OOIR: Observatory of International Research

Papers

(The TQCC of Current Protein & Peptide Science is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Withdrawal Notice: Overview of Enzyme Engineering Towards the Production of Hyaluronic Acid with Tailored Molecular Weight	31
Targeted Delivery of Diphtheria Toxin into VEGFR1/VEGFR2 Overexpressing Cells Induces Anti-angiogenesis Activity	30
Plant Lectins: A Review on their Biotechnological Potential Toward Human Pathogens	29
Revolutionizing Infertility Management through Novel Peptide-based Targets	25
Natural and Synthetic Peptides to Control Drug-resistant Pathogens	25
Outdoor Allergens of Regional Importance in Asia	22
Current Trends and Challenges in Targeting Tumor Mitochondrial Glycolysis and Oxidative Phosphorylation Pathways for Cancer Therapy	22
Review of post-translational modification of human serum albumin	21
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy	19
Aspartate β-hydroxylase (ASPH) Accelerates Intrahepatic Cholangiocarcinoma Metastasis via Upregulating SHH Signaling Pathway	18
Markers of Oxidative Stress and Tyrosinase Activity in Melasma Patients: A Biochemical Investigation	17
An Update on Dipeptidyl Peptidase-IV Inhibiting Peptides	17
Unveiling the Role of DPYS: A New Prognostic Biomarker in Sarcoma	15
Apolipoprotein-mimetic Peptides: Current and Future Prospectives	15
Structure and Function of the Important Internalins of Listeria monocytogenes	15
Histone Methylation Regulation as a Potential Target for Non-alcoholic Fatty Liver Disease	14
From Bugs to Benefits: Edible Insects as Exceptional Protein Sources	14
Current Update on New Delhi Metallo-β-lactamase (NDM) Variants: New Challenges in the Journey of Evolution	14
A Comprehensive Review on the Significance of Cysteine in Various Metabolic Disorders; Particularly CVD, Diabetes, Renal Dysfunction, and Ischemic Stroke	13
ACE2 Receptor: A Potential Pharmacological Target in COVID-19	13
Overexpression of Efflux Pumps AcrAB and OqxAB Contributes to Ciprofloxacin Resistance in Clinical Isolates of K. pneumoniae	12
Identification of Tyrosinase Inhibitory Peptides from Sea Cucumber (Apostichopus japonicus) Collagen by in silico Methods and Study of their Molecular Mechanism	12
Deciphering the Role of S-adenosyl Homocysteine Nucleosidase in Quorum Sensing Mediated Biofilm Formation	11
In Silico and In vitro Analysis of Phenolic Acids for Identification of Potential DHFR Inhibitors as Antimicrobial and Anticancer Agents	11
Nanoparticles: A Promising Tool to Promote Reactive Oxygen Species in Cancer Therapy	11

