OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Biology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The complex lipid, SPPCT-800, reduces lung damage, improves pulmonary function and decreases pro-inflammatory cytokines in the murine LPS-induced acute respiratory distress syndrome (ARDS) model	80
Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway	69
Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis	69
XiaoEr LianHuaQinqGan alleviates viral pneumonia in mice infected by influenza A and respiratory syncytial viruses	59
Flaxseed extract reduces tissue accumulation and enhances urinary excretion of chondroitin sulphate in the rat: a possible new path in substrate reduction therapy for mucopolysaccharidosis	53
Ranunculus ternatus Thunb extract attenuates renal fibrosis of diabetic nephropathy via inhibiting SMYD2	51
C-Phycocyanin prevents acute myocardial infarction-induced oxidative stress, inflammation and cardiac damage	45
Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway	44
Integrated pharmacoanalysis, bioinformatics analysis, and experimental validation to identify the ingredients and mechanisms of Xiao-Luo-Wan in uterine fibroids treatment	43
Effects of Tiaopi Xiezhuo decoction on constipation and gut dysbiosis in patients with peritoneal dialysis	42
Modified Zhibai Dihuang pill alleviated urinary tract infection induced by extended-spectrum β-lactamase Escherichia coli in rats by regulating biofilm formation	41
Protective effect of omega-3 polyunsaturated fatty acids on sepsis via the AMPK/mTOR pathway	40
Adjuvant potential of Satureja hortensis metabolites with antibiotics against Gram-positive and Gram-negative bacterial strains	39
Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis	35
Lack of pharmacokinetic interaction between derazantinib and naringin in rats	35
Design, evaluation, cytotoxic activity, molecular docking, ADMET analysis, and dynamic simulations and the preparation of new isoxazoles, thiazoles, 1,3-thiazines, and thiazolopyrimidines derived from	35
Suchilactone inhibits the growth of acute myeloid leukaemia by inactivating SHP2	34
Hyaluronic acid-engineered milk extracellular vesicles to target triple negative breast cancer through CD44	34
Antiproliferative activity, cell-cycle arrest, apoptotic induction and LC-HRMS/MS analyses of extracts from two Linum species	33
Prevention of ulcerative colitis by Huangqin decoction: reducing the intestinal epithelial cell apoptosis rate through the IFN-γ/JAK/ETS signalling pathway	32
Tongmai Yangxin pill alleviates myocardial no-reflow by activating GPER to regulate HIF-1α signaling and downstream potassium channels	32
Indigo naturalis as a potential drug in the treatment of ulcerative colitis: a comprehensive review of current evidence	32
Isoalantolactone suppresses gallbladder cancer progression via inhibiting the ERK signalling pathway	31
Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology	31
Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis	31

Chaihu Shugan San promotes gastric motility in rats with functional dyspepsia by regulating Drp-1-mediated ICC mitophagy	30
Yiqi Wenyang decoction protects against the development of atherosclerosis by inhibiting vascular inflammation	30
Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment	28
Screening of rosmarinic acid from Salvia miltiorrhizae acting on the novel target TRPC1 based on the ‘homology modelling–virtual screening–molecular docking–affinity ass	28
Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment	28
A triterpene-enriched natural extract from Eucalyptus tereticornis modulates the expression of genes involved in adipogenesis, lipolysis, and extracellular matrix remode	28
Homogeneous Polyporus polysaccharide exerts anti-bladder cancer effects via autophagy induction	27
Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis	27
Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents	27
Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labour	26
Plantamajoside alleviates acute sepsis-induced organ dysfunction through inhibiting the TRAF6/NF-κB axis	26
The BCL2/BAX/ROS pathway is involved in the inhibitory effect of astragaloside IV on pyroptosis in human umbilical vein endothelial cells	25
Paeoniflorin suppresses the apoptosis and inflammation of human coronary artery endothelial cells induced by oxidized low-density lipoprotein by regulating the Wnt/β-catenin pathway	25
Gnetum montanum extract induces apoptosis by inhibiting the activation of AKT in SW480 human colon cancer cells	25
Peptides from the croceine croaker ( Larimichthys crocea ) swim bladder attenuate busulfan-induced oligoasthenospermia in mice	25
Ginsenoside Rb1 reduces oxidative/carbonyl stress damage and ameliorates inflammation in the lung of streptozotocin-induced diabetic rats	25
