Current Drug Metabolism

Article	Citations
Safe and Effective Kinase Inhibitors for the Treatment of Gynecological Cancers: In Silico Approach	66
The Role of CYPs and Transporters in the Biotransformation and Transport of the Anti-hepatitis C Antiviral Agents Asunaprevir, Daclatasvir, and Beclabuvir: Impact of Liver Disease, Race and Drug-drug	21
The Metabolism of the New Benzodiazepine Remimazolam	20
Metabolic Stability and Metabolite Identification of CYP450 Probe Substrates in Ferret Hepatocytes	18
Stability of Ketoprofen Methylester in Plasma of Different Species	16
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans	16
Recent Insights into Nano-mediated siRNA Drug Delivery	16
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview	15
Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism	15
Novel Techniques and Models for Studying Drug Metabolism and Transport	15
Meet the Editorial Board Member	15
Evaluation of Dermorphin Metabolism Using Zebrafish Water Tank Model and Human Liver Microsomes	15
Nanocrystals: An Approachable Delivery System for Anticancer Therapeutics	14
The Impact of Certain Pharmacogenetic Differences on the Metabolism of Antiretroviral Drugs Used in A Black South African Population	13
Theoretical Evaluation of Oleocanthal Reactive Centers	13
Altitude effect on Propofol Pharmacokinetics in Rats	13
State-of-the-art Application of Artificial Intelligence to Transporter-centered Functional and Pharmaceutical Research	12
New Psychoactive Substances, New Behaviours, New Drug-drug Interactions: Pharmacology of a Slam Session	12
In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor	12
Gut Microbiota as the Potential Mechanism to Mediate Drug Metabolism Under High-altitude Hypoxia	12
Potential Alteration of Rifampicin’s Bioavailability by Phyllanthus niruri Supplementation in Tuberculosis Therapy	12
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis	11
Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery	11
Effect of Carbonized Herba schizonepetae on the Bioavailability of Eight Active Components from Pulsatillae Decoction in its Particular Adsorption and Release Performance	10
An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms	10

Characterization of Five Natural Anthraquinone Compounds as Potent Inhibitors against CYP1B1: Implications for Cancer Treatment	10
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats	9
Topical Capsaicin for the Treatment of Neuropathic Pain	9
Impact of POR*28 Variant on Tacrolimus Pharmacokinetics in Kidney Transplant Patients with Different CYP3A5 Genotypes	9
Pain Allaying Epalrestat-Loaded Lipid Nanoformulation for the Diabetic Neuropathic Pain Interventions: Design, Development, and Animal Study	9
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway	9
Covalent CES2 Inhibitors Protect against Reduced Formation of Intestinal Organoids by the Anticancer Drug Irinotecan	9
UPLC-ESI-Q-TOF/MS Based Metabolic Profiling of Protosappanin B in Rat Plasma, Bile, Feces, Urine and Intestinal Bacteria Samples	9
Which can Predict the Outcome of Antidepressants: Metabolic Genes or Pharmacodynamic Genes?	8
How Antimalarials and Antineoplastic Drugs can Interact in Combination Therapies: A Perspective on the Role of PPT1 Enzyme	8
Phytofabricated Nanoparticle Formulation for Cancer Treatment: A Comprehensive Review	8
Evaluation and Clinical Implication of Zhenwu Decoction on Seven Cytochrome P450 Enzyme in Chronic Heart Failure Rats	8
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae Semen with Hepatoprotective Effects	8
Development and Validation of a Sensitive UPLC-Q-TOF-MS/MS for the Measurement of Nine Components in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Studies with	8
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction	8
A Decade’s Review of miRNA: A Center of Transcriptional Regulation of Drugmetabolizing Enzymes and Transporters under Hypoxia	8
Quality by Design-Steered Development of Stealth Liposomal Formulation of Everolimus: A Systematic Optimization and Evaluation	7
Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats	7
The Role of Metabolism in Toxicity of Polycyclic Aromatic Hydrocarbons and their Non-genotoxic Modes of Action	7
Innovative Nanoscale Drug Delivery Strategies for Breast Carcinoma: A Comprehensive Exploration	7
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	7
Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease	7
Interactions Between Meropenem and Renal Drug Transporters	7
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism	7