Oak Pollen Allergy in Korea	11
Structural Analysis of the Interaction between Bcl-xL and the Noncanonical BH3 Domain of Non-Bcl-2 Family Proteins	10
Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and Diseases	10
Glycation of Immunoglobulin-G from Pentose Sugar: A Cause for Structural Perturbations	10
Metallopeptidases as Key Virulence Attributes of Clinically Relevant Protozoa: New Discoveries, Perspectives, and Frontiers of Knowledge	9
Small-Molecule Inhibitors Targeting eIF4A in Leukemia	9
Herbs and their Active Constituents for Gastric Cancer and Related Problems - Preclinical and Clinical Studies	9
Kenaf Seed Cysteine Protease (KSCP) Inhibits the Intrinsic Pathway of the Blood Coagulation Cascade and Platelet Aggregation	8
How Useful are Antimicrobial Peptide Properties for Predicting Activity, Selectivity, and Potency?	8
Leishmaniasis: Omics Approaches to Understand its Biology from Molecule to Cell Level	8
Bcl-2 Family Proteins in Therapeutic Arena for Cancers	8
Recovery of Proteases and Protease Inhibitors from Ganoderma spp. Cultivated in Amazonian Lignocellulose Wastes	8
Post Translational Modification and Its Pathologic Association in Rheumatoid Arthritis: A Brief Perspective	8
Chloride Intracellular Channel 1 Enhances Glioblastoma Cell Migration and Epithelial-Mesenchymal Transition by Activating the ERK1/2 Signaling Pathway	8
Anti-Platelet Peptides Targeting αIIbβ3 Outside-In Signaling Pathway	8
Trehalose and its Diverse Biological Potential	7
Structure-Function Relationship of Homogentisate 1,2-dioxygenase: Understanding the Genotype-Phenotype Correlations in the Rare Genetic Disease Alkaptonuria	7
Bacterial Pathogens: Potential Source For Antimicrobial Peptides	7
Soybean β-Conglycinin: Structure Characteristic, Allergenicity, Plasma Lipid-Controlling, Prevention of Obesity and Non-alcoholic Fatty Liver Disease	7
Manipulating Metabolic Alterations and their Consequences to Unleash the Potential of Antitumor Immunotherapy	7
The Fulcrum of Demyelination in Multiple Sclerosis	6
Glucagon-Like Peptide-2 in the Control of Gastrointestinal Motility: Physiological Implications	6
Identification of Protein Drug Targets of Biofilm Formation and Quorum Sensing in Multidrug Resistant Enterococcus faecalis	6
Protein Engineering in Cyanobacterial Biotechnology: Tools and Recent Updates	6
Programmed Cell Death in Plants: Insights into Developmental and Stress-Induced Cell Death	6
ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application	6
Understanding the Role of NRF2 Signalling in Cancer	6
Peroxiredoxin-6: A Guardian of Lung Pathophysiologies	6
Hypoxia A Typical Target in Human Lung Cancer Therapy	6
Global Trends in Hepatocellular Carcinoma and TGF-β Research: A Bibliometric and Visualization Analysis from 2000 to 2024	6
Research Progress on hCNT3 Structure/Function and Nucleoside Anticancer Drugs	6
Neurokinin B Administration Induces Dose Dependent Proliferation of Seminal Vesicles in Adult Rats	6
Birch Pollen Allergens	6
Exploring the Potential Role of Phytopharmaceuticals in Alleviating Toxicities of Chemotherapeutic Agents	6
Lactoferrin as a Potent Natural Supplement Exhibiting a Synergistic Effect with Drugs in Antimicrobial and Anticancer Therapies	6
Epigenetic Regulator ASXL2: Structure, Function and its Predictive Value in Diseases	5
Interaction of Nanomaterials with Protein-Peptide	5
Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects	5
Down-Regulated JDP2 Attenuated Trophoblast Invasion and Migration in Preeclampsia by Inhibiting Epithelial-Mesenchymal Transition through the Wnt/β-Catenin Pathway	5
In-vitro, In-silico Investigations Reveals Potential Cytotoxic Activity of Fermentation Metabolites from Actinomycetes Isolated from Lonar Soda Lake Against HeLa Cancer Cell Lines	5
PPA1, TRIM68 and FBXO46: Potential Therapeutic Targets for Triple Negative Breast Cancer	5
Biological Significance of EphB4 Expression in Cancer	5
Influences of Ipomoea batatas Anti-Cancer Peptide on Tomato Defense Genes	5
Prognostic Role of Unfolded Protein Response-Related Genes in Hepatocellular Carcinoma	5
Short Amphiphiles or Micelle Peptides May Help to Fight Against COVID-19	5
Preface	5
A Comprehensive Comparative Review of Protein Sequence-Based Computational Prediction Models of Lysine Succinylation Sites	5
Recent Advances in Molecular Imprinting for Proteins on Magnetic Microspheres	5
Measurement of High Protein Concentrations by Optical Rotation: A Case Study for Monitoring of Monoclonal Antibody Drug Downstream Processes	5
Knockdown of Ubiquitin-Conjugating Enzyme E2 T Abolishes the Progression of Head and Neck Squamous Cell Carcinoma by Inhibiting NF-Κb Signaling and inducing Ferroptosis	5

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways	5
Bioconjugation Techniques for Enhancing Stability and Targeting Efficiency of Protein and Peptide Therapeutics	5
Research Progress on Extracellular Matrix Involved in the Development of Preeclampsia	5
Targeting and Modulation of the Natriuretic Peptide System in Covid-19: A Single or Double-Edged Effect?	4
Molecular Characterization, Expression and In Situ Hybridization Analysis of a Pedal Peptide/Orcokinin-type Neuropeptide in Cuttlefish Sepiella japonica	4
Genomic Analysis of the Caleosin Family in Theaceae Reveals Lineagespecific Evolutionary Patterns	4
Cell Surface Markers and their Targeted Drugs in Breast Cancer	4
Acknowledgements to Reviewers	4
Withdrawal Notice: Novel Sequence Features of Leucine-rich Repeats in Proteins from Nucleocytoplasmic Large DNA Viruses	4
MicroRNA, a Promising Biomarker for Breast and Ovarian Cancer: A Review	4
Caspase-3 Activators as Anticancer Agents	4
Calprotectin: The Link Between Acute Lung Injury and Gastrointestinal Injury in Covid-19: Ban or Boon	4
Carboxylic Group Functionalized Carbon Quantum Dots inhibit Hen Egg White Lysozyme Amyloidogenesis, leading to the Formation of Spherical Aggregates with Reduced Toxicity and ROS Generation	4
Preface	4
Diabetic Wound: Pathophysiology, Complications and Treatment Strategies	4
Novel bone Morphogenetic Protein (BMP)-2/4 Consensus Peptide (BCP) for the Osteogenic Differentiation of C2C12 Cells	4
Bioactive Pentacyclic Triterpenes Trigger Multiple Signalling Pathways for Selective Apoptosis Leading to Anticancer Efficacy: Recent Updates and Future Perspectives	4
Evolution of Immunotherapy Against Pollen Allergy	4
Irisin, a mediator of muscle crosstalk with other organs: from metabolism regulation to protective and regenerative effects	4
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin	4
Network Pharmacology and Experiments to Verify the Effect and Potential Mechanism of Baicalein on Osteoporosis	4
Soluble Factors Associated with Denervation-induced Skeletal Muscle Atrophy	4
Comprehensive Analysis of Glycosyltransferase-Related Genes Reveals their Prognostic and Therapeutic Implications in Stomach Adenocarcinoma	4
Enzymatic Targets in the Anticancer Drug Discovery	4
Exploring the Molecular Aspects of Glycosylation in MOG Antibody Disease (MOGAD)	4
Potential of Angiotensin-(1-7) in COVID-19 Treatment	4
Plant bZIP Proteins: Potential use in Agriculture - A Review	4
α-Lipoic Acid and its Role on Female Reproduction	4