OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Biology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents	71
Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19	47
Kaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1	46
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway	45
Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis	42
Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells	41
Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling	41
Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway	40
Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis	35
Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics	33
Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis	33
Pueraria lobata root polysaccharide alleviates glucose and lipid metabolic dysfunction in diabetic db/db mice	30
Taxifolin, a novel food, attenuates acute alcohol-induced liver injury in mice through regulating the NF-κB-mediated inflammation and PI3K/Akt signalling pathways	28
Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis	26
Identification of the protective effect of Polygonatum sibiricum polysaccharide on d -galactose-induced brain ageing in mice by the sy	26
Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK	24
Eucalyptol ameliorates early brain injury after subarachnoid haemorrhage via antioxidant and anti-inflammatory effects in a rat model	24
Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis	24
Berberine alleviates myocardial ischemia–reperfusion injury by inhibiting inflammatory response and oxidative stress: the key function of miR-26b-5p-mediated PTGS2/MAPK signal transduction	23
Cardioprotective effect of rosmarinic acid against myocardial ischaemia/reperfusion injury via suppression of the NF-κB inflammatory signalling pathway and ROS production in mice	22
Ameliorative effect of chitosan nanoparticles against carbon tetrachloride-induced nephrotoxicity in Wistar rats	20
α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis	20
Folium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating	20
Bioadhesive hydrogel comprising bilirubin/β-cyclodextrin inclusion complexes promote diabetic wound healing	20
Berberine attenuates septic cardiomyopathy by inhibiting TLR4/NF-κB signalling in rats	19

In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity	19
C-Phycocyanin prevents acute myocardial infarction-induced oxidative stress, inflammation and cardiac damage	19
The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk	19
Enhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway	19
Traditional medicines and their common uses in central region of Syria: Hama and Homs – an ethnomedicinal survey	18
Anti-inflammatory action of geniposide promotes wound healing in diabetic rats	18
Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities	18
Gut microbiota and metabonomics used to explore the mechanism of Qing’e Pills in alleviating osteoporosis	17
Curcumin protects rats against gentamicin-induced nephrotoxicity by amelioration of oxidative stress, endoplasmic reticulum stress and apoptosis	17
Hepatoprotective effect of Pandanus odoratissimus seed extracts on paracetamol-induced rats	17
Naoxintong accelerates diabetic wound healing by attenuating inflammatory response	17
Evodiamine protects against airway remodelling and inflammation in asthmatic rats by modulating the HMGB1/NF-κB/TLR-4 signalling pathway	17
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein	16
A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis	16
Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia	16
Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells	16
Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and	15
Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway	15
Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways	15
Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-κB p65 pathway	15
A comprehensive study on the relieving effect of Lilium brownii on the intestinal flora and metabolic disorder in p -chlorphenylalanine in	15
Acacetin alleviates myocardial ischaemia/reperfusion injury by inhibiting oxidative stress and apoptosis via the Nrf-2/HO-1 pathway	15
New insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of Michelia champaca : an in vivo	15
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis	15
Cytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from Jasminum humile	15
Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militar	14
Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis	14
Genistein alleviates H ₂ O ₂ -induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis	14
Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation	14
Pien-Tze-Huang attenuates neuroinflammation in cerebral ischaemia-reperfusion injury in rats through the TLR4/NF-κB/MAPK pathway	13
Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis	13
Kazak faecal microbiota transplantation induces short-chain fatty acids that promote glucagon-like peptide-1 secretion by regulating gut microbiota in db/db mice	13
Protective effects of Forsythiae fructus and Cassiae semen water extract against memory deficits through the gut-microbiome-brain axis in	13
