OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Biology is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
XiaoEr LianHuaQinqGan alleviates viral pneumonia in mice infected by influenza A and respiratory syncytial viruses	88
Potential pharmacological quality control markers in the traditional Japanese medicine Hangeshashinto: identifying anti-inflammatory ingredients through a cell-based bioassay and multicomponent analys	82
Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway	74
Modified Zhibai Dihuang pill alleviated urinary tract infection induced by extended-spectrum β-lactamase Escherichia coli in rats by regulating biofilm formation	72
Comparative analysis of in vitro immunomodulatory potential of four Gentiana species	61
Lack of pharmacokinetic interaction between derazantinib and naringin in rats	59
Integrated pharmacoanalysis, bioinformatics analysis, and experimental validation to identify the ingredients and mechanisms of Xiao-Luo-Wan in uterine fibroids treatment	58
Majoon Ushba alleviated IL-17A sensitized keratinocyte ferroptosis via JAK-2-STAT-3 signaling axis and reversed imiquimod induced psoriasiform inflammation	49
Adjuvant potential of Satureja hortensis metabolites with antibiotics against Gram-positive and Gram-negative bacterial strains	47
Protective effect of omega-3 polyunsaturated fatty acids on sepsis via the AMPK/mTOR pathway	47
Design, evaluation, cytotoxic activity, molecular docking, ADMET analysis, and dynamic simulations and the preparation of new isoxazoles, thiazoles, 1,3-thiazines, and thiazolopyrimidines derived from	45
Rarely reported cases of hepatotoxicity associated with turmeric- and curcuminoid-containing dietary supplements: a comprehensive review by USP	41
Dual anti-pseudomonal and resistance-modulatory actions of Sida acuta (Malvaceae) via BamB–OprM targeting: insights from integrated metabolomics, computa	39
Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis	37
Effects of Tiaopi Xiezhuo decoction on constipation and gut dysbiosis in patients with peritoneal dialysis	37
Hyaluronic acid-engineered milk extracellular vesicles to target triple negative breast cancer through CD44	35
Rabdosin B suppresses proliferation of nonsmall cell lung cancer by regulating the SRC/PI3K/AKT signaling pathway	35
Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology	34
Yiqi Wenyang decoction protects against the development of atherosclerosis by inhibiting vascular inflammation	34
Isoalantolactone suppresses gallbladder cancer progression via inhibiting the ERK signalling pathway	34
Medicinal food plants of Sabah (Eastern Malaysia): a source of potential natural products and nutraceuticals for the fight against cancer	33
Indigo naturalis as a potential drug in the treatment of ulcerative colitis: a comprehensive review of current evidence	33
Wubie Fanchun Formula-inducible metabolites in primary ovarian insufficiency model mice that facilitate ovarian renovation	33
Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis	32
Antiproliferative activity, cell-cycle arrest, apoptotic induction and LC-HRMS/MS analyses of extracts from two Linum species	32

Chaihu Shugan San promotes gastric motility in rats with functional dyspepsia by regulating Drp-1-mediated ICC mitophagy	31
Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment	30
Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment	30
Tongmai Yangxin pill alleviates myocardial no-reflow by activating GPER to regulate HIF-1α signaling and downstream potassium channels	30
Paeoniflorin suppresses the apoptosis and inflammation of human coronary artery endothelial cells induced by oxidized low-density lipoprotein by regulating the Wnt/β-catenin pathway	29
Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labour	29
Screening of rosmarinic acid from Salvia miltiorrhizae acting on the novel target TRPC1 based on the ‘homology modelling–virtual screening–molecular docking–affinity ass	28
Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis	28
A triterpene-enriched natural extract from Eucalyptus tereticornis modulates the expression of genes involved in adipogenesis, lipolysis, and extracellul	28
Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents	28
CB001 bioactive compounds mitigate intestinal immune dysregulation induced by simulated microgravity and radiation via B cells modulation	28
The BCL2/BAX/ROS pathway is involved in the inhibitory effect of astragaloside IV on pyroptosis in human umbilical vein endothelial cells	27
Liver protective effect of chloroform extract of Bauhinia purpurea leaves is attributed partly to its antioxidant action and the presence of flavonoids	27
Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model	27
Plantamajoside alleviates acute sepsis-induced organ dysfunction through inhibiting the TRAF6/NF-κB axis	27
Ginsenoside Rb1 reduces oxidative/carbonyl stress damage and ameliorates inflammation in the lung of streptozotocin-induced diabetic rats	27
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways	26
A comprehensive review of antimalarial medicinal plants used by Tanzanians	26
Homogeneous Polyporus polysaccharide exerts anti-bladder cancer effects via autophagy induction	26
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes	26
Chinese herbal compound Huangqin Qingrechubi capsule reduces lipid metabolism disorder and inflammatory response in gouty arthritis via the LncRNA H19/APN/PI3K/AKT casca	25
Chitooligosaccharide prevents vascular endothelial cell apoptosis by attenuation of endoplasmic reticulum stress via suppression of oxidative stress through Nrf2-SOD1 up-regulation	25
Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance	25
Upregulation of claudin‑4 by Chinese traditional medicine Shenfu attenuates lung tissue damage by acute lung injury aggravated by acute gastrointestinal injury	25
