OOIR: Observatory of International Research

Papers

(The TQCC of Current Protein & Peptide Science is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Withdrawal Notice: Overview of Enzyme Engineering Towards the Production of Hyaluronic Acid with Tailored Molecular Weight	35
Targeted Delivery of Diphtheria Toxin into VEGFR1/VEGFR2 Overexpressing Cells Induces Anti-angiogenesis Activity	32
Natural and Synthetic Peptides to Control Drug-resistant Pathogens	30
Revolutionizing Infertility Management through Novel Peptide-based Targets	27
Outdoor Allergens of Regional Importance in Asia	25
Markers of Oxidative Stress and Tyrosinase Activity in Melasma Patients: A Biochemical Investigation	23
Plant Lectins: A Review on their Biotechnological Potential Toward Human Pathogens	22
Current Trends and Challenges in Targeting Tumor Mitochondrial Glycolysis and Oxidative Phosphorylation Pathways for Cancer Therapy	22
Apolipoprotein-mimetic Peptides: Current and Future Prospectives	20
Aspartate β-hydroxylase (ASPH) Accelerates Intrahepatic Cholangiocarcinoma Metastasis via Upregulating SHH Signaling Pathway	20
Review of post-translational modification of human serum albumin	19
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy	17
An Update on Dipeptidyl Peptidase-IV Inhibiting Peptides	16
From Bugs to Benefits: Edible Insects as Exceptional Protein Sources	15
A Comprehensive Review on the Significance of Cysteine in Various Metabolic Disorders; Particularly CVD, Diabetes, Renal Dysfunction, and Ischemic Stroke	15
Structure and Function of the Important Internalins of Listeria monocytogenes	15
Unveiling the Role of DPYS: A New Prognostic Biomarker in Sarcoma	15
Identification of Tyrosinase Inhibitory Peptides from Sea Cucumber (Apostichopus japonicus) Collagen by in silico Methods and Study of their Molecular Mechanism	14
ACE2 Receptor: A Potential Pharmacological Target in COVID-19	14
Overexpression of Efflux Pumps AcrAB and OqxAB Contributes to Ciprofloxacin Resistance in Clinical Isolates of K. pneumoniae	14
Current Update on New Delhi Metallo-β-lactamase (NDM) Variants: New Challenges in the Journey of Evolution	14
Histone Methylation Regulation as a Potential Target for Non-alcoholic Fatty Liver Disease	12
A Review on the Pathophysiology of Alzheimer’s Disease	11
In Silico and In vitro Analysis of Phenolic Acids for Identification of Potential DHFR Inhibitors as Antimicrobial and Anticancer Agents	11
Oak Pollen Allergy in Korea	11

