OOIR: Observatory of International Research

Papers

(The TQCC of Current Organic Chemistry is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Cruzain Inhibitors: State-of-Art of Novel Synthetic Strategies	44
Growing Impact of Bioorthogonal Click Chemistry in Cell Surface Glycan Labeling	43
Design, Synthesis, Reactions, Molecular Docking, Antitumor Activities of Novel Naphthopyran, Naphthopyranopyrimidines, and Naphthoyranotriazolopyrimidine Derivatives	36
Recent Research on Lipase Immobilization with Multipoint Covalent Treatment by Glutaraldehyde	31
Advances in the Synthesis of Diarylpyrimidine as Potent Non-nucleoside Reverse Transcriptase Inhibitors: Biological Activities, Molecular Docking Studies and Structure-activity Relationship: A Critica	27
Recent Advancement of Transition Metal-mediated Reactions of Diazomethane and (Trimethylsilyl)diazomethane	26
Cationic Ruthenium for C-H Activation Reactions	26
Bioactive Compounds Involved in the Formation of the Sparse Understory Vegetation in Pine Forests	25
A Study on Camphor Derivatives and Its Applications: A Review	25
Recent Advances in Synthesis and Biological Applications of Substituted Ureas	24
Synthesis of Spiropyrazoles Under Organic and Nonorganic Catalysis	20
Modification for Nitration of Halo-substituted meso-Tetraarylporphyrins: A Convenient Scale-up in Small Amount of Solvent	20
Friedel Crafts Reactions Revisited: Some Applications in Heterogeneous Catalysis#	19
Trihaloisocyanuric Acids: Useful Reagents for Halogenation Reactions and Heterocyclic Scaffold Construction	19
Recent Achievements in the Synthesis of Carbazole Derivatives	16
Structural Metamorphosis: Rearranging Camphor-based Systems	16
Recent Achievement in the Synthesis of Imidazoles	15
Antileishmanial Activity of Natural Diterpenoids: A Comprehensive Review	14
Harnessing the Pyrazine Moiety for Potent Anti-inflammatory Activity: A Comprehensive Review	14
A Novel Cu(II)-Iodine Catalyzed Hantzsch Type Synthesis of 2-Aminothiazole Derivatives	13
Synthetic Utility of Aminomercapto[1,2,4]triazoles in the Preparation of Fused Triazoles	13
Silver-assisted Syntheses of Fused Five-membered N-heterocycles	13
Oligomers Electrosynthesis: A Selective and Greener Synthetic Tool	12
Perspectives in Future Applications and Advancements of NMR Spectroscopy	12
Synthesis of Polynuclear Aromatic Hydrocarbons by Palladium-catalyzed C-H Bond Functionalization	12

Toolbox for α-Amination Reactions	12
Synthesis and Gas Permeation Properties of Functionalized Norbornene-Based Polymers	12
Synthesis of Phosphonates, Phosphinates and Tertiary Phosphine Oxides by Pd- or Ni-Catalyzed Microwave-Assisted P–C Coupling Reactions without the Addition of Conventional Ligands	11
Pyrazole and Benzimidazole Derivatives: Chelating Properties Towards Metals Ions and their Applications	11
An Overview of Recent Advances in Isatin-Based Multicomponent Reactions	11
Synthesis, Docking and Antimicrobials Evaluation of Novel Pyrazolotriazines as RNA Polymerase Inhibitors	11
Edible Oils and Development of New Products: Sensory, Microbiological, and Cytotoxic Aspects	11
Synthetic Development in Inulin Modification and its Applications	11
Merrifield Resin Supported Ionic Liquids: Catalytic Applications in Organic Synthesis	11
Synthesis of Pregna-1,4,16-triene-3,20-dione from a Mixture of Soybean Phytosterols using a Combination of Chemical and Microbiological Methods	10
