Current Drug Metabolism

Article	Citations
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats	26
Novel Techniques and Models for Studying Drug Metabolism and Transport	26
Potential Alteration of Rifampicin’s Bioavailability by Phyllanthus niruri Supplementation in Tuberculosis Therapy	24
In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor	24
Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery	20
HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations	19
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats	19
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism	17
Theoretical Evaluation of Oleocanthal Reactive Centers	16
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview	16
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke	15
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme	14
Targeting Metabolic Dysregulation in Alzheimer's Disease: A Potential Therapeutic Strategy	14
Meet the Section Editor	13
Interactions Between Meropenem and Renal Drug Transporters	13
Tacrolimus, Cytochrome P450, Interactions with Food Variables in Organ Transplant Recipients; A Current and Comprehensive Review	12
Regulation of Gut Microbiota by Herbal Medicines	12
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review	12
Urine Metabolites as a Predictor of Warfarin Response Based on INR in Atrial Fibrillation	12
Influence of Zhuanggu Guanjie Pill on Seven Cytochrome P450 Enzymes Based on Probe Cocktail and Pharmacokinetics Approaches	11
Meet the Associate Editorial Board Member	11
Nucleic Acid Nanomaterials: Biostability and Applications	10
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases	10
Meet the Associate Editor	10
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism	10

Suppression of Melanoma Growth in a Murine Tumour Model Using Orthosiphon stamineus Benth. Extract Loaded in Ethanolic Phospholipid Vesicles (Spherosome)	10
Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities	10
Pharmacokinetic Interaction between Imatinib and Tacrolimus in Rats	9
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies	9
Meet the Editorial Board Member	9
Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates	9
Meet the Associate Editor	9
The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease	8
Development of Transdermal Drug Delivery Approaches to Combat Diabetes: An Update	8
Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol	8
Circadian Timekeeping in Anticancer Therapeutics: An Emerging Vista of Chronopharmacology Research	8
The Magic of Drug Targeting Is “Secretly” Tied to Optimal Drug Distribution and Exposure	8
Rapid and Comprehensive Identification of Vincosamide Metabolites in vitro and in vivo in Rats by Ultra-High Performance Liquid Chromatography-Quadrupole- Exactive Orbitrap-High Resolution Mass Spectr	8
Relevance of ABC Transporters in Drug Development	8
Meet the Editorial Board Member	7
Genetic Testing is Superior Over Endogenous Pharmacometabolomic Markers to Predict Safety of Haloperidol in Patients with Alcohol-induced Psychotic Disorder	7
The Metabolic Pathways and Products of Ten Aconitum Alkaloids in Sanwujiao Pills from Eight Organs of Mice by UHPLC-Q-TOF-MS/MS	7
Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries	7
Nanostructured Therapeutic Systems of PUFAs for the Treatment of Glioblastoma Multiforme	7
Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog	7
Corrigendum To: Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	7
Influence of Orange Oil on Skin Permeability, Dermatokinetics, and In Vivo Anti-inflammatory Properties of Lornoxicam-loaded Niosomal Gel	7
Effects of Fasting andPhoenix dactyliferaon the Expression of Major Drug- Metabolizing Enzymes in the Mouse Livers	7
Worldwide Prevalence of Polypharmacy: A Systematic Review	7
Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients	7
Comparative Analysis of Pharmacokinetics and Metabolites of Three Main Terpenoids before and after Compatibility of Frankincense and Myrrh in Rats by UHPLC-MS	7
Meet the Editorial Board Member	7
Research Progress of Epigenetic Modification on the Regulation of Transporters Under Hypoxia	7
Meet the Co-Editor	6
Orchestration of Obesolytic Activity of Microbiome: Metabiotics at Centre Stage	6
Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Rats	6
The Impact of Certain Pharmacogenetic Differences on the Metabolism of Antiretroviral Drugs Used in A Black South African Population	6
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction	6
Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes	6
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling it up to Rats, Dogs, and Humans	6
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites	6
Natural Compounds as Potential Therapeutics for Pancreatic Cancer: A Narrative Review	6
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis	6
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae Semen with Hepatoprotective Effects	6
Study on the Relationship between Rivaroxaban and Factor Xa Activity in Blood Based on HPLC-MS/MS	6
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	6
Comparative In Vitro Metabolic Profile Study of Five Cathinone Derivatives	6
Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice	6
Gut Microbiota as the Potential Mechanism to Mediate Drug Metabolism Under High-altitude Hypoxia	6
Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9	5
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole- Orbitrap High-Resolution Accurate Mass Spe	5
Application of Physiologically Based Pharmacokinetic Modeling in the Research of Anti-HIV Drugs	5
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study	5
Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals	5
An Efficient Integrated Strategy for Comprehensive Metabolite Profiling of Sakurasosaponin from Aegiceras corniculatum in Rats	5

Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	5
Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction	5
Machine Learning in Drug Metabolism Study	5
Quality by Design Approach for the Development of Cariprazine Hydrochloride Loaded Lipid-Based Formulation for Brain Delivery via Intranasal Route	5
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines	5
The Application of Artificial Intelligence in Drug ADME Research	5
Evaluation of Alterations in DNA Methylation of CYP3A4 Gene Upstream Regulatory Elements in Gastric Cancer and in Response to Diazinon Treatment	5
Pharmacokinetics and Tissue Distribution of Isovitexin-2''-O-β-D-glucopyranoside (IVG) in Sprague-Dawley Rats	5
miRNAs in SARS-CoV-2 Infection: An Update	5
Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia	5
Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research	4
Acknowledgement to Reviewers	4
Pain Allaying Epalrestat-Loaded Lipid Nanoformulation for the Diabetic Neuropathic Pain Interventions: Design, Development, and Animal Study	4
Quality by Design-Steered Development of Stealth Liposomal Formulation of Everolimus: A Systematic Optimization and Evaluation	4
An Explicative Review on Nanotechnology-based Drug Delivery Systems for Alleviating Oxidative Stress-driven Pathologies	4
Effect of Wuzhi Capsule (WZC) on the Pharmacokinetics of Tacrolimus in Renal Transplantation Recipients	4
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update	4
Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats	4
Nanotechnological Approaches for the Treatment of Triple-Negative Breast Cancer: A Comprehensive Review	4
Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects	4
Impact of POR*28 Variant on Tacrolimus Pharmacokinetics in Kidney Transplant Patients with Different CYP3A5 Genotypes	4
Comprehensive Insights into Licochalcone A: its Distribution, Biosynthesis, Metabolism, and Pharmacological Effects	4
Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study	4
Meet the Editorial Board Member	4
Meet the Regional Editor	4
Development and Validation of a Sensitive UPLC-Q-TOF-MS/MS for the Measurement of Nine Components in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Studies with	4
Differential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice	4
The Metabolism of the New Benzodiazepine Remimazolam	4
DNA-based Nanomaterials in the Immunotherapy	4
In Silico Tools to Thaw the Complexity of the Data: Revolutionizing Drug Research in Drug Metabolism, Pharmacokinetics and Toxicity Prediction	4
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism	4