Aaptamine – a dual acetyl – and butyrylcholinesterase inhibitor as potential anti-Alzheimer’s disease agent	25
Therapeutic efficacy and pharmacological mechanism of Bailing capsule on chronic obstructive pulmonary disease: a meta-analysis and network pharmacology	25
Effect of Wuzi Yanzong prescription on oligoasthenozoospermia rats based on UPLC-Q-TOF-MS metabolomics	25
Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis	24
(±)-Rutacycoumarins A and B: two pairs of unprecedented coumarin enantiomers from the aerial part of Ruta graveolens L. and chemically synthesized	24
Glucocorticoid receptors involved in ginsenoside compound K ameliorate adjuvant arthritis by inhibiting the glycolysis of fibroblast-like synoviocytes via the NF-κB/HIF-1α pathway	23
Preparation, characterization, and anticancer effects of an inclusion complex of coixol with β-cyclodextrin polymers	23
Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification	23
Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice	23
Hydroethanolic extracts from Bauhinia guianensis : a study on acute toxicity in Zebrafish embryos and adults	23
Characterization of global research trends and prospects on celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F: bibliometric an	23
Assessing potential liver injury induced by Polygonum multiflorum using potential biomarkers via targeted sphingolipidomics	22
Thais savignyi tissue extract: bioactivity, chemical composition, and molecular docking	21
Clinical observations and mechanistic insights of traditional Chinese medicine in the management of diabetic retinopathy	21
Traditional Chinese medicine for breast cancer treatment: a bibliometric and visualization analysis	21
The changes of hepatic bile acid synthesis and transport and bile acids profiles in isopsoralen-induced liver injury C57BL/6J mice	21
Comparative efficacy and safety of Chinese patent medicines as an adjunctive therapy for diabetic peripheral neuropathy: systematic review and network meta-analysis of randomized controlled trials	21
A scoping review of turmeric adulteration based on data from six continents	21
Bombax ceiba flower extract enhances antioxidant defense and wound healing effects in human keratinocytes and fibroblasts	21
Optimization of a sensitive and reliable UPLC-MS/MS method to simultaneously quantify almonertinib and HAS-719 and its application to study the interaction with nicardipine	20
Tormentic acid, a triterpenoid isolated from the fruits of Chaenomeles speciose , protected indomethacin-induced gastric mucosal lesion via modulating mi	20
Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection	20
Dolichandrone serrulata flower improves seminal biochemical parameters and proteins in T2DM rats induced by a high-fat diet and streptozotocin	20
WDJ-S4 , a standardized herbal formula, promotes gastrointestinal motility via modulation of the acetylcholine pathway in a loperamide-induced functional dyspepsia mice	20
Cytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from Jasminum humile	20
Triptolide in renal disorders: dual roles of therapeutic potential and nephrotoxicity: a narrative review	19

Prediction of the mechanisms of action of Qutan Huoxue decoction in non-alcoholic steatohepatitis (NASH): a network pharmacology study and experimental validation	19
Rongjin Niantong Fang ameliorates cartilage degeneration by regulating the SDF-1/CXCR4-p38MAPK signalling pathway	19
Qushi Huayu decoction attenuated hepatic lipid accumulation via JAK2/STAT3/CPT-1A-related fatty acid β-oxidation in mice with non-alcoholic steatohepatitis	19
Morroniside ameliorates glucocorticoid-induced osteoporosis and promotes osteoblastogenesis by interacting with sodium-glucose cotransporter 2	19
Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis	19
Osteoprotective effect of Achyranthes bidentata root extract on osteoporotic rats: a systematic review and meta-analysis	19
Treatment with onion bulb extract both prevents and reverses allergic inflammation in a murine model of asthma	19
Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light	18
PI3K/AKT/SERBP-1 pathway regulates Alisma orientalis beverage treatment of atherosclerosis in APOE ^−/− high-fat diet mice	18
Swertia mussotii prevents high-fat diet-induced non-alcoholic fatty liver disease in rats by inhibiting expression the TLR4/MyD88 and the phosphorylation of NF-κB	18
Exploring the mechanisms of action of Zengye decoction (ZYD) against Sjogren’s syndrome (SS) using network pharmacology and animal experiment	18
Sinisan ameliorates colonic injury induced by water immersion restraint stress by enhancing intestinal barrier function and the gut microbiota structure	18
Hepatotoxicity of dietary supplements containing Garcinia gummi-gutta (L.) N. Robson	18
Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial	18
The effect of provenance and species on the chemical composition of Epilobium herbal tea	18
MicroRNAs from Yishen Tongluo formula can repair sperm DNA damage caused by benzo( a )pyrene	17
Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for CO	17
Herbal remedies used by traditional healers to treat haemorrhoids in Tabora region, Tanzania	17
Therapeutic potential of Asiaticoside in wound healing after endoscopic submucosal dissection (ESD)	17
Overview of current research on traditional Chinese medicine in skin disease treatment: a bibliometric analysis from 2014 to 2024	17
(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1	17
Kazinol B protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced cardiac injury by modulating the AKT/AMPK/Nrf2 signalling pathway	17
Qingyi granules ameliorate severe acute pancreatitis in rats by modulating the gut microbiota and serum metabolic aberrations	17
Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor	17
Diosgenin protects against cationic bovine serum albumin-induced membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway	17