OOIR: Observatory of International Research

Papers

(The TQCC of Current Drug Targets is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Cell Entry and Unusual Replication of SARS-CoV-2	44
SARS-Coronavirus 2, A Metabolic Reprogrammer: A Review in the Context of the Possible Therapeutic Strategies	41
The Marburg Virus Outbreak in West Africa	37
Unfurling the Potential of Antiviral Agents Aimed for RNA Virus Ailment	35
Review on the Drug Intolerance and Vaccine Development for the Leishmaniasis	35
The Development of the Combination Drug Leukovir® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review	34
Current Research Trends in Cytokine Storm: A Scientometric Study	33
Polymeric Micelle-Based Nanogels as Emerging Drug Delivery Systems in Breast Cancer Treatment: Promises and Challenges	33
Metformin: A Promising Antidiabetic Medication for Cancer Treatment	32
Possible Applications of Azurin, a Copper-Containing Protein, in Cancer Treatment: Prospects and Challenges	30
Meet the Regional Editor	29
Betaine, a Potential Therapeutic Alternative for the Treatment of Depression	28
Xerostomia: Advances and Challenges in Drug Development	26
Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery	25
Targeted Delivery Strategies of Herbal-Based Nanogels: Advancements and Applications	24
Envisioning Glucose Transporters (GLUTs and SGLTs) as Novel Intervention against Cancer: Drug Discovery Perspective and Targeting Approach	24
Exploring the Potential Molecular Mechanisms of Berberine against Gastric Cancer Liver Metastasis Based on Network Pharmacology and Bioinformatics	23
Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review	23
Targeting Neurodegeneration: The Emerging Role of Hybrid Drugs	23
COVID-19 Induces Cytokine Storm and Dysfunctional Hemostasis	23
An Updated Insight into Phytomolecules and Novel Approaches used in the Management of Breast Cancer	22
Targets Involved in the Pharmacology of Bothrops Snakebite: Statu Quo and Future Perspectives	21
Investigating Alternative Treatments for Dyslipidemia Using Bioactive Compounds Derived from Kiwifruit (Actinidia chinensis): A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulati	21
RMNet: An RNA m6A Cross-species Methylation Detection Method for Nanopore Sequencing	20
An Overview of Research Advances in Oncology Regarding the Transcription Factor ATF4	20

