Current Drug Targets

Papers
(The TQCC of Current Drug Targets is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes99
Chitosan Nanoparticles as a Novel Drug Delivery System: A Review Article37
N6-methyladenine RNA Modification (m6A): An Emerging Regulator of Metabolic Diseases33
Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology31
Natural Products as Anticancer Agents30
Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies30
Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery28
Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-1928
Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes28
Strategies and Therapies for Wound Healing: A Review27
Fluoroquinolones: Blessings Or Curses27
Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review26
Targeting Enteric Neurons and Plexitis for the Management of Inflammatory Bowel Disease25
Biopolymer-based Scaffolds for Tissue Engineering Applications24
Anti-VEGF Treatment in Corneal Diseases24
Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion23
Molecular Mechanism of Resistance to Chemotherapy in Gastric Cancers, the Role of Autophagy21
Edaravone May Prevent Ferroptosis in ALS21
Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data21
IL-37 As a Potential Biotherapeutics of Inflammatory Diseases21
Osteoblast-n-Osteoclast: Making Headway to Osteoporosis Treatment20
Alzheimer’s Disease Targeted Nano-Based Drug Delivery Systems20
Antimicrobial Terpenoids as a Potential Substitute in Overcoming Antimicrobial Resistance20
Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology19
Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance18
Recent Progress in Stimuli-Responsive Intelligent Nano Scale Drug Delivery Systems: A Special Focus Towards pH-Sensitive Systems17
Mitochondrial Dysfunction in Huntington’s Disease: Pathogenesis and Therapeutic Opportunities17
Combinational Approaches Targeting Neurodegeneration, Oxidative Stress, and Inflammation in the Treatment of Diabetic Retinopathy16
The Epigenetic Modification of Epigallocatechin Gallate (EGCG) on Cancer16
Cell-penetrating Peptide-mediated Nanovaccine Delivery16
Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment16
The Potential of PI3K/AKT/mTOR Signaling as a Druggable Target for Endometrial and Ovarian Carcinomas15
A Comprehensive Review on Chrysin: Emphasis on Molecular Targets, Pharmacological Actions and Bio-pharmaceutical Aspects15
COVID-19 and Renal Diseases: An Update15
Post-menopausal Osteoporosis and Probiotics15
The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery14
Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives14
Kratom Dependence and Treatment Options: A Comprehensive Review of the Literature14
Challenges and New Therapeutic Approaches in the Management of Chronic Wounds14
New Anti-VEGF Drugs in Ophthalmology13
Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities13
An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases13
Exploring Spike Protein as Potential Target of Novel Coronavirus and to Inhibit the Viability Utilizing Natural Agents13
A Review of Aberrant DNA Methylation and Epigenetic Agents Targeting DNA Methyltransferases in Endometriosis12
Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic Leukemia12
Lipid Metabolism and Mitochondria: Cross Talk in Cancer12
PD1 and PD-L1 Inhibitors for the Treatment of Kidney Cancer: The Role of PD-L1 Assay12
Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling12
ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors12
TL1A: A New Potential Target in the Treatment of Inflammatory Bowel Disease12
Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease11
Microbial Synthesis of Gold Nanoparticles and their Application11
Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease11
Alzheimer's Disease and β-secretase Inhibition: An Update with a Focus on Computer-aided Inhibitor Design11
Current Quest in Natural Bioactive Compounds for Alzheimer’s Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence11
Thrombosis in IBD in the Era of JAK Inhibition11
Lung Pneumonitis and Fibrosis in Cancer Therapy: A Review on Cellular and Molecular Mechanisms11
The Gut Microbiota and Traditional Chinese Medicine: A New Clinical Frontier on Cancer11
MicroRNAs in Noise-Induced Hearing Loss and their Regulation by Oxidative Stress and Inflammation11
Robotic Surgery in Inflammatory Bowel Disease11
Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy11
PD-L1 Testing for Urothelial Carcinoma: Interchangeability, Reliability and Future Perspectives11
P2X7 Receptor as a Potential Target for Major Depressive Disorder10
A Molecular Cascade Underlying Articular Cartilage Degeneration10
Anti-inflammatory Potential of GSK-3 Inhibitors10
Review of the Biological Activity of Maslinic Acid10
An Overview of Computer-aided Drug Design Tools and Recent Applications in Designing of Anti-diabetic Agents10
Immunotherapy and Radiation Therapy in Renal Cell Carcinoma10
GSK-3 Inhibitors as New Leads to Treat Type-II Diabetes10
A Review on Rheumatoid Arthritis Interventions and Current Developments10
An Insight into the Current Perspective and Potential Drug Targets for Visceral Leishmaniasis (VL)10
Plasminogen Receptors in Human Malignancies: Effects on Prognosis and Feasibility as Targets for Drug Development9
The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy9
Antibiotic Potentiation of Natural Products: A Promising Target to Fight Pathogenic Bacteria9
Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders9
A Review on Anti-urease Potential of Coumarins9
CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery9
Application of Artificial Intelligence in Targeting Retinal Diseases9