Advances in Hybrid Vesicular-based Drug Delivery Systems: Improved Biocompatibility, Targeting, Therapeutic Efficacy and Pharmacokinetics of Anticancer Drugs	6
Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers	6
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme	6
Recent Progress on Mass Spectrum Based Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Traditional Chinese Medicine	6
Differential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice	6
ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches	6
Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations	6
Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes	6
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke	6
Meet the Associate Editor	5
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats	5
Design and Evaluation of Sustained Release of Ornidazole by Dental Inserts	5
Meet the Editorial Board Member	5
Acknowledgements to Reviewers	5
Thymoquinone Lipid Nanoparticles Cut the Gordian Knots of Depression via Neuroprotective BDNF and Downregulation of Neuro-inflammatory NF-κB, IL-6, and TNF-α in LPS Treated Rats	5
A Phase I Clinical Study of the Pharmacokinetics and Safety of Prusogliptin Tablets in Subjects with Mild to Moderate Hepatic Insufficiency and Normal Liver Function	5
Pharmacokinetics and Tissue Distribution of Isovitexin-2''-O-β-D-glucopyranoside (IVG) in Sprague-Dawley Rats	5
Tacrolimus, Cytochrome P450, Interactions with Food Variables in Organ Transplant Recipients; A Current and Comprehensive Review	5
Transformative CRISPR-Cas9 Technologies: A Review of Molecular Mechanisms, Precision Editing Techniques, and Clinical Progress in Sickle Cell Disease	5
A Randomized Trial of Short-term Treatment with Folic Acid to Reduce the Oxidative Stress of Patients with Chronic Kidney Disease	5
Meet the Editorial Board Member	5
Meropenem for the Pharmacological Treatment of Severe Infections in Critically Ill Pediatric Patients: Breakthrough Standard Treatment Strategies Based on PK/PD	5
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling it up to Rats, Dogs, and Humans	5
Comprehensive Investigation of the Influence of High-Altitude Hypoxia on Clopidogrel Metabolism and Gut Microbiota	5
Characterizing Pharmacokinetic Variability of Topiroxostat in Chinese Population: Insights from a Phase I Randomized Clinical Trial	5
Changing Pain Management Strategy from Opioid-centric Towards Improve Postoperative Cognitive Dysfunction with Dexmedetomidine	5

New Methods and Technology in Drugs Metabolism and Pharmacokinetics (Part-II)	5
Meet the Section Editor	5
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice	5
Drug-Drug Interaction Potential of Remimazolam: CYP 450, Transporters, and Protein Binding	4
Study on the Relationship between Rivaroxaban and Factor Xa Activity in Blood Based on HPLC-MS/MS	4
Metabolic Pathway of Osilodrostat in Equine Urine Established through High-resolution Mass Spectrometric Characterization for Doping Control	4
Rapid Profiling of the Marker Components in Artemisia annua L. and their Metabolites in Rats Using an Improved Liquid Chromatography-tandem Highresolution Mass Spectrometry-based Technology	4
Regulation of Gut Microbiota by Herbal Medicines	4
Carboxylesterase 1-Based Drug-Drug Interaction Potential of Remimazolam: In-Vitro Studies and Literature Review	4
Meet the Editorial Board Member	4
Meet the Co-Editor	4
A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview	4
Acknowledgement to Reviewers	4
A Cross-sectional Comparative Analysis of Eleven Population Pharmacokinetic Models for Docetaxel in Chinese Breast Cancer Patients	4
The Promising Role of Natural Exosomal Nanoparticles in Cancer Chemoimmunotherapy	4
Meet the Editorial Board Member	4
Meet Our Associate Editor	4
Orchestration of Obesolytic Activity of Microbiome: Metabiotics at Centre Stage	4
Biotransformation of Drugs and other Xenobiotics as Key Modulator of Toxicity	4
Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide	4
Role of P-glycoprotein in Regulating the Efficacy, Toxicity and Pharmacokinetics of Yunaconitine	4
Meet the Editorial Board Member	4
Pharmacokinetics and Efficacy of Ceftriaxone in Staphylococcal Mastitis in Crossbred Cows Following Single Intravenous Administration	4
Structure of the Blood Brain Barrier and its Role in the Transporters for the Movement of Substrates across the Barriers	4
Comparative Pharmacokinetics of Intravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep	4