An Explainable Deep Learning Model for Clathrin Protein Prediction Using a DCT-Enhanced Position-Specific Scoring Matrix	19
Diabetic Nephropathy: Pathogenesis to Cure	19
The Role of Leukocyte Immunoglobulin-Like Receptors Focusing on the Therapeutic Implications of the Subfamily B2	19
Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials	18
IL-17 Antagonists as a Promising Therapeutic Modality for Hidradenitis Suppurativa	18
ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics	17
Innovations in Antimalarial Drug Discovery: New Targets and Leads	17
Exploring the Efficient Natural Products for the Therapy of Parkinson’s Disease via Drosophila Melanogaster (Fruit Fly) Models	16
Robust Association of Breast Cancer Co-morbidity Using Subtype-specific Expressed Genes	16
A Comprehensive Insight on Pharmaceutical Co-crystals for Improvement of Aqueous Solubility	15
Transcending Molecules: Paving the Way from Lab to Life in Drug Transport Innovation	15
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing	15
Mitochondria-Targeted Nanoformulations: New Therapeutic Strategies and Opportunities for Cancer Immunotherapy	15
Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma	15
Transcription Factors in Brain Regeneration: A Potential Novel Therapeutic Target	15
Multi-target Compounds against Trypanosomatid Parasites and Mycobacterium tuberculosis	14
Prospection of Microfluidics for Local Drug Delivery	14
Phytovesicular Nanoconstructs for Advanced Delivery of Medicinal Metabolites: An In-Depth Review	13
Targeting Creatine and Creatine Kinase in Cancer: Exploring Potential Therapeutic Strategies	13
Potential Targets in Constipation Research: A Review	12
The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization	12
Multi-targeted Mechanisms of Erianin against Pancreatic Ductal Adenocarcinoma: Integrative Network Pharmacology, Bioinformatics, and Experimental Validation	12
Identification of Natural Inhibitors against the Mycobacterium tuberculosis Proteasome: Computational Study	12
Effect of Rotenone on the Neurodegeneration among Different Models	12
Signaling Dynamics in Osteogenesis: Unraveling Therapeutic Targets for Bone Generation	12
Recent Advances in the Development of Alpha-Glucosidase and Alpha-Amylase Inhibitors in Type 2 Diabetes Management: Insights from In silico to In vitro Studies	12
Recent Advances in Biomedical Applications of Mannans and Xylans	12
RAAS Overactivation and Mitochondrial Damage Signaling as Key Players in Lethal COVID-19	12
A Review on the Current Status of Homeopathy in the Clinical Manage-ment of Cancer	12
Bidirectional Communication of Estrogen in Gut-Brain Axis: Evidence from Preclinical and Clinical Studies	11
Microbial Proteases: Pioneering Tools for Modern Therapeutic Innovations	11
Novel Approaches to Diagnosing and Treating Non-alcoholic Fatty Liver Disease: Opportunities and Accomplishments	11
MiRNAs Overexpression and Their Role in Breast Cancer: Implications for Cancer Therapeutics	11
Evaluating the Biological Activities of Oleanolic Acid and Apigenin in a 2-in-1 Nanoparticulate System: A Proof-of-concept Study	11
Targeted Covalent Inhibition: A Prospective Way to Develop Novel HSP90 C-terminal Inhibitor	10
An Exploratory Review on the Hypoglycemic Action of Unani Anti-diabetic Drugs via Possible Modulation of Gut Microbiota	10
Emerging Threats and Challenges of Monkeypox Virus: Exploration and Sensitivity	10
FGMA: A Functional Group-enhanced Deep Learning Method for Drug Toxicity Prediction	10
Meet the Editorial Board Member	10
Proteasome as a Drug Target in Trypanosomatid Diseases	10
Exploring the SARS-Cov-2 Main Protease (Mpro) and RdRp Targets by Updating Current Structure-based Drug Design Utilizing Co-crystals to Combat COVID-19	10
Nanoformulations - Insights Towards Characterization Techniques	9
Advances in Understanding and Managing Alzheimer's Disease: From Pathophysiology to Innovative Therapeutic Strategies	9
Co-Crystallization: A Novel Technique to Improvise the Pharmaceutical Characteristics of API’s	9
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead	9
Statin Therapy and C-reactive Protein in Patients with Kidney Disease: A Systematic Review and Meta-analysis of Randomized Clinical Trials	9
Skin Microbial Composition and Genetic Mutation Analysis in Precision Medicine for Epidermolysis Bullosa	9
Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-analysis of Randomized Controlled Trials	8
Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment	8
Diabetic Wound Healing: Factors, Mechanisms, and Treatment Strategies Using Herbal Components	8

Vaccine for Targeted Therapy of Lung Cancer: Advances and Developments	8
Superoxide Dismutase Inhibitors against Malaria, Leishmaniasis, and Chagas Disease: Systematic Review	8
A Review of Amylin Peptide Receptor Activators for Obesity Pharmacotherapy	8
Sepsis-Associated Brain Dysfunction: Mechanisms, Clinical Insights, and Therapeutic Strategies	8
Investigating the Mechanism of Astragalus mongholicus-Mediated Treatment of Silicosis in Mice from the Perspective of Alternative Splicing	8
Acknowledgements to Reviewers	8
Precision Targeting of BET Proteins - Navigating Disease Pathways, Inhibitor Insights, and Shaping Therapeutic Frontiers: A Comprehensive Review	8
Multitarget Compounds for Neglected Diseases: A Review	8
Proteases and Osteoporosis: A Comprehensive Review of Their Role in Bone Health	8
Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy	8
Meet the Associate Editorial Board Member	8
Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy	8
Meet the Editorial Board Member	7
Differential Drug Permeability across Biofilms	7
Surface Functionalized Lipid Nanoparticles in Promoting Therapeutic Outcomes: An Insight View of the Dynamic Drug Delivery System	7
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review	7
CRISPR-Cas9 Gene Editing: Promising Therapeutics for HPV-driven Cervical Cancer	7
Long Non-coding RNAs in Non-small Cell Lung Carcinoma: Regulatory Mechanisms, Diagnostic Potential, and Therapeutic Perspectives	7
Anti-Degenerative Effect of Melatonin on Intervertebral Disc: Protective Contribution against Inflammation, Oxidative Stress, Apoptosis, and Autophagy	7
An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis	7
Systematic Identification and Characterization of Causal Risk Genes Implicated in Colorectal Cancer by Integrating GWAS, eQTL, and mQTL Data	7
Beneficial Outcomes of Cancer Therapeutic Modalities Based on Targeting Apoptosis	7
The Resurgence of H3N2 in India: Is it Life-threatening?	7