Liver protective effect of chloroform extract of Bauhinia purpurea leaves is attributed partly to its antioxidant action and the presence of flavonoids	25
Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model	25
Chitooligosaccharide prevents vascular endothelial cell apoptosis by attenuation of endoplasmic reticulum stress via suppression of oxidative stress through Nrf2-SOD1 up-regulation	24
Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats	24
Therapeutic efficacy and pharmacological mechanism of Bailing capsule on chronic obstructive pulmonary disease: a meta-analysis and network pharmacology	24
Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis	24
A comprehensive review of antimalarial medicinal plants used by Tanzanians	24
Effect of Wuzi Yanzong prescription on oligoasthenozoospermia rats based on UPLC-Q-TOF-MS metabolomics	24
Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis	23
Upregulation of claudin‑4 by Chinese traditional medicine Shenfu attenuates lung tissue damage by acute lung injury aggravated by acute gastrointestinal injury	23
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways	23
Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance	23
Clinical observations and mechanistic insights of traditional Chinese medicine in the management of diabetic retinopathy	22
Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification	22
Curcumin inhibits cerebral ischaemia–reperfusion injury and cell apoptosis in rats through the ERK–CHOP–caspase-11 pathway	22
An integrated strategy for the comprehensive profiling of the chemical constituents of Aspongopus chinensis using UPLC-QTOF-MS combined with molecular networking	22
Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism	22
Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice	22
Aaptamine – a dual acetyl – and butyrylcholinesterase inhibitor as potential anti-Alzheimer’s disease agent	22
Glucocorticoid receptors involved in ginsenoside compound K ameliorate adjuvant arthritis by inhibiting the glycolysis of fibroblast-like synoviocytes via the NF-κB/HIF-1α pathway	22
Cardamonin suppressed the migration, invasion, epithelial mesenchymal transition (EMT) and lung metastasis of colorectal cancer cells by down-regulating ADRB2 expression	22
Characterization of global research trends and prospects on celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F: bibliometric analysis	22
Hydroethanolic extracts from Bauhinia guianensis : a study on acute toxicity in Zebrafish embryos and adults	22
Chinese herbal compound Huangqin Qingrechubi capsule reduces lipid metabolism disorder and inflammatory response in gouty arthritis via the LncRNA H19/APN/PI3K/AKT casca	22
The changes of hepatic bile acid synthesis and transport and bile acids profiles in isopsoralen-induced liver injury C57BL/6J mice	21
Tormentic acid, a triterpenoid isolated from the fruits of Chaenomeles speciose , protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CX	21
Comparative efficacy and safety of Chinese patent medicines as an adjunctive therapy for diabetic peripheral neuropathy: systematic review and network meta-analysis of randomized controlled trials	21
Dolichandrone serrulata flower improves seminal biochemical parameters and proteins in T2DM rats induced by a high-fat diet and streptozotocin	21
The traditional ethnic herb Tadehagi triquetrum from China: a review of its phytochemistry and pharmacological activities	21
Thais savignyi tissue extract: bioactivity, chemical composition, and molecular docking	20
Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway	20
Assessing potential liver injury induced by Polygonum multiflorum using potential biomarkers via targeted sphingolipidomics	20
Phytochemical and biological activities of some Iranian medicinal plants	20
Preparation, characterization, and anticancer effects of an inclusion complex of coixol with β-cyclodextrin polymers	20

Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder	20
Rongjin Niantong Fang ameliorates cartilage degeneration by regulating the SDF-1/CXCR4-p38MAPK signalling pathway	19
Effect of Er Miao San on peritoneal macrophage polarisation through the miRNA-33/NLRP3 signalling pathway in a rat model of adjuvant arthritis	19
M2b macrophages stimulate lymphangiogenesis to reduce myocardial fibrosis after myocardial ischaemia/reperfusion injury	19
Traditional Chinese medicine for breast cancer treatment: a bibliometric and visualization analysis	19
Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection	19
Systematic identification of the interventional mechanism of Qingfei Xiaoyan Wan (QFXYW) in treatment of the cytokine storm in acute lung injury using transcriptomics-based system pharmacological anal	19