Combining Growth Factor and Stem Cell Therapy for Stroke Rehabilitation, A Review9
Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy9
Status of Programmed Death Ligand 1 (PD-L1) by Immunohistochemistry and Scoring Algorithms9
Nanotechnology Based Approach for Hepatocellular Carcinoma Targeting9
Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle-Based Targeted Drug Delivery System9
Biodegradable Nanoparticles: A Recent Approach and Applications8
Thioethers: An Overview8
Molecular Modeling Targeting Transmembrane Serine Protease 2 (TMPRSS2) as an Alternative Drug Target Against Coronaviruses8
Challenges with Wound Infection Models in Drug Development8
Targeting mTOR Signaling in Type 2 Diabetes Mellitus and Diabetes Complications8
3D Printing Technology in Pharmaceutical Dosage Forms: Advantages and Challenges8
Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis8
Current and Future Prospective of a Versatile Moiety: Imidazole8
The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy8
Tissue Factor and COVID-19: An Update8
Inhibition of Virulence Factors and Biofilm Formation ofAcinetobacter Baumanniiby Naturally-derived and Synthetic Drugs8
Self-Assembled Micelles of Amphiphilic PEGylated Drugs for Cancer Treatment8
Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat8
Antibiotic Adjuvants: A Promising Approach to Combat Multidrug Resistant Bacteria8
The Association and Influencing Factors between Antipsychotics Exposure and the Risk of VTE and PE: A Systematic Review and Meta-analysis8
Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: An Overview8
Antimycotic Drugs and their Mechanisms of Resistance to Candida Species8
Faecal Microbiota Transplantation in Inflammatory Bowel Disease: Current Concepts and Future Challenges8
Prediction of Late Recurrence and Distant Metastasis in Early-stage Breast Cancer: Overview of Current and Emerging Biomarkers8
Insights into the Mechanism of the Therapeutic Potential of Herbal Monoamine Oxidase Inhibitors in Neurological Diseases8
An Updated Review for the Diabetic Wound Healing Systems8
Role of GSK-3 in Cardiac Health: Focusing on Cardiac Remodeling and Heart Failure8
Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-197
Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer7
Targeting Triglyceride Metabolism for Colorectal Cancer Prevention and Therapy7
A Review on CRISPR-mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer7
The Role of Immune and Epithelial Stem Cells in Inflammatory Bowel Disease Therapy7
Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates7
Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches7
Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines7
Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace7
Adenosine Dysfunction in Epilepsy and Associated Comorbidities7
Application of Ultrasound Elastography for Assessing Intestinal Fibrosis in Inflammatory Bowel Disease: Fiction or Reality?7
The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy7
Facts and Myths: Efficacies of Repurposing Chloroquine and Hydroxychloroquine for the Treatment of COVID-197
BRCA Mutational Status is a Promising Predictive Biomarker for Platinum- based Chemotherapy in Triple-Negative Breast Cancer7
Central Effects of Ivermectin in Alleviation of Covid-19-induced Dysauto-nomia7
Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors7
Targeting Hepatic Stellate Cell Death to Reverse Hepatic Fibrosis7
Vaginitis: Review on Drug Resistance7
Anti-VEGF Therapy in Myopic CNV7
Promising Protective Effects of Chrysin in Cardiometabolic Diseases7
Herbal Medicine in the Treatment of Epilepsy7
Metformin: A Promising Antidiabetic Medication for Cancer Treatment7
A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders7
Overview on Thioredoxin-Interacting Protein (TXNIP): A Potential Target for Diabetes Intervention7
Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression7
Targeted Drug Delivery Using Tuftsin-bearing Liposomes: Implications in the Treatment of Infectious Diseases and Tumors7
Elabela Peptide: An Emerging Target in Therapeutics6
GSK-3 Inhibitors: A New Class of Drugs for Alzheimer’s Disease Treatment6
Nutritional Support and Probiotics as a Potential Treatment of IBD6
Research Progress of PARP Inhibitor Monotherapy and Combination Therapy for Endometrial Cancer6
Unveiling the Targets Involved in the Quest of Antileishmanial Leads Using In silico Methods6
Molecular Signaling Pathways and Essential Metabolic Elements in Bone Remodeling: An Implication of Therapeutic Targets for Bone Diseases6
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead6
Berberine Administration in Treatment of Colitis: A Review6
Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment6
Neoadjuvant Strategies Before Radical Prostatectomy for High Risk Prostate Cancer in the Era of New Hormonal Agents6
PD1/PD-L1 Axis in Uro-oncology6
Is HE4 Superior over CA-125 in the Follow-up of Patients with Epithelial Ovarian Cancer?6
Venom of Viperidae: A Perspective of its Antibacterial and Antitumor Potential6
Recent Advances in Psoriasis Therapy: Trends and Future Prospects6
MiRNA, a New Treatment Strategy for Pulmonary Fibrosis6
Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy6
Anti-VEGF and Retinal Dystrophies6
Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s Disease: An Overview6
Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review6
Is Galanin a Promising Therapeutic Resource for Neural and Nonneural Diseases?6
Epigenetic Modifications as Therapeutic Targets6
Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?6
Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches6
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