OOIR: Observatory of International Research

Papers

(The TQCC of Current Drug Targets is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Cell Entry and Unusual Replication of SARS-CoV-2	43
SARS-Coronavirus 2, A Metabolic Reprogrammer: A Review in the Context of the Possible Therapeutic Strategies	39
The Marburg Virus Outbreak in West Africa	35
Review on the Drug Intolerance and Vaccine Development for the Leishmaniasis	34
Unfurling the Potential of Antiviral Agents Aimed for RNA Virus Ailment	33
Polymeric Micelle-Based Nanogels as Emerging Drug Delivery Systems in Breast Cancer Treatment: Promises and Challenges	32
The Development of the Combination Drug Leukovir® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review	32
Current Research Trends in Cytokine Storm: A Scientometric Study	32
Metformin: A Promising Antidiabetic Medication for Cancer Treatment	30
Possible Applications of Azurin, a Copper-Containing Protein, in Cancer Treatment: Prospects and Challenges	30
Meet the Regional Editor	28
Betaine, a Potential Therapeutic Alternative for the Treatment of Depression	28
Xerostomia: Advances and Challenges in Drug Development	26
Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery	24
Targeted Delivery Strategies of Herbal-Based Nanogels: Advancements and Applications	23
Envisioning Glucose Transporters (GLUTs and SGLTs) as Novel Intervention against Cancer: Drug Discovery Perspective and Targeting Approach	23
COVID-19 Induces Cytokine Storm and Dysfunctional Hemostasis	22
Targeting Neurodegeneration: The Emerging Role of Hybrid Drugs	22
An Explainable Deep Learning Model for Clathrin Protein Prediction Using a DCT-Enhanced Position-Specific Scoring Matrix	21
Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review	21
Targets Involved in the Pharmacology of Bothrops Snakebite: Statu Quo and Future Perspectives	21
An Overview of Research Advances in Oncology Regarding the Transcription Factor ATF4	21
An Updated Insight into Phytomolecules and Novel Approaches used in the Management of Breast Cancer	21
RMNet: An RNA m6A Cross-species Methylation Detection Method for Nanopore Sequencing	20
Investigating Alternative Treatments for Dyslipidemia Using Bioactive Compounds Derived from Kiwifruit (Actinidia chinensis): A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulati	20

Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials	19
The Role of Leukocyte Immunoglobulin-Like Receptors Focusing on the Therapeutic Implications of the Subfamily B2	19
Diabetic Nephropathy: Pathogenesis to Cure	19
IL-17 Antagonists as a Promising Therapeutic Modality for Hidradenitis Suppurativa	18
Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma	17
ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics	17
Robust Association of Breast Cancer Co-morbidity Using Subtype-specific Expressed Genes	17
Innovations in Antimalarial Drug Discovery: New Targets and Leads	16
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing	15
Transcription Factors in Brain Regeneration: A Potential Novel Therapeutic Target	15
Exploring the Efficient Natural Products for the Therapy of Parkinson’s Disease via Drosophila Melanogaster (Fruit Fly) Models	15
A Comprehensive Insight on Pharmaceutical Co-crystals for Improvement of Aqueous Solubility	15
Mitochondria-Targeted Nanoformulations: New Therapeutic Strategies and Opportunities for Cancer Immunotherapy	15
Transcending Molecules: Paving the Way from Lab to Life in Drug Transport Innovation	14
Potential Targets in Constipation Research: A Review	14
Multi-target Compounds against Trypanosomatid Parasites and Mycobacterium tuberculosis	13
Prospection of Microfluidics for Local Drug Delivery	13
Effect of Rotenone on the Neurodegeneration among Different Models	13
Targeting Creatine and Creatine Kinase in Cancer: Exploring Potential Therapeutic Strategies	12
Phytovesicular Nanoconstructs for Advanced Delivery of Medicinal Metabolites: An In-Depth Review	12
Signaling Dynamics in Osteogenesis: Unraveling Therapeutic Targets for Bone Generation	12
Recent Advances in Biomedical Applications of Mannans and Xylans	12
A Review on the Current Status of Homeopathy in the Clinical Manage-ment of Cancer	12
RAAS Overactivation and Mitochondrial Damage Signaling as Key Players in Lethal COVID-19	12
Recent Advances in the Development of Alpha-Glucosidase and Alpha-Amylase Inhibitors in Type 2 Diabetes Management: Insights from In silico to In vitro Studies	12
Identification of Natural Inhibitors against the Mycobacterium tuberculosis Proteasome: Computational Study	12
The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization	12
Multi-targeted Mechanisms of Erianin against Pancreatic Ductal Adenocarcinoma: Integrative Network Pharmacology, Bioinformatics, and Experimental Validation	11
Meet the Editorial Board Member	11
Bidirectional Communication of Estrogen in Gut-Brain Axis: Evidence from Preclinical and Clinical Studies	11
MiRNAs Overexpression and Their Role in Breast Cancer: Implications for Cancer Therapeutics	11
Exploring the SARS-Cov-2 Main Protease (Mpro) and RdRp Targets by Updating Current Structure-based Drug Design Utilizing Co-crystals to Combat COVID-19	10
An Exploratory Review on the Hypoglycemic Action of Unani Anti-diabetic Drugs via Possible Modulation of Gut Microbiota	10
Advances in Understanding and Managing Alzheimer's Disease: From Pathophysiology to Innovative Therapeutic Strategies	10
Statin Therapy and C-reactive Protein in Patients with Kidney Disease: A Systematic Review and Meta-analysis of Randomized Clinical Trials	10
FGMA: A Functional Group-enhanced Deep Learning Method for Drug Toxicity Prediction	10
Emerging Threats and Challenges of Monkeypox Virus: Exploration and Sensitivity	10
Targeted Covalent Inhibition: A Prospective Way to Develop Novel HSP90 C-terminal Inhibitor	10
Co-Crystallization: A Novel Technique to Improvise the Pharmaceutical Characteristics of API’s	10
Nanoformulations - Insights Towards Characterization Techniques	9
Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment	9
Proteasome as a Drug Target in Trypanosomatid Diseases	9
Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy	9
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead	9
Skin Microbial Composition and Genetic Mutation Analysis in Precision Medicine for Epidermolysis Bullosa	9
Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-analysis of Randomized Controlled Trials	8
Sepsis-Associated Brain Dysfunction: Mechanisms, Clinical Insights, and Therapeutic Strategies	8
Acknowledgements to Reviewers	8
Vaccine for Targeted Therapy of Lung Cancer: Advances and Developments	8
Proteases and Osteoporosis: A Comprehensive Review of Their Role in Bone Health	8

