OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Bioscience and Bioengineering is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Effects of genome instability of parental CHO cell clones on chromosome number distribution and recombinant protein production in parent-derived subclones	76
Deletion of Aspergillus nidulans cpsA/rseA induces increased extracellular hydrolase production in solid-state culture partly through the high osmolarity glycerol pathway	71
Establishment of a novel cell line, CHO-MK, derived from Chinese hamster ovary tissues for biologics manufacturing	55
Blending of selected yeast extract and peptone for inducible and constitutive protein production in Escherichia coli using the pET system	42
Simultaneous production of cellobiose and xylobiose from alkali-treated bagasse using cellulase secreted by Fe-ion-irradiated Trichoderma reesei mutant	41
Synergistic effect of glucagon-like peptide-1 analogue liraglutide and ZnO on the antibacterial, hemostatic, and wound healing properties of nanofibrous dressings	41
Hapten-labeled fusion-polymerase chain reaction of multiple marker genes for the application of immunochromatographic test	37
Selection of methanotrophic platform for methanol production using methane and biogas	30
Effect of yeast chromosome II aneuploidy on malate production in sake brewing	29
Three 4-monosubstituted butyrolactones from a regulatory gene mutant of Streptomyces rochei 7434AN4	29
Metabolomics approach to elucidate the importance of count size in commercial penaeid shrimps: white leg shrimp (Litopenaeus vannamei) and black tiger shrimp (Penaeus monodon)	29
Effect of humic acid on aerobic denitrification by Achromobacter sp. strain GAD-3	28
Suppression of Alternaria brassicicola infection by volatile compounds from spent mushroom substrates	27
Developing a simple activity test to estimate nitrous oxide production from sewage treatment	27
Production and evaluation of enzyme-modified cheese adding protease or lipase to improve quality properties	26
Novel promoter of Pseudozyma antarctica exhibits stable glucose-mediated activation and copper-mediated suppression of flanking genes	25
Soft-sensor development for monitoring the lysine fermentation process	25
Identification and characterization of a chc gene cluster responsible for the aromatization pathway of cyclohexanecarboxylate degradation in Sinomonas cyclohexanicum ATCC 51369	24
Fermentation of rose residue by Lactiplantibacillus plantarum B7 and Bacillus subtilis natto promotes polyphenol content and beneficial bioactivity	24
Bioconversion of C20- and C22-polyunsaturated fatty acids into 9S,15S- and 11S,17S-dihydroxy fatty acids by Escherichia coli expressing double-oxygenating 9S-lipoxygenase from Sphingopyxis macrogoltab	23
Non-coating method for non-adherent cell culture using high molecular weight dextran sulfate and bovine serum albumin	22
Potassium ion leakage impairs thermotolerance in Corynebacterium glutamicum	22
Chemicals behind the use of Strombus tricornis opercula in traditional sudanese perfumery and medicine	21
Catalytic potential of a fungal indole prenyltransferase toward β-carbolines, harmine and harman, and their prenylation effects on antibacterial activity	21
Metagenomic profiling of antibiotic resistance genes and their associations with the bacterial community along the Kanda River, an urban river in Japan	20

Whole-genome sequence and characterization of a marine red yeast, Rhodosporidium sphaerocarpum GDMCC 60679, featuring the assimilation of ammonia nitrogen	20
Drug in adhesive transdermal patch containing antibiotic-loaded solid lipid nanoparticles	20
Triacetic acid lactone production using 2-pyrone synthase expressing Yarrowia lipolytica via targeted gene deletion	20
Preparation and performance of biocompatible gadolinium polymer as liver-targeting magnetic resonance imaging contrast agent	19
Coculture model of a liver sinusoidal endothelial cell barrier and HepG2/C3a spheroids-on-chip in an advanced fluidic platform	19
Longitudinal gut mycobiota changes in Japanese infants during first three years of life	19
Effect of sodium metabisulfite treatment and storage condition on metabolic profile of young coconut (Cocos nucifera L.)	19
Achyranthes bidentate extracts protect the IL-1β-induced osteoarthritis of SW1353 chondrocytes	19
Environmental factors drive microbial community succession in biofortified wheat Qu and its improvement on the quality of Chinese huangjiu	18
Identification of tryptophanase from Escherichia coli for the synthesis of S-allyl-l-cysteine and related S-substituted cysteine derivatives	18