Umbelliferone Enhances Immune Function in Cyclophosphamide-Induced Immunosuppressed Mice via Histidine and Purine Metabolism Regulation	4
Framework Nucleic Acids: A Promising Vehicle for Small Molecular Cargos	3
Metabolic Pathway of Osilodrostat in Equine Urine Established through High-resolution Mass Spectrometric Characterization for Doping Control	3
Pharmacokinetic Drug-Drug Interactions Involving Antiretroviral Agents: An Update	3
A Phase I Clinical Study of the Pharmacokinetics and Safety of Prusogliptin Tablets in Subjects with Mild to Moderate Hepatic Insufficiency and Normal Liver Function	3
Mass Balance and Metabolic Profiling of Avacopan, a Selective C5a Receptor 1 Antagonist, in Healthy Humans	3
Inhibition of Cytochrome P450 Enzyme and Drug-Drug Interaction Potential of Acid Reducing Agents Used in Management of CDK Inhibitors for Breast Cancer Chemotherapy	3
Design and Construction of Carboxylesterase 2c Gene Knockout Rats by CRISPR/Cas9	3
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery	3
Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9)	3
Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide	3
Advances in Controlled Release Formulations for Ocular Diseases: Improving Patient Compliance and Therapeutic Outcomes	3
Comparative Study of Binding Pockets in Human CYP1A2, CYP3A4, CYP3A5, and CYP3A7 with Aflatoxin B1, a Hepato-Carcinogen, by Molecular Dynamics Simulation & Principal Component Analysis	3
Meet the Editorial Board Member	3
Meropenem for the Pharmacological Treatment of Severe Infections in Critically Ill Pediatric Patients: Breakthrough Standard Treatment Strategies Based on PK/PD	3
Comprehensive Investigation of the Influence of High-Altitude Hypoxia on Clopidogrel Metabolism and Gut Microbiota	3
Comparative Pharmacokinetics of Intravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep	3
Transcriptomic and Proteomics Analysis of a Lipid-Loaded HepaRG Model for Steatosis Reveals Altered Regulation in Lipid and Xenobiotic Metabolism	3
Advances in Nanomedicine: Transforming Diagnostic Imaging with Novel Contrast Agents	2
Nanomedicine for Cancer: Targeted Therapy, Vaccination, Pharmacokinetics, and Challenges	2
Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Prediction	2
Elevated Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Predict Drug-Induced Acute Kidney Injury	2
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice	2
Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD	2
Study on Cytochrome P450 Metabolic Profile of Paclitaxel on Rats using QTOF-MS	2
Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review	2
Meet the Associate Editor	2
Amino Acid and Biogenic Amine Adductions Derived from Reactive Metabolites	2
In-vitro and In-vivo Identification, Absorbtion and Metabolism Network Analysis of Filifolium sibiricum Flavonoids Dropping Pill by UHPLC-Q-TOF-MS	2
Factors Influencing ADME Properties Of Drugs: Advances and Applications (Part II)	2
TOX4 Inhibition in Chronic Hyperglycemia: Effects on Glycation Stress, Hepatic Protection, Epigenetic Mechanisms, Signaling Pathways, and Beta Cell Dynamics	2
Pharmacokinetics-based Chronotherapy	2
Review of the Clinical Pharmacokinetics, Efficacy and Safety of Pembrolizumab	2
Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition	2
m6A Modified-CYP1B1 Promotes HCC Cell Proliferation by Inhibiting Ferroptosis	2
Characterization of Dicaffeoylspermidine Derivatives from Wolfberry as Potent and Selective Inhibitors of Human Cytochrome P450 46A1 In vitro	2
UPLC-LTQ-Orbitrap Study on Rat Urinary Metabolites of 5-Methoxy-Alpha-Methyltryptamine	2
A Population Pharmacokinetics Model of Busulfan in Pediatric Patients with Thalas-semia Major	2
Bioactive Herbs for Liver Disorders: A Phyto-Pharmacological Review	2
Meet the Editorial Board Member	2
Meet the Associate Editor	2
Comparative Pharmacokinetics of Scoparone and its Metabolite Scopoletin in Normal and ANIT-induced Intrahepatic Cholestatic Rats	2
Hepatic Metabolic Enzyme Activity with Endogenous Substances-Current Status, Challenges and Limitations	2
A Comparative Study on Sedation Efficacy Between General and Regional Anesthesia with Dexmedetomidine in Patients Under Maxillofacial Surgery	2