Maculosin, a non-toxic antioxidant compound isolated from Streptomyces sp. KTM18	13
Network pharmacology and in vitro experimental verification to explore the mechanism of Sanhua decoction in the treatment of ischaemic stroke	13
Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action	13
Antithrombotic effects of Huanglian Jiedu decoction in a rat model of ischaemia-reperfusion-induced cerebral stroke	13
Advances for pharmacological activities of Polygonum cuspidatum - A review	13
Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect	13
Effect of Er Miao San on peritoneal macrophage polarisation through the miRNA-33/NLRP3 signalling pathway in a rat model of adjuvant arthritis	13
Echinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress	13
Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling	13
Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway	13
Research progress on the protective effects of aucubin in neurological diseases	12
Mechanism of Elian granules in the treatment of precancerous lesions of gastric cancer in rats through the MAPK signalling pathway based on network pharmacology	12
Evaluation of the inhibitory effect of quercetin on the pharmacokinetics of tucatinib in rats by a novel UPLC–MS/MS assay	12
Astragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages	12
Sanziguben polysaccharides improve diabetic nephropathy in mice by regulating gut microbiota to inhibit the TLR4/NF-κB/NLRP3 signalling pathway	12
Methyl-β-cyclodextrin suppresses the monocyte-endothelial adhesion triggered by lipopolysaccharide (LPS) or oxidized low-density lipoprotein (oxLDL)	12
Hypouricaemic and nephroprotective effects of Poria cocos in hyperuricemic mice by up-regulating ATP-binding cassette super-family G member 2	12

Nanoencapsulation of sulforaphane in broccoli membrane vesicles and their in vitro antiproliferative activity	12
Selenium-containing protein from selenium-enriched Spirulina platensis antagonizes oxygen glucose deprivation-induced neurotoxicity by inhibiting ROS-mediated oxidative	12
Modified BuShenYiQi formula alleviates experimental allergic asthma in mice by negative regulation of type 2 innate lymphoid cells and CD4 ⁺ type 9 helper T cells an	12
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia	12
Deer antler based active ingredients have protective effects on LPS/ d -GalN-induced acute liver injury in mice through MAPK and NF-κB signalling pathways	12
Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling	11
Eriodictyol attenuates dextran sodium sulphate-induced colitis in mice by regulating the sonic hedgehog signalling pathway	11
RETRACTED ARTICLE: Pristimerin inhibits neuronal inflammation and protects cognitive function in mice with sepsis-induced brain injuries by regulating PI3K/Akt signalling	11
Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial	11
Clinacanthus nutans attenuates atherosclerosis progression in rats with type 2 diabetes by reducing vascular oxidative stress and inflammation	11
Isovitexin alleviates acute gouty arthritis in rats by inhibiting inflammation via the TLR4/MyD88/NF-κB pathway	11
Mechanism of allergic rhinitis treated by Centipeda minima from different geographic areas	11
Epigallocatechin-3- O -gallate promotes extracellular matrix and inhibits inflammation in IL-1β stimulated chondrocytes by the PTEN/miRNA-29b pathway	11
The safety and tolerability of alkaloids from Alstonia scholaris leaves in healthy Chinese volunteers: a single-centre, randomized, double-blind, placebo-controlled phas	11
Quercetin improves contrast-induced acute kidney injury through the HIF-1α/lncRNA NEAT1/HMGB1 pathway	11
α-Amylase and dipeptidyl peptidase-4 (DPP-4) inhibitory effects of Melicope latifolia bark extracts and identification of bioactive constituents using in	11
Evaluation of the anti-inflammatory and antioxidant pharmcodynamic compoents of naoxintong capsules as a basis of broad spectrum effects	11
1α, 25-Dihydroxyvitamin D3 protects gastric mucosa epithelial cells against Helicobacter pylori -infected apoptosis through a vitamin D receptor-dependent c-Raf/MEK/ERK	11
Artesunate alleviates the inflammatory response of ulcerative colitis by regulating the expression of miR-155	11
Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses	11
Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis	11
Genistein-induced mitochondrial dysfunction and FOXO3a/PUMA expression in non-small lung cancer cells	10
Anticancer effect of myristicin on hepatic carcinoma and related molecular mechanism	10
M2b macrophages stimulate lymphangiogenesis to reduce myocardial fibrosis after myocardial ischaemia/reperfusion injury	10
Deciphering the molecular mechanism of tetrandrine in inhibiting hepatocellular carcinoma and increasing sorafenib sensitivity by combining network pharmacology and experimental evaluation	10
Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice	10
Paclitaxel induces cognitive impairment via necroptosis, decreased synaptic plasticity and M1 polarisation of microglia	10
Combination of paeoniflorin and calycosin-7-glucoside alleviates ischaemic stroke injury via the PI3K/AKT signalling pathway	10