Aspergillus oryzae FaeA is responsible for the release of ferulic acid, a precursor of off-odor 4-vinylguaiacol in sake brewing	18
Development of Monascus purpureus monacolin K-hyperproducing mutant strains by synchrotron light irradiation and their comparative genome analysis	18
Succession of microbial community of the pit mud under the impact of Daqu of Nongxiang Baijiu	18
Application of gas chromatography-mass spectrometry-based metabolomics in food science and technology	17
Insight investigation into the response pattern of microbial assembly succession and volatile profiles during the brewing of sauce-flavor baijiu based on bioaugmentation	17
Development of a simple cultured cell–anaerobic microbial co-culture system using liquid paraffin	17
Application of peptide barcoding to obtain high-affinity anti-PD-1 nanobodies	17
Intraspecific comparison of mitochondrial genomes reveals the evolution in medicinal fungus Ganoderma lingzhi	17
Current advancements in systems and synthetic biology studies of Saccharomyces cerevisiae	16
Creation of a novel lipid-trehalose derivative showing positive interaction with the cell membrane and verification of its cytoprotective effect during cryopreservation	16
Effect of hydrothermal treatment on organic matter degradation, phytotoxicity, and microbial communities in model food waste composting	16
Microbial glycosylation of antitubercular agent chlorflavonin	16
Mechanisms of production and control of acetate esters in yeasts	16
Novel transgenic Chlamydomonas reinhardtii strain with retargetable genomic transgene integration using Cre-loxP system	16
Yeast diversity during the spontaneous fermentation of wine in a winery and in a laboratory using sterilized equipment	16
Exosomes for hair growth and regeneration	16
Comparison of a new peak detection function for selecting a phase-appropriate multi-attribute method system	16
Promotion of a green economy with the palm oil industry for biodiversity conservation: A touchstone toward a sustainable bioindustry	16
High accumulation of the Man5GlcNAc2 structure by combining N-acetylglucosaminyltransferase I gene suppression and mannosidase I gene overexpression in Nicotiana tabacum SR1	16
Genomic analysis of Paenibacillus macerans strain I6, which can effectively saccharify oil palm empty fruit bunches under nutrient-free conditions	15
The bio3 mutation in sake yeast leads to changes in organic acid profiles and ester levels but not ethanol production	15
Galactosylation of cell-surface glycoprotein required for hyphal growth and cell wall integrity in Schizosaccharomyces japonicus	15
Production of GABA-enriched tomato juice by Lactiplantibacillus plantarum KB1253	15
One-pot synthesis of fibrillar-shaped functional nanomaterial using microbial transglutaminase	14
Hypoxia transactivates cholecystokinin gene expression in 3D-engineered muscle	14
Sequence features around cleavage sites are highly conserved among different species and a critical determinant for RNA cleavage position across eukaryotes	14
Characterization of the bacterial community structure in traditional Gifu ayu-narezushi (fermented sweetfish)	14
Anti-microbial, anti-oxidant and wound healing capabilities of Aloe vera-incorporated hybrid nanoflowers	14
Generation of a plasmid series for rapid sub-cloning and use in various Enterobacteriaceae	14
Identification and characterization of bacteriocin biosynthetic gene clusters found in multiple bacteriocins producing Lactiplantibacillus plantarum PUK6	14
Combinational manipulation of transcription factors, CreA and ClbR, is a viable strategy to improve cellulolytic enzyme production in Aspergillus aculeatus	14
Effects of fatty acid synthase-inhibitors on polyunsaturated fatty acid production in marine diatom Fistulifera solaris JPCC DA0580	14
Effect of S-adenosyl-methionine accumulation on hineka odor in sake brewed with a non-Kyokai yeast	13
Roles of water in improved production of mycelial biomass and lignocellulose-degrading enzymes by water-supply solid-state fermentation of Ganoderma lucidum	13
Characterization of unique EDTA-insensitive methylthioalkylmalate synthase from Eutrema japonicum and its potential application in synthetic biology	13
Characteristics of kopyor coconut (Cocos nucifera L.) using sensory analysis and metabolomics-based approach	13
Generation of novel respiratory syncytial virus vaccine candidate antigens that can induce high levels of prefusion-specific antibodies	13
