OOIR: Observatory of International Research

Papers

(The TQCC of Current Drug Metabolism is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Novel Techniques and Models for Studying Drug Metabolism and Transport	40
Potential Alteration of Rifampicin’s Bioavailability by Phyllanthus niruri Supplementation in Tuberculosis Therapy	38
Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery	34
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme	22
HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations	22
Targeting Metabolic Dysregulation in Alzheimer’s Disease: A Potential Therapeutic Strategy	18
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats	17
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats	17
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview	17
Theoretical Evaluation of Oleocanthal Reactive Centers	17
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke	17
In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor	16
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism	14
Network Pharmacology and Metabolomics to Uncover the Multi-Target Anti-Non-Small Cell Lung Cancer Mechanism of Baicalin Mediated by Purine Metabolism	14
Meet the Section Editor	14
Regulation of Gut Microbiota by Herbal Medicines	13
Tacrolimus, Cytochrome P450, Interactions with Food Variables in Organ Transplant Recipients; A Current and Comprehensive Review	13
Meet the Associate Editor	12
Meet the Associate Editorial Board Member	12
Nucleic Acid Nanomaterials: Biostability and Applications	11
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies	11
Influence of Zhuanggu Guanjie Pill on Seven Cytochrome P450 Enzymes Based on Probe Cocktail and Pharmacokinetics Approaches	11
Rapid and Comprehensive Identification of Vincosamide Metabolites in vitro and in vivo in Rats by Ultra-high Performance Liquid Chromatography-Quadrupole-Exactive Orbitrap-high Resolution Mass Spectro	10
Meet the Associate Editor	10
Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities	10

The Magic of Drug Targeting Is “Secretly” Tied to Optimal Drug Distribution and Exposure	10
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases	10
Acknowledgements to Reviewers	10
The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease	10
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism	10
Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates	10
Development of Transdermal Drug Delivery Approaches to Combat Diabetes: An Update	9
Pharmacokinetic Interaction between Imatinib and Tacrolimus in Rats	9
Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol	9
Meet the Editorial Board Member	8
Corrigendum To: Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	8
Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production	8
Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients	8
Deciphering the Impact of Protein Corona on Biological Fate of Nanomedicine-Loaded Microneedles	7
Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog	7
Worldwide Prevalence of Polypharmacy: A Systematic Review	7
The Metabolic Pathways and Products of Ten Aconitum Alkaloids in Sanwujiao Pills from Eight Organs of Mice by UHPLC-Q-TOF-MS/MS	7
Influence of Orange Oil on Skin Permeability, Dermatokinetics, and In Vivo Anti-inflammatory Properties of Lornoxicam-loaded Niosomal Gel	7
Meet the Editorial Board Member	7
Comparative Analysis of Pharmacokinetics and Metabolites of Three Main Terpenoids before and after Compatibility of Frankincense and Myrrh in Rats by UHPLC-MS	7
Genetic Testing is Superior Over Endogenous Pharmacometabolomic Markers to Predict Safety of Haloperidol in Patients with Alcohol-induced Psychotic Disorder	7
Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice	7
Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Rats	6
Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries	6
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites	6
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction	6
Meet the Co-Editor	6
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae Semen with Hepatoprotective Effects	6
Research Progress of Epigenetic Modification on the Regulation of Transporters Under Hypoxia	6
Comparative In Vitro Metabolic Profile Study of Five Cathinone Derivatives	6
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis	6
In Vitro Drug–Drug Interactions between Oxycodone and Commonly Co-Consumed Drugs in Rat and Human Liver Microsomes	6
Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes	6
The Impact of Certain Pharmacogenetic Differences on the Metabolism of Antiretroviral Drugs Used in A Black South African Population	6
Effects of Fasting andPhoenix dactyliferaon the Expression of Major Drug- Metabolizing Enzymes in the Mouse Livers	6
Natural Compounds as Potential Therapeutics for Pancreatic Cancer: A Narrative Review	6
Comparative Proteomics of Hepatocytes And Hepatic Cell Lines Using Swath-MS Reveals Significant Variations In Proteins Involved In Energy, Lipid, And Xenobiotic Metabolism	6
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	6
The Application of Artificial Intelligence in Drug ADME Research	6
Pharmacokinetics and Tissue Distribution of Isovitexin-2''-O-β-D-glucopyranoside (IVG) in Sprague-Dawley Rats	5
Unraveling the Gut Microbiota-Mediated Mechanism of Guogong Jiu for Rheumatoid Arthritis Treatment through Network Pharmacology and Metabolomics	5
Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9	5
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling it up to Rats, Dogs, and Humans	5
Application of Physiologically Based Pharmacokinetic Modeling in the Research of Anti-HIV Drugs	5
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole- Orbitrap High-Resolution Accurate Mass Spe	5
The Multifaceted Role of Cytochrome P450 Isoenzymes in Alcoholic and Metabolic (Dysfunction) Fatty Liver Diseases	5
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study	4
Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals	4
An Efficient Integrated Strategy for Comprehensive Metabolite Profiling of Sakurasosaponin from Aegiceras corniculatum in Rats	4
Effect of Wuzhi Capsule (WZC) on the Pharmacokinetics of Tacrolimus in Renal Transplantation Recipients	4

Lung-Targeting Cepharanthine Polymer Micelles Modified with Mannose: Effectiveness against Acute Lung Injury Evaluated Using in vitro and in vivo Analyses	4
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update	4
Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia	4
Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study	4
Comprehensive Insights into Licochalcone A: its Distribution, Biosynthesis, Metabolism, and Pharmacological Effects	4
DNA-based Nanomaterials in the Immunotherapy	4
Machine Learning in Drug Metabolism Study	4
Quality by Design Approach for the Development of Cariprazine Hydrochloride Loaded Lipid-Based Formulation for Brain Delivery via Intranasal Route	4
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines	4
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism	4
An Explicative Review on Nanotechnology-based Drug Delivery Systems for Alleviating Oxidative Stress-driven Pathologies	4
Meet the Regional Editor	4