Interaction of Intestinal Microbiota with Medications	2
Synthesis and Antimicrobial Activity of Silver/Copper Oxide/Clay HybridNanocomposites Against Gram-Positive and Gram-Negative Bacteria	2
Physiologically Based Pharmacokinetic Model for Older Adults and Its Application in Geriatric Drug Research	2
Rapid Chemical Profiling of Compound Huanggen Granules and Absorbed Prototypes in Cynomolgus Monkey Plasma by Integrating UHPLC-Q-TOF-MSE Method and Data Post-Processing Strategy	2
Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer's, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System	2

Acknowledgements to Reviewers	1
A Randomized Trial of Short-term Treatment with Folic Acid to Reduce the Oxidative Stress of Patients with Chronic Kidney Disease	1
Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes	1
Artificial Intelligence in Drug Formulation and Development: Applications and Future Prospects	1
A Review on Drug-Metabolizing Enzymes, Transporters, and Gut Microbiota on Pharmacokinetics in High-Altitude Environment	1
A Cross-sectional Comparative Analysis of Eleven Population Pharmacokinetic Models for Docetaxel in Chinese Breast Cancer Patients	1
Effect of Atorvastatin on Single Oral Pharmacokinetics and Safety of Daclatasvir in Rats: Emphasis on P-glycoprotein and Cytochrome P450	1
Evaluation of Intracellular Metabolism of Methotrexate in Hepatocytes and Embryonic Kidney Cells based on Folylpolyglutamate Synthetase and Gamma-Glutamyl Hydrolase Expression	1
Identification of the Metabolites of Scutebarbatine A in Rat Plasma, Bile, Urine, and feces by Using Ultra-high-performance Liquid Chromatography Coupled with Q Exactive Hybrid Quadrupole-orbitrap Hig	1
Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients	1
Physiologically-Based Pharmacokinetic Modeling of Tenofovir Disoproxil Fumarate in Pregnant Women	1
Targeting the Pathological Hallmarks of Alzheimer’s Disease Through Nanovesicleaided Drug Delivery Approach	1
Disposition Kinetics of Cathinone and its Metabolites after Oral Administration in Rats	1
Acknowledgement to Reviewers	1
Characterization of Five Natural Anthraquinone Compounds as Potent Inhibitors against CYP1B1: Implications for Cancer Treatment	1
Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats	1
Ceftobiprole and Cefiderocol for Patients on Extracorporeal Membrane Oxygenation: The Role of Therapeutic Drug Monitoring	1
Where will Medicines that Serve the Global South and Economically Disadvantaged People Come From?	1
Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations	1
No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects	1
Unveiling the Interplay: Antioxidant Enzyme Polymorphisms and Oxidative Stress in Preterm Neonatal Renal and Hepatic Functions	1
Biopharmaceutical Factors Involved in the Disposition of Mycophenolic Acid: A Comprehensive Review of ADME Properties and Their Potential Impact on Mycophenolic Acid Plasma Exposure	1
Drug-Protein Interactions Prediction Models Using Feature Selection and Classification Techniques	1
A Data Mining Approach on Polypharmacy and Drug-drug Interactions of Common Diabetes Medications	1
The Promising Role of Natural Exosomal Nanoparticles in Cancer Chemoimmunotherapy	1
Meet the Editorial Board Member	1
Meet the Editorial Board Member	1
Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic	1
Biomimetic Nanoscale Systems for Targeted Delivery in Cancer: Current Advances and Future Prospects	1
Metabolic Stability and Metabolite Identification of CYP450 Probe Substrates in Ferret Hepatocytes	1
State-of-the-art Application of Artificial Intelligence to Transporter-centered Functional and Pharmaceutical Research	1
Herbal Medicines as Adjuvants for the Treatment of Chemotherapy-Induced Diarrhea	1
Comprehensive Analysis of Chemical Ingredients of Waiganfengsha Granule and Absorbed Components in Rat Plasma Based on UHPLC-Q-TOF-MS	1
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model	1
Emerging Approaches in Data-Driven Drug Discovery for Rare Diseases	1
Phytofabricated Nanoparticle Formulation for Cancer Treatment: A Comprehensive Review	1
A Mini-review on Recent Strategies and Applications of Nanomedicines to Combat Antimicrobial Resistance	1