Bacterial removal using liposomes and an anionic adsorber	13
Gel-in-water nanodispersion for potential application in intravenous delivery of anticancer drugs	12
Biotransformation-guided purification of a novel glycoside derived from the extracts of Chinese herb Baizhi	12

Identification of 2-furanmethanethiol contributing to roast aroma in honkaku shochu and awamori	12
Enhancing intracellular NADPH bioavailability through improving pentose phosphate pathway flux and its application in biocatalysis asymmetric reduction reaction	12
Domain structure and function of α-1,3-glucanase Agl-EK14 from the gram-negative bacterium Flavobacterium sp. EK-14	12
Optimization of bacteriophage propagation in high-yield continuous culture (cellstat) meeting the constraints of industrial manufacturing processes	12
Role of low-level alternating current and impedance for enhancing microalgae biomass and lipid production	12
Bioinformatics in bioscience and bioengineering: Recent advances, applications, and perspectives	12
Topical delivery of gel-in-oil emulsion cocktail with growth factors for the treatment of diabetic pressure ulcers	11
Immobilization of nitrifying bacteria on composite based on polymers and eggshells for nitrate production	11
Hypoxia-responsive expression of vascular endothelial growth factor for induction of angiogenesis in artificial three-dimensional tissues	11
Reduction of the alcohol-stimulative taste of Japanese pot-distilled spirits	11
Enhancing synthesis of ethyl lactate in rice baijiu fermentation by adding recovered granular cells	11
Elucidation of d-allulose recognition mechanism in ketose 3-epimerase	11
Highly genomic instability of super-polyploid strains of Saccharomyces cerevisiae	11
Overexpression of the DHA1 family, ChlH and ChlK, leads to enhanced dicarboxylic acids production in koji fungi, Aspergillus luchuensis mut. kawachii and Aspergillus oryzae	11
Isolation of arginine deiminase system-deficient mutants of Tetragenococcus halophilus using arginine analog canavanine	11
Peptide array screening with anti-GLP-1 monoclonal antibody: Discovery of cysteine-containing DPP-IV inhibitory peptides	11
Isolation and characterization of koji mold (Aspergillus oryzae) from nature in Niigata	11
Expansion of human mesenchymal stem cells on poly(vinyl alcohol) microcarriers	11
Isolation of aflatoxin biosynthetic inhibitor from Chondrostereum purpureum mushroom culture filtrate	11
Role of bacterial community succession in flavor formation during Sichuan sun vinegar grain (Cupei) fermentation	11
Development of a gel-in-oil emulsion as a transdermal drug delivery system for successful delivery of growth factors	10
Regulation of alcohol oxidase gene expression in methylotrophic yeast Ogataea minuta	10
Correction of substitution, deletion, and insertion mutations by 5′-tailed duplexes	10
Cell-penetrating activity of a short-chain ε-poly-l-α-lysine	10
Control of carbon dioxide concentration in headspace of multiple flasks using both non-electric bellows pump and shaking incubator	10
History of hair analysis by mass spectrometry imaging	10
Characterization of five Indonesian mangoes using gas chromatography–mass spectrometry-based metabolic profiling and sensory evaluation	10
Characterization of Zymomonas mobilis promoters that are functional in Escherichia coli	10
Efficient yeast breeding using a sake metabolome analysis for a strain evaluation	10
Enrichment of thermophilic methanogenic microflora from mesophilic waste activated sludge for anaerobic digestion of garbage slurry	10
Functional analysis of a putative type III polyketide synthase from deep-sea sediment metagenome	10
Identification and characterization of rabbit scFv antibodies suitable for immuno-affinity separation of recombinant human kynureninase from Escherichia coli cell lysate	10
Biomimetic conjugation inspired from pheomelanin via thiol–quinone addition for enzymatic functionalization of fibroin	10
In-situ collagen mineralization modulates metastatic properties of breast cancer cells	10
Quantification of leuco-indigo in indigo-dye-fermenting suspension by normal pulse voltammetry	10
Characterization of entrapment behavior of polyphenols in nanostructured lipid carriers and its effect on their antioxidative activity	9
Beneficial effect of optimizing the expression balance of the mevalonate pathway introduced into the mitochondria on terpenoid production in Saccharomyces cerevisiae	9
Efficient production and characterization of soluble active human β-1,2-N-acetylglucosaminyltransferase II in bacteria	9