The vital role of animal, marine, and microbial natural products against COVID-19	19
FAEE exerts a protective effect against osteoporosis by regulating the MAPK signalling pathway	19
Qiangli Wuhu mixture alleviates LPS-induced pneumonia by inhibiting the TLR4/NF-κB/NLRP3 pathway: a study based on network pharmacology	19
Cytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from Jasminum humile	19
Morroniside ameliorates glucocorticoid-induced osteoporosis and promotes osteoblastogenesis by interacting with sodium-glucose cotransporter 2	18
Optimization of a sensitive and reliable UPLC-MS/MS method to simultaneously quantify almonertinib and HAS-719 and its application to study the interaction with nicardipine	18
Ocimum sanctum , Zingiber officinale, and Piper nigrum extracts and their effects on gut microbiota modulations (prebio	18
Prediction of the mechanisms of action of Qutan Huoxue decoction in non-alcoholic steatohepatitis (NASH): a network pharmacology study and experimental validation	18
WDJ-S4 , a standardized herbal formula, promotes gastrointestinal motility via modulation of the acetylcholine pathway in a loperamide-induced functional dyspepsia mice	18
Osteoprotective effect of Achyranthes bidentata root extract on osteoporotic rats: a systematic review and meta-analysis	17
Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis	17
Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light	17
Qushi Huayu decoction attenuated hepatic lipid accumulation via JAK2/STAT3/CPT-1A-related fatty acid β-oxidation in mice with non-alcoholic steatohepatitis	17
Sinisan ameliorates colonic injury induced by water immersion restraint stress by enhancing intestinal barrier function and the gut microbiota structure	17
Treatment with onion bulb extract both prevents and reverses allergic inflammation in a murine model of asthma	17
Isolation, characterisation and complement fixation activity of acidic polysaccharides from Argemone mexicana used as antimalarials in Mali	17
Ginsenoside Rc attenuates myocardial ischaemic injury through antioxidative and anti-inflammatory effects	17
Efficacy of Yougui pill combined with Buzhong Yiqi decoction in alleviating the sexual dysfunction in female rats through modulation of the gut microbiota	17
MicroRNAs from Yishen Tongluo formula can repair sperm DNA damage caused by benzo( a )pyrene	17
Exploring the mechanisms of action of Zengye decoction (ZYD) against Sjogren’s syndrome (SS) using network pharmacology and animal experiment	17
Overview of current research on traditional Chinese medicine in skin disease treatment: a bibliometric analysis from 2014 to 2024	17
(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1	16
Protective effects of vitamin D ₃ (cholecalciferol) on vancomycin-induced oxidative nephrotoxic damage in rats	16
Stachydrine is effective and selective against blast phase chronic myeloid leukaemia through inhibition of multiple receptor tyrosine kinases	16
Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor	16
Kazinol B protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced cardiac injury by modulating the AKT/AMPK/Nrf2 signalling pathway	16
Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription JieZe-1 in protecting against HSV-2 infection	16
Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial	16
Biologically active withanolides from Physalis peruviana	16
Herbal remedies used by traditional healers to treat haemorrhoids in Tabora region, Tanzania	16
PI3K/AKT/SERBP-1 pathway regulates Alisma orientalis beverage treatment of atherosclerosis in APOE ^−/− high-fat diet mice	16
Swertia mussotii prevents high-fat diet-induced non-alcoholic fatty liver disease in rats by inhibiting expression the TLR4/MyD88 and the phosphorylation of NF-κB	16
Morinda officinalis polysaccharide enable suppression of osteoclastic differentiation by exosomes derived from rat mesenchymal stem cells	15
Seed extract of Thai Mucuna pruriens reduced male reproductive damage in rats induced by chronic stress	15
Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment	15
Mechanism of Elian granules in the treatment of precancerous lesions of gastric cancer in rats through the MAPK signalling pathway based on network pharmacology	15
Gut microbiota and metabonomics used to explore the mechanism of Qing’e Pills in alleviating osteoporosis	15
Qingyi granules ameliorate severe acute pancreatitis in rats by modulating the gut microbiota and serum metabolic aberrations	15
Correction	15
Diosgenin protects against cationic bovine serum albumin-induced membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway	15
Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity	15
Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking andin vivoexperimental verification	15