhibitors: Conferring antimicrobial peptides with stable antibacterial activity under physiological conditions to combat multidrug-resistant bacteria	81
Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection	80
Molecular subtype changes after acquiring resistance to tarlatamab in small cell lung cancer	80
Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer	79
GATA3 mediates doxorubicin resistance by inhibiting CYB5R2-catalyzed iron reduction in breast cancer cells	76
LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein	72
Overexpression of ABCC1 and ABCG2 confers resistance to talazoparib, a poly (ADP-Ribose) polymerase inhibitor	70
Silver-dendrimer nanocomposite as emerging therapeutics in anti-bacteria and beyond	69

Intersecting pathways: The role of hybrid E/M cells and circulating tumor cells in cancer metastasis and drug resistance	68
Plasmid-borne tigecycline resistance gene tet(X4) in Salmonella enterica and Escherichia coli isolates from a pediatric patient with diarrhea	67
Prophylactic use of antibiotics – A strategy with unforeseen risks?	64
Widespread loss-of-function mutations implicating preexisting resistance to new or repurposed anti-tuberculosis drugs	64
The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity	56
Pyrazinamide-resistant Tuberculosis Obscured From Common Targeted Molecular Diagnostics	53
Acquired non-thermal plasma resistance mediates a shift towards aerobic glycolysis and ferroptotic cell death in melanoma	51
CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification	48
A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis	48
Circulating tumor cells with increasing aneuploidy predict inferior prognosis and therapeutic resistance in small cell lung cancer	47
Targeting undruggable phosphatase overcomes trastuzumab resistance by inhibiting multi-oncogenic kinases	47
CCT251545 enhances drug delivery and potentiates chemotherapy in multidrug-resistant cancers by Rac1-mediated macropinocytosis	47
MAFF confers vulnerability to cisplatin-based and ionizing radiation treatments by modulating ferroptosis and cell cycle progression in lung adenocarcinoma	47
CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance	46
lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2	45
CEA-induced PI3K/AKT pathway activation through the binding of CEA to KRT1 contributes to oxaliplatin resistance in gastric cancer	44
Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment	43
CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal cancer	42
A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in lung adenocarcinoma	42
Novel nanomedicines to overcome cancer multidrug resistance	41
Hypoxia as a driver of resistance to immunotherapy	39
Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance	39
Antibiotic failure: Beyond antimicrobial resistance	37
Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance	37
Blockade of purine metabolism reverses macrophage immunosuppression and enhances anti-tumor immunity in non-small cell lung cancer	37
Molecular Modeling Strategies of Cancer Multidrug Resistance	37
Hallmarks of anticancer and antimicrobial activities of corroles	36
Editorial Board	35
Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy	35
B7-H3-liquid biopsy for the characterization and monitoring of the dynamic biology of prostate cancer	34
Harnessing phytochemicals: Innovative strategies to enhance cancer immunotherapy	32
Corrigendum to “Molecular basis of bacterial disinfectant resistance” [Drug Resist. Updates 48 (2020) 100672]	31
Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer	31
Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer	31
Osmotic stress influences microtubule drug response via WNK1 kinase signaling	31
Editorial Board	30
Overexpression of blaGES-1 due to a strong promoter in the class 1 integron contributes to decreased ceftazidime-avibactam susceptibility in carbapenem-resistant Pseudomonas aeruginosa ST235	29
Editorial Board	29
Targeting ACYP1-mediated glycolysis reverses lenvatinib resistance and restricts hepatocellular carcinoma progression	28
New emerging SARS-CoV-2 variants and antiviral agents	28
Effective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells	28
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects	28
Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma	27
Cellular and molecular mechanisms of gastrointestinal cancer liver metastases and drug resistance	26
AI-driven visualization tool for analyzing data and predicting drug-resistant outbreaks	25
Characterization difference of typical KL1, KL2 and ST11-KL64 hypervirulent and carbapenem-resistant Klebsiella pneumoniae	24
Understanding ER homeostasis and the UPR to enhance treatment efficacy of acute myeloid leukemia	24
crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer	24