OOIR: Observatory of International Research

Papers

(The TQCC of Current Drug Metabolism is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
2020 FDA Drug-drug Interaction Guidance: A Comparison Analysis and Action Plan by Pharmaceutical Industrial Scientists	77
ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches	41
Salidroside - Can it be a Multifunctional Drug?	35
Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application	29
Polymeric Nanoparticles for Brain Drug Delivery - A Review	27
Tumor Angiogenesis and VEGFR-2: Mechanism, Pathways and Current Biological Therapeutic Interventions	27
Dietary Baicalin Zinc Supplementation Alleviates Oxidative Stress and Enhances Nutrition Absorption in Deoxynivalenol Challenged Pigs	25
Chemical Metabolism of Xenobiotics by Gut Microbiota	24
Genistein: Its Role in Breast Cancer Growth and Metastasis	24
The Current State of Potential Therapeutic Modalities for Glioblastoma Multiforme: A Clinical Review	23
Nano Phytomedicine Based Delivery System for CNS Disease	22
Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections	22
Biosurfactants as a Novel Additive in Pharmaceutical Formulations: Current Trends and Future Implications	18
Therapeutics and Research Related to Glioblastoma: Advancements and Future Targets	18
A Review: Effects of Macrolides on CYP450 Enzymes	17
Tubulin Proteins in Cancer Resistance: A Review	17
Exosome-based Tumor Therapy: Opportunities and Challenges	17
Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2	16
Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations	16
Topical Capsaicin for the Treatment of Neuropathic Pain	16
Metabolite Identification in the Preclinical and Clinical Phase of Drug Development	15
Natural Compounds as Source of Aldose Reductase (AR) Inhibitors for the Treatment of Diabetic Complications: A Mini Review	15
Clinical Pharmacokinetics of Propranolol Hydrochloride: A Review	15
Murburn Precepts for Cytochrome P450 Mediated Drug/Xenobiotic Metabolism and Homeostasis	15
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review	15

Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review	14
Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters	13
Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C93 and CYP2C193 Gene Variations With Type 2 Diabetes: A Case-Control Study	13
HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview	13
Metabolism and Pharmacological Mechanisms of Active Ingredients in Erigeron breviscapus	12
Stem Cells in Tumour Microenvironment Aid in Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment	12
Recent Advances in Biotransformation by Cunninghamella Species	11
Gold Nanoparticles; Potential Nanotheranostic Agent in Breast Cancer: A Comprehensive Review with Systematic Search Strategy	11
Prognostic Role of Hedgehog-GLI1 Signaling Pathway in Aggressive and Metastatic Breast Cancers	11
Inhibition of Efflux Pumps by Monoterpene (α-pinene) and Impact on Staphylococcus aureus Resistance to Tetracycline and Erythromycin	11
Medicinal Plants and Natural Products: More Effective and Safer Pharmacological Treatment for the Management of Obesity	11
Talin: A Potential Drug Target for Cancer Therapy	11
Effect of Nigella sativa and Fenugreek on the Pharmacokinetics and Pharmacodynamics of Amlodipine in Hypertensive Rats	10
Application of Advanced Technologies in Natural Product Research: A Review with Special Emphasis on ADMET Profiling	10
The Potential Role of Serum Exosomes in Preeclampsia	10
Research Progress of Herbal Medicines on Drug Metabolizing Enzymes: Consideration Based on Toxicology	10
A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview	10
The Influence of Different Disease States on Rituximab Pharmacokinetics	10
Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies	10
Naphthalene Toxicity in Clinical Practice	9
Mechanism of the Intestinal Absorption of Six Flavonoids from Zizyphi Spinosi Semen Across Caco-2 Cell Monolayer Model	9
Thymoquinone Lipid Nanoparticles Cut the Gordian Knots of Depression via Neuroprotective BDNF and Downregulation of Neuro-inflammatory NF-κB, IL-6, and TNF-α in LPS Treated Rats	9
Development and Validation of a Sensitive UPLC-Q-TOF-MS/MS for the Measurement of Nine Components in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Studies with	9
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling: Part 1	9
Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management	9
Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy	9
Decoding Novel Mechanisms and Emerging Therapeutic Strategies in Breast Cancer Resistance	9
An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms	9
Applications of Machine Learning in Drug Target Discovery	9
Absorption, Distribution, Metabolism, and Excretion of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Humans	9
Secondary Metabolites in the Treatment of Diabetes Mellitus: A Paradigm Shift	9
The Role of Metabolism in Toxicity of Polycyclic Aromatic Hydrocarbons and their Non-genotoxic Modes of Action	9
Physiologically-based Pharmacokinetic (PBPK) Modelling of Transporter Mediated Drug Absorption, Clearance and Drug-drug Interactions	9
Protective Effects of Grape Seed Proanthocyanidin Extract in Preventing DSS Induced Ulcerative Colitis Based on Pharmacodynamic, Pharmacokinetic and Tissue Distribution	8
Isolation, Docking and In Silico ADME-T Studies of Acacianol: Novel Antibacterial Isoflavone Analogue Isolated from Acacia leucophloea Bark	8
Nanocrystals: An Approachable Delivery System for Anticancer Therapeutics	8
Pharmacogenetic Evaluation of Metformin and Sulphonylurea Response in Mexican Mestizos with Type 2 Diabetes	8
The Metabolism and Pharmacokinetics of Rhein and Aurantio-Obtusin	8
Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease	8
An Update on the Recent Advances in Cubosome: A Novel Drug Delivery System	8
Interactions Between Meropenem and Renal Drug Transporters	8
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling - Part 3	7
Role of Exosomes in the Exchange of Spermatozoa after Leaving the Seminiferous Tubule: A Review	7
Antibiotics as Inhibitor of Glutathione S-transferase: Biological Evaluation and Molecular Structure Studies	7
Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations	7
Tumor-targeted Drug Delivery by Nanocomposites	7
Role of Genetic Polymorphisms of Cytochrome P450 2C19 in Pantoprazole Metabolism and Pantoprazole-based Helicobacter pylori Eradication Regimens	7
Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis	7
Changes of Transporters and Drug-metabolizing Enzymes in Nephrotic Syndrome	7
Review of the Clinical Pharmacokinetics, Efficacy and Safety of Pembrolizumab	7