Prediction of Pharmacokinetics of Valeric Acid: Alternative Tool to Minimize Animal Studies	3
Meet the Editorial Board Member	3
Design and Construction of Carboxylesterase 2c Gene Knockout Rats by CRISPR/Cas9	3
Pharmacokinetic Drug-Drug Interactions Involving Antiretroviral Agents: An Update	3
Urine Metabolites as a Predictor of Warfarin Response Based on INR in Atrial Fibrillation	3
Effect of High Altitude Environment on Pharmacokinetic and Pharmacodynamic of Warfarin in Rats	3
Simultaneous Determination of Saponins and Lignans in Rat Plasma by UPLC- MS/MS and its Application to a Pharmacokinetic Study of Shenqi Jiangtang Granule	3
Inhibition of Cytochrome P450 Enzyme and Drug-Drug Interaction Potential of Acid Reducing Agents Used in Management of CDK Inhibitors for Breast Cancer Chemotherapy	3
Disposition Kinetics of Cathinone and its Metabolites after Oral Administration in Rats	3
Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients	3
Synthesis and Biomedical Applications of DNA Hydrogel	3
Effects of CPY3A5 Genetic Polymorphisms on the Pharmacokinetics of Extendedrelease and Immediate-release Tacrolimus Formulations in Renal Transplant Recipients: A Systematic Review and Meta-analysis	3
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review	3
Characterization of Metabolites of α-mangostin in Bio-samples from SD Rats by UHPLC-Q-exactive Orbitrap MS	3
Comparative Study of Binding Pockets in Human CYP1A2, CYP3A4, CYP3A5, and CYP3A7 with Aflatoxin B1, a Hepato-Carcinogen, by Molecular Dynamics Simulation & Principal Component Analysis	3
Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease	3
A Mini-review on Recent Strategies and Applications of Nanomedicines to Combat Antimicrobial Resistance	3
Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9)	3
Metabolism Pathways of Major Therapeutics for Treating Monkeypox Mono- and Co-infection with Human Immunodeficient Virus or SARS-CoV-2	3
Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes	3
Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	3
Unraveling the Structure-Dependent Inhibitory Effects of Ginsenoside Series Compounds on Human Cytochrome P450 1B1	3
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery	3
Framework Nucleic Acids: A Promising Vehicle for Small Molecular Cargos	3
Comparative Pharmacokinetics of Scoparone and its Metabolite Scopoletin in Normal and ANIT-induced Intrahepatic Cholestatic Rats	2
Influence of Zhuanggu Guanjie Pill on Seven Cytochrome P450 Enzymes Based on Probe Cocktail and Pharmacokinetics Approaches	2
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole- Orbitrap High-Resolution Accurate Mass Spe	2
Regulatory Effects of N-3 PUFAs on Pancreatic β-cells and Insulin-sensitive Tissues	2
Impact of Pharmacogenetic Determinants of Tacrolimus and Mycophenolate on Adverse Events in Renal Transplant Patients	2
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases	2
Meet the Associate Editor	2
Elevated Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Predict Drug-Induced Acute Kidney Injury	2
Meet the Editorial Board Member	2
Interaction of Intestinal Microbiota with Medications	2
Meet the Associate Editorial Board Member	2
Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction	2
Clay-based Formulations for Bioavailability Enhancement of Poorly Water-soluble Drugs	2
Absorption, Metabolism, Distribution, and Excretion of Letermovir	2
Comprehensive Analysis of Chemical Ingredients of Waiganfengsha Granule and Absorbed Components in Rat Plasma Based on UHPLC-Q-TOF-MS	2
Application of Nucleic Acid Nanomaterials in the Treatment of Endocrine and Metabolic Diseases	2
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies	2
Comprehensive Identification of Astilbin Metabolites in Rats Based on Multiple Metabolite Templates Combined with UHPLC-Q-Exactive Mass Spectrometry	2
Role of Natural Products in the Treatment of Obesity: Nanotechnological Perspectives	2
Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole against Human Carboxylesterase 2	2
Corrigendum to: Chloro-s-triazenes-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations	2
Meet the Co-Editor	2
An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder	2
Evaluation of Alterations in DNA Methylation of CYP3A4 Gene Upstream Regulatory Elements in Gastric Cancer and in Response to Diazinon Treatment	2
Meet the Associate Editorial Board Member	2
Where will Medicines that Serve the Global South and Economically Disadvantaged People Come From?	2
Review of the Clinical Pharmacokinetics, Efficacy and Safety of Pembrolizumab	2
Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9	2
Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications for Herb-drug Combination	2
The Function of Multidrug Resistance-associated Protein 3 in the Transport of Bile Acids under Normal Physiological and Lithocholic Acid-induced Cholestasis Conditions	2
No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects	2

Nucleic Acid Nanomaterials: Biostability and Applications	2
Different Inductive Effects of Praziquantel Racemate and its Enantiomers on the Enzyme CYP3A4 Mediated by Pregnane X Receptor and its Variants	2
Development in Drug Metabolite Profiling (Part-I)	2
A Comparative Study on Sedation Efficacy Between General and Regional Anesthesia with Dexmedetomidine in Patients Under Maxillofacial Surgery	2
Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems	2
Nanomedicine for Cancer: Targeted Therapy, Vaccination, Pharmacokinetics, and Challenges	2
Pharmacokinetics-based Chronotherapy	2
Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates	2
Evaluation of Intracellular Metabolism of Methotrexate in Hepatocytes and Embryonic Kidney Cells based on Folylpolyglutamate Synthetase and Gamma-Glutamyl Hydrolase Expression	1
New Horizons in the Treatment of Neurological Disorders with Tailorable Gold Nanoparticles	1
Targeting the Pathological Hallmarks of Alzheimer’s Disease Through Nanovesicleaided Drug Delivery Approach	1
Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol	1
Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities	1
Meet the Editorial Board Member	1
Factors Influencing ADME Properties of Therapeutic Antisense Oligonucleotides: Physicochemical Characteristics and Beyond	1
Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer's, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System	1
Study on Cytochrome P450 Metabolic Profile of Paclitaxel on Rats using QTOF-MS	1
Effect of Aging on Deferasirox Therapy in Transfusion-dependent Patients. A Prospective- Retrospective, Cohort-study	1
Meet the Editorial Board Member	1
WITHDRAWN: Pharmaceutical Nanoemulsion System: A Strategy to Enhance the Bioavailability of Drugs	1
An Update on the Recent Advances in Cubosome: A Novel Drug Delivery System	1
Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Prediction	1
Where is the Study of mRNA Vaccine Disposition?	1
Application of UPLC-MS/MS to Study Cellular Pharmacokinetics of Seven Active Components of Cnidii Fructus Extracts	1
Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD	1
Hepatic Metabolic Enzyme Activity with Endogenous Substances-Current Status, Challenges and Limitations	1
Reassessment of Radiation Exposure From Bone Scintigraphy	1
Factors Influencing ADME Properties Of Drugs: Advances and Applications (Part II)	1
Relevance of ABC Transporters in Drug Development	1
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update	1
Meet the Editorial Board Member	1
Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals	1
Meet the Associate Editor	1
Classical and Machine Learning Methods for Protein - Ligand Binding Free Energy Estimation	1
Meet the Editorial Board Member	1
Nanotechnology Driven Approaches for the Management of Parkinson’s Disease: Current Status and Future Perspectives	1
Unveiling the Role of Cytochrome P450 (2E1) in Human Brain Specifically in Parkinson’s Disease - Literature Review	1
Meet the Associate Editor	1
Suppression of Melanoma Growth in a Murine Tumour Model Using Orthosiphon stamineus Benth. Extract Loaded in Ethanolic Phospholipid Vesicles (Spherosome)	1
Recent Patents, Regulatory Issues, and Toxicity of Nanoparticles in Neuronal Disorders	1
Antibiotics as Inhibitor of Glutathione S-transferase: Biological Evaluation and Molecular Structure Studies	1
Meet the Editorial Board Member	1
Safety Issues of Herb-Warfarin Interactions	1
Trends in Rationalized Brain Targeted Nanoparticles in Neurological Disorders (Part-III)	1
Nano-Neurotherapeutics (NNTs): An Emergent and Multifaceted Tool for CNS Disorders	1
An Efficient Integrated Strategy for Comprehensive Metabolite Profiling of Sakurasosaponin from Aegiceras corniculatum in Rats	1
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism	1
miRNAs in SARS-CoV-2 Infection: An Update	1
The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease	1
Meet the Editorial Board Member	1
Emerging Trends in Hybrid Nanoparticles: Revolutionary Advances and Promising Biomedical Applications	1
Circadian Timekeeping in Anticancer Therapeutics: An Emerging Vista of Chronopharmacology Research	1