Supramolecular Chirality in Porphyrin Self-Assembly Systems in Aqueous Solution	10
Recent Developments in the Transformation of 3-amino-2-azetidinones	10
A Review on Piezoelectric-mediated Mechanoredox Reactions by Ball Milling in Organic Synthesis	10
Recent Progress in Hydrogen Bond-Mediated Transformations to Chiral Medicinal Drugs by Phosphoric Acid and Thiourea Derived Organocatalysts	10
Light-responsive Polymers: Developments in Drug Delivery Systems	10
Synthesis of Epichlorohydrin-based Click-dendrons with Different Functional Groups	10
Catalysts For Propargylamines Synthesis Via A3, AHA, and KA2 Coupling - A Review	10
Functional Chitosan: Recent Gamma Radiation Chemistry of Organic Derivatives	10
NMR and FT-IR Investigation Study and Topological Analysis of Various Conformations of 2,5-dimethyl-2,5-dihydroxyl-1,4-dithian using Density Functional Theory Method	9
Ultrasound-assisted Synthesis of Biologically Promising Organoselenium Scaffolds	9
Non-conventional Approaches Towards Various Organic Transformations – (Part 1)	9
Greener Approaches to Selected Asymmetric Addition Reactions Relevant to Drug Development	9
Condensed Pyridopyrimidines and Pyridopyrazines Containing a Bridgehead Nitrogen Atom: Synthesis, Chemical Properties and Biological Activity	9
Hedychium coronariumJ. Koenig: Traditional Uses, Phytochemistry, Biological Activities and Future Aspects	9
Mechanisms, Copper Catalysts, and Ligands Involved in the Synthesis of 1,2,3- Triazoles Using Click Chemistry	9
Ruthenium-catalyzed Aromatic meta-C-H Nitration of 1,2,4-thiadiazoles	9
Electrochemistry: A Versatile Tool for Organic Synthesis	9
Solid-Phase Synthesis of Asymmetric Cyanine Dyes	9
Current Status and Applications of Gamma Radiation-induced Graft Copolymerized Chitosan	9
Anthracycline in Medicinal Chemistry: Mechanism of Cardiotoxicity, Preventive and Treatment Strategies	9
Recently Published Patents on Janus Base Nanomaterials for RNA Delivery	9
Efficient Synthesis and Characterization of 6-substituted-N-p-tolyl-imidazo[1,2- a]pyridine-8-carboxamide: A Promising Scaffold for Drug Development	9
Recent Advancements in Glycosylation Reactions: An Access to Privileged C- and S-glycosides	9
New Insights into Organic Chemistry (Part 2)	8
“Green” Synthesis of Substituted Tetraketones with Prominent Bactericide Effect	8
Phytochemical, Pharmacological Profile and Biotechnology Approaches in the Production of Coriandrum sativum Linn.	8
Recent Advances in the Synthesis and Applications of Partially Protected N-Glycosylamines	8
Synthetic Strategies to Substituted Chiral Furans: A Review	8
4-Aminocoumarin Derivatives as Multifaceted Building Blocks for the Development of Various Bioactive Fused Coumarin Heterocycles: A Brief Review	8
Bioactive Compounds from Polar Regions: An Account of Chemical Ecology and Biotechnological Applications	8
Electrochemical Method: A Green Approach for the Synthesis of Organic Compounds	8
Recent Advances in Microwave-Assisted Synthesis and Functionalization of 1,2,3- and 1,2,4-triazoles	8
Coumarin Derivatives: Pioneering New Frontiers in Biological Applications	8
Phytochemistry, Pharmacological Targets, Biological Mechanisms and Patented Formulations of Salacia reticulata Wight (Celastaceae): An Appraisal of its Potential	8