Versatility of Collagen as a Natural Biopolymer for Biomedical, Food, and Cosmetic Applications	11
Small-Molecule Inhibitors Targeting eIF4A in Leukemia	10
Herbs and their Active Constituents for Gastric Cancer and Related Problems - Preclinical and Clinical Studies	10
Deciphering the Role of S-adenosyl Homocysteine Nucleosidase in Quorum Sensing Mediated Biofilm Formation	10
Recovery of Proteases and Protease Inhibitors from Ganoderma spp. Cultivated in Amazonian Lignocellulose Wastes	10
Nanoparticles: A Promising Tool to Promote Reactive Oxygen Species in Cancer Therapy	10
Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and Diseases	10
Anti-Platelet Peptides Targeting αIIbβ3 Outside-In Signaling Pathway	9
Chloride Intracellular Channel 1 Enhances Glioblastoma Cell Migration and Epithelial-Mesenchymal Transition by Activating the ERK1/2 Signaling Pathway	9
Metallopeptidases as Key Virulence Attributes of Clinically Relevant Protozoa: New Discoveries, Perspectives, and Frontiers of Knowledge	9
Bcl-2 Family Proteins in Therapeutic Arena for Cancers	8
Kenaf Seed Cysteine Protease (KSCP) Inhibits the Intrinsic Pathway of the Blood Coagulation Cascade and Platelet Aggregation	8
Bacterial Pathogens: Potential Source For Antimicrobial Peptides	8
Glycation of Immunoglobulin-G from Pentose Sugar: A Cause for Structural Perturbations	8
Structural Analysis of the Interaction between Bcl-xL and the Noncanonical BH3 Domain of Non-Bcl-2 Family Proteins	8
Post Translational Modification and Its Pathologic Association in Rheumatoid Arthritis: A Brief Perspective	8
How Useful are Antimicrobial Peptide Properties for Predicting Activity, Selectivity, and Potency?	8
Leishmaniasis: Omics Approaches to Understand its Biology from Molecule to Cell Level	8
Manipulating Metabolic Alterations and their Consequences to Unleash the Potential of Antitumor Immunotherapy	8
Trehalose and its Diverse Biological Potential	7
Identification of Protein Drug Targets of Biofilm Formation and Quorum Sensing in Multidrug Resistant Enterococcus faecalis	7
Research Progress on hCNT3 Structure/Function and Nucleoside Anticancer Drugs	7
Structure-Function Relationship of Homogentisate 1,2-dioxygenase: Understanding the Genotype-Phenotype Correlations in the Rare Genetic Disease Alkaptonuria	7
Understanding the Role of NRF2 Signalling in Cancer	7
Birch Pollen Allergens	7
Soybean β-Conglycinin: Structure Characteristic, Allergenicity, Plasma Lipid-Controlling, Prevention of Obesity and Non-alcoholic Fatty Liver Disease	7
Neurokinin B Administration Induces Dose Dependent Proliferation of Seminal Vesicles in Adult Rats	7
Glucagon-Like Peptide-2 in the Control of Gastrointestinal Motility: Physiological Implications	7
Hypoxia A Typical Target in Human Lung Cancer Therapy	6
Exploring the Potential Role of Phytopharmaceuticals in Alleviating Toxicities of Chemotherapeutic Agents	6
Biological Significance of EphB4 Expression in Cancer	6
Profilin and Its Isoforms: Unravelling the Functional Diversity Across Life Forms	6
Decoding the Molecular Mechanisms of miRNAs: Protein Interactions in Schizophrenia Pathogenesis	6
The Fulcrum of Demyelination in Multiple Sclerosis	6
Research Progress on Extracellular Matrix Involved in the Development of Preeclampsia	6
Artificial Intelligence in Proteins and Peptides: A Comprehensive Overview from Hybrid Modeling to Deep Learning	6
Recent Advances in Molecular Imprinting for Proteins on Magnetic Microspheres	6
ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application	6
Protein Engineering in Cyanobacterial Biotechnology: Tools and Recent Updates	6
Programmed Cell Death in Plants: Insights into Developmental and Stress-Induced Cell Death	6
Global Trends in Hepatocellular Carcinoma and TGF-β Research: A Bibliometric and Visualization Analysis from 2000 to 2024	6
A Comprehensive Comparative Review of Protein Sequence-Based Computational Prediction Models of Lysine Succinylation Sites	6
Knockdown of Ubiquitin-Conjugating Enzyme E2 T Abolishes the Progression of Head and Neck Squamous Cell Carcinoma by Inhibiting NF-Κb Signaling and inducing Ferroptosis	5
Measurement of High Protein Concentrations by Optical Rotation: A Case Study for Monitoring of Monoclonal Antibody Drug Downstream Processes	5
Influences of Ipomoea batatas Anti-Cancer Peptide on Tomato Defense Genes	5
PPA1, TRIM68 and FBXO46: Potential Therapeutic Targets for Triple Negative Breast Cancer	5
Preface	5
Novel bone Morphogenetic Protein (BMP)-2/4 Consensus Peptide (BCP) for the Osteogenic Differentiation of C2C12 Cells	5
Prognostic Role of Unfolded Protein Response-Related Genes in Hepatocellular Carcinoma	5
In-vitro, In-silico Investigations Reveals Potential Cytotoxic Activity of Fermentation Metabolites from Actinomycetes Isolated from Lonar Soda Lake Against HeLa Cancer Cell Lines	5

Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects	5
Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways	5
Bioconjugation Techniques for Enhancing Stability and Targeting Efficiency of Protein and Peptide Therapeutics	5
Withdrawal Notice: Novel Sequence Features of Leucine-rich Repeats in Proteins from Nucleocytoplasmic Large DNA Viruses	5
Epigenetic Regulator ASXL2: Structure, Function and its Predictive Value in Diseases	5
Interaction of Nanomaterials with Protein-Peptide	5
Short Amphiphiles or Micelle Peptides May Help to Fight Against COVID-19	5
Cell Surface Markers and their Targeted Drugs in Breast Cancer	5
Exploring the Molecular Aspects of Glycosylation in MOG Antibody Disease (MOGAD)	5
Down-Regulated JDP2 Attenuated Trophoblast Invasion and Migration in Preeclampsia by Inhibiting Epithelial-Mesenchymal Transition through the Wnt/β-Catenin Pathway	5