A Decade’s Review of miRNA: A Center of Transcriptional Regulation of Drugmetabolizing Enzymes and Transporters under Hypoxia	7
Relevance of ABC Transporters in Drug Development	6
Versatile and Valuable Utilization of Amidohydrolase L-glutaminase in Pharma and Food industries: A Review	6
The Genetic Polymorphism of CYP3A4 rs2242480 is Associated with Sirolimus Trough Concentrations Among Adult Renal Transplant Recipients	6
Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein	6
Hepatoprotective Role of Berberine on Doxorubicin Induced Hepatotoxicity - Involvement of Cyp	6
Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Prediction	6
Study on the Plasma Protein Binding Rate and Compatibility Regularity of the Constituents Migrating to Blood of Simiao Yong’an Decoction	6
Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers	6
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	6
Clinical Application of Thiopurine Pharmacogenomics in Pediatrics	6
Recent Advances in Nanotechnology: A Novel Therapeutic System for the Treatment of Alzheimer’s Disease	6
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update	6
Absorption, Metabolism, Distribution, and Excretion of Letermovir	6
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery	6
Pain Allaying Epalrestat-Loaded Lipid Nanoformulation for the Diabetic Neuropathic Pain Interventions: Design, Development, and Animal Study	6
Bibliometric Analysis of Current Drug Metabolism: The Twentieth Anniversary from 2000-2019	6
Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric Characterization of its Novel Metabolites in Equines for the Purpose of Doping Control	5
Receptor-Mediated Targeting in Breast Cancer through Solid Lipid Nanoparticles and Its Mechanism	5
Annonaceae Family Alkaloids as Agents Against Leishmaniasis: A Review and Molecular Docking Evaluation	5
Recent Patents, Regulatory Issues, and Toxicity of Nanoparticles in Neuronal Disorders	5
Regulatory Effects of N-3 PUFAs on Pancreatic β-cells and Insulin-sensitive Tissues	5
Structure of the Blood Brain Barrier and its Role in the Transporters for the Movement of Substrates across the Barriers	5
Risk Assessment of Veterinary Drug Residues in Meat Products	5
Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic	5
Modulation of the Drug Resistance by Platonia insignis Mart. Extract, Ethyl Acetate Fraction and Morelloflavone/Volkensiflavone (Biflavonoids) in Staphylococcus aureus Strains Overexpressing Efflux Pu	5
Rapid Profiling and Identification of Vitexin Metabolites in Rat Urine, Plasma and Faeces after Oral Administration Using a UHPLC-Q-Exactive Orbitrap Mass Spectrometer Coupled with Multiple Data-minin	5
Withania somnifera in Neurological Disorders: Ethnopharmacological Evidence, Mechanism of Action and its Progress in Delivery Systems	5
Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer's, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System	5
Role of Natural Products in the Treatment of Obesity: Nanotechnological Perspectives	5
Curcumin Nanoemulsions Stabilized with Modified Phosphatidylcholine on Skin Carcinogenesis Protocol	5
Molecular Modeling Studies on Cytochrome P450-mediated Drug Metabolism	5
The Role of Biotransformation in the Activity of Endocrine Disruptors	5
The Current Application of LC-MS/MS in Pharmacokinetics of Traditional Chinese Medicines (Recent Three Years): A Systematic Review	5
Recent Advances on Antioxidant Identification Based on Machine Learning Methods	5
A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer’s Disease	5
Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants	5
Role of Glucose Transporters in Drug Membrane Transport	5
Recent Progress on Mass Spectrum Based Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Traditional Chinese Medicine	5
Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research	5