Anti-neuroinflammatory effects of alkaloid-enriched extract from Huperzia serrata on lipopolysaccharide-stimulated BV-2 microglial cells	10
Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation	10
Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice	10
Schizandrin A ameliorates cognitive functions via modulating microglial polarisation in Alzheimer’s disease mice	9
Effect of Huangqin decoction on regulating intestinal flora in colitis mice characterized as inhibition of the NOD2-dependent pathway	9
Morinda officinalis polysaccharide enable suppression of osteoclastic differentiation by exosomes derived from rat mesenchymal stem cells	9
Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood–brain barrier pathway	9
The effective constituent puerarin, from Pueraria lobata , inhibits the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3	9
Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway	9
Cordycepin mitigates spermatogenic and redox related expression in H ₂ O ₂ -exposed Leydig cells and regulates testicular oxidativ	9
Aucubin slows the development of osteoporosis by inhibiting osteoclast differentiation via the nuclear factor erythroid 2-related factor 2-mediated antioxidation pathway	9
Lappaol F, an anticancer agent, inhibits YAP via transcriptional and post-translational regulation	9
Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats	9
HPLC-UV/HRMS methods for the unambiguous detection of adulterations of Ginkgo biloba leaves with Sophora japonica fruits on an extract lev	9
Comparative study on the gastrointestinal- and immune- regulation functions of Hedysari Radix Praeparata Cum Melle and Astragali Radix Praeparata cum Melle in rats with spleen-qi deficiency, based on	9
Phytochemical and biological activities of some Iranian medicinal plants	9
Phytochemicals with protective effects against acute pancreatitis: a review of recent literature	9
Study on the protective effects of danshen-honghua herb pair (DHHP) on myocardial ischaemia/reperfusion injury (MIRI) and potential mechanisms based on apoptosis and mitochondria	9
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway	9
Ginsenoside Rc attenuates myocardial ischaemic injury through antioxidative and anti-inflammatory effects	9
Antidepressant effects of total alkaloids of Fibraurea recisa on improving corticosterone-induced apoptosis of HT-22 cells and chronic unpredictable mild stress-induced	9
Hepatoprotective effect and metabonomics studies of radix gentianae in rats with acute liver injury	9
Amelioration effects of the soybean lecithin–gallic acid complex on iron-overload-induced oxidative stress and liver damage in C57BL/6J mice	8
Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness	8
The anti-breast cancer property of physcion via oxidative stress-mediated mitochondrial apoptosis and immune response	8
Shenlian extract attenuates myocardial ischaemia-reperfusion injury via inhibiting M1 macrophage polarization by silencing miR-155	8
Therapeutic potential of plant iridoids in depression: a review	8
Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation	8
Osthole exhibits an antitumor effect in retinoblastoma through inhibiting the PI3K/AKT/mTOR pathway via regulating the hsa_circ_0007534/miR-214-3p axis	8
Gastroprotective effects of water extract of domesticated Amauroderma rugosum against several gastric ulcer models in rats	8
Acteoside and ursolic acid synergistically protects H ₂ O ₂ -induced neurotrosis by regulation of AKT/mTOR signalling: from networ	8
Moringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism	8
The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review	8
In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model	8
Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11	8
Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway	8
Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence	8
Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from Inula racemosa	8
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway	8
Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway	8
Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology	8
PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling	8
Myristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K/Akt	8
Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF‐κB signalling to suppress osteoclastogenesis	8
Ocimum sanctum , Zingiber officinale, and Piper nigrum extracts and their effects on gut microbiota modulations (prebio	8
Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models	8
Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas , Cnidium officinale , and Paeo	8
Metabolomics coupled with network pharmacology study on the protective effect of Keguan-1 granules in LPS-induced acute lung injury	8
Bersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells	8
Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression	8
Delphinidin-3- O -glucoside, an active compound of Hibiscus sabdariffa calyces, inhibits oxidative stress and inflammation in rabbits with	8
Sauropus brevipes ethanol extract negatively regulates inflammatory responses in vivo and in vitro by targeting Src, Sy	8