Recent advances in animal cell technologies for industrial and medical applications	9
Ergothioneine production by Corynebacterium glutamicum harboring heterologous biosynthesis pathways	9
Selective and high-yield production of ethyl α-d-glucopyranoside by the α-glucosyl transfer enzyme of Xanthomonas campestris WU-9701 and glucose isomerase	9
Controlling the carbon flux between glycolysis and the pentose phosphate pathway via targeted protein degradation in Corynebacterium glutamicum	9
Potato pomace: An efficient resource for Monascus pigments production through solid-state fermentation	9
Characterization and application of Lachancea thermotolerans isolates for sake brewing	9
Prediction of antibody production performance change in Chinese hamster ovary cells using morphological profiling	9
Recent advances in single-cell RNA sequencing of bacteria: Techniques, challenges, and applications	9
Hydrogen-producing conditions and mutation mechanisms of a highly efficient mutant strain Ethanoligenens harbinense YR-3	9
Recent advances in plant-based bioproduction	9
Enhanced recovery of astaxanthin from recombinant Kluyveromyces marxianus with ultrasonication-assisted alcohol/salt aqueous biphasic system	9
Modeling the sake brewing characteristics of rice from brown rice metabolites	9
High cellulolytic potential of the Ktedonobacteria lineage revealed by genome-wide analysis of CAZymes	9
Rapid and marker-free gene replacement in citric acid-producing Aspergillus tubingensis (A. niger) WU-2223L by the CRISPR/Cas9 system-based genome editing technique using DNA fragments encoding sgRNAs	9
Gene identification and enzymatic characterization of the initial enzyme in pyrimidine oxidative metabolism, uracil-thymine dehydrogenase	8
Nitrite is reduced by nitrite reductase NirB without small subunit NirD in Escherichia coli	8
Different traits for cold tolerance of extremely thermophilic Calditerricola strains isolated from mesothermal municipal sewage sludge and its hyperthermal compost	8
Osteogenic effect of polymethyl methacrylate bone cement with surface modification of lactoferrin	8
Biochemical characterization of l-asparagine synthetase from Streptococcus thermophilus and its application in the enzymatic synthesis of β-aspartyl compounds	8
Expression of His-tagged NADPH-dependent acetoacetyl-CoA reductase in recombinant Escherichia coli BL-21(DE3)	8
Triple gene expressions in yeast, Escherichia coli, and mammalian cells by transferring DNA fragments amplified from a mother yeast expression plasmid	8
Silica adsorption tag derived from the silica polycondensation protein glassin for the immobilization of soluble proteins	8
Expression of heterochromatin protein 1 affects citric acid production in Aspergillus luchuensis mut. kawachii	8
Corrigendum to ‘Metabolomic insight into the synergistic mechanism of action of a bacterial consortium in plant growth promotion’ [J. Biosci. Bioeng. 134 (5) (2022) 399–406]	8
Discovery of long-chain polyamines embedded in the biosilica on the Bacillus cereus spore coat	8
Genome editing by miniature CRISPR/Cas12f1 enzyme in Escherichia coli	8
Expansion of omega-3 polyunsaturated fatty acid metabolism of the oleaginous diatom Fistulifera solaris by genetic engineering	8
Analysis of bacterial flora of indigo fermentation fluids utilizing composted indigo leaves (sukumo) and indigo extracted from plants (Ryukyu-ai and Indian indigo)	8
Semi-wet methanogen cathode composed of oak white charcoal for developing sustainable microbial fuel cells	8
Construction of a fusion protein consisting of α-1,3-glucan-binding domains and tetrameric red fluorescent protein, which is involved in the aggregation of α-1,3-glucan and inhibition of fungal biofil	8
Superior high-efficiency and high-throughput volatile flavor extraction of Japanese fermented seasonings by solvent-assisted stir bar solid extraction with reverse extraction	8
Optimization of tyrosol-producing pathway with tyrosine decarboxylase and tyramine oxidase in high-tyrosine-producing Escherichia coli	8
Decolorization of cationic dyes under alkaline conditions by Iodidimonas sp. Q-1 multicopper oxidase	8
Key media microsupplements for boosting de novo lipogenesis in an oleaginic yeast isolate	8
Extra copy of the mitochondrial cytochrome-c peroxidase gene confers a pyruvate-underproducing characteristic of sake yeast through respiratory metabolism	8
Optimizing in vitro expression balance of central dogma-related genes using parallel reaction monitoring	8
Analysis of nitrogen source assimilation in industrial strains of Aspergillus oryzae	8