Diabetic Wound Healing: Factors, Mechanisms, and Treatment Strategies Using Herbal Components	8
Meet the Associate Editorial Board Member	8
A Review of Amylin Peptide Receptor Activators for Obesity Pharmacotherapy	8
Investigating the Mechanism of Astragalus mongholicus-Mediated Treatment of Silicosis in Mice from the Perspective of Alternative Splicing	8
Multitarget Compounds for Neglected Diseases: A Review	8
Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy	8
Superoxide Dismutase Inhibitors against Malaria, Leishmaniasis, and Chagas Disease: Systematic Review	7
Differential Drug Permeability across Biofilms	7
Anti-Degenerative Effect of Melatonin on Intervertebral Disc: Protective Contribution against Inflammation, Oxidative Stress, Apoptosis, and Autophagy	7
An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis	7
Long Non-coding RNAs in Non-small Cell Lung Carcinoma: Regulatory Mechanisms, Diagnostic Potential, and Therapeutic Perspectives	7
Beneficial Outcomes of Cancer Therapeutic Modalities Based on Targeting Apoptosis	7
The Resurgence of H3N2 in India: Is it Life-threatening?	7
Meet the Editorial Board Member	7
Precision Targeting of BET Proteins - Navigating Disease Pathways, Inhibitor Insights, and Shaping Therapeutic Frontiers: A Comprehensive Review	7
Systematic Identification and Characterization of Causal Risk Genes Implicated in Colorectal Cancer by Integrating GWAS, eQTL, and mQTL Data	7
Surface Functionalized Lipid Nanoparticles in Promoting Therapeutic Outcomes: An Insight View of the Dynamic Drug Delivery System	7
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review	7
Meet the Editorial Board Member	6
Polypharmacology-Driven Discovery and Design of Highly Selective, Dual and Multitargeting Inhibitors of Mycobacterium tuberculosis - A Review	6
E2 Protein of Chikungunya Virus: A Narrative Review of Its Potential as a Therapeutic Target	6
Mechanistic Approach to Ferroptosis in Cancer and Neurological Diseases	6
Meet the Editorial Board Member	6
CRISPR-Cas9 Gene Editing: Promising Therapeutics for HPV-driven Cervical Cancer	6
(E)-Labda dial-Loaded Nanoparticles for Triple Negative Breast Cancer	6
An Insight into Diverse Activities and Targets of Flavonoids	6
NLRP3: A Promising Therapeutic Target for Inflammatory Bowel Disease	6
A Comprehensive Review on Therapeutic Potential of a Natural Anthraquinone Derivative Emodin in Brain-related Disorders	6
Bidirectional Relations Between Anxiety, Depression, and Cancer: A Review	6
Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle	6
Beyond AlphaFold: Charting the Future of AI in Protein Structure Prediction	6
Meet the Regional Editor	6
An Update On Proficiency of Voltage-gated Ion Channel Blockers in the Treatment of Inflammation-associated Diseases	6
Two Decades Rituximab Therapy in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis	6
Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies	6
Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation of Mucuna pruriens for Parkinson's Disease Treatment	6
Targeted Regulation of Intracellular Signal Transduction: A New Paradigm for Stimulation of Neurogenesis in Alzheimer's Disease	6
Cellular Therapeutics for Chronic Wound Healing: Future for Regenerative Medicine	6