Synthesis of Polyoxygenated 4,5-Diarylpyridazines with Antiproliferative and Antitubulin Activity via Inverse Electron-Demand Diels-Alder Reaction of 1,2,4,5- Tetrazine	8
1,4-Diazabicyclo[2.2.2]octane (DABCO) in Organic Synthesis and Catalysis: A Quinquennial Report (2019-to Date)	8
Green Strategies for Sustainable C–H Bond Functionalizations	8
Recent Developments in the Synthesis of Five- and Six-membered N-heterocycles from Dicarbonyl Compounds	8
Comparative Study on Catalysis Strategies: Friedel-Crafts Alkylation vs. Michael Addition of Indoles to Nitroalkenes	8
Ultrasound-assisted Synthesis of Nitrogen and Oxygen Containing Heterocycles	8

Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Some Novel 3,5-disubstituted-1-phenyl-4,5-dihydro-1H-pyrazole Derivatives	7
Regioselectivity Inversion in Hydroformylation of Aryl Alkenes with a Diphosphoramidite-rhodium Catalyst	7
Preface	7
An Overview of Ruthenium-Catalyzed Multicomponent Reactions	7
Direct Catalytic Conversion of Biomass-derived Carbohydrates to Ethyl Levulinate	7
Construction of C-S and C-Se Bonds Mediated by Hypervalent Iodine Reagents Under Metal-Free Conditions	7
Non-conventional Approaches towards Various Organic Transformations – (Part II)	7
N-Silylmethyl-2-(1-Naphthyl)Acetamides: Synthesis, Structure and Computational Screening	7
Green Synthesis of Pyridine and their Fused System: Harnessing the Catalytic Power of Ionic Liquids for Sustainable and Efficient Multicomponent Reaction	7
Methods for Direct Conversion of Primary Nitroalkanes to Nitriles	7
Facile Synthesis of Organic Compounds in PEG, ScCO₂ and H₂O: A Review	7
A New Perspective on the Molecular Targets, Mechanisms of Action, and Clinical Significance of Ursolic Acid’s Multifaceted Anti-cancer Effects	7
Recent Advances in Biocatalytic Acylation of Alcohols as a Sustainable Target for Flavor and Fragrance Compounds	7
Green Synthesis and Acetylcholinesterase Inhibition of Coumarin-1,2,4-Triazole Hybrids	7
Modified Synthesis and Isolation of an Advanced Intermediate of Remdesivir	7
Undirected, Selective Csp2-H Alkynylation of Five-membered Heteroarenes	7
Recent Advances in [5+2] Cycloadditions	7
Boron in Medicinal and Organic Chemistry	7
Recent Progress in the Synthesis of Isoxazoles	7
Application of Ionic Liquids in Environmental and Food Fields	7
Recent Progress of Calcium-Based Catalysts in Organic Transformations	6
Green Methodologies for the Synthesis of Thiophene Chalcone Derivatives: A Review	6
Recent Insights into the Synthesis of Oligosaccharides from Escherichia coli: Review	6
Bioisosteric Replacement through 1,2,3-triazolyl Linkage Significantly Potentiate Biological Activity in Lidocaine and Etidocaine Analogs: Rational Design and Local Anesthetic Activity	6
A Comprehensive Review on the Synthesis of Mangiferin Derivatives and their Multiple Biological Activities	6
Recent Advances in Utilization of Deep Eutectic Solvents: An Environmentally Friendly Pathway for Multi-component Synthesis	6
Connection Number-based Multiplicative Zagreb Indices of Chemical Structures	6
Multiple and One-Pot Synthetic Strategies for Pyrimido-Thiazine and their Derivatives	6
Amines via Hydroaminomethylation: An Updated Overview	6
Applications of Transesterification in the Synthesis of Commercial and Noncommercial β -Ketoesters/Esters, Medicinally Important Heterocycles and Production of Biodiesel	6
A Review on Traditional and Modern Methods for the Synthesis of Aromatic Azo Compounds	6
Application of Aromatic Substituted 2,2,2-Trifluoro Diazoethanes in Organic Reactions	6
Recent Advancements in the Synthesis of Pyrazole Derivative for the Treatment of Alzheimer's Disease	6
A Review on Green Synthesis and Biological Activities of Medicinally Important Nitrogen and Oxygen Containing Heterocycles	6
Design, Synthesis, Antimicrobial Activity and Molecular Docking of Novel Pyridine, Thiophene, and Thiadiazole Scaffolds Utilizing 2-Cyano-N-(4-(1-(2-(2-cyanoacetyl) hydrazineylidene)ethyl)phenyl)aceta	6
1,3,5 and 1,2,4-triazines as Potent Scaffolds for Molecules Potentially Attenuating Breast Cancer Cell Lines	6
Synthesis of 1,4-Benzodiazepines by Palladium-Catalyzed C-N Coupling	5
In Silico ADME And Molecular Docking Studies of New Thiazolyl-bipyrazole, Pyrazolopyridine and Pyrano[2,3-d]pyrazolopyridine Derivatives as Antibacterial Agents	5
A Visible-Light-Induced Cyclization Reaction	5
Catalytic Syntheses of Pyrano[3,2-c]Quinolone and -Quinoline Derivatives and their Potential Therapeutic Agents	5
Recent Progress in the Synthetic Methods of Pyrazoloquinoline Derivatives	5
Synthetic Aspects of Condensed Pyrimidine Derivatives	5
The Direct use of Metallic Ore Minerals as Catalysts in Organic Syntheses	5
Theoretical Study of Methylaluminoxane Formation	5
Functional Group Transformation in Naphthoquinones: Strategies for the Synthesis of Mono- and Bis(Amino-1,4-Naphthoquinones)	5
Comparative Studies of Mechanochemically Synthesized Insoluble Beta-Cyclodextrin Polymers	5
Cholapod and Cholaphanes for Recognition of Anions	5
Reusable Iron/Iron Oxide-based Nanoparticles Catalyzed Organic Reactions	5
5-Aminotetrazoles – An Overview of Synthetic Methodologies through the Desulfurization of Thioureas	5
An Expeditious Synthesis of Ethyl-2-(4-(arylmethylene)-5-oxo-4,5-dihydroisoxazol-3- yl)acetate Derivatives	5
Preface	5
The Photochemical Isomerisation of Hexatomic Heterocyclic Compounds	5
Microwave Assisted Grafting Technique for Modification of Polysaccharides	5
Multi-component Reactions for the Synthesis of Biologically Relevant Molecules Under Environmentally Benign Conditions	5
Di-tert-butyl Peroxide (DTBP)-Promoted Heterocyclic Ring Construction	5
The Chemistry and Biological Effects of Fused 1,2,4-triazolo[4,3-c]pyrimidines and their Isomeric 1,2,4-triazolo[1,5-c]pyrimidines	5
Recent Advances in Smart Polymers	5
Preface	5
Recent Achievements in the Synthesis of Oxazoles	5
Cocaine: From a Controlled Drug by the DEA to an Approved Drug by the FDA	5
Synthesis, Thermotropic Properties, and Applications of Porphyrin-based Liquid Crystals: A Comprehensive Review	5
Synthesis, Biological Activity and DFT Studies of 1,3,4-oxadiazole Ring in Combination with Pyridinium Salt	5
The Chemical Synthesis of the 1-C-Alkyl Substituted Pyrrolidine and Piperidine Iminosugar Natural Products and their Analogues	5
Recent Innovations in Synthetic Methodologies and Patent Landscape of Quinoline Analogues: A Comprehensive Review	5
Triazole: A New Perspective in Medicinal Chemistry and Material Science	5
Microwave-induced Reactions for Pyrrole Synthesis	5
The Potential of Microwaves in Organophosphorus Syntheses	5
3,4-Dihydropyrimidine-2(1H)-one/thione Derivatives as Anti-inflammatory and Antioxidant Agents: Synthesis, Biological activity, and Docking Studies	5